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CN-122005715-A - Ginseng and gastrodia elata orally disintegrating tablet as well as preparation method and application thereof

CN122005715ACN 122005715 ACN122005715 ACN 122005715ACN-122005715-A

Abstract

The invention discloses a ginseng gastrodia elata orally disintegrating tablet, a preparation method and application thereof, wherein the ginseng gastrodia elata orally disintegrating tablet comprises, by mass, 5-10% of cross-linked carboxymethyl saponin sodium polysaccharide and 90% -95% of fresh ginseng and gastrodia elata active freeze-dried powder, and the fresh ginseng and gastrodia elata active freeze-dried powder takes fresh ginseng and fresh gastrodia elata as raw materials in a mass ratio of (1:5) - (5:1). The ginseng and gastrodia elata orally disintegrating tablet disclosed by the technical scheme of the invention can improve the utilization value of ginseng and gastrodia elata, is convenient to take or eat so as to meet the needs of specific people, and can be used for relieving headache.

Inventors

  • XU CONGLI
  • ZHANG JIAQIU
  • CHENG LIHONG

Assignees

  • 通化鑫业生物科技研发有限公司

Dates

Publication Date
20260512
Application Date
20260214

Claims (11)

  1. 1. An orally disintegrating tablet of ginseng and gastrodia tuber is characterized by comprising 5-10% of cross-linked carboxymethyl saponin rice polysaccharide sodium and 90% 95% Of fresh ginseng and gastrodia elata active freeze-dried powder, wherein the fresh ginseng and gastrodia elata active freeze-dried powder takes fresh ginseng and gastrodia elata as raw materials in a mass ratio of (1:5) - (5:1).
  2. 2. The ginseng and gastrodia elata orally disintegrating tablet according to claim 1, characterized in that the weight content of ginsenoside Rg1 in the fresh ginseng and gastrodia elata active freeze-dried powder is more than 1%.
  3. 3. The ginseng gastrodia elata orally disintegrating tablet according to claim 1, wherein the crosslinked carboxymethyl saponated rice polysaccharide sodium is prepared by the following method: Dispersing the saposhnikovia polysaccharide in an organic solvent to form an emulsion, wherein the mass percentage of the saposhnikovia polysaccharide is 35% 45%; Adding 15% of emulsion mass to the emulsion 20% Of sodium-containing alkaline substance and 0.1% of spinach by mass 0.15% Of a cross-linking agent, pre-treatment being carried out at a first temperature; Adding 15% of emulsion mass into the pretreated system 20% Of a carboxymethylation reagent, and carrying out carboxymethylation reaction at a second temperature; Neutralizing and filtering the reacted system in turn, and washing the obtained filter cake; drying at a third temperature to obtain the cross-linked sodium carboxymethyl saponaria polysaccharide.
  4. 4. A ginseng gastrodia elata orally disintegrating tablet according to claim 3, characterized in that the organic solvent comprises ethanol and the washing liquid used in washing the filter cake comprises ethanol.
  5. 5. A ginseng gastrodia elata orally disintegrating tablet according to claim 3, characterized in that the sodium-containing alkaline substance comprises sodium hydroxide, the cross-linking agent comprises epichlorohydrin, and the carboxymethylation agent comprises chloroacetic acid.
  6. 6. The ginseng gastrodia elata orally disintegrating tablet according to claim 3, wherein the first temperature is 30 40 ℃, The pretreatment time is 15 DEG C 30Min, the second temperature is 50 60 ℃, The time of the carboxymethylation reaction is 2 DEG C 3H, the third temperature is 40 55°C。
  7. 7. A preparation method of ginseng gastrodia elata orally disintegrating tablet is characterized by comprising the following steps: The mass percentage is 90 percent Mixing 95% of fresh ginseng and gastrodia elata active freeze-dried powder with 5-10% of cross-linked carboxymethyl saponin sodium rice polysaccharide by mass percent to form a mixture, wherein the fresh ginseng and gastrodia elata active freeze-dried powder takes fresh ginseng and gastrodia elata as raw materials in a mass ratio of (1:5) - (5:1); the weight ratio of the mixture to water is 1 (1) 5) Mixing to obtain active freeze-dried powder suspension of fresh ginseng and gastrodia tuber; And performing a second freeze drying process on the active freeze-dried powder suspension of the fresh ginseng and the gastrodia elata.
  8. 8. The method for preparing an orally disintegrating tablet of ginseng and gastrodia elata according to claim 7, characterized in that the second freeze-drying process comprises: Cooling the active freeze-dried powder suspension of the fresh ginseng and the gastrodia elata to be cooled 60~ 70 ℃ And maintained for 1-2 hours; maintaining the temperature of the active freeze-dried powder suspension of fresh ginseng and gastrodia elata at the same time 20~ 25 ℃ Until the frozen ice in the active freeze-dried powder suspension of the fresh ginseng and the gastrodia elata is sublimated; heating the active freeze-dried powder suspension of fresh ginseng and gastrodia elata after sublimating frozen ice to 25 At 35 ℃ and maintained until lyophilization is complete.
  9. 9. The method for preparing orally disintegrating tablet of ginseng and gastrodia elata according to claim 7, characterized in that the method for preparing the active freeze-dried powder of fresh ginseng and gastrodia elata comprises the following steps: At 25 Extracting the cleaned and crushed fresh ginseng and fresh gastrodia elata by taking water as an extraction solvent at the temperature of 35 ℃, wherein the mass ratio of the fresh ginseng to the fresh gastrodia elata is (1:5) - (5:1); At 8000 Separating under 25000 rpm centrifugal force to obtain separated liquid; Concentrating the separation liquid to obtain a concentrated liquid; the concentrated solution is subjected to a first freeze drying process to obtain active freeze-dried powder of the fresh ginseng and the gastrodia elata, wherein the weight of the active freeze-dried powder of the fresh ginseng and the gastrodia elata is 10 percent of the total dry weight of the fresh gastrodia elata participated in by a fresh person 15%, Wherein the weight content of ginsenoside Rg1 in the fresh ginseng and gastrodia elata active freeze-dried powder is more than 1%.
  10. 10. The method for preparing orally disintegrating tablets of ginseng and gastrodia elata according to claim 9, characterized in that the first freeze-drying method comprises: cooling the concentrate to a temperature 55~ 45 ℃ And remain 3 5 Hours; maintaining the temperature of the concentrate at a temperature 20~ 25 ℃ Until the frozen ice in the concentrated solution is sublimated; heating the concentrated solution after sublimating the frozen ice to 20 33 ℃ And maintained until lyophilization is complete.
  11. 11. Use of an orally disintegrating tablet of ginseng and gastrodia elata according to any one of claims 1-6 or prepared according to the method of any one of claims 7-10 in the preparation of a medicament, food or health care product for alleviating headache.

Description

Ginseng and gastrodia elata orally disintegrating tablet as well as preparation method and application thereof Technical Field The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a ginseng gastrodia elata orally disintegrating tablet, and a preparation method and application thereof. Prior Art Headache, asthenopia and reduced cognitive function are common sub-health problems in modern society, especially in long-term use of eyes, high mental stress or middle-aged and elderly people. The traditional Chinese medicine theory holds that headache is mostly related to liver yang hyperactivity, qi and blood deficiency or phlegm dampness blocking collaterals, while 'the aim is to achieve the effect of liver resuscitation' and 'the kidney is to promote bone marrow production and to promote brain', so the effects of improving eyesight and developing intelligence are usually achieved from the aspects of tonifying qi and nourishing yin, suppressing hyperactive liver and calming endogenous wind, tonifying kidney and replenishing essence. Ginseng radix (Panax ginseng C.A. Mey.) has slightly bitter nature Wen Weigan, has effects of invigorating primordial qi, recovering pulse, relieving depletion, improving intelligence, and tranquilizing mind, and rhizoma Gastrodiae (Gastrodia elata Blume) has slightly sweet taste, enters liver channel, has good effect in calming liver, calming endogenous wind, dredging collaterals, and relieving pain, and is commonly used for treating headache, giddiness, limbs numbness, etc. Modern pharmacological research shows that ginsenoside has nerve protecting, antioxidant, memory improving, sedative, anticonvulsant, cerebral blood flow improving, and therapeutic effects on migraine and tension type headache. However, the existing commercial products are mainly prepared into capsules, oral liquid or common tablets after being extracted from dry medicinal materials, and have the problems of high loss of active ingredients, low bioavailability, poor taste, poor stability and the like. In addition, the fresh gastrodia elata has more complete active ingredient retention, but is difficult to directly apply due to high water content and easy decay. Therefore, development of a novel preparation which can keep fresh rhizoma Gastrodiae active ingredient, is convenient for storage and administration and has good efficacy is needed. Disclosure of Invention The invention aims to develop an active ginseng and gastrodia elata orally disintegrating tablet so as to improve the utilization value of the gastrodia elata, and simultaneously, the tablet is convenient to take or eat so as to meet the needs of specific people. In order to solve the technical problems, the technical proposal of the invention provides a ginseng gastrodia elata orally disintegrating tablet which comprises 5 to 10 percent of cross-linked carboxymethyl saponin rice polysaccharide sodium and 90 percent by mass percent95% Of fresh ginseng and gastrodia elata active freeze-dried powder, wherein the fresh ginseng and gastrodia elata active freeze-dried powder takes fresh ginseng and gastrodia elata as raw materials in a mass ratio of (1:5) - (5:1). The average disintegration time of the ginseng gastrodia elata orally disintegrating tablet is 1-50 seconds. Optionally, in the fresh ginseng and gastrodia elata active freeze-dried powder, the weight content of ginsenoside Rg1 is more than 1%. Alternatively, the cross-linked carboxymethyl polysaccharide sodium salt is prepared by dispersing the polysaccharide in an organic solvent to form an emulsion, wherein the mass percentage of the polysaccharide is 35%45% Of emulsion mass 15% is added to the emulsion20% Of sodium-containing alkaline substance and 0.1% of spinach by mass0.15% Of cross-linking agent, pretreating at a first temperature, adding 15% of emulsion mass into the pretreated systemAnd (3) carrying out a carboxymethylation reaction on 20% of a carboxymethylation reagent at a second temperature, sequentially neutralizing and filtering a reacted system, washing an obtained filter cake, and drying at a third temperature to obtain the crosslinked carboxymethyl saponaria alternate polysaccharide sodium. Optionally, the organic solvent comprises ethanol, and the washing liquid used for washing the filter cake comprises ethanol. Alternatively, the sodium-containing alkaline substance comprises sodium hydroxide, the crosslinking agent comprises epichlorohydrin, and the carboxymethylation reagent comprises chloroacetic acid. Optionally, the first temperature is 3040 ℃, The pretreatment time is 15 DEG C30Min, the second temperature is 5060 ℃, The time of the carboxymethylation reaction is 2 DEG C3H, the third temperature is 4055°C。 On the other hand, the invention provides a preparation method of the ginseng gastrodia elata orally disintegrating tablet, which comprises the following steps of mixing 90% by mass percentMixing 95% of f