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CN-122005755-A - Application of blue copper peptide composition in preventing pigmentation and accelerating wound healing after phototherapy microneedle operation

CN122005755ACN 122005755 ACN122005755 ACN 122005755ACN-122005755-A

Abstract

The invention belongs to the technical field of skin repair and medical skin care products, and discloses application of a blue copper peptide composition in preventing pigmentation and accelerating wound healing after phototherapy of microneedle operation. The active ingredients of the composition are blue copper peptide, line grain energy peptide, snMS protein, nicotinamide and hyaluronic acid, and the components are compounded according to a specific proportion. The high-quality healing of wound surfaces and the prevention of pigmentation are realized through gene resetting and system repair, matrix clearing-reconstruction biphase regulation and control, activating SIRT1/STAT3 repair shafts and a multi-target linkage mechanism for multi-channel pigmentation inhibition. The composition has no cytotoxicity, can obviously reduce ROS content, inhibit inflammatory factor expression, promote melanin inhibition rate and collagen synthesis amount, solve the problems of single target point and function fragmentation of the existing postoperative repair products, and upgrade postoperative care from passive injury repair to active regeneration guide.

Inventors

  • XIE JIESI
  • ZHONG YANAN
  • HE LIZHONG
  • ZHANG JIAQUAN

Assignees

  • 百葵锐(深圳)生物科技有限公司

Dates

Publication Date
20260512
Application Date
20260313

Claims (10)

  1. 1. Use of a blue copper peptide composition for the preparation of a product for preventing pigmentation after phototherapy of microneedle surgery.
  2. 2. The application of the blue copper peptide composition in preparing products for accelerating wound healing after phototherapy microneedle operation.
  3. 3. The use according to any one of claims 1-2, wherein the active ingredients of the blue copper peptide composition comprise blue copper peptide, line energy peptide, snMS protein, nicotinamide and hyaluronic acid, preferably the blue copper peptide composition further comprises a pharmaceutically acceptable carrier.
  4. 4. The use according to claim 3, wherein the amino acid sequence of the line granule energy peptide is shown in SEQ ID NO.1 and the amino acid sequence of the SnMS protein is shown in SEQ ID NO. 2.
  5. 5. The use according to claim 4, wherein the proportion of each active ingredient in the blue copper peptide composition is, by weight, 0.01% -0.5% of blue copper peptide, 0.001% -1% of line grain energy peptide, 0.1% -10% of SnMS protein, 0.1% -5% of nicotinamide, 0.01% -2% of hyaluronic acid, preferably the proportion of each active ingredient in the blue copper peptide composition is, by weight, 0.1% -0.3% of blue copper peptide, 0.01% -0.1% of line grain energy peptide, 1% -5% of SnMS protein, 1% -3% of nicotinamide, 0.05% -1% of hyaluronic acid, more preferably, 0.1% of blue copper peptide, 0.02% of line grain energy peptide, 5% of SnMS protein, 1% of nicotinamide, and 0.05% of hyaluronic acid.
  6. 6. The use according to claim 5, wherein the blue copper peptide composition further comprises panthenol, sodium 2-hydroxy pyruvate, polyethylene glycol, glycerin, allantoin, betaine and xanthan gum, preferably, the components are, by weight, 0.5% -2% of panthenol, 0.1% -0.5% of sodium 2-hydroxy pyruvate, polyethylene glycol-8 1% -7%, 1% -5% of glycerin, 0.1% -0.5% of allantoin, 0.01-0.5% of betaine, 0.05-0.3% of xanthan gum, more preferably, 1% -1.5% of panthenol, 0.1% -0.3% of sodium 2-hydroxy pyruvate, 0.1% -5% of polyethylene glycol-8 3%, 3% -5% of glycerin, 0.1% -0.3% of allantoin, 0.1-0.2% of betaine and 0.1-0.15% of xanthan gum.
  7. 7. The use according to any one of claims 1-2, wherein the blue copper peptide composition achieves anti-inflammatory effect by down-regulating IL-6, TNF- α inflammatory factor expression, black inhibition by inhibiting melanosome transport, and simultaneously directs the ordered arrangement of new collagen fibers by stimulating type I, type III collagen and decorin synthesis.
  8. 8. The use according to any one of claims 1-2, wherein the phototherapy is lattice laser, intense pulsed light and/or radiofrequency microneedle based micro-created phototherapy.
  9. 9. The use according to any one of claims 1-2, wherein the product comprises a pharmaceutical product, a skin care product or a medical dressing.
  10. 10. Use according to claim 8, wherein the product is in the form of a gel, cream, emulsion or aqueous, spray.

Description

Application of blue copper peptide composition in preventing pigmentation and accelerating wound healing after phototherapy microneedle operation Technical Field The invention belongs to the technical field of skin repair and medical skin care products, and particularly relates to a blue copper peptide composition, in particular to application of the blue copper peptide composition in preventing pigmentation and accelerating wound healing after phototherapy microneedle operation. Background With the popularization and the fine development of skin beauty technology, medical and aesthetic means such as lattice laser, intense Pulsed Light (IPL), radio frequency micro-needles and various minimally invasive phototherapy are widely applied to skin improvement, color spot removal, scar repair and skin rejuvenation treatment, and become the main stream selection in clinic and consumer end. The technology starts the skin self-repair and collagen remodeling mechanism by forming controllable minimally invasive damage to skin tissues, thereby realizing the improvement of the skin structure and appearance. However, in clinical application, the integrity of skin barrier is destroyed after phototherapy and microneedle surgery, and obvious acute inflammatory reaction, oxidative stress injury and abnormal activation of melanocyte are accompanied, so that two outstanding clinical problems are brought about, namely, the incidence rate of Pigmentation (PIH) after inflammation is high, local pigmentation and mottle blackening are more likely to occur under the stimulation of inflammation due to higher sensitivity of melanocyte of Asian population, the treatment effect and patient compliance are obviously reduced, the wound healing speed is slow, the repair quality is insufficient, the reconstruction of epidermis barrier is delayed, the arrangement of dermal collagen fiber is disordered, dryness, desquamation, redness, sensitivity and scar hyperplasia are likely to occur, and the traditional nursing is difficult to realize efficient and ordered tissue regeneration .（Mei, X. L., & Wang, L. (2018). Ablative fractional carbon dioxide laser combined with intense pulsed light for the treatment of photoaging skin in Chinese population: A split-face study. Medicine, 97(3), e9494. https://doi.org/10.1097/MD.0000000000009494）. Most of the repairing products take single functional components as main components, such as Epidermal Growth Factor (EGF), basic fibroblast growth factor (bFGF) and the like, mainly act on epidermal cell proliferation, only relieve acute-phase symptoms such as red swelling and pain of anti-inflammatory relieving components such as dipotassium glycyrrhizinate, bisabolol and the like with limited effects of controlling and controlling inflammatory signals and preventing pigment, and the like on collagen remodelling of dermis, can not actively guide skin tissue accurate repairing (CN 116509752A published day: 2023.08.01), the whitening components such as nicotinamide, arbutin and the like mainly act on generated melanin, and can not inhibit the activation of melanocytes from inflammatory sources, and the preventive effect is weaker than （Burger, P.; Landreau, A.; Azoulay, S.; Michel, T.; Fernandez, X. Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners. Cosmetics 2016, 3, 36. https://doi.org/10.3390/cosmetics3040036）., and the prior art is mostly remained on the aspects of passive moisturizing, anti-inflammatory and anti-infection, has single acting target point and independent path, lacks an integrated synergistic mechanism of inhibiting excessive inflammation, controlling cell repairing and promoting the orderly generation of collagen to blocking abnormal pigment, fails to form a synergistic mechanism of accelerating from gene regulation and control substrate accurate wound surface to prevent pigmentation, and can not synchronously and efficiently solve the requirements of pigmentation after the core pigmentation and the cooperative healing. The blue copper peptide can be used as a tripeptide-copper compound with multiple biological activities, can participate in the regulation and control of signal paths related to skin repair, promotes fibroblast proliferation and collagen synthesis, has the potential （Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2015). GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed research international, 2015, 648108. https://doi.org/10.1155/2015/648108）; for resisting inflammation, resisting oxidation and promoting wound repair, has single action mode and insufficient targeting when being independently applied, and is difficult to systematically cover the whole flow of postoperative inflammation control, barrier reconstruction, collagen remodeling and pigment prevention. The existing single-component product containing blue copper peptide or nicotinamide is not optimized for the composition acco