CN-122005705-A - A Chinese medicinal herbal composition for treating pneumoconiosis and pulmonary fibrosis, and its preparation method

Abstract

The invention belongs to the technical field of Chinese herbal medicines, and in particular relates to a Chinese herbal medicine composition for treating pneumoconiosis and pulmonary fibrosis and a preparation method thereof. The traditional Chinese medicine herbal composition comprises lily, dark plum, dried orange peel, perilla, platycodon grandiflorum, poria cocos, chinese date, fried almond, donkey-hide gelatin beads, ophiopogon root, asparagus root, loquat leaf, green olive, white mustard seed, schisandra chinensis, liquorice, fried mulberry bark, fried fritillary bulb and pear flower honey. The Chinese medicinal materials are combined, so that the effects of tonifying the chest atmosphere, nourishing yin, moistening lung, regulating qi, resolving phlegm, clearing lung and benefiting diaphragm, breaking stagnation and resolving masses, releasing qi movement, astringing qi, promoting fluid production, clearing gold and dissolving water are achieved for pneumoconiosis and pulmonary fibrosis, the effects of conditioning and maintaining bowel relaxing are achieved, and the curative effects of pneumoconiosis and pulmonary fibrosis are comprehensively improved. In addition, the traditional Chinese medicine composition is a pure traditional Chinese medicine formula, has high safety and definite curative effect, and has wide application prospect in the field of prevention and treatment of occupational diseases.

Inventors

• LI BAOPING
• ZHOU YUNZHI
• WANG WENMING
• LEI JIN
• YUAN SHOUJUN
• WANG CHEN

Assignees

• 应急总医院
• 北京阳光基业医药科技有限公司

Dates

Publication Date

20260512

Application Date

20251226

Claims (10)

1. 1. A traditional Chinese medicine herbal composition for treating pneumoconiosis and pulmonary fibrosis is characterized by being prepared from, by weight, 5-12 parts of lily, 3-12 parts of dark plum, 1-6 parts of dried orange peel, 2-8 parts of perilla, 6-15 parts of platycodon grandiflorum, 3-10 parts of poria cocos, 5-12 parts of jujube, 2-8 parts of fried almond, 3-10 parts of donkey-hide gelatin beads, 5-15 parts of ophiopogon root, 5-15 parts of radix asparagi, 3-10 parts of loquat leaves, 2-8 parts of olive, 3-12 parts of white mustard seed, 2-8 parts of schisandra chinensis, 3-12 parts of radix glycyrrhizae preparata, 3-10 parts of fried mulberry bark, 5-15 parts of fried fritillary bulb and 3-12 parts of pear flower honey.
2. 2. The herbal composition for treating pneumoconiosis and pulmonary fibrosis according to claim 1, wherein the herbal composition is mainly prepared from the following raw materials, by weight, 6 parts of lily, 6 parts of dark plum, 3 parts of dried orange peel, 3 parts of perilla, 8 parts of platycodon grandiflorum, 6 parts of poria cocos, 5 parts of jujube, 3 parts of stir-fried almond, 3 parts of donkey-hide gelatin beads, 6 parts of ophiopogon root, 6 parts of radix asparagi, 3 parts of loquat leaf, 3 parts of olive, 3 parts of white mustard seed, 3 parts of shizandra berry, 6 parts of radix glycyrrhizae preparata, 8 parts of stir-fried mulberry bark, 8 parts of stir-fried fritillary bulb and 6 parts of pear flower honey.
3. 3. A method of preparing a herbal composition for the treatment of pneumoconiosis and pulmonary fibrosis as claimed in claim 1, comprising the steps of: (1) Taking lily, dark plum, dried orange peel, perilla fruit, platycodon root, poria cocos, chinese date, fried almond, donkey-hide gelatin beads, dwarf lilyturf tuber, asparagus root, loquat leaf, green olive, white mustard seed, shizandra berry, liquorice, fried mulberry bark and fried fritillary bulb according to the formula, mixing and crushing to obtain traditional Chinese medicine superfine powder; (2) Mixing the traditional Chinese medicine superfine powder with water, stirring and curing for the first time, filtering, adding pear flower honey, mixing, and stirring and curing for the second time to obtain traditional Chinese medicine liquid; (3) Sterilizing the traditional Chinese medicine liquid to obtain the traditional Chinese medicine herbal composition for treating pneumoconiosis and pulmonary fibrosis.
4. 4. The method for preparing a herbal composition for treating pneumoconiosis and pulmonary fibrosis according to claim 3, wherein the pulverizing is carried out at ultra-low temperature, and the mesh size of the superfine powder of the herbal composition is 800-1200 mesh.
5. 5. The method for preparing a herbal composition for treating pneumoconiosis and pulmonary fibrosis according to claim 3, wherein the temperature of the primary stirring and curing treatment is 70-90 ℃ for 2-6 hours.
6. 6. The method for preparing a herbal composition for treating pneumoconiosis and pulmonary fibrosis according to claim 3, wherein the primary stirring and curing treatment is carried out in a curing tank, and the external of the curing tank is connected with a colloid mill for synchronous shearing wall breaking treatment.
7. 7. The method of preparing a herbal composition for treating pneumoconiosis and pulmonary fibrosis according to any one of claims 3-6, wherein the filtration is carried out by a 200-400 mesh filter.
8. 8. The method of preparing a herbal composition for treating pneumoconiosis and pulmonary fibrosis according to any one of claims 3-6, wherein the secondary stirring and curing treatment is carried out at a temperature of 100-120 ℃ for a period of 2-6 hours.
9. 9. The method of preparing a herbal composition for treating pneumoconiosis and pulmonary fibrosis according to any one of claims 3-6, wherein the sterilization is carried out at a temperature of 105-115 ℃ for a time of 30-60 min.
10. 10. The use of the herbal composition of claim 1 or the herbal composition of any one of claims 3 to 9 in the manufacture of a medicament for the treatment of pneumoconiosis and pulmonary fibrosis, wherein the medicament is a herbal liquid oral formulation.

Description

A Chinese medicinal herbal composition for treating pneumoconiosis and pulmonary fibrosis, and its preparation method Technical Field The invention belongs to the technical field of Chinese herbal medicines, and in particular relates to a Chinese herbal medicine composition for treating pneumoconiosis and pulmonary fibrosis and a preparation method thereof. Background Pneumoconiosis is a systemic disease mainly comprising diffuse fibrosis of lung tissues caused by long-term inhalation of a large amount of dust, and the occurrence of pneumoconiosis is closely related to professional environment, and is mainly found in high-dust industries such as mines, stone processing, ceramic manufacturing and the like, and is high in incidence rate of professional diseases in China. Pneumoconiosis is a chronic and irreversible disease, once the disease is difficult to cure thoroughly, the patient often has symptoms such as dyspnea, cough, chest pain and the like along with the progress of the disease, and simultaneously has accompanying symptoms such as hypodynamia, night sweat, hemoptysis, limb edema and the like, so that the physical and mental health of the patient is seriously affected. Epidemiological characteristics of pneumoconiosis reveal the critical reality and urgency of control of this occupational disease. Pneumoconiosis has clear etiology, but its long-term and cryptic nature makes its control challenging. The pathogenesis of the disease mainly involves diffuse fibrosis of lung tissues, severely affecting lung function, leading to reduced quality of life and increased economic burden for patients. Among these, pulmonary fibrosis is the most severe and typical pathological feature of pneumoconiosis. Despite extensive research by researchers in pneumoconiosis, the incidence remains high and no drugs or measures are currently available to clearly and effectively delay or block the progression of pneumoconiosis and pulmonary fibrosis. At present, the conventional treatment means for pneumoconiosis generally comprise anti-infection intervention by adopting antibiotics, anti-inflammation by adopting glucocorticoids and theophyllines, bronchus smooth muscle expansion, high stress reaction of the airway improvement to improve the pulmonary ventilation function of patients, oxygen inhalation support treatment for patients with dyspnea and the like. The adoption of the treatment means has a certain treatment effect, but only relieves apparent symptoms of patients with pneumoconiosis, so that the patients are difficult to completely cure, the patients often have repeated or recurrent illness after stopping taking medicines, and the sensitivity of the patients to medicines is reduced and tolerance is generated after long-term medicine treatment, so that the further clinical application is limited. Along with the vigorous development of traditional Chinese medicine technology, the traditional Chinese medicine formula is paid attention to by virtue of small side effect, comprehensive effect and the like. Therefore, how to develop a traditional Chinese medicine composition for effectively preventing and treating pulmonary fibrosis and pneumoconiosis has important theoretical significance and practical significance in the field of preventing and treating occupational diseases. Disclosure of Invention In order to overcome the defects of the prior art, the invention aims to provide a traditional Chinese medicine composition for treating pneumoconiosis and pulmonary fibrosis and application thereof. The traditional Chinese medicine composition provided by the invention has a good curative effect on pneumoconiosis and pulmonary fibrosis. The etiology of traditional Chinese medicine states that in the analysis of pneumoconiosis, the interaction of internal and external factors is emphasized, and the occurrence of pneumoconiosis is considered to be the result of the combined action of internal and external factors rather than the simple external factor. From the perspective of traditional Chinese medicine, the etiology of pneumoconiosis can be summarized into the aspects of invasion of exogenous evil, physical weakness, qi stagnation and blood stasis, phlegm dampness endogenous and the like. Firstly, invasion of exogenous pathogens, namely exogenous factors of pneumoconiosis, mainly refer to productive dust existing in the environment, and the dust enters the lung through the respiratory tract to cause lung tissue damage. The traditional Chinese medicine considers that dust is taken as external evil, firstly attacks lung defensive qi to cause damage of lung qi and dysfunction of lung defensive qi, thereby affecting the clearing and dispersing functions of lung to form lung accumulation. Dust retention in the lung, long-term phlegm turbidity, qi stagnation, become the foundation for pneumoconiosis. Secondly, the physical weakness, the physical factor, plays an important role in the occurrence and development of pneumoconiosis. Th