Search

CN-122005731-A - Traditional Chinese medicine composition and ointment for improving male sexual function and preparation method thereof

CN122005731ACN 122005731 ACN122005731 ACN 122005731ACN-122005731-A

Abstract

The invention discloses a traditional Chinese medicine composition and paste for improving male sexual function and a preparation method thereof, wherein the traditional Chinese medicine composition and paste are prepared from, by weight, 90-100 parts of rhizoma polygonati, 30-40 parts of medlar, 20-30 parts of angelica sinensis, 20-30 parts of pawpaw, 10-12 parts of cistanche deserticola, 9-11 parts of ginseng, 8-10 parts of calcined oyster, 5-6 parts of dogwood, 5-6 parts of fructus alpiniae oxyphyllae, 3-4 parts of walnut kernel, 3-4 parts of perilla fruit, 3-4 parts of rice sprout, 3-4 parts of raw rice sprout, 3-4 parts of poria cocos and 5-6 parts of liquorice. The traditional Chinese medicine ointment prepared by the invention is suitable for physical fitness and comprehensive improvement of male sexual functions, is suitable for long-term administration, and is safe and reliable.

Inventors

  • ZHENG GANG
  • WU ZHONGBAO
  • DU XIAOQIN
  • CHENG YAQUN

Assignees

  • 重庆市合信农业科技有限公司
  • 重庆市药物种植研究所

Dates

Publication Date
20260512
Application Date
20260410

Claims (10)

  1. 1. The traditional Chinese medicine composition for improving male sexual function is characterized by being prepared from, by weight, 90-100 parts of rhizoma polygonati, 30-40 parts of medlar, 20-30 parts of angelica sinensis, 20-30 parts of papaya, 10-12 parts of cistanche deserticola, 9-11 parts of ginseng, 8-10 parts of calcined oyster, 5-6 parts of dogwood, 5-6 parts of fructus alpiniae oxyphyllae, 3-4 parts of walnut kernel, 3-4 parts of perilla fruit, 3-4 parts of rice sprouts, 3-4 parts of raw rice sprouts, 3-4 parts of poria cocos and 5-6 parts of liquorice.
  2. 2. The use of the Chinese medicinal composition of claim 1 in the preparation of a paste for improving male sexual function.
  3. 3. A paste for improving male sexual function, comprising the Chinese medicinal composition of claim 1.
  4. 4. A method for preparing the paste for improving male sexual function according to claim 3, comprising the specific steps of: (1) Mixing radix Angelicae sinensis and fructus Chaenomelis, stirring and dispersing in deionized water, regulating pH, sterilizing, inoculating lactobacillus plantarum fungus solution, fermenting, and filtering to obtain filtrate to obtain fermentation broth; (2) Taking medlar, dogwood, fructus alpiniae oxyphyllae, walnut kernel, perilla fruit, rice sprout and raw rice sprout according to the formula, adding clear water for complete soaking, performing coupling extraction by a pulse magnetic field and ultrasonic waves under the action of magnetic nano microspheres, filtering to obtain filtrate, obtaining pre-extracted liquid medicine, and recycling the magnetic nano microspheres by using a magnet; (3) Adding the cistanche deserticola and the calcined oyster according to the formula, completely immersing in clear water, soaking for 60-70 minutes, boiling with strong fire, decocting with slow fire for 30-40 minutes, adding the Polygonatum sibiricum, the ginseng, the Poria cocos and the liquorice according to the formula, boiling with strong fire, decocting with slow fire for 40-50 minutes, filtering to obtain filtrate, cooling the filtrate, uniformly mixing the filtrate with fermentation liquor and pre-extracted liquor, and concentrating under reduced pressure to obtain the ointment.
  5. 5. The preparation method of the lactobacillus plantarum powder, which is disclosed in claim 4, is characterized in that in the step (1), the dosage of deionized water is 10-12 times of the mass of the angelica papaya powder, the volume inoculation amount of lactobacillus plantarum bacterial liquid is 1.5-2%, the pH=6.0 is adjusted by using 1mol/L citric acid solution, and the viable bacterial concentration of the lactobacillus plantarum bacterial liquid is 3×10 8 cfu/mL.
  6. 6. The preparation method of the lactobacillus plantarum bacterial liquid according to claim 4, wherein in the step (1), lactobacillus plantarum is activated and then inoculated into a sterile MRS culture medium according to the volume inoculum concentration of 3 percent, and subjected to anaerobic culture at 37 ℃ for 36 hours to obtain a culture liquid, and then the culture liquid is inoculated into the sterile MRS culture medium according to the volume inoculum concentration of 3 percent, and subjected to anaerobic culture at 37 ℃ for 24 hours to obtain the lactobacillus plantarum bacterial liquid; sterilizing at 121deg.C under 0.1MPa for 25 min; The fermentation condition is that the temperature is 30-35 ℃ and the fermentation is carried out for 55-65 hours, and the stirring is carried out every 12 hours during the fermentation, and the stirring condition is that the stirring is 200r/min and the stirring is carried out for 10 minutes.
  7. 7. The preparation method of claim 4, wherein in the step (2), the amount of the clean water and the magnetic nano-microspheres is 10-12 times and 0.1-0.2 times of the total mass of all the traditional Chinese medicine components in the step.
  8. 8. The preparation method of the magnetic nanoparticle according to claim 4, wherein in the step (2), firstly, ferric trichloride hexahydrate is dissolved in ethylene glycol, the mixture is uniformly mixed, then ammonium acetate and trisodium citrate are added, stirring is carried out for 50-60 minutes at room temperature, the mixture is transferred to an oil bath at 170-180 ℃ for stirring for 1-2 hours, heating is continued to 190-200 ℃, stirring reaction is carried out for 12-15 hours, natural cooling is carried out to room temperature, particles are obtained by filtering, washing is carried out with absolute ethyl alcohol and water in sequence, and drying is carried out for 12 hours at 50-60 ℃, wherein the dosage ratio of ferric trichloride hexahydrate, ethylene glycol, ammonium acetate and trisodium citrate is 2-3 g/80-100 mL/7-8 g/0.8-1 g.
  9. 9. The preparation method of the ultrasonic wave coupling extraction device, which is characterized in that in the step (2), the process conditions of the pulse magnetic field and the ultrasonic wave coupling extraction are that the magnetic field strength is 4-6T, the pulse number is 10-12, the pulse duration is 50-60 ms, the ultrasonic wave power is 200-300W, the frequency is 40-50 kHz, and the extraction time is 10-12 minutes.
  10. 10. The preparation method according to claim 4, wherein in the step (3), the amount of clear water is 10-12 times of the total mass of all the traditional Chinese medicine components in the step; in the step (3), the mixture is concentrated under reduced pressure until the relative density is 1.25-1.35.

Description

Traditional Chinese medicine composition and ointment for improving male sexual function and preparation method thereof Technical Field The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition and paste for improving male sexual function and a preparation method thereof. Background With the continuous improvement of life quality, males increasingly pay attention to their own health conditions, and harmony of couple relations is also receiving attention. With the increase of working pressure and living pressure in recent years, more and more patients with sexual dysfunction or sexual hypofunction diseases have become a key factor affecting harmony of couples. Patients with sexual dysfunction have a tendency to younger, accompanied by various factors such as an increase in the pace of life and irregular diet. Sexual dysfunction is clinically manifested as sexual desire disorder, impotence, premature ejaculation, spermatorrhea, non-ejaculation, retrograde ejaculation and the like, so that the patient cannot smoothly perform sexual life, the daily life of the patient is greatly disturbed, even mental health is greatly disturbed, and in severe cases, the problem of sterility can be caused. Male sexual dysfunction is mostly treated by surgery, western medicines, traditional Chinese medicines and the like. Among them, the price of the surgical treatment is high, the postoperative pain is high, and most patients do not want to select the surgical method for treatment; the traditional Chinese medicine has the advantages of less adverse reaction, suitability for long-term administration, safety, reliability, low price and the like, but the traditional Chinese medicine has single treatment effect and can not achieve the effect of treating both symptoms and root causes. Therefore, a pharmaceutical study for male sexual dysfunction is very necessary. Disclosure of Invention Accordingly, the invention aims to provide a traditional Chinese medicine composition and paste for improving male sexual function and a preparation method thereof, which are suitable for long-term administration, safe and reliable. In order to achieve the above purpose, the present invention provides the following technical solutions: The invention provides a traditional Chinese medicine composition for improving male sexual function, which is prepared from, by weight, 90-100 parts of rhizoma polygonati, 30-40 parts of medlar, 20-30 parts of angelica sinensis, 20-30 parts of papaya, 10-12 parts of cistanche salsa, 9-11 parts of ginseng, 8-10 parts of calcined oyster, 5-6 parts of dogwood, 5-6 parts of fructus alpiniae oxyphyllae, 3-4 parts of walnut kernel, 3-4 parts of perilla fruit, 3-4 parts of rice sprout, 3-4 parts of raw rice sprout, 3-4 parts of poria cocos and 5-6 parts of liquorice. The invention also provides application of the traditional Chinese medicine composition in preparing a paste for improving male sexual function. The invention also provides a paste for improving male sexual function, which comprises the traditional Chinese medicine composition. The invention also provides a preparation method of the paste for improving male sexual function, which comprises the following specific steps: (1) Mixing radix Angelicae sinensis and fructus Chaenomelis, stirring and dispersing in deionized water, regulating pH, sterilizing, inoculating lactobacillus plantarum fungus solution, fermenting, and filtering to obtain filtrate to obtain fermentation broth; (2) Taking medlar, dogwood, fructus alpiniae oxyphyllae, walnut kernel, perilla fruit, rice sprout and raw rice sprout according to the formula, adding clear water for complete soaking, performing coupling extraction by a pulse magnetic field and ultrasonic waves under the action of magnetic nano microspheres, filtering to obtain filtrate, obtaining pre-extracted liquid medicine, and recycling the magnetic nano microspheres by using a magnet; (3) Adding the cistanche deserticola and the calcined oyster according to the formula, completely immersing in clear water, soaking for 60-70 minutes, boiling with strong fire, decocting with slow fire for 30-40 minutes, adding the Polygonatum sibiricum, the ginseng, the Poria cocos and the liquorice according to the formula, boiling with strong fire, decocting with slow fire for 40-50 minutes, filtering to obtain filtrate, cooling the filtrate, uniformly mixing the filtrate with fermentation liquor and pre-extracted liquor, and concentrating under reduced pressure to obtain the ointment. Preferably, in the step (1), the dosage of deionized water is 10-12 times of the mass of the angelica papaya powder, the volume inoculation amount of lactobacillus plantarum bacterial liquid is 1.5-2%, the pH=6.0 is adjusted by using 1mol/L citric acid solution, and the viable bacteria concentration of the lactobacillus plantarum bacterial liquid is 3×10 8 cfu/mL. Preferably, in the step (1),