CN-122005738-A - Traditional Chinese medicine composition and application thereof in preparation of medicines for treating atherosclerosis

Abstract

The invention provides a traditional Chinese medicine composition and application thereof in preparing medicines for treating atherosclerosis, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises, by mass, 8-10 parts of Guangxi curcuma zedoary, 8-12 parts of peach kernels, 8-12 parts of cassia twig, 8-12 parts of poria cocos, 25-35 parts of raw astragalus mongholicus, 8-12 parts of cortex moutan, 8-12 parts of red paeony root, 10-20 parts of fructus crataegi, 10-15 parts of herba lycopi and 25-35 parts of oyster. The traditional Chinese medicine composition can improve the pathological changes of atherosclerosis, reduce the blood lipid level and reduce the generation of atheromatous plaques, thereby improving atherosclerosis, and simultaneously has the functions of resisting AS in the aspects of stabilizing vulnerable plaques, promoting reverse cholesterol transport, regulating mitochondrial energy metabolism and water metabolism, resisting inflammation and resisting oxidative stress.

Inventors

• HAO ERWEI
• DENG JIAGANG
• HOU XIAOTAO
• DU ZHENGCAI
• HUANG YUCHAN
• XIE JINLING
• WU HANGXUAN

Assignees

• 广西中医药大学

Dates

Publication Date

20260512

Application Date

20260409

Claims (10)

1. 1. The traditional Chinese medicine composition is characterized by comprising the following raw material components in parts by weight: 8-10 parts of Guangxi curcuma zedoary, 8-12 parts of peach kernel, 8-12 parts of cassia twig, 8-12 parts of poria cocos, 25-35 parts of raw astragalus membranaceus, 8-12 parts of cortex moutan, 8-12 parts of red paeony root, 10-20 parts of Guangxi hawthorn, 10-15 parts of herba lycopi and 25-35 parts of oyster.
2. 2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw material components in parts by mass: 9-11 parts of Guangxi curcuma zedoary, 9-11 parts of peach kernel, 9-11 parts of cassia twig, 9-11 parts of poria cocos, 28-32 parts of raw astragalus membranaceus, 9-11 parts of tree peony bark, 9-11 parts of red paeony root, 14-18 parts of Guangxi hawthorn, 12-14 parts of herba lycopi and 28-32 parts of oyster.
3. 3. The traditional Chinese medicine composition according to claim 1, wherein the dosage form of the traditional Chinese medicine composition comprises a solution.
4. 4. The method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 3, comprising the following steps: (1) Mixing Curcumae rhizoma, semen Persicae, ramulus Cinnamomi, poria, radix astragali, cortex moutan, radix Paeoniae Rubra, fructus crataegi and herba Lycopi, soaking in water to obtain pretreated mixed medicinal materials; (2) And (3) decocting soaked oyster for 15-25 min, adding the pretreated mixed medicinal material obtained in the step (1), and performing secondary decoction to obtain the traditional Chinese medicine composition.
5. 5. The preparation method of claim 4, wherein the water in the step (1) is added in an amount 5-10 times the total mass of the mixed medicinal materials.
6. 6. The method according to claim 4, wherein the soaking temperature in the step (1) is 20-30 ℃, and the soaking time is 25-35 min.
7. 7. The method according to claim 4, wherein the soaked oyster in the step (2) is obtained by soaking oyster in water 5-10 times of the oyster in mass of the oyster for 25-35 min.
8. 8. The preparation method according to claim 4, wherein the temperature of the decoction in the step (2) is 80-120 ℃, and the time of the decoction is 18-22 min.
9. 9. The preparation method according to claim 4, wherein the temperature of the secondary decoction in the step (2) is 80-120 ℃, and the time of the secondary decoction is 25-35 min.
10. 10. The use of a Chinese medicinal composition according to any one of claims 1-3 in the preparation of a medicament for treating atherosclerosis.

Description

Traditional Chinese medicine composition and application thereof in preparation of medicines for treating atherosclerosis Technical Field The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition and application thereof in preparing medicines for treating atherosclerosis. Background Atherosclerosis (AS) is one of the common diseases of cardiovascular diseases. The traditional Chinese medicine belongs to atherosclerosis with symptoms of blood stasis, phlegm, apoplexy, chest obstruction and the like. The pathogenesis of AS is considered AS the deficiency of the root and the excess of the cause are stasis and phlegm. The "blood stasis" substantially includes pathological changes such AS AS plaque formation, thrombosis, hypercoagulability of blood, and hyperlipidemia. Lipid metabolism abnormalities are known in the traditional Chinese medicine to be an important factor in the formation of AS. The pathogenesis of lipid metabolism is that the water-dampness is not transformed and the turbid phlegm is the disease, and viscera dysfunction is mostly caused by diet, daily life, emotion, congenital endowment and the like, so the treatment is carried out by adopting a method of activating blood and inducing diuresis. In the prior art, a traditional Chinese medicine classical prescription aiming at atherosclerosis under the guidance of an innovative theory of promoting blood circulation and removing water is not available. Therefore, it is necessary to provide a Chinese medicinal composition which can be used for treating atherosclerosis. Disclosure of Invention The invention aims to provide a traditional Chinese medicine composition and application thereof in preparing medicines for treating atherosclerosis, wherein the traditional Chinese medicine composition has the effects of improving the atherosclerosis lesion degree, reducing the blood lipid level and reducing the generation of atheromatous plaques. In order to achieve the above object, the present invention provides the following technical solutions: The invention provides a traditional Chinese medicine composition which comprises the following raw material components in parts by weight: 8-10 parts of Guangxi curcuma zedoary, 8-12 parts of peach kernel, 8-12 parts of cassia twig, 8-12 parts of poria cocos, 25-35 parts of raw astragalus membranaceus, 8-12 parts of cortex moutan, 8-12 parts of red paeony root, 10-20 parts of Guangxi hawthorn, 10-15 parts of herba lycopi and 25-35 parts of oyster. Preferably, the material comprises the following raw material components in parts by weight: 9-11 parts of Guangxi curcuma zedoary, 9-11 parts of peach kernel, 9-11 parts of cassia twig, 9-11 parts of poria cocos, 28-32 parts of raw astragalus membranaceus, 9-11 parts of tree peony bark, 9-11 parts of red paeony root, 14-18 parts of Guangxi hawthorn, 12-14 parts of herba lycopi and 28-32 parts of oyster. Preferably, the dosage form of the traditional Chinese medicine composition comprises a solution. The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: (1) Mixing Curcumae rhizoma, semen Persicae, ramulus Cinnamomi, poria, radix astragali, cortex moutan, radix Paeoniae Rubra, fructus crataegi and herba Lycopi, soaking in water to obtain pretreated mixed medicinal materials; (2) And (3) decocting soaked oyster for 15-25 min, adding the pretreated mixed medicinal material obtained in the step (1), and performing secondary decoction to obtain the traditional Chinese medicine composition. Preferably, the adding amount of the water in the step (1) is 5-10 times of the total mass of the mixed medicinal materials. Preferably, the soaking temperature in the step (1) is 20-30 ℃, and the soaking time is 25-35 min. Preferably, the soaked oyster in the step (2) is obtained by soaking oyster in water with the mass of 5-10 times of that of the oyster for 25-35 min. Preferably, the temperature of the decoction in the step (2) is 80-120 ℃, and the time of the decoction is 18-22 min. Preferably, the temperature of the secondary decoction in the step (2) is 80-120 ℃, and the time of the secondary decoction is 25-35 min. The invention also provides application of the traditional Chinese medicine composition in preparation of medicines for treating atherosclerosis. Compared with the prior art, the invention has the beneficial effects that: The traditional Chinese medicine composition is based on the innovative traditional Chinese medicine academic idea of promoting blood circulation to remove water, and the formula of the traditional Chinese medicine composition is firstly formulated according to the theory of simultaneous treatment of blood and water, and the traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, promoting diuresis and removing phlegm for atherosclerosis and