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CN-122005768-A - Rhodiola rosea-containing composite antibacterial oral antibacterial paste

CN122005768ACN 122005768 ACN122005768 ACN 122005768ACN-122005768-A

Abstract

The invention belongs to the technical field of oral care, and discloses a compound antibacterial oral antibacterial paste containing rhodiola rosea, which is prepared by compounding five-component compound antibacterial components such as rhodiola rosea, tea polyphenol and the like with auxiliary materials such as sorbitol and the like according to a precise proportion. The invention constructs a triple system of instant sterilization, lasting bacteriostasis and ecological restoration, and has the inhibition rate to oral pathogenic bacteria such as escherichia coli, staphylococcus aureus and the like reaching more than 99.9 percent through detection by a third party, and has multiple effects of resisting bacteria, diminishing inflammation, protecting gingiva, preventing caries and the like. The method solves the problems of single antibacterial property, narrow antibacterial spectrum and low rhodiola rosea utilization rate of the existing product, and has the advantages of undetected heavy metal, excellent stability, low irritation, suitability for long-term use, remarkable innovation and industrialization value.

Inventors

  • DENG XIAOWEI
  • MAO YUMEI

Assignees

  • 江西捷康生物科技有限公司

Dates

Publication Date
20260512
Application Date
20260209

Claims (6)

  1. 1. A compound antibacterial oral antibacterial ointment containing rhodiola rosea is characterized by comprising the following components, by mass, 5g of rhodiola rosea, 3g of tea polyphenol, 2g of lysozyme, 2.5g of lactobacillus, 286g of sorbitol, 400 g of polyethylene glycol-37 g, 3g of sodium carboxymethyl cellulose, 360g of silicon dioxide, 4g of sodium benzoate, 8g of glycerol, 3g of hydroxyethyl cellulose, 20g of sodium dodecyl sulfate, 1g of cetylpyridinium chloride, 2g of sodium bicarbonate, 2g of sodium fluoride and 6g of peppermint, wherein the total mass is 1000g.
  2. 2. The rhodiola rosea-containing composite antibacterial oral bacteriostatic ointment according to claim 1, which is characterized in that rhodiola rosea is a rhodiola rosea rhizome superfine crushed material, a rhodiola rosea ethanol extract or a rhodiola rosea supercritical CO 2 extract, wherein the particle size of the superfine crushed material is less than or equal to 50 μm, the content of salidroside in the ethanol extract and the supercritical CO 2 extract is more than or equal to 1.5%, preferably the content of the supercritical CO 2 extract and the content of the salidroside is more than or equal to 1.8%.
  3. 3. The rhodiola rosea-containing composite antibacterial oral antibacterial paste according to claim 1, wherein the lactic acid bacteria are at least one of lactobacillus acidophilus and lactobacillus plantarum, the viable count is not less than 1×10 8 CFU/g, the silicon dioxide is precipitated silicon dioxide, the particle size is 5-20 μm, and the mohs hardness is 5.5-6.0.
  4. 4. A method for preparing the rhodiola rosea-containing composite antibacterial oral antibacterial cream according to any one of claims 1-3 is characterized by comprising the following steps of (1) preprocessing, namely, carrying out superfine grinding, ethanol extraction or supercritical CO 2 extraction on rhodiola rosea for later use, freeze-drying lactobacillus to prepare bacterial powder for later use, (2) mixing auxiliary materials, namely, sequentially adding sorbitol, polyethylene glycol-400, glycerol, sodium carboxymethyl cellulose, hydroxyethyl cellulose, sodium dodecyl sulfate, sodium bicarbonate and sodium benzoate into a stirring tank, stirring for 30-40min at 40-50 ℃ to form uniform colloid, (3) adding active components, cooling to 25-30 ℃, introducing nitrogen with the flow rate of 0.5-1.0L/min for protection, stirring for 20-25min, then adding lactobacillus powder and mint, continuing stirring for 15-20min, forming, namely, adding silicon dioxide, dispersing for 10-15min at high speed at 3000-4000r/min, degassing, and sealing to obtain the rhodiola rosea product.
  5. 5. The preparation method of claim 4, wherein the supercritical CO 2 extraction process parameters of the rhodiola rosea in the step (1) are that the extraction temperature is 35-45 ℃, the extraction pressure is 25-35MPa, the extraction time is 2-3h, the entrainer is absolute ethanol and the amount is 5-10% of the rhodiola rosea raw material mass, and the optimal parameters are that the extraction temperature is 40 ℃, the pressure is 30MPa, the time is 2.5h and the entrainer amount is 8%.
  6. 6. The use of the rhodiola rosea-containing composite antibacterial oral bacteriostatic ointment according to any one of claims 1-3 for inhibiting oral pathogenic bacteria including at least one of streptococcus mutans, porphyromonas gingivalis, staphylococcus aureus and candida albicans, improving gingival health or preventing dental caries.

Description

Rhodiola rosea-containing composite antibacterial oral antibacterial paste Technical Field The invention relates to the technical field of oral care, in particular to a rhodiola rosea-containing composite antibacterial oral antibacterial paste which is particularly suitable for daily oral care scenes of inhibiting reproduction of oral pathogenic bacteria, improving gum health and preventing dental caries. Background The oral health is closely related to the overall health of human body, and the occurrence of common oral diseases such as decayed tooth, gingivitis, periodontitis and the like is mainly caused by mass reproduction of pathogenic bacteria in the oral cavity, oral microecological unbalance and local immunity function reduction. The existing oral antibacterial products on the market have various types, but have the technical defects that firstly, the antibacterial components are single, chemical antibacterial agents such as chlorhexidine and cetylpyridinium chloride or single natural components are relied on, the antibacterial spectrum is narrow, a plurality of pathogenic bacteria in the oral cavity are difficult to treat, and bacterial resistance is easily caused after long-term use, secondly, the chemical antibacterial agents are strong in irritation, the oral mucosa barrier is possibly damaged after long-term use, adverse reactions such as dry mouth and abnormal taste are caused, thirdly, the addition amount of active components in the natural component-containing products is generally low (for example, the rhodiola rosea content in the existing rhodiola rosea-containing oral product is only 0.02-0.1%), the efficacy is insufficient, and the multi-component synergistic design is lacked, and fourthly, most products only pay attention to the antibacterial function, ignore the oral microecology restoration and the immune regulation, and can not radically improve the oral health condition. Rhodiola rosea is used as a natural plant with antibacterial, anti-inflammatory and immunoregulatory effects, and has potential application value in the field of oral care, but the prior art mostly adopts simple pulverization or conventional solvent extraction process for treating rhodiola rosea, has the problems of low extraction rate of active ingredients, easy degradation of active ingredients, high impurity content and the like, and further limits the efficacy. The supercritical CO 2 extraction technology has the advantages of high extraction efficiency, good active ingredient retention, no solvent residue and the like, has been applied to the field of natural product extraction, but has not been reported on the application of the supercritical CO 2 extraction technology in rhodiola rosea extraction for oral antibacterial cream. Therefore, developing a composite antibacterial oral antibacterial paste which is based on multicomponent synergistic antibacterial design, adopts an optimized rhodiola rosea extraction process, has multiple effects and is high in safety becomes an urgent need in the technical field of current oral care. Disclosure of Invention The invention aims to solve the technical problems of single antibacterial component, narrow antibacterial spectrum, strong irritation and limited efficacy of the traditional oral antibacterial product and low utilization rate of active ingredients caused by the lag of the rhodiola rosea treatment process, and provides a compound antibacterial oral antibacterial paste containing rhodiola rosea, which realizes the multiple oral care effects of bacteriostasis, anti-inflammation, microecological restoration and moth prevention through the synergistic effect of the compound antibacterial component and the optimized rhodiola rosea extraction process. The core technical scheme of the invention is that the composite antibacterial ingredient synergy + the rhodiola rosea extraction process + the accurate auxiliary material proportion is specifically designed as follows: (1) The design of the composite antibacterial components comprises selecting rhodiola rosea, tea polyphenol, lysozyme, lactobacillus and cetylpyridinium chloride as five-element composite antibacterial components, and compounding the components according to a specific proportion to form a synergistic antibacterial system. Wherein, the content of rhodiola rosea is 5g (0.5 percent) which is far higher than that of the prior art by 0.02-0.1 percent, the contained components such as rhodioside, tyrosol and the like can inhibit pathogenic bacteria metabolism and enhance the immunity of oral tissues, 3g of tea polyphenol can destroy the cell membrane structure of bacteria and inhibit adhesion of pathogenic bacteria and neutralize bad breath, 2g of lysozyme can decompose bacterial cell wall peptidoglycan, has remarkable effect on gram positive bacteria, 2.5g of lactobacillus can regulate the microecological balance of oral cavity and inhibit the reproduction of harmful bacteria, and 1g of cetylpyridinium chloride