CN-122005733-A - Composition with hypoglycemic activity and preparation method and application thereof

Abstract

The invention provides a composition with hypoglycemic activity, a preparation method and application thereof, and belongs to the technical field of biological medicines. The composition of the invention takes cinnamon, turmeric and red ginseng with homology of medicine and food as core raw materials, and is compounded with eggshell membrane extract, after scientific formulation by weight, the raw materials realize synergistic effect, can obviously improve the inhibition rate of alpha-glucosidase, and a hyperglycemic model rat test proves that the composition can obviously reduce the blood sugar concentration, and zebra fish tests show that the composition can obviously reduce the insulin content and the glucose level, has obvious blood sugar reducing effect, and can be effectively applied to the treatment of blood sugar reduction and diabetes. The composition has the advantages of simple components, clear constitution, high raw material safety and no toxic or side effect, effectively avoids the liver injury risk possibly caused by the combination of a plurality of traditional Chinese medicines, and greatly improves the medication safety and the compliance of patients.

Inventors

• HOU SHUQI
• LI JIA
• CHEN SHENG
• He Qizhe
• DING ZHIWEI
• HUANG JIALI
• ZHANG YAN

Assignees

• 江苏艾兰得营养品有限公司

Dates

Publication Date

20260512

Application Date

20260128

Claims (9)

1. 1. A composition with hypoglycemic activity is characterized by comprising the following raw materials of cinnamon, turmeric and red ginseng.
2. 2. The composition according to claim 1, which is composed of the following raw materials, by weight, 2-9 parts of cinnamon, 0.5-5 parts of red ginseng and 0.5-3 parts of turmeric.
3. 3. The composition of any one of claims 1-2, wherein the composition further comprises eggshell membrane extract.
4. 4. A composition according to claim 3, wherein the eggshell membrane extract is present in an amount of 0.5 to 3 parts by weight.
5. 5. The composition according to any one of claims 3 to 4, wherein the composition is composed of 2 to 9 parts by weight of cinnamon, 0.5 to 5 parts by weight of red ginseng, 0.5 to 3 parts by weight of turmeric and 0.5 to 3 parts by weight of eggshell membrane extract.
6. 6. A pharmaceutical composition comprising the composition of any one of claims 1-5.
7. 7. The pharmaceutical composition of claim 6, further comprising a pharmaceutically acceptable adjuvant or carrier.
8. 8. Use of a composition according to any one of claims 1 to 5 for the preparation of a product having hypoglycemic efficacy.
9. 9. The use according to claim 8, wherein the product comprises a pharmaceutical product, a food product or a health product.

Description

Composition with hypoglycemic activity and preparation method and application thereof Technical Field The invention belongs to the technical field of biological medicines, and particularly relates to a composition with hypoglycemic activity, and a preparation method and application thereof. Background Diabetes mellitus is taken as a global high-incidence chronic metabolic disease, and a plurality of limitations exist in the current blood sugar reducing treatment means commonly used clinically, such as the combination of multiple drugs required by oral administration, not only the adverse reaction risk is increased, but also the treatment complexity is improved, the problems of unstable absorption, poor compliance and the like are faced in insulin treatment, and the overall curative effect and convenience are urgently optimized. Therefore, the development of natural source hypoglycemic products with safety, effectiveness, high bioavailability and small side effect becomes a research hotspot in the current diabetes prevention and treatment field. Alpha-glucosidase is an intestinal cell membrane enzyme whose main physiological role is to hydrolyze polysaccharides, and thus, controlling the activity of alpha-glucosidase is an effective method of treating pre-diabetic patients and alleviating symptoms of diabetes. The Chinese herbal medicine has remarkable effect in preventing and treating various chronic complications of diabetes, and because the safety and multiple effects of the Chinese herbal medicine are concerned, various medicinal and edible food materials and natural extracts are proved to have potential hypoglycemic activity. The active ingredients such as cinnamaldehyde and cinnamic acid in cinnamon can assist in regulating blood sugar by improving insulin sensitivity, inhibiting carbohydrate absorption and other mechanisms, clinical researches prove that the active ingredients can obviously reduce fasting blood sugar and glycosylated hemoglobin level of diabetics, curcumin in turmeric has anti-inflammatory and antioxidant effects, can improve insulin resistance and indirectly regulate sugar metabolism balance, and red ginseng is used as a traditional rare traditional Chinese medicine, and the ingredients such as ginsenoside contained in the red ginseng can promote insulin secretion, improve islet beta cell function and play an important role in regulating blood sugar. Modern researches show that eggshell membrane is rich in active ingredients such as collagen, fibronectin and the like, and the extract and enzymolysis products thereof have various physiological functions such as blood sugar reduction, anti-inflammation, antioxidation and the like, have the advantages of low allergy and high biosafety, and have great application potential in the fields of foods and medicines. Although the single hypoglycemic activity of the extracts of cinnamon, red ginseng, turmeric and eggshell membrane is partially verified, the single substance has limited effect, is difficult to meet the requirement of complex blood sugar regulation, has not been reported in the prior art on reasonable compatibility of the raw materials and synergistic hypoglycemic effect, and meanwhile, the traditional Chinese medicine formula has wider application in the hypoglycemic field, but the traditional Chinese medicine formula has the problem of complex components, so that the traditional Chinese medicine formula has the problems of fuzzy core action mechanism, large quality control difficulty, and increases the production and processing cost and the potential safety hazard of medicine application, the curative effect of the traditional Chinese medicine is not simple superposition of the component quantity, and the targeted synergy is easier to realize through scientific and simplified compatibility. Based on the hypoglycemic mechanism and the action complementarity of the raw materials, the invention abandons complex components, only three medicinal materials of cinnamon, red ginseng and turmeric are matched with eggshell membrane extracts or accurately, and the synergistic effect among the components is realized through scientific formula, so that the hypoglycemic effect can be improved, the dosage of a single component can be reduced, the safety and the functionality of medication can be considered, the complex technical defects of the traditional compound components are overcome due to simple components and clear constitution, a brand new natural hypoglycemic selection is provided for diabetics, and the development of the composition with the synergistic hypoglycemic activity has important practical significance and application value. Disclosure of Invention In order to solve the existing problems, the invention optimizes and combines the hypoglycemic composition prepared from cinnamon, red ginseng and turmeric on the basis of combining modern pharmaceutical scientific research literature, and combines eggshell membrane extracts, ther