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CN-122005699-A - A Chinese medicinal composition for treating vitiligo, and its preparation method

CN122005699ACN 122005699 ACN122005699 ACN 122005699ACN-122005699-A

Abstract

The invention provides a traditional Chinese medicine composition for treating vitiligo and a preparation method thereof, and relates to the technical field of preparation of traditional Chinese medicines for treating vitiligo. The Chinese medicinal composition is divided into an external composition and an internal composition, wherein the external composition is prepared from nux vomica, cantharides, walnut skin, green persimmon, green fig, grass cream and red skin garlic according to a specific weight ratio, the internal composition is prepared from black wheat, black beans, black sesame, polygonum multiflorum and fructus psoraleae according to a specific weight ratio, and when the external composition is prepared, the external composition is fermented in a dark place and then decocted into paste, and the internal composition is fried and ground into powder. The invention fully exerts the synergistic effect of the traditional Chinese medicines by combining external application and internal administration, can effectively improve the skin leukoplakia symptoms of patients with vitiligo, has wide medicinal material sources and simple preparation process, and is suitable for popularization and application in clinic and daily treatment.

Inventors

  • ZHAO ZHE

Assignees

  • 赵哲

Dates

Publication Date
20260512
Application Date
20260320

Claims (8)

  1. 1. A Chinese medicinal composition for treating vitiligo is characterized by comprising an external composition and an internal composition; The external composition comprises, by weight, 2-4 parts of nux vomica, 2-4 parts of cantharides, 480-520 parts of walnut skin, 240-260 parts of green persimmon, 90-110 parts of green figs, 280-320 parts of grass cream and 70-90 parts of red garlic; the oral composition comprises, by weight, 1900-2100 parts of rye seeds, 900-1100 parts of black beans, 900-1100 parts of black sesame seeds, 240-260 parts of polygonum multiflorum and 140-160 parts of fructus psoraleae.
  2. 2. The traditional Chinese medicine composition for treating vitiligo according to claim 1, which comprises an external composition and an internal composition; The external composition comprises the following raw materials, by weight, 3 parts of nux vomica, 3 parts of cantharis, 500 parts of walnut skin, 250 parts of green persimmon, 100 parts of green figs, 300 parts of grass cream and 80 parts of red skin garlic; the oral composition comprises the following raw materials, by weight, 2000 parts of rye seeds, 1000 parts of black beans, 1000 parts of black sesame, 250 parts of polygonum multiflorum and 150 parts of fructus psoraleae.
  3. 3. The traditional Chinese medicine composition for treating vitiligo according to claim 1, which comprises an external composition and an internal composition; The external composition comprises the following raw materials, by weight, 2 parts of nux vomica, 2 parts of cantharides, 480 parts of walnut peel, 240 parts of green persimmon, 90 parts of green figs, 280 parts of grass cream and 70 parts of red skin garlic; The oral composition comprises the following raw materials, by weight, 1900 parts of rye seeds, 900 parts of black beans, 900 parts of black sesame, 240 parts of polygonum multiflorum and 140 parts of fructus psoraleae.
  4. 4. The traditional Chinese medicine composition for treating vitiligo according to claim 1, which comprises an external composition and an internal composition; The external composition comprises the following raw materials, by weight, 4 parts of nux vomica, 4 parts of cantharis, 520 parts of walnut skin, 260 parts of green persimmon, 110 parts of green figs, 320 parts of grass cream and 90 parts of red skin garlic; The oral composition comprises 2100 parts of rye seeds, 1100 parts of black beans, 1100 parts of black sesame, 260 parts of polygonum multiflorum and 160 parts of fructus psoraleae.
  5. 5. The method for preparing a traditional Chinese medicine composition for treating vitiligo according to claim 1, which is characterized by comprising the following steps: step S1, preparation of an external composition ① . Weighing nux vomica, cantharides, walnut peel, green persimmon, green fig, grass cream and red-skin garlic according to parts by weight, cleaning all raw materials, removing the kernels of the green persimmon and the green fig, and peeling the red-skin garlic; ② . Placing the treated raw materials into a closed vessel, placing the closed vessel filled with the raw materials in a dark and dry environment with the temperature kept at 15-25 ℃, and fermenting for 100 days; ③ . After fermentation, transferring all the raw materials in a vessel into an iron pan, adding purified water 2-3 times of the total weight of the raw materials, heating to boiling with strong fire, then continuously boiling with small fire for 2-3 hours, continuously stirring until the materials are pasty, stopping heating, and cooling to obtain external traditional Chinese medicine slurry; s2, preparation of an oral composition ① . Weighing black wheat, black beans, black sesame, polygonum multiflorum and fructus psoraleae according to parts by weight, screening all raw materials to remove impurities, cleaning and airing the surface water respectively; ② . Putting the dried raw materials into an iron pan together, and stir-frying with medium fire, wherein black wheat, black beans and black sesame are stir-fried until the surfaces are slightly yellow and fragrance overflows, and the polygonum multiflorum and the fructus psoraleae are stir-fried until the surfaces are deepened and the textures are slightly crisp, and continuously stirring the raw materials during the period to avoid local stir-frying; ③ . Cooling the fried raw materials to room temperature, then putting into a stone mill, grinding into powder, and sieving to obtain the oral Chinese medicinal powder.
  6. 6. The method for preparing a pharmaceutical composition for treating vitiligo according to claim 5, wherein in the process ② of step S1, ventilation of the vessel is performed for 1-2 hours every 20 days during fermentation, thereby ensuring normal fermentation process.
  7. 7. The method for preparing a pharmaceutical composition for treating vitiligo according to claim 5, wherein the fineness of the ground powder is 80-100 mesh in the process ③ of step S2.
  8. 8. The method of using a Chinese medicinal composition for treating vitiligo according to claims 1-7, wherein the topical Chinese medicinal slurry is applied 2-3 times a day, and each time a proper amount of the slurry is applied to the affected part of vitiligo uniformly, the thickness of the applied slurry is 0.5-1mm, and the skin of the affected part is kept clean after the application, so that friction is avoided; the oral Chinese medicinal powder is administered 3 times per day, 1 spoon per time, with warm boiled water, or mixed with porridge and soybean milk.

Description

A Chinese medicinal composition for treating vitiligo, and its preparation method Technical Field The invention relates to the technical field of preparation of traditional Chinese medicines for treating vitiligo, in particular to a traditional Chinese medicine composition for treating vitiligo and a preparation method thereof. Background Vitiligo is a common acquired pigment-deprived skin mucosa disease, has non-infectivity, has a pathogenesis which is not completely defined, and is currently generally considered to be related to various factors such as heredity, autoimmunity, oxidative stress, neuropsychiatric factors and the like. The main clinical manifestation of the disease is that one or several white patches of different sizes appear on the skin, which can occur on any part of the body, usually on exposed, rubbed and wrinkled parts such as face, neck, dorsum of hand, wrist, forearm, lumbosacral part, etc., usually without subjective symptoms, and few patients can feel slight itching in the early and progressive stages of the disease. Along with the progress of the disease, the white spot area of the vitiligo patient can be gradually enlarged and increased in number, so that the appearance and the appearance of the patient are seriously affected, and the patient is further caused to generate anxiety, depression and other bad psychological emotions, and the quality of life is reduced. In addition, vitiligo may be complicated with other diseases of body systems, such as hyperthyroidism, hypothyroidism, autoimmune polyadenopathy, diabetes mellitus, alopecia areata, etc., further increasing the physical burden of the patient. At present, the clinic treatment methods for the vitiligo mainly comprise drug treatment, phototherapy, hormone treatment, small-area skin transplantation and the like. The medicine is mainly prepared from external glucocorticoids, calcineurin inhibitors and the like, but adverse reactions such as skin atrophy, telangiectasis and the like can be caused by long-term use, phototherapy is mainly used for promoting regeneration of melanocytes through ultraviolet irradiation, the treatment period is longer, partial patients are insensitive to phototherapy, hormone treatment is suitable for patients with advanced vitiligo, the disease development can be controlled through oral administration or injection of glucocorticoids, systemic side effects such as blood sugar elevation and osteoporosis can be caused by long-term use of hormones, small-area skin transplantation is suitable for patients with small skin damage area in a stable period, certain wounds exist in operation, and the problems such as uneven pigments and transplantation failure can occur after transplantation. Because of the differences among different patient disease types (such as segmental type and non-segmental type), disease severity, disease parts and individual physique, the existing treatment methods are difficult to realize effective treatment of all patients, and part of treatment methods have the problems of large side effect, long treatment period and high cost. Therefore, research and development of a medicament for treating vitiligo, which has definite curative effect, high safety, simple preparation and low cost, becomes an urgent need in the current medical field. Disclosure of Invention (One) solving the technical problems Aiming at the defects of the prior art, the invention provides a traditional Chinese medicine composition for treating vitiligo and a preparation method thereof, and the traditional Chinese medicine composition adopts a mode of combining external use and internal use, can effectively improve the leukoplakia symptoms of patients with vitiligo, has wide medicinal material sources, simple preparation process and safe use, and can solve the problems of large side effect and unstable curative effect of the traditional treatment method. In order to achieve the above purpose, the invention is realized by the following technical scheme: a Chinese medicinal composition for treating vitiligo comprises topical composition and oral composition; The external composition comprises, by weight, 2-4 parts of nux vomica, 2-4 parts of cantharides, 480-520 parts of walnut skin, 240-260 parts of green persimmon, 90-110 parts of green figs, 280-320 parts of grass cream and 70-90 parts of red garlic; the oral composition comprises, by weight, 1900-2100 parts of rye seeds, 900-1100 parts of black beans, 900-1100 parts of black sesame seeds, 240-260 parts of polygonum multiflorum and 140-160 parts of fructus psoraleae. Further, it includes external compositions and internal compositions; The external composition comprises the following raw materials, by weight, 3 parts of nux vomica, 3 parts of cantharis, 500 parts of walnut skin, 250 parts of green persimmon, 100 parts of green figs, 300 parts of grass cream and 80 parts of red skin garlic; the oral composition comprises the following raw materials, by weight, 2000