CN-122005704-A - Composition for repairing immune injury and preparation method and application thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a composition for repairing immune injury, and a preparation method and application thereof. The invention provides a composition for repairing immune injury, which comprises, by weight, 10-20 parts of astragalus mongholicus, 1-4 parts of schisandra chinensis, 2-6 parts of ginseng, 2-6 parts of radix ophiopogonis, 2-6 parts of dried orange peel, 2-6 parts of bitter almonds and 2-6 parts of Chinese angelica. The composition can promote the immune recovery of immunocompromised mice after chemotherapy and restore the quantity of immune cells and bone marrow cells, thereby being capable of being used for repairing the immunocompromised caused by the chemotherapy, and having good prospect in the aspects of preparing medicaments for regulating the immunity or repairing the immunocompromised and preparing health care foods for enhancing the immunity.

Inventors

• Sun Sijuan
• WANG DONG
• WANG YUMEI

Assignees

• 成都中医药大学

Dates

Publication Date

20260512

Application Date

20251110

Priority Date

20241111

Claims (10)

1. 1. The composition is characterized by comprising the following raw materials in parts by weight: 10-20 parts of astragalus membranaceus, 1-4 parts of schisandra chinensis, 2-6 parts of ginseng, 2-6 parts of radix ophiopogonis, 2-6 parts of dried orange peel, 2-6 parts of bitter apricot kernel and 2-6 parts of Chinese angelica.
2. 2. The composition according to claim 1, characterized by comprising the following raw materials in parts by weight: 15 parts of astragalus membranaceus, 2 parts of schisandra chinensis, 3 parts of ginseng, 3 parts of radix ophiopogonis, 3 parts of dried orange peel, 3 parts of bitter apricot seed and 3 parts of Chinese angelica.
3. 3. A method of preparing the composition of claim 1, comprising the steps of: step 1, weighing raw materials of astragalus, schisandra chinensis, ginseng, ophiopogon root, dried orange peel, bitter apricot seed and angelica in proportion; And 2, adding water into the raw materials for decoction, and obtaining the traditional Chinese medicine.
4. 4. Use of a composition according to claim 1 for the preparation of a medicament for modulating immunity and/or repairing immune lesions.
5. 5. The method according to claim 4, wherein the immune injury is an immune injury caused by chemotherapy.
6. 6. The method of claim 5, wherein the chemotherapy is paclitaxel therapy.
7. 7. Use of the composition of claim 1 for the preparation of a health food useful for enhancing immunity.
8. 8. A medicament comprising the composition of claim 1 as an active ingredient and pharmaceutically acceptable excipients or auxiliary ingredients.
9. 9. The medicine according to claim 8, wherein the preparation is a decoction, a paste, a granule, a capsule, a tablet, a syrup, or a pill.
10. 10. A health food which is obtained by taking the composition of claim 1 as an active ingredient and adding auxiliary materials or auxiliary ingredients acceptable in the field of health foods.

Description

Composition for repairing immune injury and preparation method and application thereof Technical Field The invention relates to the technical field of traditional Chinese medicines, in particular to a composition for repairing immune injury, a preparation method and application thereof. Background Chemotherapy is one of the common means of treating cancer, but it kills cancer cells and, at the same time, also causes damage to normal cells and the immune system. In particular, the damage to immune cells can lead to the reduction of the immunity of patients, increase the infection risk and influence the treatment effect and the life quality. With the intensive research of combining traditional Chinese medicine and western medicine for treating cancers, the effect of traditional Chinese medicine in repairing immune injury caused by chemotherapy is increasingly emphasized. Modern pharmacological studies have shown that the active ingredients in traditional Chinese medicine can repair immune injury caused by chemotherapy through various mechanisms. With further research on active ingredients and action mechanisms of traditional Chinese medicines, the actions of the traditional Chinese medicines in tumor immunotherapy are more definite, and the traditional Chinese medicines are expected to provide safer and more effective treatment options for cancer patients. Although studies have shown that a single Chinese medicine or a simple combination thereof can regulate immune response or repair immune injury caused by chemotherapy, the existing technical means are difficult to fully resolve and explain due to the complexity of the active ingredients of the Chinese medicine and the action mechanism thereof. In addition, the complexity of the compatibility of the traditional Chinese medicines has a significant influence on the curative effect. Therefore, how to perform scientific compatibility according to the primary and secondary relations of the traditional Chinese medicine components so as to achieve the expected treatment effect is a great challenge facing the current research field. Disclosure of Invention Aiming at the problems in the prior art, the invention provides a composition for repairing immune injury, a preparation method and application thereof. The invention provides a composition which comprises the following raw materials in parts by weight: 10-20 parts of astragalus membranaceus, 1-4 parts of schisandra chinensis, 2-6 parts of ginseng, 2-6 parts of radix ophiopogonis, 2-6 parts of dried orange peel, 2-6 parts of bitter apricot kernel and 2-6 parts of Chinese angelica. Preferably, the composition comprises the following raw materials in parts by weight: 15 parts of astragalus membranaceus, 2 parts of schisandra chinensis, 3 parts of ginseng, 3 parts of radix ophiopogonis, 3 parts of dried orange peel, 3 parts of bitter apricot seed and 3 parts of Chinese angelica. The invention provides a preparation method of the composition, which comprises the following steps: step 1, weighing raw materials of astragalus, schisandra chinensis, ginseng, ophiopogon root, dried orange peel, bitter apricot seed and angelica in proportion; And 2, adding water into the raw materials for decoction, and obtaining the traditional Chinese medicine. Preferably, the number of times of the decoction is 1-2 times. Preferably, the water adding and decocting process comprises adding 10 times of water for 30-40 minutes for the first time and adding 8 times of water for the second time for 30-40 minutes. The invention provides application of the composition in preparing medicines for regulating immunity and/or repairing immune injury. Preferably, the immune injury is chemotherapy-induced immune injury. Preferably, the chemotherapy is paclitaxel therapy. The invention provides application of the composition in preparing health-care food for enhancing immunity. The invention provides a medicine, which is a preparation obtained by taking the composition as an active ingredient and adding pharmaceutically acceptable auxiliary materials or auxiliary ingredients. Preferably, the preparation is decoction, paste, granule, capsule, tablet, syrup, or pill. The invention also provides a health food which is obtained by adding auxiliary materials or auxiliary components acceptable in the field of health foods into the composition serving as an active ingredient. The invention provides a prescription, which is prepared by reusing astragalus root, tonifying qi of lung and spleen to obtain resource, and by using angelica, qi and blood are both tonifying, qi is overabundant and circulation of qi is achieved, and ying and wei circulation is achieved, so that the qi and blood are not fast generated, the qi is overabundant and is fast and firm, the prescription is taken as monarch drug, ginseng is ministerial drug, and is greatly tonified to primordial qi, and helps spleen and benefit lung, so as to strengthen the qi and benefit, ophiopogon root nouris