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CN-122005825-A - Health care method based on targeted drug delivery

CN122005825ACN 122005825 ACN122005825 ACN 122005825ACN-122005825-A

Abstract

The invention relates to the technical field of biological pharmacy, discloses a health-care method based on targeted drug delivery, and solves the problems that the existing targeted drug delivery mode is mostly realized through an oral or injection mode, wherein the oral mode can influence the accuracy of the targeted drug delivery, and the injection mode usually needs complicated steps to be carried out, so that the health-care effect of the targeted drug delivery is greatly influenced. The medicine is absorbed through skin, enters human blood circulation through skin, achieves effective blood concentration, and realizes a new administration way for treating or preventing diseases.

Inventors

  • XIN YICHENG

Assignees

  • 辛易澄

Dates

Publication Date
20260512
Application Date
20241112

Claims (8)

  1. 1. A health care method based on targeted drug delivery is characterized by comprising the following steps: Dissolving chitosan in acetic acid solution, carrying out oil bath stirring, adding a proper amount of ammonium persulfate under the protection of inert gas, then adding methacryloxyethyl trimethyl ammonium chloride for reaction, dialyzing a reaction product by deionized water to remove unreacted micromolecule monomers and other impurities, and putting the reaction product into a freezer for freeze drying treatment to obtain quaternized chitosan; Dripping the polypeptide solution into the quaternized chitosan acetic acid solution, adding the layered crystal sodium disilicate solution, adding the solution into a stirring reactor for stirring operation, and after stirring, performing vibration extraction operation on the solution, and pouring the upper layer solution into a separation chamber to obtain quaternized chitosan nanoparticles carrying the polypeptide; Preparing inner cores of the first nano-particles and the second nano-particles respectively, preparing intermediate layers on the surfaces of the two inner cores respectively, preparing an aptamer and a paired DNA on the surfaces of the two intermediate layers respectively, obtaining the first nano-particles and the second nano-particles, and packaging respectively; Step four, packaging the first nano particles and the second nano particles in the step three in the electret in the step two; and fifthly, placing the packaged electrets into a cooling and drying chamber, drying, placing for two to three hours, taking out, placing in a condensing chamber after taking out, and attaching the electrets in the step two to obtain targeted drug delivery.
  2. 2. The method of claim 1, wherein the ratio of chitosan to acetic acid solution in the first step is controlled to be one to three, and the inert gas can be nitrogen or helium, wherein the flow rate of the inert gas is controlled to be twenty-six hundred milliliters per minute.
  3. 3. The method of claim 1, wherein the ratio of the content of the methacryloxyethyl trimethyl ammonium chloride to the quaternized chitosan acetic acid solution in the first step is controlled to be one to five, and the washing time of deionized water is controlled to be twenty to thirty minutes.
  4. 4. A targeted drug delivery-based health care method according to claim 1, wherein the layered crystalline sodium disilicate content of the layered crystalline sodium disilicate solution in the step two is controlled to be zero one milligram to one point two milligrams per milliliter.
  5. 5. A targeted drug delivery-based healthcare method according to claim 1, wherein the temperature of the stirring reactor in the second step is controlled to be between forty-five and fifty-five degrees, the rotational speed is controlled to be between two hundred and three hundred and fifty rotational speeds per minute, and the stirring reactor is subjected to vibration extraction for thirty to forty minutes.
  6. 6. The method for targeted drug delivery-based health care according to claim 1, wherein the first nanoparticle and the second nanoparticle in the third step are core-shell structures, and the core-shell structures comprise an inner core, an intermediate layer and an outer layer.
  7. 7. The method of claim 1, wherein in the first nanoparticle, the inner core is made of a first drug loaded by a carrier material, the middle layer is a cationic material layer, and the outer layer is an aptamer.
  8. 8. The method for targeted drug delivery-based health care according to claim 1, wherein the inner core in the second nanoparticle is made of a second drug loaded by a carrier material, the middle layer is a cationic material layer, the outer layer is a pairing DNA for specific binding with the first nanoparticle modified by the aptamer.

Description

Health care method based on targeted drug delivery Technical Field The invention relates to the technical field of biological pharmacy, in particular to a health care method based on targeted drug delivery. Background A targeted drug delivery based healthcare approach is a therapeutic approach that delivers drugs directly to these target sites by precisely identifying and locating specific cells or tissues. The method is characterized in that the high specificity of the medicine is utilized to ensure that the medicine only acts on the part needing to be treated, the damage to normal tissues is reduced, and the basic principle of targeted administration comprises the following aspects that the specific recognition and targeted medicine can specifically recognize antigens or receptors on the surfaces of cancer cells, so that the medicine only acts on the cancer cells, the damage to the normal cells is reduced, the growth of tumor cells is inhibited, the growth and proliferation of the tumor cells are inhibited by the modes of interfering growth factors required by the tumor cells, blocking cell signaling paths or inducing apoptosis and the like, and the side effects are reduced, and the side effects such as rash, edema and the like caused by systemic administration can be reduced because the medicine only acts on the specific part. The application of the targeted drug in health care mainly comprises the following aspects of wide application of cancer treatment and targeted drug in the cancer treatment, accurate treatment through specific identification of cancer cells, reduction of damage to normal tissues, chronic disease management, and the targeted drug administration for some chronic diseases such as cardiovascular diseases, diabetes and the like, and local treatment can be realized through accurate identification of lesion sites, so that side effects caused by systemic drug administration are reduced. The application number CN202310747794.7 relates to a nanoparticle composition, a preparation method, a targeting preparation and a targeting administration method thereof. The nanoparticle composition comprises a nanoparticle I and a nanoparticle II which are respectively and independently packaged, wherein the nanoparticle I and the nanoparticle II are of a core-shell structure, the core-shell structure comprises an inner core, an intermediate layer and an outer layer, the inner core is a drug loaded by a carrier material, the intermediate layer is a cationic material layer, the outer layer of the nanoparticle I is an aptamer, and the outer layer of the nanoparticle II is a pairing DNA and is used for being specifically combined with the nanoparticle I modified by the aptamer. The nanoparticle I can act on the targeting lesion area through the high affinity of the aptamer and the target cell, and the delivery of the drug is realized to the targeting lesion area, meanwhile, a binding target is provided for the nanoparticle II, the capacity of delivering the drug to a disease part is obviously increased, the existing targeting drug delivery mode is mostly realized through an oral or injection mode, wherein the oral mode can influence the targeting drug delivery accuracy, and the injection mode usually needs complicated steps to carry out, so that the health care effect of the targeting drug delivery is greatly influenced. The problems described above are addressed. For this purpose, a targeted drug delivery-based healthcare method is proposed. Disclosure of Invention The invention aims to provide a health care method based on targeted drug delivery, which adopts the device to work, thereby solving the problems that the existing targeted drug delivery mode is mostly realized by oral administration or injection, wherein the oral administration mode can influence the accuracy of the targeted drug delivery, and the injection mode usually needs complicated steps to be carried out, and the health care effect of the targeted drug delivery is greatly influenced. In order to achieve the aim, the invention provides the following technical scheme that the health care method based on targeted drug delivery is characterized by comprising the following steps: Dissolving chitosan in acetic acid solution, carrying out oil bath stirring, adding a proper amount of ammonium persulfate under the protection of inert gas, then adding methacryloxyethyl trimethyl ammonium chloride for reaction, dialyzing a reaction product by deionized water to remove unreacted micromolecule monomers and other impurities, and putting the reaction product into a freezer for freeze drying treatment to obtain quaternized chitosan; Dripping the polypeptide solution into the quaternized chitosan acetic acid solution, adding the layered crystal sodium disilicate solution, adding the solution into a stirring reactor for stirring operation, and after stirring, performing vibration extraction operation on the solution, and pouring the upper layer solution i