Search

CN-122005700-A - Traditional Chinese medicine composition for treating skin inflammation and preparation method and application thereof

CN122005700ACN 122005700 ACN122005700 ACN 122005700ACN-122005700-A

Abstract

The invention discloses a traditional Chinese medicine composition for treating skin inflammation, a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises, by weight, 5-30 parts of snake slough, 5-30 parts of cortex dictamni, 10-50 parts of dark plum, 5-30 parts of cortex fraxini, 5-30 parts of lithospermum, 10-40 parts of radix isatidis, 10-40 parts of rhizoma anemarrhenae, 10-40 parts of gypsum and 5-30 parts of dyers woad leaf. The traditional Chinese medicine composition can effectively inhibit itching and inflammatory reaction caused by various dermatitis including neurodermatitis, accelerate tissue repair and healing process of burns and scalds, promote red and swollen elimination caused by mosquito bites, relieve local edema and discomfort and promote body function recovery.

Inventors

  • MA WENPING

Assignees

  • 马文平

Dates

Publication Date
20260512
Application Date
20260205

Claims (10)

  1. 1. The traditional Chinese medicine composition for treating the dermatitis is characterized by comprising, by weight, 5-30 parts of snake slough, 5-30 parts of cortex dictamni, 10-50 parts of dark plum, 5-30 parts of cortex fraxini, 5-30 parts of lithospermum, 10-40 parts of radix isatidis, 10-40 parts of rhizoma anemarrhenae, 10-40 parts of gypsum and 5-30 parts of dyers woad leaf.
  2. 2. The traditional Chinese medicine composition according to claim 1, wherein snake slough, cortex dictamni, dark plum, cortex fraxini, lithospermum, radix isatidis, rhizoma anemarrhenae, gypsum and dyers woad leaf are used as traditional Chinese medicine raw materials for ageing, and the ageing time is 3-8 years.
  3. 3. The traditional Chinese medicine composition according to claim 1, wherein the effective components in the traditional Chinese medicine composition comprise rosmarinic acid, rutin, gallic acid, caffeic acid, chlorogenic acid, shikonin a, quercetin, salvianolic acid B, acetylshikonin, alkannic acid, citric acid, quinic acid, catechin, malic acid, chlorinated mallet pigment, 7-methoxycoumarin, myricetin, aesculin, hexadecyloxycoumarin and succinic acid.
  4. 4. The method for preparing the traditional Chinese medicine composition according to any one of claims 1-3, which is characterized by comprising the steps of mixing raw materials, adding an ethanol solution, sealing and fermenting, and removing dregs to obtain the traditional Chinese medicine composition.
  5. 5. The preparation method of claim 4, wherein the mass-to-volume ratio of the bulk drug to the ethanol solution is 1g (1-5) mL.
  6. 6. The method according to claim 4, wherein the concentration of the ethanol solution is 70% -80%.
  7. 7. The method according to claim 4, wherein the fermentation temperature is 20-25 ℃, and the fermentation time is 55-65 days.
  8. 8. The method according to claim 4, wherein the step of removing the residue further comprises a step of filtering, wherein the pore size of the filter is not more than 0.22. Mu.m.
  9. 9. The use of the Chinese medicinal composition according to any one of claims 1 to 3 in the preparation of a medicament for preventing and/or treating skin inflammation or vitiligo.
  10. 10. The use according to claim 9, wherein the skin inflammation comprises neurodermatitis, stasis dermatitis, pompholyx, nummular eczema, hormone-dependent dermatitis, rash, urticaria, solar dermatitis, perioral erythema, mouth Zhou Qiuzhen, exfoliative dermatitis, chemotherapeutic dermatitis, seborrheic dermatitis, contact dermatitis, allergic dermatitis, atopic dermatitis, dermatitis caused by mosquito bites, or dermatitis caused by burns and scalds.

Description

Traditional Chinese medicine composition for treating skin inflammation and preparation method and application thereof Technical Field The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating skin inflammation, and a preparation method and application thereof. Background Skin inflammation is a clinically common skin disorder, has high incidence rate, and is easily repeatedly attacked by various causes such as stress factors, external stimulus and the like. The disease is often accompanied with uncomfortable symptoms such as itching, pain, swelling, skin damage and the like, and the patient may also cause cross infection after scratching, so that not only the daily life and the working quality are seriously affected, but also the treatment difficulty is increased. At present, the treatment medicines and schemes aiming at skin inflammation are more, but the main stream treatment means is mainly western medicines, wherein most medicines contain hormone components. Although the hormone medicine can quickly relieve symptoms such as inflammation, itch and the like in a short period, the long-term application of the hormone medicine has obvious defects that, on one hand, skin atrophy, pigmentation, immunity decline and other adverse reactions are easy to cause for long-term use, and extra injury is caused to a human body, and on the other hand, long-term dependence on hormone treatment is easy to cause drug resistance of a patient, so that the treatment effect of the medicine is gradually weakened or even completely fails, and the treatment scheme is required to be continuously adjusted, thereby increasing the burden of the patient. Besides hormone drugs, physical treatment means such as liquid nitrogen freezing are also commonly adopted in clinic, but most of the methods can only realize short-term symptom control, can not fundamentally improve the skin inflammation state, and the inflammation is easy to recur again after the skin is repaired, so that the treatment effect lacks durability. Meanwhile, the applicability of the existing therapeutic drugs is limited, most of the drugs are designed aiming at specific expression forms of skin inflammations, and the therapeutic requirements of various skin inflammations are difficult to be fully covered. Therefore, research and development of the drug-resistant medicament with small side effect and difficult generation of drug resistance can simultaneously meet the treatment requirements of various skin inflammations, and the drug-resistant medicament is a technical problem to be solved in the current field. Disclosure of Invention Therefore, the invention aims to provide the traditional Chinese medicine composition for treating the skin inflammation, which can remove inflammatory reaction, alleviate tissue edema and promote the recovery of body functions, and has good treatment effect on different types of skin inflammation such as neurodermatitis, mosquito bites, burns and scalds and the like. The invention also aims at providing a preparation method of the traditional Chinese medicine composition. The invention also aims at providing an application of the traditional Chinese medicine composition in preparing medicines for preventing and/or treating skin inflammation. In order to achieve the above object, the present invention provides the following technical solutions: the invention provides a traditional Chinese medicine composition for treating skin inflammation, which comprises, by weight, 5-30 parts of snake slough, 5-30 parts of cortex dictamni, 10-50 parts of dark plum fruit, 5-30 parts of cortex fraxini, 5-30 parts of lithospermum, 10-40 parts of radix isatidis, 10-40 parts of rhizoma anemarrhenae, 10-40 parts of gypsum and 5-30 parts of dyers woad leaf. The traditional Chinese medicine composition comprises, by weight, 10-20 parts of snake slough, 10-20 parts of cortex dictamni, 20-40 parts of dark plum, 10-20 parts of cortex fraxini, 10-20 parts of lithospermum, 15-25 parts of radix isatidis, 15-25 parts of rhizoma anemarrhenae, 15-25 parts of gypsum and 10-20 parts of dyers woad leaf. Preferably, the traditional Chinese medicine composition comprises the following raw materials of, by weight, 15 parts of snake slough, 15 parts of cortex dictamni, 30 parts of dark plum fruit, 15 parts of ash bark, 15 parts of lithospermum, 20 parts of radix isatidis, 20 parts of rhizoma anemarrhenae, 20 parts of gypsum and 15 parts of dyers woad leaf. Preferably, the snake slough, the cortex dictamni, the dark plum, the ash bark, the lithospermum, the radix isatidis, the rhizoma anemarrhenae, the gypsum and the dyers woad leaf are aged traditional Chinese medicine raw materials. Preferably, the aging time is 3-8 years. Preferably, the effective components in the traditional Chinese medicine composition comprise rosmarinic acid, rutin, gallic acid, caffeic acid, chlorogen