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CN-122005817-A - Spermidine composition for inhibiting hair follicle stem cell aging and promoting growth phase to enter and application

CN122005817ACN 122005817 ACN122005817 ACN 122005817ACN-122005817-A

Abstract

The invention discloses an spermidine composition for inhibiting hair follicle stem cell aging and promoting growth phase entry and application thereof, and relates to the technical field of biological medicine and functional skin care. A spermidine composition for inhibiting hair follicle stem cell aging and promoting growth phase entry comprises, by mass, 0.5-3 parts of spermidine, 0.2-2 parts of autophagy activator, 0.5-4 parts of antioxidant, 0.1-2 parts of mitochondrial function promoter, 0.2-3 parts of microcirculation promoter, 1-6 parts of skin penetration promoter, 0.2-1 part of preservative, 0.05-0.4 part of pH regulator and 60-95 parts of carrier matrix. The composition can effectively reduce the aging rate of the hair follicle stem cells, obviously improve the proliferation activity of the hair follicle stem cells, effectively remove active oxygen free radicals around the hair follicle stem cells by adding the antioxidant with a novel structure, reduce the damage of external stimulus to the hair follicle, and form a systematic cell protection and repair mechanism.

Inventors

  • ZHANG WEI
  • WU MENGYAO

Assignees

  • 上海麦角硫因生物科技集团有限公司

Dates

Publication Date
20260512
Application Date
20260306

Claims (10)

  1. 1. The spermidine composition for inhibiting hair follicle stem cell aging and promoting anagen phase entry is characterized by comprising, by mass, 0.5-3 parts of spermidine, 0.2-2 parts of autophagy activator, 0.5-4 parts of antioxidant, 0.1-2 parts of mitochondrial function promoter, 0.2-3 parts of microcirculation promoter, 1-6 parts of skin penetration promoter, 0.2-1 part of preservative, 0.05-0.4 part of pH regulator and 60-95 parts of carrier matrix; the antioxidant is a compound shown in a formula 1; formula 1: 。
  2. 2. A spermidine composition according to claim 1, wherein the spermidine composition is used for inhibiting the senescence of hair follicle stem cells and promoting the entry of the anagen phase, the autophagy activator is one or more of rapamycin, resveratrol and epigallocatechin gallate.
  3. 3. The spermidine composition for inhibiting hair follicle stem cell aging and promoting anagen phase entry according to claim 1, wherein the mitochondrial function promoter is one or more of nicotinamide mononucleotide, nicotinamide riboside, and alpha-lipoic acid.
  4. 4. A spermidine composition according to claim 1 for inhibiting aging of hair follicle stem cells and promoting entry of anagen phase, the microcirculation promoter is one or more of ginger extract, ginsenoside and ginkgo extract.
  5. 5. The spermidine composition according to claim 1, wherein the skin penetration enhancer is one or more of azone, propylene glycol, and glycerin.
  6. 6. The spermidine composition for inhibiting hair follicle stem cell aging and promoting anagen phase entry according to claim 1, wherein the preservative is one or more of phenoxyethanol, methylparaben, and ethylhexyl glycerol; The pH regulator is one or more of citric acid, sodium citrate and sodium dihydrogen phosphate.
  7. 7. A spermidine composition according to claim 1, wherein the carrier matrix is one or more of water, glycerol, propylene glycol, lanolin, petrolatum, carbomers, for inhibiting aging of hair follicle stem cells and promoting anagen phase entry.
  8. 8. A process for the preparation of an spermidine composition according to any of claims 1 to 7 for inhibiting the senescence of hair follicle stem cells and promoting the entry of the anagen phase, characterized in that it comprises the following steps: S1, taking the carrier matrix, placing the carrier matrix in a sterile reaction kettle, heating to 45-60 ℃, and uniformly stirring and mixing to obtain a matrix solution; S2, sequentially adding the mitochondrial function promoter, the autophagy activator, the antioxidant and the microcirculation promoter into the matrix solution, maintaining the temperature at 40-55 ℃, and stirring at the rotating speed of 300-500r/min for 20-30min to obtain a mixture A; S3, reducing the temperature of the reaction kettle to 25-35 ℃, adding spermidine and skin penetration enhancer into the mixture A, regulating the stirring rotation speed to 200-300r/min, and continuing stirring for 15-25min to obtain a mixture B; S4, adding the preservative and the pH regulator into the mixture B, stirring for 10-15min, and regulating the pH to 5.5-7.0 to obtain a crude product composition; s5, homogenizing the crude product composition under 15-25MPa for 5-10min, cooling to room temperature, filtering, and sealing to obtain spermidine composition for inhibiting hair follicle stem cell aging and promoting growth phase.
  9. 9. The method for preparing the spermidine composition for inhibiting hair follicle stem cell aging and promoting anagen phase entry according to claim 8, wherein the heating rate in step S1 is 2-4 ℃ per minute, and the stirring speed is 300-500r/min; and in the step S5, a filter membrane with the thickness of 0.22 mu m is adopted for vacuum filtration, and the vacuum degree is 0.06-0.08MPa.
  10. 10. Use of a spermidine composition according to any of claims 1 to 7 for inhibiting hair follicle stem cell senescence and promoting anagen phase entry in the preparation of a skin care product or pharmaceutical preparation for inhibiting hair follicle stem cell senescence and promoting hair follicle entry anagen phase.

Description

Spermidine composition for inhibiting hair follicle stem cell aging and promoting growth phase to enter and application Technical Field The invention relates to the technical field of biological medicine and functional skin care, in particular to an spermidine composition for inhibiting hair follicle stem cell aging and promoting growth phase entry and application thereof. Background Alopecia is a common skin problem that afflicts hundreds of millions of people worldwide, and its pathogenesis is complex, involving multiple pathophysiological processes such as genetics, hormones, immunity, aging, environmental factors, etc. Functional decline and aging of hair follicle stem cells are one of the core mechanisms responsible for the disorder of the hair follicle cycle, shortening of the anagen phase and hair rarefaction. Hair follicle stem cells are localized to the follicular process, have self-renewal and multi-directional differentiation capabilities, and are critical to maintaining the normal growth cycle of hair follicles. However, with aging or external stimuli such as oxidative stress and inflammation, hair follicle stem cells gradually enter an aging state, which is manifested by reduced cell proliferation capacity, impaired autophagy function and mitochondrial dysfunction, and finally, hair follicles are difficult to transform from resting phase to growing phase, and clinically visible alopecia symptoms are formed. Currently, treatments for the problem of hair loss mainly include minoxidil, finasteride and other chemical drugs, as well as hair transplantation procedures. Minoxidil as a potassium channel opener can prolong the growth period of hair follicles to a certain extent, but has the limitations of large individual difference in curative effect, long-term maintenance and use, possibility of scalp irritation or untouched disease and other adverse reactions of partial patients, and finasteride can reduce the production of dihydrotestosterone by inhibiting 5 alpha-reductase, is effective only on androgenic alopecia and can cause systemic side effects such as sexual dysfunction. Furthermore, existing anti-hair-loss products focus on nutritional supplements or scalp surface care, lacking a systematic solution for targeted intervention of hair follicle stem cell senescence from the cellular level. Spermidine, a natural polyamine substance, is widely found in living bodies, and has been found to have biological activities such as induction of autophagy, delay of cell senescence, and protection of mitochondrial function in recent years. However, the single use of spermidine has the problems of low bioavailability, poor transdermal absorption, single action target point and the like, and the potential value of spermidine in hair follicle regeneration and repair is difficult to fully develop. Therefore, the composition which takes spermidine as a core, cooperates with a plurality of functional components and controls the microenvironment of the hair follicle stem cells by multiple targets is developed, and has important scientific significance and application prospect for fundamentally improving the aging state of the hair follicle and promoting the growth phase to enter. Disclosure of Invention Aiming at the problems existing in the prior art, the invention provides an spermidine composition for inhibiting hair follicle stem cell aging and promoting the growth phase to enter and application thereof, so as to solve the problems of large individual difference of curative effect, side effect, lack of systemic scheme for targeted intervention of hair follicle stem cell aging from a cell level in the existing alopecia treatment means, and the like, and aim to fundamentally improve the hair follicle aging state and promote the hair follicle to enter the growth phase through multicomponent synergistic effect. In order to achieve the above purpose, the invention adopts the following technical scheme: A spermidine composition for inhibiting hair follicle stem cell aging and promoting growth phase entry comprises, by mass, 0.5-3 parts of spermidine, 0.2-2 parts of autophagy activator, 0.5-4 parts of antioxidant, 0.1-2 parts of mitochondrial function promoter, 0.2-3 parts of microcirculation promoter, 1-6 parts of skin penetration promoter, 0.2-1 part of preservative, 0.05-0.4 part of pH regulator and 60-95 parts of carrier matrix; the antioxidant is a compound shown in a formula 1; formula 1: 。 Further, the autophagy activator is one or more of rapamycin, resveratrol and epigallocatechin gallate. Further, the mitochondrial function promoter is one or more of nicotinamide mononucleotide, nicotinamide riboside and alpha-lipoic acid. Further, the microcirculation promoter is one or more of rhizoma Zingiberis recens extract, ginsenoside, and semen Ginkgo extract. Further, the skin penetration enhancer is one or more of azone, propylene glycol and glycerin. Further, the preservative is one or more of phenoxyethanol, met