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CN-122005712-A - Preparation method of traditional Chinese medicine gel emplastrum for relieving ulcerative colitis

CN122005712ACN 122005712 ACN122005712 ACN 122005712ACN-122005712-A

Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a preparation method of traditional Chinese medicine gel plaster for relieving ulcerative colitis. The invention provides a traditional Chinese medicine gel plaster for relieving ulcerative colitis, which is prepared from the following raw materials of coptis chinensis, radix sophorae flavescentis, rhizoma bletillae, garden burnet, stir-fried bighead atractylodes rhizome and purslane; the preparation method of the fried bighead atractylodes rhizome comprises the steps of removing impurities from bighead atractylodes rhizome, cleaning and moistening thoroughly, cutting into 2-4 mm bighead atractylodes rhizome slices, preheating a frying container to 110-130 ℃, adding a frying medium, stir-frying with slow fire until the surface of bighead atractylodes rhizome is light yellow and has burnt fragrance, taking out the medium, screening out the medium, and cooling to room temperature. The invention realizes double leaps of transdermal absorption efficiency and stability of the medicine, and provides core support for long-acting and stable curative effect of the traditional Chinese medicine gel plaster.

Inventors

  • REN JIANHONG
  • SHI YING

Assignees

  • 乾县中医医院

Dates

Publication Date
20260512
Application Date
20260317

Claims (10)

  1. 1. A traditional Chinese medicine gel plaster for relieving ulcerative colitis is characterized in that, The active ingredients of the traditional Chinese medicine gel plaster are prepared from coptis chinensis, kuh-seng, rhizoma bletillae, garden burnet, stir-fried bighead atractylodes rhizome and purslane; the preparation method of the stir-fried bighead atractylodes rhizome comprises the steps of removing impurities from bighead atractylodes rhizome, cleaning and moistening thoroughly, cutting into 2-4 mm bighead atractylodes rhizome slices, preheating a stir-frying container to 110-130 ℃, adding a stir-frying medium, stir-frying with slow fire until the surface of bighead atractylodes rhizome is light yellow and has burnt fragrance, taking out the stir-fried medium, screening out, and cooling to room temperature.
  2. 2. The traditional Chinese medicine gel plaster according to claim 1, wherein the stir-frying medium comprises rice bran, rice hull carbon and dried orange peel powder in a mass ratio of 4-6:2-4:1-3.
  3. 3. The traditional Chinese medicine gel plaster according to claim 1, wherein the mass ratio of the bighead atractylodes rhizome slices to the stir-fried medium is 100:10-15.
  4. 4. The traditional Chinese medicine gel patch according to claim 2, wherein, The grain size of the rice hull carbon is 100-120 meshes; The dried orange peel powder is prepared by crushing dried orange peel and sieving the crushed dried orange peel with a 80-100 mesh sieve.
  5. 5. The traditional Chinese medicine gel plaster according to claim 1, wherein the active ingredients of the traditional Chinese medicine gel plaster are prepared from the following raw materials, by weight, 8-15 parts of coptis chinensis, 10-20 parts of radix sophorae flavescentis, 6-12 parts of rhizoma bletillae, 8-16 parts of garden burnet, 12-25 parts of fried bighead atractylodes rhizome and 15-30 parts of purslane.
  6. 6. The traditional Chinese medicine gel plaster according to claim 5, wherein the active ingredients of the traditional Chinese medicine gel plaster are prepared from the following raw materials, by weight, 12 parts of coptis chinensis, 15 parts of radix sophorae flavescentis, 9 parts of rhizoma bletillae, 12 parts of garden burnet, 18 parts of stir-fried bighead atractylodes rhizome and 22 parts of purslane.
  7. 7. A method of preparing the traditional Chinese medicine gel patch of any one of claims 1-6, comprising the steps of: Pulverizing the raw materials, sieving with a 60-80 mesh sieve to obtain fine powder of the raw materials, uniformly mixing the fine powder of the raw materials to obtain composite medicine fine powder, adding 70-80% ethanol, reflux-extracting for 2 times each time for 1.5-2.5 h, combining the extracting solutions, concentrating under reduced pressure to obtain an extract with the relative density of 1.15-1.25, vacuum-drying, pulverizing, sieving with a 100-120 mesh sieve to obtain active dry powder of the traditional Chinese medicine; Mixing 3-5 parts of carbomer 940, 1-2 parts of sodium alginate, 2-4 parts of hydroxypropyl methyl cellulose, 15-20 parts of glycerol and 8-12 parts of propylene glycol according to parts by weight, adding 80-100 parts of deionized water, stirring at room temperature until the carbomer is fully swelled, and adding 0.5-1.0 part of triethanolamine to adjust the pH to 6.5-7.5 to obtain a blank gel matrix; Mixing the traditional Chinese medicine active dry powder with a blank gel matrix according to a mass ratio of 1:4-6, adding 0.3-0.5 part of permeation enhancer and 0.1-0.2 part of preservative, stirring at a constant temperature of 35-45 ℃ for 30-40 min, then performing ultrasonic degassing for 15-20 min, and homogenizing to obtain a uniform composite paste; And uniformly coating the composite paste on a medical non-woven fabric backing layer, wherein the coating amount is 0.2-0.3 g per square centimeter, standing for 12-16 hours at room temperature for curing, covering a polysiloxane anti-sticking layer, and cutting according to specifications to obtain the traditional Chinese medicine gel paste.
  8. 8. The method of claim 7, wherein the penetration enhancer comprises eucalyptus oil, chitosan oligosaccharide and laurocapram in a mass ratio of 0.8-1.2:0.8-1.2:1.8-2.2, and the preservative is ethylparaben.
  9. 9. The method according to claim 7, wherein the reflux extraction temperature is 75-85 ℃, the vacuum degree of reduced pressure concentration is-0.08 to-0.095 MPa, and the vacuum drying temperature is 50-60 ℃.
  10. 10. Use of a traditional Chinese medicine gel patch according to any one of claims 1-6 for the preparation of a medicament for the alleviation of ulcerative colitis, characterized in that said medicament is acting by application to the shenque acupoint, guan Yuanxue and/or to the zu-sanli acupoint.

Description

Preparation method of traditional Chinese medicine gel emplastrum for relieving ulcerative colitis Technical Field The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a preparation method of traditional Chinese medicine gel plaster for relieving ulcerative colitis. Background Ulcerative colitis is a chronic nonspecific inflammatory disease of intestinal tract with a not completely defined etiology, and the lesions are mainly limited to the mucous membrane and submucosa of the large intestine, and clinically represent symptoms such as diarrhea, mucopurulent bloody stool, abdominal pain and the like which are continuously or repeatedly attacks, so that the life quality of patients is seriously affected. In recent years, the incidence rate of the traditional Chinese medicine is on the rising trend on the global scale, and the traditional Chinese medicine has become one of the difficult and complicated symptoms of the digestive system. At present, medicines such as an aminosalicylic acid preparation, glucocorticoid, an immunosuppressant and the like are mainly adopted for treating ulcerative colitis by Western medicine, and although symptoms can be relieved to a certain extent, the medicines have the problems of large side effect, easiness in recurrence, poor long-term use tolerance and the like. For example, chronic use of glucocorticoids may cause adverse reactions such as osteoporosis, hypertension, diabetes, etc., and immunosuppressants may cause serious complications such as infection, myelosuppression, etc. Therefore, searching for a safe and effective therapeutic method with little side effects is a hotspot of current research. The traditional Chinese medicine has unique advantages in the aspect of treating ulcerative colitis, and can effectively improve clinical symptoms of patients, regulate intestinal microecological balance and promote intestinal mucosa repair through overall conditioning and dialectical treatment. The external plaster of the traditional Chinese medicine is used as one of the important dosage forms of the traditional Chinese medicine, and has the advantages of convenient use, direct effect of the medicine on the affected parts, gastrointestinal tract irritation avoidance and the like. However, the existing traditional Chinese medicine plaster still has defects in the aspects of transdermal absorption efficiency, stability, curative effect and the like. Disclosure of Invention The invention aims to overcome the defects of the prior art, and the traditional Chinese medicine gel plaster for relieving ulcerative colitis is prepared with good stability by optimizing the traditional Chinese medicine formula and improving the transdermal absorption effect of the medicine. In order to achieve the above purpose, the technical scheme of the invention is as follows: in one aspect, the invention provides a traditional Chinese medicine gel plaster for relieving ulcerative colitis, The active ingredients of the traditional Chinese medicine gel plaster are prepared from coptis chinensis, kuh-seng, rhizoma bletillae, garden burnet, stir-fried bighead atractylodes rhizome and purslane; the preparation method of the stir-fried bighead atractylodes rhizome comprises the steps of removing impurities from bighead atractylodes rhizome, cleaning and moistening thoroughly, cutting into 2-4 mm bighead atractylodes rhizome slices, preheating a stir-frying container to 110-130 ℃, adding a stir-frying medium, stir-frying with slow fire until the surface of bighead atractylodes rhizome is light yellow and has burnt fragrance, taking out the stir-fried medium, screening out, and cooling to room temperature. Preferably, the stir-frying medium consists of rice bran, rice hull carbon and dried orange peel powder in a mass ratio of 4-6:2-4:1-3. Preferably, the mass ratio of the bighead atractylodes rhizome slices to the stir-fried medium is 100:10-15. Preferably, the grain size of the rice hull carbon is 100-120 meshes; The dried orange peel powder is prepared by crushing dried orange peel and sieving the crushed dried orange peel with a 80-100 mesh sieve. Preferably, the active ingredients of the traditional Chinese medicine gel plaster are prepared from the following raw materials, by weight, 8-15 parts of coptis chinensis, 10-20 parts of radix sophorae flavescentis, 6-12 parts of rhizoma bletillae, 8-16 parts of garden burnet, 12-25 parts of fried bighead atractylodes rhizome and 15-30 parts of purslane. More preferably, the active ingredients of the traditional Chinese medicine gel plaster are prepared from the following raw materials, by weight, 12 parts of coptis chinensis, 15 parts of radix sophorae flavescentis, 9 parts of rhizoma bletillae, 12 parts of garden burnet, 18 parts of stir-fried bighead atractylodes rhizome and 22 parts of purslane. In another aspect, a method for preparing the traditional Chinese medicine gel plaster of the invention is provid