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CN-122005873-A - Medical ultrasound coupling gel and preparation method thereof

CN122005873ACN 122005873 ACN122005873 ACN 122005873ACN-122005873-A

Abstract

The invention provides medical ultrasonic coupling gel and a preparation method thereof, wherein the medical ultrasonic coupling gel comprises, by mass, 3.5-4.5 parts of probiotic micro-bubble powder, 8-12 parts of surfactant, 6-8 parts of glycerol, 2.5-3.5 parts of sodium hyaluronate, 0.5-0.8 part of xanthan gum, 1.1-1.8 parts of plant extract, 60-70 parts of deionized water, and the probiotic micro-bubble powder comprises a gas core taking perfluorocarbon gas as a core, a shell material wrapping the gas core and probiotics loaded on the shell material. According to the invention, the probiotic microbubbles are introduced into the ultrasound coupling gel to realize the dual-function coordination of the ultrasound imaging quality improvement and the skin microecology regulation, and simultaneously, in the ultrasound inspection process, the probiotic microbubbles release active probiotics to regulate the skin microecology under the slight mechanical shearing action of the body temperature and the probe.

Inventors

  • CHEN SHUXIAO
  • LIU BAOYU
  • JIA XINQING
  • ZHANG JINQIU
  • ZHAO MEIZHEN
  • SU HONGHONG
  • LI XIAOYAN
  • LIU CHUANRUI

Assignees

  • 海氏海诺健康科技股份有限公司

Dates

Publication Date
20260512
Application Date
20260228

Claims (10)

  1. 1. The medical ultrasonic coupling gel is characterized by comprising, by mass, 3.5-4.5 parts of probiotic micro-bubble powder, 8-12 parts of a surfactant, 6-8 parts of glycerol, 2.5-3.5 parts of sodium hyaluronate, 0.5-0.8 part of xanthan gum, 1.1-1.8 parts of a plant extract and 60-70 parts of deionized water; the probiotic micro-bubble powder comprises a gas core taking perfluorocarbon gas as a core, a shell material wrapping the gas core and probiotics loaded on the shell material.
  2. 2. The medical ultrasound coupling gel according to claim 1, wherein the particle size of the probiotic micro-bubble powder is 1-5 μm.
  3. 3. The medical ultrasound coupling gel according to claim 1, wherein the mass ratio of the gas core, the shell material and the probiotics is 1:15-20:2-3.
  4. 4. The medical ultrasound coupling gel according to claim 1, wherein the shell material comprises a phospholipid monolayer formed by lecithin, a composite polysaccharide layer formed by chitosan and sodium alginate, and a protective outer layer formed by trehalose, and the probiotics are loaded on the protective outer layer.
  5. 5. The medical ultrasound coupling gel according to claim 4, wherein the mass ratio of lecithin, chitosan, sodium alginate and trehalose is 17-20:4.5-5.5:3.0-3.8:43-48.
  6. 6. The medical ultrasound coupling gel according to claim 1, wherein the perfluorocarbon gas is perfluorohexane or perfluoropropane.
  7. 7. The medical ultrasound coupling gel according to claim 1, wherein the mass ratio of perfluorocarbon gas, shell material and probiotics is 1:15-25:2-3.
  8. 8. A method of preparing a medical ultrasound coupling gel according to any one of claims 1 to 7, comprising the steps of: s1, preparing probiotic micro-bubble powder, namely dispersing probiotics in a shell material, introducing perfluorocarbon gas, performing ultrasonic emulsification to obtain micro-bubble suspension, and performing freeze drying on the suspension to obtain the probiotic micro-bubble powder; s2, adding glycerol, sodium hyaluronate and xanthan gum into deionized water, mixing and dispersing to obtain a first mixture; S3, adding a plant extract into the first mixture, and stirring to obtain a second mixture; S10, adding a surfactant into the second mixture for emulsification to obtain a gel matrix; and S11, adding the probiotic micro-bubble powder prepared in the step S1 into the gel matrix at the temperature lower than 37 ℃, stirring, performing ultrasonic treatment, and filtering to obtain the coupling gel.
  9. 9. The method for preparing the medical ultrasound coupling gel according to claim 8, wherein in the step S1, probiotics and a trehalose solution are mixed to prepare a bacterial suspension, lecithin, chitosan and sodium alginate are mixed according to a proportion, perfluorocarbon gas is introduced, ultrasonic emulsification and freeze drying are carried out to obtain blank microbubble powder, and the blank microbubble powder is added into the bacterial suspension to be mixed and then freeze-dried again to obtain the probiotics microbubble powder.
  10. 10. The method for preparing a medical ultrasound coupling gel according to claim 9, wherein the probiotic micro-bubble powder is added in three times in step S11, and the process parameters of the ultrasound are that the ultrasound frequency is 40 kHz, the power is 140-160W, and the processing time is 10-40 min.

Description

Medical ultrasound coupling gel and preparation method thereof Technical Field The invention relates to the technical field of medical treatment, in particular to medical ultrasonic coupling gel and a preparation method thereof. Background The medical ultrasonic couplant is an indispensable acoustic matching medium between the ultrasonic probe and the skin, and is used for removing an air gap, realizing acoustic impedance matching, reducing ultrasonic reflection loss and providing lubrication. With the development of high molecular material science, gel-type couplant using high molecular polymers such as carboxymethyl cellulose, polyethylene glycol, carbomer and the like as matrixes gradually becomes the mainstream. However, with the popularity of ultrasound examinations and the increasing frequency of probe reuse, the risk of cross-infection becomes a significant challenge in the clinic. As a high-frequency contact medical instrument, the ultrasonic probe may develop bacteria, fungi or even viruses on its surface during the continuous examination of different patients. The common couplant has no disinfection function and even can cause secondary pollution due to repeated opening and use. To solve this problem, a sterilizing type ultrasonic coupling agent has been developed, and the probe surface is immediately sterilized while acoustic coupling is achieved by adding chemical sterilizing components such as parachlorometaxylenol, iodine, etc. Although the existing disinfection couplant reduces the risk of cross infection to a certain extent, a plurality of technical bottlenecks still exist, namely, chemical disinfectants can generate stimulation to sensitive skin, partial components can cause corrosion damage to a precise probe, and the bacteriostasis spectrum is often not comprehensive enough. For example, the disinfection type aerosol couplant disclosed in CN202110919564.5 introduces chemical bactericides such as trichlorohydroxydiphenyl ether, chlorhexidine gluconate and the like and plant extracts, but has strong skin irritation, probe corrosion risk and no enhancement effect on an ultrasonic probe although the disinfection effect is enhanced. Further improvements and developments are therefore needed. Disclosure of Invention Aiming at various defects in the prior art, in order to solve the problems, a medical ultrasound coupling gel and a preparation method thereof are provided, and the following technical scheme is provided: The medical ultrasonic coupling gel comprises, by mass, 3.5-4.5 parts of probiotic micro-bubble powder, 8-12 parts of a surfactant, 6-8 parts of glycerol, 2.5-3.5 parts of sodium hyaluronate, 0.5-0.8 part of xanthan gum, 1.1-1.8 parts of a plant extract and 60-70 parts of deionized water, wherein the probiotic micro-bubble powder comprises a gas core taking perfluorocarbon gas as a core, a shell material wrapping the gas core and probiotics loaded on the shell material. Further, the particle size of the probiotic micro-bubble powder is 1-5 μm. Further, the mass ratio of the gas core to the shell material to the probiotics is 1:15-20:2-3. Further, the shell material comprises a phospholipid monomolecular layer formed by lecithin, a composite polysaccharide layer formed by chitosan and sodium alginate and a protective outer layer formed by trehalose, and the probiotics are loaded on the protective outer layer. Further, the mass ratio of lecithin, chitosan, sodium alginate and trehalose is 17-20:4.5-5.5:3.0-3.8:43-48. Further, the perfluorocarbon gas is perfluorohexane or perfluoropropane. Further, the mass ratio of the perfluorocarbon gas to the shell material to the probiotics is 1:15-25:2-3. In addition, the application provides a preparation method of the medical ultrasound coupling gel, which comprises the following steps: s1, preparing probiotic micro-bubble powder, namely dispersing probiotics in a shell material, introducing perfluorocarbon gas, performing ultrasonic emulsification to obtain micro-bubble suspension, and performing freeze drying on the suspension to obtain the probiotic micro-bubble powder; s2, adding glycerol, sodium hyaluronate and xanthan gum into deionized water, mixing and dispersing to obtain a first mixture; S3, adding a plant extract into the first mixture, and stirring to obtain a second mixture; S10, adding a surfactant into the second mixture for emulsification to obtain a gel matrix; and S11, adding the probiotic micro-bubble powder prepared in the step S1 into the gel matrix at the temperature lower than 37 ℃, stirring, performing ultrasonic treatment, and filtering to obtain the coupling gel. In the step S1, probiotics and trehalose solution are mixed to prepare bacterial suspension, lecithin, chitosan and sodium alginate are mixed according to a certain proportion, perfluorocarbon gas is introduced, ultrasonic emulsification and freeze drying are carried out to obtain blank micro-bubble powder, and the blank micro-bubble powder is added into the