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CN-122005732-A - Mongolian medicine composition for treating liver-heat type hepatopathy

CN122005732ACN 122005732 ACN122005732 ACN 122005732ACN-122005732-A

Abstract

The invention relates to the technical field of Mongolian medicines, and discloses a Mongolian medicine composition for treating liver-heat type liver diseases, aiming at solving the problems that when the traditional Mongolian medicine scheme is used for treating complex diseases with liver parenchyma injury and liver and gall dysfunction, the effects of clearing liver heat and regulating hertz are not enough and are difficult to be integrally interfered, the Mongolian medicine composition provided by the invention comprises twenty medicinal materials such as kudingdan, coptis chinensis, gardenia, bistort, bear gall powder, fructus choerospondiatis, costustoot, flos caryophylli, fructus tsaoko, nutmeg and the like, the total weight proportion of the heat-clearing and detoxicating medicinal material group, the He-Yi medicinal material group and the blood-cooling and gallbladder-benefiting medicinal material group is limited, so that the whole formula realizes the synergy of liver heat clearing and qi regulating, and is prepared by adopting a sectional extraction process, the effects of protecting liver, reducing enzyme, benefiting gallbladder, removing jaundice and improving gastrointestinal functions are comprehensively exerted, and the medicine, alcoholic and nonalcoholic fatty liver injury are better comprehensively treated and safely.

Inventors

  • HUANG JIREN
  • Zhao Sarula
  • DUO LAN
  • Haobu Riqi Ge
  • Siqingtunala
  • WU RINA

Assignees

  • 鄂尔多斯市蒙医医院(鄂尔多斯市蒙医研究所)

Dates

Publication Date
20260512
Application Date
20260414

Claims (10)

  1. 1. The Mongolian medicine composition for treating the liver-heat liver disease is characterized by comprising, by weight, bunge corydalis herb, coptis chinensis, fringed pink, gardenia, trogopterus dung, safflower, dwarf lilyturf tuber, myrobalan, szechwan chinaberry fruit, red sage root, shizandra berry, liquorice, cynomorium songaricum, flos caryophylli, costustoot, tsaoko cardamom, coastal glehnia root, bistort rhizome, fructus choerospondiatis and bear gall powder; the total weight ratio of the Heyi drug to the blood cooling and cholagogic drug is 1.8-2.2:1.5-1.9:1, the Heyi drug comprises herba violae and coptis chinensis, the Heyi drug comprises fructus choerospondiatis, radix aucklandiae, flos caryophylli, fructus tsaoko and nutmeg, and the blood cooling and cholagogic drug comprises fructus gardeniae, rhizoma bistort and bear gall powder.
  2. 2. The Mongolian medicine composition for treating the liver-heat liver disease according to claim 1, wherein the Mongolian medicine composition comprises, by weight, 10-15 parts of bunge corydalis herb, 8-12 parts of coptis chinensis, 8-12 parts of fringed pink herb, 5-7 parts of cape jasmine, 2-3 parts of trogopterus dung, 3-5 parts of safflower, 3-4 parts of dwarf lilyturf tuber, 1-2 parts of myrobalan, 1-2 parts of szechwan chinaberry fruit, 3-5 parts of red sage root, 3-5 parts of shizandra berry, 6-9 parts of liquorice, 3-5 parts of cynomorium songaricum, 3-5 parts of flos caryophylli, 3-5 parts of costustoot, 2-3 parts of fructus tsaoko, 2-3 parts of nutmeg, 2-3 parts of glehnia root, 2-3 parts of bistort, 3-5 parts of fructus zizyphi spinosae and 1-2 parts of bear gall powder.
  3. 3. The Mongolian medicine composition for treating liver-heat type hepatopathy according to claim 2, wherein the Mongolian medicine composition comprises 12 parts of bunge corydalis herb, 10 parts of coptis chinensis, 10 parts of fringed pink, 6 parts of gardenia, 3 parts of trogopterus dung, 4 parts of safflower, 4 parts of dwarf lilyturf tuber, 2 parts of myrobalan, 2 parts of szechwan chinaberry fruit, 4 parts of red sage root, 4 parts of shizandra berry, 8 parts of liquorice, 4 parts of cynomorium songaricum, 4 parts of flos caryophylli, 4 parts of costustoot, 3 parts of fructus tsaoko, 3 parts of nutmeg, 3 parts of radix glehniae, 3 parts of bistort, 4 parts of fructus guangdali and 2 parts of bear gall powder.
  4. 4. The Mongolian medicine composition for treating liver-heat type hepatopathy according to claim 1, wherein the heat-clearing and detoxifying medicine consists of bunge corydalis herb and coptis chinensis, the He-Yi medicine consists of fructus choerospondiatis, elecampane, flos caryophylli, fructus tsaoko and nutmeg, and the blood-cooling and cholagogic medicine consists of fructus gardeniae, bistort and bear gall powder.
  5. 5. The Mongolian medicine composition for treating liver-heat type hepatopathy according to claim 1, wherein the total weight ratio of the heat-clearing and detoxifying medicine, the He-Yi medicine and the blood-cooling and cholagogue medicine is 2.0-2.2:1.7-1.9:1.
  6. 6. A method for preparing a Mongolian composition for treating liver disease of the cooperative liver-heat type, for preparing the Mongolian composition for treating liver disease of the cooperative liver-heat type according to any one of claims 1 to 5, comprising the steps of: s1, taking the prescription amount of herba corydalis Bungeanae, coptis chinensis, gardenia and bistort rhizome, mixing, adding 6-10 times of 60% -70% ethanol solution, heating and reflux-extracting, combining the extracting solutions, filtering and concentrating to obtain fluid extract; S2, taking the prescription amount of fructus choerospondiatis, costus root, flos caryophylli, fructus tsaoko and nutmeg, crushing, extracting volatile oil by adopting a steam distillation method, collecting the volatile oil for standby, and collecting dregs and distilled water solution for standby; s3, drying, crushing and sieving the red sage root and the safflower with the prescription amount to obtain fine powder for standby; S4, mixing the medicinal residues obtained in the step2 of prescription amount of fringed pink, dwarf lilyturf tuber, myrobalan, szechwan chinaberry fruit, chinese magnoliavine fruit, liquorice, cynomorium songaricum and north sand, adding water for decoction, mixing the water decoction with the distilled water solution obtained in the step2, filtering, and concentrating to obtain thick paste; S5, drying, crushing and sieving the trogopterus dung with the prescription amount to obtain fine powder for later use, mixing and grinding the bear gall powder with the prescription amount, beta-cyclodextrin and water, carrying out inclusion pretreatment, drying and grinding for later use; and S6, uniformly mixing the fluid extract obtained in the step S1 with the thick paste obtained in the step S4, sequentially adding the fine powder obtained in the step S3, the trogopterus dung fine powder obtained in the step S5 and the bear gall powder pretreatment, finally adding the volatile oil obtained in the step S2, uniformly mixing, preparing a soft material, and drying to obtain the finished product.
  7. 7. The method of claim 6, wherein the step of extracting the Mongolian medicine composition for treating liver-heat type hepatopathy is performed by heating and refluxing in the step S1 to 75-85 ℃ for 2 times each for 1-1.5 hours, and the step of concentrating the Mongolian medicine composition under reduced pressure to a relative density of 1.15-1.25.
  8. 8. The method of claim 6, wherein the S2 is prepared by soaking the Mongolian medicinal composition in water for 0.5h before steam distillation for 3h or more, and extracting the volatile oil with diethyl ether or petroleum ether and recovering solvent.
  9. 9. The method for preparing a Mongolian composition for treating liver-heat type hepatopathy according to claim 6, wherein the step S4 is carried out by adding water and decocting for 2-3 times by adding 8-12 times of water, each time for 1-2 hours, and the concentration is carried out by concentrating under reduced pressure until the relative density is 1.30-1.40.
  10. 10. The method for preparing a Mongolian composition for treating liver-heat type hepatopathy according to claim 6, wherein the amount of beta-cyclodextrin in S5 is 1-2 times of the weight of bear gall powder.

Description

Mongolian medicine composition for treating liver-heat type hepatopathy Technical Field The invention relates to the technical field of Mongolian medicines, in particular to a Mongolian medicine composition for treating liver-heat type hepatopathy. Background The liver heat is one of the nuclear heart disease symptoms of liver and gall system in the Mongolian medical theory, the pathological basis is that the liver heat is paced with the blood heat, the modern medicine mostly corresponds to acute and chronic liver injury caused by various factors, and is often accompanied with bile metabolic disorder and gastrointestinal dysfunction, the clinical manifestation of the disease is complex, the symptoms of liver parenchyma damage such as abnormal liver function biochemical indexes, liver region distending pain and the like can be seen, and symptoms of liver and gall qi imbalance such as anorexia, abdominal distention, dyspepsia and the like can be seen, and the treatment needs to be combined with liver heat clearing, blood cooling and liver and gall qi movement harmonizing so as to realize the integral intervention on pathological links. The traditional Mongolian medicine scheme for treating the diseases mainly comprises two types, wherein one type is a fixed proportion compound following a classical theory, medicinal materials comprise kudingchi, coptis chinensis, gardenia, fringed pink and the like, the other type is a preparation prepared by improving a classical small compound through a modern technology, for example, a Chinese patent with the publication number of CN114470062B, a Mongolian medicine comprising four medicinal materials of herba Gei, fringed pink, gardenia and picrorhiza in a fixed proportion is disclosed, the Mongolian medicine is prepared into particles through the modern technologies of leaching, concentrating, spray drying, dry granulating and the like, the purpose of enriching active ingredients and reducing cost is achieved, and for example, the Chinese patent with the publication number of CN109394818A discloses a Mongolian medicine for clearing liver heat, the raw materials comprise geniposide, crocin, fringed pink and akebia, and the like, and decoction, powder, pill or tablet are prepared after crushing, so that the problems of large dosage, poor taste and the like of the traditional Mongolian medicine are solved. However, the prior art scheme has limitations when dealing with complex diseases of liver parenchyma injury and liver and gall dysfunction, the large compound with fixed proportion is difficult to finely regulate and control the synergistic relationship among medicinal materials with different effects, while the modern process improvement of the classical small compound improves the preparation level, but the medicinal materials mainly focus on the single efficacy directions of clearing liver heat or cooling blood and the like, and the complex pathological links of the liver heat and Heryi disturbance interweaving in the theory of the Xueri liver heat are covered insufficiently in the whole, so that the deep synergy and balanced improvement of the effects of clearing liver heat and adjusting Heryi are difficult to realize. Disclosure of Invention The invention aims to solve the technical problems that when the traditional Mongolian medicine scheme is used for coping with complex diseases of liver parenchyma injury and liver and gall dysfunction, the effects of clearing liver heat and regulating Heryi are insufficient in synergy and are difficult to interfere integrally, and therefore, the Mongolian medicine composition for treating the liver disease with the syndrome of cooperative liver heat is provided. The Mongolian medicine composition for treating the liver-heat type hepatopathy of the cooperative day adopts the following technical scheme that the Mongolian medicine composition comprises bunge corydalis herb, coptis chinensis, fringed pink, gardenia, trogopterus dung, safflower, dwarf lilyturf tuber, myrobalan, szechwan chinaberry fruit, red sage root, chinese magnoliavine fruit, liquorice, cynomorium songaricum, flos caryophylli, costustoot, tsaoko cardamom, coastal glehnia root, bistort rhizome, fructus choerospondiatis and bear gall powder, and the total weight ratio of the He-regulating medicine to the blood cooling and gall-benefiting medicine is 1.8-2.2:1.5-1.9:1, wherein the He-regulating medicine comprises bunge corydalis herb and coptis chinensis, the He-regulating medicine comprises fructus zizyphi spinosae, costustoot, flos caryophylli, fructus tsaoko, nutmeg, and the blood cooling and gall-benefiting medicine comprises gardenia, bistort and bear gall powder. Preferably, the Mongolian medicine composition comprises, by weight, 10-15 parts of bunge corydalis herb, 8-12 parts of coptis chinensis, 8-12 parts of fringed pink, 5-7 parts of cape jasmine, 2-3 parts of trogopterus dung, 3-5 parts of safflower, 3-4 parts of dwarf lilyturf tuber, 1-2 parts of myrobal