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CN-122005711-A - Night dressing containing phellodendron composition and preparation method and application thereof

CN122005711ACN 122005711 ACN122005711 ACN 122005711ACN-122005711-A

Abstract

The application discloses a night dressing containing a phellodendron composition, and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The night dressing comprises, by weight, 30-50 parts of a yellow Bai Yao slag extract, 30-50 parts of radix sophorae flavescentis, 45-90 parts of honeysuckle, 30-50 parts of radix scutellariae, 45-60 parts of Chinese angelica, 40-60 parts of radix polygonati officinalis, and 10-15 parts of sodium hyaluronate and 40-60 parts of glycerol. The night dressing containing the phellodendron bark composition can resist and inhibit inflammation, block malignant circulation of inflammation, accelerate skin barrier repair and treat facial hormone-dependent dermatitis.

Inventors

  • REN YANRU
  • ZHANG CHAO
  • WANG LU
  • ZHANG XIAO
  • CHEN LI

Assignees

  • 山东汉方制药股份有限公司

Dates

Publication Date
20260512
Application Date
20260326

Claims (10)

  1. 1. The night dressing containing the phellodendron composition is characterized by comprising, by weight, 30-50 parts of a yellow Bai Yao slag extract, 30-50 parts of kuh-seng, 45-90 parts of honeysuckle, 30-50 parts of radix scutellariae, 45-60 parts of Chinese angelica and 40-60 parts of radix polygonati officinalis; The auxiliary materials comprise 10-15 parts of sodium hyaluronate and 40-60 parts of glycerol.
  2. 2. The night dressing containing the phellodendron composition according to claim 1, wherein the auxiliary material further comprises 1-2 parts of phenoxyethanol.
  3. 3. The night dressing containing the phellodendron bark composition according to claim 1, wherein the weight ratio of phellodendron bark residue extract to honeysuckle and angelica is 1 (1.5-1.8) (1.2-1.5).
  4. 4. The night dressing containing the phellodendron composition according to claim 1, wherein the crude drug comprises 40-50 parts of yellow Bai Yao slag extract, 40-50 parts of kuh-seng, 70-90 parts of honeysuckle, 40-50 parts of baikal skullcap root, 50-60 parts of Chinese angelica and 50-60 parts of fragrant solomonseal rhizome.
  5. 5. The night dressing containing the phellodendron bark composition according to claim 1, wherein the phellodendron bark residue extract is prepared by the steps of subjecting phellodendron bark residue to enzymolysis by cellulase and pectase, and fermenting by Saccharomyces cerevisiae and Lactobacillus plantarum.
  6. 6. A method of preparing a night dressing comprising a phellodendron composition according to any one of claims 1-5, comprising the steps of: (1) Preparation of cortex Phellodendri residue extract: a. Repeatedly washing cortex Phellodendri residue with water, drying, pulverizing, adding chitosan solution and montmorillonite powder, stirring, filtering, and collecting residue; b. adding deionized water into the collected residues, adding 0.1 mol/L citric acid-sodium citrate buffer solution to adjust the pH of the system to 4.5-5.0, adding cellulase and pectase for enzymolysis, and heating to deactivate enzyme after finishing the enzymolysis; c. filtering and collecting enzymolysis liquid after the completion, transferring the enzymolysis liquid into a fermentation tank, adding glucose, peptone and magnesium sulfate, uniformly mixing, adding 1 mol/L hydrochloric acid to adjust the pH of the system to 6.0, and then sterilizing; inoculating activated Saccharomyces cerevisiae bacteria liquid after sterilization for sealing fermentation, inoculating lactobacillus plantarum bacteria liquid after 2-4 hours for sealing fermentation for 24-48 hours, sterilizing after finishing, performing centrifugal separation, collecting supernatant, concentrating and drying to obtain cortex phellodendri slag extract; (2) Washing radix Sophorae Flavescentis, flos Lonicerae, scutellariae radix, radix Angelicae sinensis, rhizoma Polygonati Odorati, mashing, decocting with cortex Phellodendri residue extract in water, and filtering to obtain primary solution; (3) Adding water into the filtered residues again, boiling, filtering to obtain two solutions, and mixing with the primary solution to obtain a liquid medicine; (4) Mixing the medicinal liquid with adjuvant to obtain night dressing.
  7. 7. The method of preparing night dressing containing the composition of phellodendron as claimed in claim 6, wherein the chitosan solution in the step a has a concentration of 4-8wt%, and/or The addition amount of the chitosan solution is 2-4% of the mass of the yellow Bai Yao slag, and/or The addition amount of the montmorillonite powder is 1-2% of the mass of the yellow Bai Yao slag.
  8. 8. The method of preparing a night dressing containing a phellodendron composition according to claim 6, wherein the mass ratio of the collected residue to deionized water in step b is 1:12-15, and/or The mass ratio of the cellulase to the pectase is 1:0.5-1, the enzyme activity of the cellulase is more than or equal to 5000U/g, the enzyme activity of the pectase is more than or equal to 3000U/g, and/or The addition amount of the cellulase and the pectase is 1-3% of the mass of the dregs.
  9. 9. The method for preparing night dressing containing cortex Phellodendri composition as claimed in claim 6, wherein the glucose in step c is added in an amount of 2-4% of the mass of the enzymolysis solution, and/or The addition amount of peptone is 0.4-0.6% of the mass of enzymolysis liquid, and/or The addition amount of the magnesium sulfate is 0.04-0.06% of the mass of the enzymolysis liquid, and/or The total addition amount of the saccharomyces cerevisiae and the lactobacillus plantarum is 1-2% of the mass of the enzymolysis liquid, the bacterial activity of the lactobacillus plantarum is more than or equal to 10 8 CFU/g, and the bacterial activity of the saccharomyces cerevisiae is more than or equal to 10 7 CFU/g.
  10. 10. Use of a night dressing comprising a phellodendron composition according to any one of claims 1-5 or a method of preparing a night dressing comprising a phellodendron composition according to any one of claims 6-9 for the treatment of facial hormone dependent dermatitis.

Description

Night dressing containing phellodendron composition and preparation method and application thereof Technical Field The application relates to a night dressing containing a phellodendron composition, and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. Background Facial hormone-dependent dermatitis is a facial inflammatory disease caused by long-term improper external hormone medicines or hormone-containing skin care products, western medicine routinely relieves dependence by gradually reducing hormone intensity or frequency, but symptoms rebound occur after about 70% of patients stop taking the medicines, and the traditional Chinese medicine adopts medicines with heat-clearing and detoxifying effects such as phellodendron and the like as external medicines for treatment, for example, patent CN105796851A discloses a traditional Chinese medicine composition for treating hormone-dependent dermatitis, wherein the raw materials of the traditional Chinese medicine composition comprise glossy privet fruit, wild chrysanthemum, cortex dictamni, campsis grandiflora, oldenlandia diffusa, pearl lotus, radix sophorae flavescentis, lithospermum, white leaf, herba lycopodii, duckweed, radix asparagi, radix puerariae, caulis sargentgloryvine stem, chinese fevervine root, coptis, chinese brake herb, shrubalthea flower, cortex phellodendri, herba polygoni, and liquorice, but the transdermal efficiency of the cortex phellodendri composition used in the prior art is low, and the curative effect is limited. In addition, the treatment of the phellodendron bark dregs is mainly discarded, which is easy to cause resource waste and pollution, and because the phellodendron bark dregs still contain active ingredients, the phellodendron bark dregs are necessary to be extracted for the second time and are compatible with other traditional Chinese medicine ingredients, so that the combined medicine with high curative effect for treating the facial hormone-dependent dermatitis is obtained. Disclosure of Invention The night dressing containing the phellodendron composition can resist inflammation and inhibit bacteria, block inflammation malignant circulation, accelerate skin barrier repair and treat facial hormone-dependent dermatitis. According to a first aspect of the application, the application provides a night dressing containing a phellodendron composition, which comprises raw materials and auxiliary agents, wherein the raw materials comprise, by weight, 30-50 parts of a yellow Bai Yao slag extract, 30-50 parts of kuh-seng, 45-90 parts of honeysuckle, 30-50 parts of scutellaria baicalensis, 45-60 parts of angelica sinensis and 40-60 parts of polygonatum odoratum; The auxiliary materials comprise 10-15 parts of sodium hyaluronate and 40-60 parts of glycerol. According to the night dressing containing the phellodendron bark composition for treating the face hormone-dependent dermatitis, phellodendron bark dregs extract, kuh-seng, honeysuckle, baical skullcap root, chinese angelica, fragrant solomonseal rhizome and the like are adopted as raw material medicines to prepare the night dressing containing the phellodendron bark composition for treating the face hormone-dependent dermatitis, the components are matched with each other, and the night dressing has the effects of clearing heat, drying dampness, purging pathogenic fire and removing toxin, meanwhile, the components such as the Chinese angelica, the fragrant solomonseal rhizome and the like can supplement skin body fluid due to rapid loss of skin moisture at night, and the components such as the dry and desquamation of a patient suffering from the hormone-dependent dermatitis can balance the bitter and cold property of phellodendron bark and the kuh-seng, so that the serious dryness is avoided, and the curative effect on the face hormone-dependent dermatitis is remarkable. The sodium hyaluronate is used as a medicine carrier, so that the dressing is molded and is easy to smear, and the glycerol is used as a humectant to assist in improving skin dryness and enhancing the night repair effect. Cortex Phellodendri, has effects of clearing heat and eliminating dampness, purging pathogenic fire and removing toxic substances, and relieving deficiency heat, and can be used for treating damp-heat dysentery, jaundice, leukorrhagia, pyocutaneous disease, toxic swelling, yin deficiency, and excessive fire. Kuh-seng is bitter in taste, cold in nature, enters heart, liver, stomach, large intestine and bladder meridian, and has the effects of clearing heat and drying dampness, killing parasites and relieving itching, cooling blood and stopping bleeding. The honeysuckle has the effects of clearing heat and detoxicating, resisting bacteria and diminishing inflammation, dispelling wind and heat, cooling blood and stopping dysentery and the like, and is mainly used for treating diseases such as wind-heat type common cold, carbuncle and