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CN-122005740-A - Herbal composition for nasal cavity nursing and preparation method thereof

CN122005740ACN 122005740 ACN122005740 ACN 122005740ACN-122005740-A

Abstract

The invention provides a herbal composition for nasal cavity nursing and a preparation method thereof, and belongs to the technical field of health care products. The composition comprises sweet potato vinegar raw pulp, fructus Xanthii, flos Magnoliae, radix Angelicae Dahuricae and other herbal extracts, and Bulbus Allii, mel and other adjuvants. The preparation method comprises the steps of raw material pretreatment, step dynamic countercurrent extraction, flavor and thermosensitive component integrated extraction, precise separation and refining, controllable homogenization and stabilization, sterile filling and the like. The invention can comprehensively relieve uncomfortable symptoms such as nasal cavity dryness, tightness, unsmooth ventilation and the like through multi-component cooperation, the process of the invention improves the extraction efficiency of active ingredients and the stability of products, and the composition of the invention is mild, has no stimulation to nasal mucosa and has high safety.

Inventors

  • LIU WEIMIN
  • LIU QIFAN

Assignees

  • 刘伟民

Dates

Publication Date
20260512
Application Date
20260127

Claims (8)

  1. 1. The herbal composition for nasal cavity nursing is characterized by comprising, by weight, 800-1200 parts of sweet potato vinegar raw pulp, 12-18 parts of fructus xanthii, 6-10 parts of flos magnoliae, 4-8 parts of radix angelicae, 3-5 parts of perilla leaf, 25-35 parts of garlic, 4-6 parts of pepper, 4-6 parts of sesame oil, 5-7 parts of honey, 2-4 parts of ginger, 2-4 parts of fistular onion stalk, 4-6 parts of radix sophorae flavescentis and 0.8-1.2 parts of charcoal.
  2. 2. The herbal composition for nasal cavity care according to claim 1, wherein the herbal composition comprises, by weight, 1000 parts of sweet potato vinegar raw pulp, 15 parts of fructus xanthii, 8 parts of flos magnoliae, 6 parts of radix angelicae, 4 parts of perilla leaf, 30 parts of garlic, 5 parts of pepper, 5 parts of sesame oil, 6 parts of honey, 3 parts of ginger, 3 parts of fistular onion stalk, 5 parts of radix sophorae flavescentis and 1 part of charcoal.
  3. 3. A method of preparing a herbal composition for nasal care according to claims 1-2, comprising the steps of: S1, preprocessing raw materials, namely cleaning and selecting fructus xanthil, flos magnoliae, radix angelicae and radix sophorae flavescentis, drying by microwaves until the water content is less than or equal to 8%, crushing by a universal crusher, sieving by a 80-mesh sieve to obtain herbal powder, cleaning perilla leaves, ginger and fistular onion stalk, sterilizing by ozone water, respectively cutting into fragments with the specification of 5+/-1 mm to obtain fresh materials for later use, peeling and cleaning garlic, crushing the garlic and the fructus zanthoxyli by a low-temperature airflow crusher until the particle size D90 is less than or equal to 150 mu m to obtain minced garlic micropowder and fructus zanthoxyli micropowder, ultrafine crushing charcoal under the protection of inert gas, sieving by a 800-mesh sieve to obtain ultrafine charcoal powder, and placing the ultrafine charcoal powder in a dampproof container for later use; S2, step-by-step dynamic countercurrent extraction, namely, putting the herbal powder obtained in the step S1 and all sweet potato vinegar raw pulp into a multifunctional thermal reflux extraction tank, starting stirring, heating to 50+/-2 ℃ at the speed of 1.5 ℃ per minute, preserving heat, carrying out ultrasonic auxiliary extraction for 45 minutes at the power density of 50W/L, continuously heating to 68+/-2 ℃ at the speed of 1 ℃ per minute, carrying out dynamic countercurrent circulation extraction for 4 hours at the temperature, keeping the micro negative pressure in the tank to-0.02 to-0.03 MPa in the extraction process, and cooling the feed liquid to below 40 ℃ through a built-in cooling coil after the extraction is finished to obtain primary alcohol extract; S3, integrated extraction of flavor and thermosensitive components, namely adding fresh materials, minced garlic micro powder and pepper micro powder which are obtained in the step S1 into the primary alcohol extract together, and performing warm leaching extraction for 90min at a stirring speed of 120rpm under the conditions of 60+/-2 ℃ and sealing; S4, precise separation and refining, namely conveying the mixed material after the step S3 to a tubular centrifuge, performing solid-liquid separation under the centrifugal force of 10000G, and collecting supernatant; S5, controllable homogenization and stabilization, namely, introducing the clarified extract into a blending tank with jacket cooling, cooling and maintaining the temperature at 25+/-3 ℃, slowly and uniformly adding sesame oil and honey into the tank under the continuous stirring of 80rpm/min, stirring for 20min to completely emulsify and disperse, and uniformly sucking the superfine charcoal powder obtained in the step S1 into an emulsifying machine head through a vacuum feeding device under the starting state of a high-speed shearing emulsifying machine of 10000rpm/min, and continuously homogenizing for 15min to form a stable suspension system; s6, aseptic filling, namely filtering the homogenized semi-finished product through a 0.45 mu m terminal sterilizing filter, introducing the filtered semi-finished product into an aseptic temporary storage tank, and filling and capping the semi-finished product in a B-level clean environment by adopting a medicinal nose drop bottle or a spray bottle with light shielding and excellent sealing performance to obtain the herbal composition finished product for nasal cavity nursing.
  4. 4. A method of preparing a herbal composition for nasal care according to claim 3, wherein the dynamic countercurrent circulation extraction in step S2 is performed by pumping the feed liquid at the bottom of the extraction tank to the tank top spraying device to form a continuous internal circulation with a circulation flow rate of 2-3 times the volume of the tank.
  5. 5. A method for preparing a herbal composition for nasal care according to claim 3, wherein in step S4, after the tube-type centrifugal separation, the obtained solid residue is rinsed with purified water of 30% by mass, and the rinsing solution is separately collected, concentrated at low temperature and then returned to the supernatant to increase the transfer rate of the target component.
  6. 6. A method of preparing a herbal composition for nasal care according to claim 3, wherein in step S5, the sesame oil is deoxygenated by nitrogen bubbling for 10min before use, and the honey is filtered through a 40 mesh screen to remove crystalline particles and impurities.
  7. 7. A method of preparing a herbal composition for nasal care according to claim 3, wherein in step S5, the ultra-fine charcoal powder is pre-mixed with an equal weight of the clarified extract to form a slurry before inhalation, and then quantitatively delivered to the emulsifying head by a peristaltic pump.
  8. 8. A method of preparing a herbal composition for nasal care according to claim 3, wherein in step S6, high purity nitrogen is introduced into the sterile temporary storage tank to replace the tank top air for 10min before filling, and a slight positive nitrogen pressure of 0.03-0.05MPa is maintained in the tank until filling is completed.

Description

Herbal composition for nasal cavity nursing and preparation method thereof Technical Field The invention relates to the technical field of health care products, in particular to a herbal composition for nasal cavity nursing and a preparation method thereof. Background The nasal cavity serves as the primary portal of the respiratory system, and its health status is directly related to respiratory comfort and local immune defence functions. Discomfort such as nasal dryness, tightness, abnormal secretions and the like has become a common problem affecting the quality of life of a wide population. At present, products and technical solutions for nasal cavity nursing are various, but the prior art still has a plurality of limitations from the aspects of formulation and implementation. In the prior art, nasal care products mainly comprise nasal drops or sprays mainly composed of chemical synthetic components, such as physiological saline, seawater sprays or preparations containing decongestants and antihistamines. Although the product can take effect quickly, the long-term use of chemical medicines can bring risks of mucous membrane dryness, drug rhinitis or drug resistance, and the like, and the effect is often single, and the comprehensive conditioning effect on the nasal cavity environment is lacked. And secondly, traditional preparations based on single or few traditional Chinese medicinal materials, such as partial Chinese medicinal nasal drops or medicinal oil. Although the product utilizes certain characteristics of natural herbs, the functions of all the components are isolated due to simple formula components, the synergistic compound nursing effect is difficult to form, and the product has limited effects in improving the use experience and relieving various compound uncomfortable feeling. SUMMARY OF THE PATENT FOR INVENTION In view of the foregoing, it is desirable to provide a herbal composition for nasal care and a preparation method thereof, so as to solve or alleviate the technical problems in the prior art. The technical scheme of the embodiment of the invention is realized by the following components, by weight, 800-1200 parts of sweet potato vinegar primary pulp, 12-18 parts of fructus xanthil, 6-10 parts of flos magnoliae, 4-8 parts of radix angelicae, 3-5 parts of perilla leaf, 25-35 parts of garlic, 4-6 parts of pepper, 4-6 parts of sesame oil, 5-7 parts of honey, 2-4 parts of ginger, 2-4 parts of fistular onion stalk, 4-6 parts of radix sophorae flavescentis and 0.8-1.2 parts of charcoal. The improved sweet potato vinegar comprises, by weight, 1000 parts of sweet potato vinegar primary pulp, 15 parts of fructus xanthil, 8 parts of flos magnoliae, 6 parts of radix angelicae, 4 parts of perilla leaf, 30 parts of garlic, 5 parts of pepper, 5 parts of sesame oil, 6 parts of honey, 3 parts of ginger, 3 parts of fistular onion stalk, 5 parts of radix sophorae flavescentis and 1 part of charcoal. A method of preparing an herbal composition for nasal care comprising the steps of: S1, preprocessing raw materials, namely cleaning and selecting fructus xanthil, flos magnoliae, radix angelicae and radix sophorae flavescentis, drying by microwaves until the water content is less than or equal to 8%, crushing by a universal crusher, sieving by a 80-mesh sieve to obtain herbal powder, cleaning perilla leaves, ginger and fistular onion stalk, sterilizing by ozone water, respectively cutting into fragments with the specification of 5+/-1 mm to obtain fresh materials for later use, peeling and cleaning garlic, crushing the garlic and the fructus zanthoxyli by a low-temperature airflow crusher until the particle size D90 is less than or equal to 150 mu m to obtain minced garlic micropowder and fructus zanthoxyli micropowder, ultrafine crushing charcoal under the protection of inert gas, sieving by a 800-mesh sieve to obtain ultrafine charcoal powder, and placing the ultrafine charcoal powder in a dampproof container for later use; S2, step-by-step dynamic countercurrent extraction, namely, putting the herbal powder obtained in the step S1 and all sweet potato vinegar raw pulp into a multifunctional thermal reflux extraction tank, starting stirring, heating to 50+/-2 ℃ at the speed of 1.5 ℃ per minute, preserving heat, carrying out ultrasonic auxiliary extraction for 45 minutes at the power density of 50W/L, continuously heating to 68+/-2 ℃ at the speed of 1 ℃ per minute, carrying out dynamic countercurrent circulation extraction for 4 hours at the temperature, keeping the micro negative pressure in the tank to-0.02 to-0.03 MPa in the extraction process, and cooling the feed liquid to below 40 ℃ through a built-in cooling coil after the extraction is finished to obtain primary alcohol extract; S3, integrated extraction of flavor and thermosensitive components, namely adding fresh materials, minced garlic micro powder and pepper micro powder which are obtained in the step S1 into the primary alcohol extract toge