CN-122005747-A - Dian white bead spray and preparation method thereof

Abstract

The invention belongs to the technical field of Yunnan white bead preparations, and provides a Yunnan white bead spray and a preparation method thereof. The Yunnan white bead spray comprises mixed essential oil, a penetration enhancer and water, wherein the mixed essential oil comprises the Yunnan white bead crude oil, peppermint oil, ginger oil, aromatic wood oil and arborvitae oil in specific parts by weight. The spray disclosed by the invention takes the Yunnan white pearl crude oil as a main core component, is compounded with the peppermint oil, the ginger oil, the aromatic wood oil and the arborvitae oil, has the effects of diminishing inflammation and easing pain, cooling and itching relieving the peppermint oil, activating blood and dissolving stasis, warming channels and dispelling cold, has antibacterial and antibacterial effects, can play a role in synergism, relieves muscle pain, local swelling and pain, and has an antibacterial effect, and the mixed essential oil further enables the mixed essential oil to quickly permeate the skin surface layer by being matched with the compound penetration enhancer of lecithin and dipropylene glycol, and reaches a damaged part in a targeted manner, so that the effect of relieving is achieved.

Inventors

• ZHANG MANCHANG
• YANG BIHAO
• YANG SHIBO
• LIU JIABAO
• ZHAO XIA
• ZHANG HONGXIAN
• Yin Xingzhang
• Cao Puqiong
• SHEN HONGCHUN
• FAN JIE
• HU ANXU
• Yang Shenying
• ZHANG ZHIXUE
• SONG XIAODONG
• Tao Mingbao
• YANG LIYING
• Li Xiaoken
• ZHU JING
• LUO ZHIHUI
• SUN LIANJIE
• LI JINGFANG
• YANG SHUYUN
• YANG XIAOWEN
• WU YAN
• DUAN SHENGZHI
• HU XIAOLIN
• WANG JIANFEN

Assignees

• 保山市药品检验检测研究院

Dates

Publication Date

20260512

Application Date

20260415

Claims (8)

1. 1. The Yunnan white bead spray is characterized by comprising mixed essential oil, a penetration enhancer and water, wherein the mixed essential oil comprises the following raw materials in parts by weight: 70-85 parts of Yunnan white bead crude oil, 15-30 parts of peppermint oil, 5-20 parts of ginger oil, 10-20 parts of aromatic wood oil and 15-20 parts of arborvitae oil.
2. 2. The Yunnan white bead spray of claim 1, wherein the mixed essential oil comprises the following raw materials in parts by weight: 72-82 parts of Yunnan white bead crude oil, 18-27 parts of peppermint oil, 8-16 parts of ginger oil, 12-18 parts of aromatic wood oil and 16-19 parts of arborvitae oil.
3. 3. The Yunnan white bead spray of claim 2, wherein the mixed essential oil comprises the following raw materials in parts by weight: 75-80 parts of Yunnan white bead crude oil, 20-24 parts of peppermint oil, 10-14 parts of ginger oil, 14-16 parts of aromatic wood oil and 17-18 parts of arborvitae oil.
4. 4. The Dian white bead spray according to any one of claims 1-3, wherein the penetration enhancer comprises lecithin and dipropylene glycol, and the mass ratio of the lecithin to the dipropylene glycol is 0.3-0.8:1.
5. 5. The yunnan white bead spray according to claim 4, wherein the penetration enhancer is 12-20% by mass of the mixed essential oil and the water is 3-5 times by mass of the mixed essential oil.
6. 6. The method for preparing the phyllanthus emblica spray of any one of claims 1-5, which is characterized by comprising the following steps: 1) Mixing Yunnan white bead crude oil, peppermint oil, ginger oil, aromatic wood oil and arborvitae oil to obtain mixed essential oil; 2) Adding the mixed essential oil and the penetration enhancer into water, homogenizing under high pressure, and then adjusting the pH value to obtain spray liquid; 3) And (5) filling the spray liquid to obtain the Yunnan white bead spray.
7. 7. The method according to claim 6, wherein the high-pressure homogenizing pressure in step 2) is 20000 to 40000psi, and the number of times of high-pressure homogenizing is 2 to 4.
8. 8. The method according to claim 6 or 7, wherein the pH of the spray liquid in step 2) is 5 to 6.5.

Description

Dian white bead spray and preparation method thereof Technical Field The invention relates to the technical field of Yunnan white bead preparations, in particular to a Yunnan white bead spray and a preparation method thereof. Background The Yunnan white pearl (Gaultheria leucocarpa Bl. Var. Yunnanensis (Franch.) T.Z. Hsuet R.C. Fang) belongs to the genus Begonia of the family Ericaceae, is a evergreen shrub, can be used as a medicine by a whole plant, is distributed in the south of the Yangtze river, yunnan is the distribution center, and Yunnan is the core production area. The Dian white beads are common medicinal materials of more than 20 nationalities, such as white, liu, yi nationality and the like in southwest regions of China, are very important one medicine in national medicinal plants, and are originally carried in Yunnan Ben Cao (Ming's Yuan Shen, alias name); the preparation method comprises the steps of white birthwort, garden balsam stem, dahurian rhododendron leaf, common jasminorange leaf, aromatic vanilla, chicken bone, bristled, carbonized human hair, coal seed coal fruit, bath leaf, herba Sagittariae Sagittifoliae, herba Begoniae Laciniatae, herba Sambuci Williamsii, radix et rhizoma Fagopyri Dibotryis, herba Cynanchi Paniculati, radix Cynanchi Paniculati, herba Eriobotryae, and flos Nelumbinis, spicy and hot, warm in nature, has the effects of dispelling wind and removing dampness, promoting blood circulation and removing obstruction in collaterals, dispelling cold and relieving pain, eliminating phlegm and relieving asthma, washing wind and cold arthralgia, arthralgia and myalgia, warming tendons and bones and the like. The Yunnan white beads mainly contain salicylate, flavonoid, lignans, organic acid, coumarin, terpenes, sterols, volatile oil and the like, and the active ingredients endow the Yunnan white beads with the effects of resisting bacteria, resisting oxidation, resisting inflammation, easing pain, dispelling wind, removing dampness, clearing heat, detoxicating, promoting blood circulation, removing blood stasis, guiding qi downward, relieving asthma, improving small intestine function, relieving diarrhea and the like, and can be used for relieving rheumatic arthralgia, traumatic injury, muscle strain and the like. At present, aiming at the condition of external application of the Yunnan white beads, main researches focus on preparations such as compound essential oil, ointment and the like. The compound essential oil mainly combines the Yunnan white beads with various essential oils to generate efficacy synergy and realize efficacy expansion. In general, the transdermal absorption of compound essential oil depends on the compound system of the essential oil, which may cause insufficient performance of the phyllanthus emblica. The ointment preparation needs to be smeared, has poor dispersibility in epidermis and general transdermal absorption effect, and has more auxiliary materials, thus being easy to cause skin irritation and other safety problems. The spray is convenient to carry and use, has rapid effect and controllable administration dosage, becomes a preferred dosage form in the field of external medicines, but the Yunnan white pearl spray rarely appears in the market at present. Therefore, the invention aims to provide the Yunnan white bead spray, which has a plurality of effects such as anti-inflammatory and analgesic effects by compounding the Yunnan white beads with the essential oil with the synergistic effect, has high transdermal absorptivity, can reach the pain site quickly and in a targeted way, plays an effect, and has important significance for widening the dosage form and application of the Yunnan white beads. Disclosure of Invention The invention aims to provide a Yunnan white bead spray and a preparation method thereof, aiming at the defects of the prior art. In order to achieve the above object, the present invention provides the following technical solutions: The invention provides a Yunnan white bead spray which comprises mixed essential oil, a penetration enhancer and water, wherein the mixed essential oil comprises the following raw materials in parts by weight: 70-85 parts of Yunnan white bead crude oil, 15-30 parts of peppermint oil, 5-20 parts of ginger oil, 10-20 parts of aromatic wood oil and 15-20 parts of arborvitae oil. Preferably, the mixed essential oil comprises the following raw materials in parts by weight: 72-82 parts of Yunnan white bead crude oil, 18-27 parts of peppermint oil, 8-16 parts of ginger oil, 12-18 parts of aromatic wood oil and 16-19 parts of arborvitae oil. Preferably, the mixed essential oil comprises the following raw materials in parts by weight: 75-80 parts of Yunnan white bead crude oil, 20-24 parts of peppermint oil, 10-14 parts of ginger oil, 14-16 parts of aromatic wood oil and 17-18 parts of arborvitae oil. Preferably, the permeation enhancer comprises lecithin and dipropylene glycol, wherein the mass ratio of the l