CN-122005725-A - Traditional Chinese medicine composition, traditional Chinese medicine extract and related preparation method and application

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition, a traditional Chinese medicine extracting solution, and a related preparation method and application. The Chinese medicinal composition comprises folium Eucommiae, corni fructus, cistanchis herba, radix astragali, coicis semen, radix Angelicae sinensis, radix Codonopsis, rhizoma Polygonati, rhizoma Dioscoreae, and Glycyrrhrizae radix. Compared with the related art, in the traditional Chinese medicine composition provided by the embodiment of the invention, eucommia ulmoides She Bugan kidney and tendons and bones are strengthened, astragalus membranaceus tonifies qi and relieves arthralgia, coix seeds dehumidify and relieve arthralgia, dogwood, cistanche salsa tonify kidney yang, rhizoma polygonati and yam assist kidney yin, angelica sinensis enrich blood and dangshen tonifies qi, and liquorice harmonize various medicines, so that liver and kidney can be effectively tonified, spleen and qi are strengthened, blood circulation is promoted to remove blood stasis, articular cartilage repair is promoted, osteoarthritis related symptoms are improved, and side effects are small.

Inventors

• ZHANG LEI
• REN GUILIN
• Shi Haohang
• ZHOU XIN
• HUANG SIQIAN

Assignees

• 西南医科大学附属中医医院

Dates

Publication Date

20260512

Application Date

20260227

Claims (10)

1. 1. A Chinese medicinal composition is characterized by comprising folium cortex eucommiae, dogwood, cistanche, astragalus membranaceus, semen coicis, angelica sinensis, codonopsis pilosula, rhizoma polygonati, chinese yam and liquorice.
2. 2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising, by mass, 4-6 parts of eucommia ulmoides leaves, 5-7 parts of dogwood, 4-6 parts of cistanche deserticola, 12-18 parts of astragalus mongholicus, 12-18 parts of coix seeds, 5-7 parts of angelica sinensis, 12-18 parts of codonopsis pilosula, 6-8 parts of rhizoma polygonati, 5-7 parts of Chinese yam and 4-6 parts of liquorice.
3. 3. The traditional Chinese medicine composition according to claim 2, which is characterized by comprising, by mass, 5 parts of eucommia ulmoides leaves, 6 parts of dogwood, 5 parts of cistanche salsa, 15 parts of astragalus membranaceus, 15 parts of coix seeds, 6 parts of angelica sinensis, 15 parts of codonopsis pilosula, 7.5 parts of rhizoma polygonati, 6 parts of Chinese yam and 5 parts of liquorice.
4. 4. The traditional Chinese medicine composition according to claim 2, which is characterized by comprising, by mass, 4-5 parts of eucommia ulmoides leaves, 5-6 parts of dogwood, 4-5 parts of cistanche salsa, 12-15 parts of astragalus mongholicus, 12-15 parts of coix seeds, 6-7 parts of angelica sinensis, 15-18 parts of codonopsis pilosula, 7.5-8 parts of rhizoma polygonati, 6-7 parts of Chinese yam and 5-6 parts of liquorice.
5. 5. The traditional Chinese medicine composition according to claim 2, which is characterized by comprising, by mass, 5-6 parts of eucommia ulmoides leaves, 6-7 parts of dogwood, 5-6 parts of cistanche deserticola, 15-18 parts of astragalus mongholicus, 15-18 parts of coix seeds, 5-6 parts of angelica sinensis, 12-15 parts of codonopsis pilosula, 6-7.5 parts of rhizoma polygonati, 5-6 parts of Chinese yam and 4-5 parts of liquorice.
6. 6. A Chinese medicinal extract, which is prepared from the Chinese medicinal composition according to any one of claims 1 to 5.
7. 7. A preparation method of a traditional Chinese medicine extract is characterized by comprising the following steps: mixing the Chinese medicinal composition with water, decocting, and performing solid-liquid separation to obtain Chinese medicinal extractive solution, wherein the Chinese medicinal composition is according to any one of claims 1-5.
8. 8. The method for preparing a Chinese medicinal extract according to claim 7, further comprising, before the decocting step: Soaking the traditional Chinese medicine composition.
9. 9. The method for preparing a Chinese medicinal extract according to claim 7, wherein the decoction process comprises the steps of: Mixing the traditional Chinese medicine composition with water for first decoction treatment, and carrying out solid-liquid separation to obtain a first extract and first residues; Mixing the first residues with water for a second decoction treatment, and performing solid-liquid separation to obtain a second extract and second residues; mixing the second medicinal residue with water, performing third decoction treatment, and performing solid-liquid separation to obtain a third extract and third medicinal residue; and combining the first extract, the second extract and the third extract to obtain the traditional Chinese medicine extract.
10. 10. Use of the Chinese medicinal composition of any one of claims 1-5 in the preparation of a medicament for treating osteoarthritis.

Description

Traditional Chinese medicine composition, traditional Chinese medicine extract and related preparation method and application [ Field of technology ] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition, a traditional Chinese medicine extracting solution, and a related preparation method and application. [ Background Art ] Osteoarthritis is a chronic joint disease with articular cartilage degeneration and hyperosteogeny as main pathological characteristics, often manifested by symptoms of joint pain, stiffness, limited movement and the like, and seriously affecting the life quality of patients. Currently, western medicine is mostly used for treating osteoarthritis by adopting non-steroidal anti-inflammatory drugs and glucocorticoids, wherein the non-steroidal anti-inflammatory drugs reduce the generation of inflammatory mediator prostaglandins by inhibiting Cyclooxygenase (COX), and the glucocorticoids are used for comprehensively inhibiting inflammation and immune response by directly regulating and controlling gene expression in nuclei. Non-steroidal anti-inflammatory drugs and glucocorticoids can only inhibit inflammatory symptoms, cannot promote articular cartilage repair, and are easy to produce side effects after long-term use. [ Invention ] In order to solve the problems that the nonsteroidal anti-inflammatory drugs and the glucocorticoid can only inhibit inflammatory symptoms and can not promote articular cartilage repair, the invention provides a traditional Chinese medicine composition, a traditional Chinese medicine extract and related preparation methods and applications. The first aspect of the embodiment of the invention provides a traditional Chinese medicine composition which comprises eucommia ulmoides leaves, dogwood, cistanche salsa, astragalus membranaceus, coix seeds, angelica sinensis, codonopsis pilosula, rhizoma polygonati, chinese yam and liquorice. In some embodiments, the Chinese medicinal composition comprises, by mass, 4-6 parts of eucommia ulmoides leaves, 5-7 parts of dogwood, 4-6 parts of cistanche salsa, 12-18 parts of astragalus membranaceus, 12-18 parts of coix seeds, 5-7 parts of angelica sinensis, 12-18 parts of codonopsis pilosula, 6-8 parts of rhizoma polygonati, 5-7 parts of Chinese yam and 4-6 parts of liquorice. In some embodiments, the Chinese medicinal composition comprises, by mass, 5 parts of eucommia ulmoides leaves, 6 parts of dogwood, 5 parts of cistanche salsa, 15 parts of astragalus membranaceus, 15 parts of coix seeds, 6 parts of angelica sinensis, 15 parts of codonopsis pilosula, 7.5 parts of rhizoma polygonati, 6 parts of Chinese yam and 5 parts of liquorice. In some embodiments, the Chinese medicinal composition comprises, by mass, 4-5 parts of eucommia ulmoides leaves, 5-6 parts of dogwood, 4-5 parts of cistanche salsa, 12-15 parts of astragalus membranaceus, 12-15 parts of coix seeds, 6-7 parts of angelica sinensis, 15-18 parts of codonopsis pilosula, 7.5-8 parts of rhizoma polygonati, 6-7 parts of Chinese yam and 5-6 parts of liquorice. In some embodiments, the Chinese medicinal composition comprises, by mass, 5-6 parts of eucommia ulmoides leaves, 6-7 parts of dogwood, 5-6 parts of cistanche salsa, 15-18 parts of astragalus membranaceus, 15-18 parts of coix seeds, 5-6 parts of angelica sinensis, 12-15 parts of codonopsis pilosula, 6-7.5 parts of rhizoma polygonati, 5-6 parts of Chinese yam and 4-5 parts of liquorice. In a second aspect, the present invention provides a Chinese medicinal extract, which is prepared from the Chinese medicinal composition provided in the first aspect. A third aspect of the embodiment of the present invention provides a method for preparing a traditional Chinese medicine extract, including: mixing a traditional Chinese medicine composition with water, decocting, and performing solid-liquid separation to obtain a traditional Chinese medicine extract, wherein the traditional Chinese medicine composition is provided in the first aspect. In some embodiments, the method further comprises soaking the Chinese medicinal composition prior to the decocting. In some embodiments, the decoction process comprises the steps of: Mixing the traditional Chinese medicine composition with water for first decoction treatment, and carrying out solid-liquid separation to obtain a first extract and first residues; Mixing the first residues with water for a second decoction treatment, and performing solid-liquid separation to obtain a second extract and second residues; mixing the second medicinal residue with water, performing third decoction treatment, and performing solid-liquid separation to obtain a third extract and third medicinal residue; and combining the first extract, the second extract and the third extract to obtain the traditional Chinese medicine extract. According to a fourth aspect of the embodiment of the invention, the application of the trad