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CN-122005745-A - Application of traditional Chinese medicine composition in preparation of medicines for treating persistent pneumonia

CN122005745ACN 122005745 ACN122005745 ACN 122005745ACN-122005745-A

Abstract

The invention discloses an application of a traditional Chinese medicine composition in preparing medicines for treating persistent pneumonia, the composition is prepared from a plurality of medicinal materials such as fried hawthorn, betel nut, immature bitter orange and the like, the traditional Chinese medicine composition is prepared by adopting a differential extraction process according to the properties of the medicinal materials, and the two components can be mixed or combined for use in a separate preparation. The traditional Chinese medicine composition disclosed by the invention is matched with physiological characteristics, can relieve respiratory symptoms of persistent pneumonia, improve systemic symptoms such as low fever and anorexia, and reduce repeated upper respiratory tract infection. The traditional Chinese medicine composition has scientific compatibility and synergistic effect, realizes the compatibility of both principal and secondary aspects of disease, has obvious curative effect and high safety, can reduce the recurrence risk of illness state, avoid serious complications, solve the limitations of the existing treatment scheme, and is suitable for clinical treatment and organism conditioning of persistent pneumonia.

Inventors

  • BAI LIPING
  • MENG FANQIANG
  • Qi shuang

Assignees

  • 山东新时代药业有限公司

Dates

Publication Date
20260512
Application Date
20260414

Claims (10)

  1. 1. A traditional Chinese medicine composition for treating pneumonia is characterized by being prepared from the following raw materials, by weight, 80-120 parts of fried hawthorn, 80-120 parts of betel nut, 80-120 parts of immature bitter orange, 80-120 parts of honey loquat leaf, 110-160 parts of snakegourd fruit, 80-120 parts of fried radish seed, 80-120 parts of fried semen lepidii, 80-120 parts of platycodon grandiflorum, 80-120 parts of fructus forsythiae, 50-80 parts of periostracum cicada, 50-85 parts of codonopsis pilosula, 110-160 parts of fried bighead atractylodes rhizome, 50-85 parts of roasted astragalus root, 25-45 parts of roasted liquorice, 110-160 parts of poria cocos, 110-160 parts of prepared polygala tenuifolia, 50-85 parts of fried spina date seed, 110-160 parts of longan pulp, 110-160 parts of Chinese angelica, 25-45 parts of costustoot, 25-45 parts of jujube and 12-22 parts of ginger.
  2. 2. The traditional Chinese medicine composition according to claim 1, which is characterized by being prepared from the following raw materials, by weight, 100 parts of fried hawthorn, 100 parts of betel nut, 100 parts of immature bitter orange, 100 parts of honey loquat leaf, 134 parts of snakegourd fruit, 100 parts of fried radish seed, 100 parts of fried semen lepidii, 100 parts of platycodon grandiflorum, 100 parts of weeping forsythiae capsule, 66 parts of cicada slough, 68 parts of dangshen, 136 parts of fried bighead atractylodes rhizome, 68 parts of roasted astragalus root, 34 parts of roasted liquorice, 136 parts of poria cocos, 136 parts of prepared polygala tenuifolia, 68 parts of fried spina date seed, 136 parts of longan pulp, 136 parts of angelica sinensis, 34 parts of costustoot, 34 parts of jujube and 17 parts of ginger.
  3. 3. The traditional Chinese medicine composition according to any one of claims 1-2, wherein the traditional Chinese medicine composition is divided into a component A and a component B, wherein the component A is prepared from fried hawthorn, betel nut, immature bitter orange, loquat leaf, snakegourd fruit, fried radish seed, fried semen lepidii, platycodon grandiflorum, fructus forsythiae and periostracum cicadae, and the component B is prepared from dangshen, fried bighead atractylodes rhizome, radix astragali preparata, radix glycyrrhizae preparata, poria cocos, polygala tenuifolia, fried spina date seed, arillus longan, angelica sinensis, costustoot, jujube and ginger.
  4. 4. The composition of claim 3, wherein the composition is used for clinical use in a dosage ratio of 1-3 years old, 5ml each time, 3 times each time, 5ml each time, 2 times each time, 3-6 years old, 10ml each time, 3 times each time, 10ml each time, 2 times each time, and 10-20ml each time, 3 times each time, and 10-20ml each time.
  5. 5. The traditional Chinese medicine composition according to any one of claims 1-2, characterized in that the preparation method thereof comprises the following steps: 1) Decocting parched fructus crataegi, arecae semen, fructus Aurantii Immaturus, folium Eriobotryae, fructus Trichosanthis, parched Raphani semen, parched semen Lepidii, radix Platycodi, fructus forsythiae and periostracum Cicadae in water twice, mixing decoctions, filtering, concentrating the filtrate under reduced pressure to appropriate amount, adding ethanol to alcohol content of 60%, standing, filtering, recovering ethanol from the filtrate and concentrating, adding appropriate amount of water, stirring, refrigerating, filtering, adding beta-cyclodextrin into the filtrate, stirring for clathrating, adding sucrose, stirring, adding water to appropriate amount to obtain component A; 2) Extracting volatile oil from parched Atractylodis rhizoma, radix aucklandiae and radix Angelicae sinensis by distillation respectively, percolating radix Angelicae sinensis residue with 50% ethanol as solvent, collecting percolate, recovering ethanol, decocting Atractylodis rhizoma and radix aucklandiae residue with other radix Codonopsis, radix astragali Preparata, radix Glycyrrhizae Preparata, poria, radix Polygalae Preparata, parched semen Ziziphi Spinosae, arillus longan, fructus Jujubae and rhizoma Zingiberis recens with water for three times, mixing decoctions, filtering, concentrating filtrate to appropriate amount, mixing with above percolate, standing, filtering, concentrating filtrate to appropriate amount, adding sodium benzoate, cooling, adding above volatile oil, and adding water to appropriate amount to obtain component B; 3) The component A and the component B are mixed according to the clinical dosage proportion, or are prepared into preparations respectively and then are used together.
  6. 6. The composition of claim 5, wherein in step 1), water is added for two times, each time for 1.5 hours, the filtrate is concentrated under reduced pressure to a clear paste with a relative density of 1.10-1.15, the refrigerating time is 24 hours, the addition amount of beta-cyclodextrin is 10 parts by weight, the addition amount of sucrose is 200 parts by weight, and finally water is added to 1000 parts by weight.
  7. 7. The Chinese medicinal composition according to claim 5, wherein in step 2), water is added for three times, the first time is 2 hours, the second time is 1.5 hours, the third time is 1 hour, the angelica residue is immersed for 24 hours before being percolated with 50% ethanol, 1000 parts by weight of percolate is collected, the adding amount of sodium benzoate is 3 parts by weight, and finally water is added to 1000 parts by weight.
  8. 8. Use of the traditional Chinese medicine composition according to claims 1-2 in the preparation of a medicament for treating persistent pneumonia.
  9. 9. The use of the Chinese medicinal composition of claim 8 in preparing a medicament for treating infantile persistent pneumonia.
  10. 10. The use according to claim 8, wherein the Chinese medicinal composition is used for relieving/treating persistent dry cough or symptoms associated with small amount of sticky phlegm, cough aggravation after morning/night/activity, airway wheezing and pulmonary thin and moist continuous lasting respiratory tract symptoms caused by persistent pneumonia, and improving systemic symptoms of low fever, repeated repetition, slow weight gain, listlessness, anorexia and hypodynamia, and reducing symptoms associated with repeated upper respiratory tract infection caused by illness lasting.

Description

Application of traditional Chinese medicine composition in preparation of medicines for treating persistent pneumonia Technical Field The invention belongs to the technical field of medicines, and particularly relates to application of a traditional Chinese medicine composition in preparation of a medicine for treating persistent pneumonia. Background The persistent pneumonia is a common chronic lung inflammatory disease in pediatrics, the diagnosis standard is definitely that the course of the pneumonia exceeds 1 month and is less than 3 months, the lung is continuously infiltrated by inflammation, and the persistent pneumonia is accompanied with repeated or persistent respiratory symptoms, so that the persistent pneumonia is one of the types of respiratory diseases of children with higher treatment difficulty and easy recurrence. Clinical study data shows that the incidence of antibiotics has been on a slow rise in recent years with irrational use. The clinical symptoms of the disease have specificity, and are mainly characterized in that cough and persistent recovery are mostly caused by paroxysmal dry cough or cough with a small amount of sticky sputum, cough is aggravated after activity, night or after catching cold, partial infants can generate low fever, wheeze, chest distress, auscultation by lung, audible and wet rally or dry rally, meanwhile, the infants often suffer from inappetence, dyspepsia, listlessness, facial bloom, slow weight growth, anemia and further immunity decline can occur in serious infants, even growth and development are influenced, partial infants can also develop chronic pneumonia and pulmonary fibrosis, and heavy economic burden and mental stress are brought to families of the infants. At present, the core scheme of Western medicine treatment of persistent pneumonia is anti-infection, phlegm eliminating, cough relieving, asthma relieving and nutrition supporting, and specific treatment measures comprise selecting proper antibiotics (such as cephalosporins and macrolide antibiotics) according to phlegm culture and drug sensitivity test results, combining expectorants (such as ambroxol and acetylcysteine), bronchodilators, and if necessary, giving glucocorticoid anti-inflammatory and immune regulator to enhance organism resistance. However, this treatment scheme has many limitations, and it is difficult to meet clinical treatment requirements. At present, the traditional Chinese medicine preparations commonly used in clinic are mainly divided into two types, namely one type mainly comprising dispersing lung qi and eliminating phlegm, clearing heat and relieving cough, and mainly focusing on eliminating evil, being applicable to acute stage of pneumonia or phlegm-heat stagnation in lung syndrome, but being not applicable to pathogenesis of persistent pneumonia caused by deficiency of vital qi and evil after long-term use, the other type mainly comprising tonifying qi and strengthening spleen and strengthening body resistance, and mainly focusing on strengthening body resistance, and being applicable to lung and spleen deficiency syndrome, but lacking the efficacy of eliminating phlegm and resolving masses and eliminating residual evil, and being difficult to quickly relieve clinical symptoms such as cough, expectoration and the like. In the prior art, although some compound traditional Chinese medicines are tried to be used for treating the persistent pneumonia, the problems of unreasonable compatibility, inaccurate curative effect, single application pattern and the like exist. Therefore, research and development of a traditional Chinese medicine composition with scientific compatibility, definite dosage range, obvious curative effect and high safety becomes a technical problem to be solved urgently in the current traditional Chinese medicine field. Disclosure of Invention The invention aims to overcome the technical defects that medicines for treating the persistent pneumonia are unreasonable in compatibility, unfixed in curative effect and single in applicable pattern, western medicine treatment schemes are limited, and single traditional Chinese medicine preparation cannot simultaneously clear pathogenic factors and strengthen body vital qi, and provides a traditional Chinese medicine composition which is scientific in compatibility, clear in dosage range, obvious in curative effect and high in safety. The invention provides a traditional Chinese medicine composition for treating pneumonia, which is prepared from the following raw materials, by weight, 80-120 parts of fried hawthorn, 80-120 parts of betel nut, 80-120 parts of immature bitter orange, 80-120 parts of honey loquat leaf, 110-160 parts of snakegourd fruit, 80-120 parts of fried radish seed, 80-120 parts of fried semen lepidii, 80-120 parts of platycodon grandiflorum, 80-120 parts of fructus forsythiae, 50-80 parts of periostracum cicada, 50-85 parts of codonopsis pilosula, 110-160 parts of fried bighead atractylod