CN-122005719-A - External traditional Chinese medicine composition for treating periodontitis and preparation method and application thereof

Abstract

The invention provides an external traditional Chinese medicine composition for treating periodontitis, a preparation method and application thereof, the external traditional Chinese medicine composition for treating periodontitis comprises dried orange peel, chicken's gizzard-skin, lophatherum gracile, dandelion, divaricate saposhnikovia root, asarum herb, peppermint, dahurian angelica root, chinese prickly ash, fructus psoraleae, eclipta alba, cuttlebone and borneol. The external traditional Chinese medicine composition for treating periodontitis has the advantages that all components of the external traditional Chinese medicine composition for treating periodontitis have synergistic effect, all the medicines are combined, the periodontal local inflammation microenvironment is synergistically improved from multiple layers, and the treatment characteristics of multi-component and multi-target comprehensive intervention of the traditional Chinese medicine on periodontitis are reflected.

Inventors

• XU XUJIE
• WANG WENLI
• WANG ZHENG

Assignees

• 嘉兴大学

Dates

Publication Date

20260512

Application Date

20260203

Claims (10)

1. 1. A topical Chinese medicinal composition for treating periodontitis is characterized by comprising dried orange peel, chicken's gizzard-skin, lophatherum gracile, dandelion, radix sileris, asarum, peppermint, radix angelicae, pepper, fructus psoraleae, eclipta alba, cuttlebone and borneol.
2. 2. The external traditional Chinese medicine composition for treating periodontitis according to claim 1, wherein the external traditional Chinese medicine composition for treating periodontitis comprises, by weight, 0.5-2 parts of dried orange peel, 1-3 parts of chicken's gizzard-skin, 0.05-2 parts of lophatherum gracile, 0.5-2 parts of fructus psoraleae, 8-12 parts of pepper, 1-3 parts of radix angelicae, 1-3 parts of peppermint, 2-4 parts of dandelion, 1-3 parts of eclipta alba, 0.5-2 parts of radix sileris, 0.5-2 parts of asarum, 0.5-1.5 parts of borneol and 1-3 parts of cuttlebone.
3. 3. The external traditional Chinese medicine composition for treating periodontitis according to claim 1, wherein the external traditional Chinese medicine composition for treating periodontitis comprises, by weight, 1-1.5 parts of dried orange peel, 1.5-2.5 parts of chicken's gizzard-skin, 0.5-1 part of lophatherum gracile, 0.5-1 part of fructus psoraleae, 9-11 parts of pepper, 1.5-2.5 parts of radix angelicae, 1.5-2.5 parts of peppermint, 2.5-3.5 parts of dandelion, 1.5-2.5 parts of eclipta alba, 1-1.5 parts of radix sileris, 1-1.5 parts of asarum, 0.8-1 part of borneol and 1.5-2.5 parts of cuttlebone.
4. 4. The external traditional Chinese medicine composition for treating periodontitis according to claim 1, wherein the external traditional Chinese medicine composition for treating periodontitis comprises, by weight, 1 part of dried orange peel, 2 parts of chicken's gizzard-skin, 1 part of lophatherum gracile, 1 part of fructus psoraleae, 10 parts of pepper, 2 parts of radix angelicae, 2 parts of peppermint, 3 parts of dandelion, 2 parts of eclipta alba, 1 part of radix sileris, 1 part of asarum, 1 part of borneol and 2 parts of cuttlebone.
5. 5. The external Chinese medicinal composition for treating periodontitis according to claim 1, further comprising an adsorbent.
6. 6. The external Chinese medicinal composition for treating periodontitis according to claim 5, wherein the adsorbent is one or both of kaolin and activated carbon.
7. 7. The external traditional Chinese medicine composition for treating periodontitis according to claim 6, wherein the adsorbent is used in an amount of 5-10 parts by weight.
8. 8. The external traditional Chinese medicine composition for treating periodontitis according to claim 7, further comprising salt, wherein the salt is used in an amount of 0.5-2 parts by weight.
9. 9. A method for preparing the external traditional Chinese medicine composition for treating periodontitis according to any one of claims 1 to 8, which is characterized in that the external traditional Chinese medicine composition for treating periodontitis is prepared by uniformly mixing the components and grinding the mixture into fine powder.
10. 10. Use of the external traditional Chinese medicine composition for treating periodontitis according to any one of claims 1-8 in preparation of a medicament for treating periodontitis.

Description

External traditional Chinese medicine composition for treating periodontitis and preparation method and application thereof Technical Field The invention relates to the technical field of traditional Chinese medicines, in particular to an external traditional Chinese medicine composition for treating periodontitis and a preparation method and application thereof. Background Periodontitis is a chronic oral inflammatory disease mainly characterized by gingivitis, periodontal support tissue destruction and alveolar bone resorption, and is clinically manifested by redness and swelling of gums, bleeding, deepening of periodontal pockets, loosening of teeth, and the like, which seriously affects the oral function and quality of life of patients. Modern medicine holds that the occurrence and development of periodontitis are closely related to persistent inflammatory response caused by dental plaque biomembrane stimulation and unbalance of host immune regulation, and are one of important reasons for tooth loss of adults. At present, the clinical treatment of periodontitis is mainly mechanical scaling and scraping combined local or systemic anti-infection treatment, and although acute inflammation can be effectively controlled, partial patients still have the problems of unstable curative effect, high recurrence rate and the like. Therefore, the exploration of safe and effective auxiliary treatment means with the multi-target comprehensive regulation and control advantages has important clinical significance. The traditional Chinese medicine has long knowledge of periodontal disease, and the traditional Chinese medicine considers that periodontitis is mainly caused by internal accumulation of pathogenic factors such as wind, fire, heat, dampness and the like, or spleen and stomach disharmony and qi-blood disharmony, and is characterized in that the traditional Chinese medicine has the effects of clearing heat and detoxicating, dispelling wind and relieving pain, astringing and inducing astringency and harmonizing viscera. At present, no report is found on an external traditional Chinese medicine composition for treating periodontitis. Disclosure of Invention In view of the above-mentioned drawbacks of the prior art, the present invention aims to provide an external traditional Chinese medicine composition for treating periodontitis, and a preparation method and application thereof, which are used for solving the problems of unstable curative effect and high recurrence rate of partial patients existing in the existing methods for treating periodontitis, mainly comprising mechanical scaling and scraping combined local or systemic anti-infection treatment. In order to achieve the above and other related objects, the invention provides an external traditional Chinese medicine composition for treating periodontitis, which is characterized by comprising dried orange peel, chicken's gizzard-skin, lophatherum gracile, dandelion, radix sileris, asarum, peppermint, radix angelicae, pepper, fructus psoraleae, eclipta alba, cuttlebone and borneol. The external traditional Chinese medicine composition for treating periodontitis has the advantages that dandelion and lophatherum gracile have the effects of clearing heat and detoxicating, relieving swelling and inflammation, reducing gingival inflammatory reaction, preventing wind, asarum and mint, dispelling wind and dredging collaterals, relieving pain and swelling, helping to relieve local discomfort around teeth, warming the middle warmer and relieving pain, reducing sensitivity of nerve endings, tonifying kidney and inducing astringency, strengthening periodontal tissues, eclipta has the effects of nourishing and anti-inflammation, facilitating tissue repair, strengthening spleen and regulating qi of dried orange peel and chicken gizzard membrane, helping transportation and resolving dampness, improving tolerance capability of organisms to inflammatory stimuli from the whole body, and enabling borneol to have aromatic resuscitation and drug introduction and penetration. The medicines are combined, the periodontal local inflammation microenvironment is synergistically improved from multiple layers, and the treatment characteristics of multi-component and multi-target comprehensive intervention periodontitis of the traditional Chinese medicine are reflected. The early clinical application shows that the external traditional Chinese medicine composition for treating periodontitis can improve clinical symptoms of periodontitis patients to a certain extent, but the molecular action mechanism of the external traditional Chinese medicine composition is not explained systematically. Along with the development of network pharmacology, the research mode of a traditional Chinese medicine compound 'multi-component-multi-target-multi-channel' synergistic action mechanism is revealed from the whole layer, and a new thought is provided for elucidating the action foundation of traditional Chi