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CN-122005875-A - Ultrasonic coupling bag, ultrasonic coupling agent and preparation method of ultrasonic coupling agent

CN122005875ACN 122005875 ACN122005875 ACN 122005875ACN-122005875-A

Abstract

The application discloses an ultrasonic coupling bag, an ultrasonic coupling agent and a preparation method thereof. The ultrasonic coupling agent comprises a first component and a second component, wherein the first component is prepared from the following raw materials, by weight, 90-110 parts of phenylxylylethane, 0.8-1.2 parts of 2, 5-diphenyl oxazole, 7-12 parts of polymethyl methacrylate, 90-110 parts of methylene dichloride, 202-3 parts of span, 90-110 parts of deionized water, and the second component comprises poloxamer F188 and deionized water, wherein the mass ratio of the first component poloxamer F188 to the deionized water is (2-3): 1 (4-6).

Inventors

  • Mao Cuilian
  • ZHANG YANYAN
  • WEI ZONGKAI

Assignees

  • 江苏省人民医院（南京医科大学第一附属医院）

Dates

Publication Date
20260512
Application Date
20260323

Claims (10)

  1. 1. An ultrasonic couplant, characterized in that the ultrasonic couplant comprises a first component and a second component; the first component is prepared from the following raw materials in parts by weight: phenyl xylylethane 90-110; 0.8-1.2 of 2, 5-diphenyl oxazole; 7-12 parts of polymethyl methacrylate; 90-110 parts of dichloromethane; span 202-3; 90-110 parts of deionized water; The second component comprises poloxamer F188 and deionized water; Wherein the mass ratio of the first component of poloxamer F188 to deionized water is (2-3) 1 (4-6).
  2. 2. The ultrasonic couplant of claim 1, wherein the first component is prepared from the following raw materials in parts by weight: phenyl xylylethane 100; 2, 5-diphenyloxazole 1; polymethyl methacrylate 9; Dichloromethane 100; span 202.5; deionized water 100; Optionally, the mass ratio of the first component to poloxamer F188 to deionized water is 2.5:1:5.
  3. 3. A method of preparing the ultrasonic couplant of claim 1 or 2, comprising: 2, 5-diphenyl oxazole is dripped into phenyl xylylethane to prepare 2, 5-diphenyl oxazole-phenyl xylylethane solution; adding polymethyl methacrylate into dichloromethane to prepare polymethyl methacrylate solution; mixing the 2, 5-diphenyloxazole-phenylxylylethane solution with the polymethyl methacrylate solution to form an oil phase; Mixing the oil phase with an aqueous solution of span 20 to obtain a suspension, and drying to obtain powder; and mixing and dissolving the powder and poloxamer F188 in deionized water to prepare the ultrasonic coupling agent.
  4. 4. The method for preparing an ultrasonic coupling agent according to claim 3, wherein the volume ratio of the 2, 5-diphenyloxazole-phenylxylylethane solution to the polymethyl methacrylate solution is 1 (4-5); Optionally, the volume ratio of the oil phase to the span 20 aqueous solution is 1 (10-20); Optionally, the volume ratio of the oil phase to the span 20 aqueous solution is 1:15.
  5. 5. The method for preparing an ultrasonic couplant according to claim 3, wherein the mass concentration of poloxamer F118 dissolved in deionized water is 15% -25%.
  6. 6. An ultrasonic coupling bag, characterized by comprising the ultrasonic coupling agent according to claim 1 or 2 or the ultrasonic coupling agent prepared by the preparation method according to any one of claims 3 to 5.
  7. 7. The ultrasound coupling bag according to claim 6, wherein the ultrasound couplant is encapsulated in an ultrasound coupling bag prepared by a polyolefin elastomer-TiO 2 /PWA film.
  8. 8. The ultrasound coupling bag according to claim 7, wherein the polyolefin elastomer-TiO 2 /PWA film is prepared by a process comprising: Poloxamer F127 is mixed with absolute ethyl alcohol to obtain a first mixed solution; Adding titanium tetrachloride into the first mixed solution to obtain a second mixed solution; Adding a phosphotungstic acid aqueous solution into the second mixed solution to obtain a TiO 2 /PWA suspension; Dipping the polyolefin elastomer into the TiO 2 /PWA suspension by adopting a pulling dipping method to prepare the polyolefin elastomer-TiO 2 /PWA film; Optionally, the weight ratio of poloxamer F127 to absolute ethyl alcohol is 1 (25-35); Optionally, the weight ratio of the first mixed solution to the titanium tetrachloride is 5 (1-1.3); optionally, the volume ratio of the second mixed solution to the aqueous solution of phosphotungstic acid is 1 (0.8-1.2).
  9. 9. The ultrasonic coupling bag according to claim 8, wherein the ultrasonic coupling bag comprises a couplant storage unit for storing the ultrasonic couplant; an adjusting unit located between the couplant storage unit and the probe scanning unit, the adjusting unit being openable and closable for controlling the flow of the ultrasonic couplant, and And a probe scanning unit.
  10. 10. The ultrasound coupling bag according to claim 9, wherein the adjustment unit is a sealing bar of a male and female bone; optionally, the probe scanning unit has a groove design; Optionally, the bottom thickness of the probe scanning unit is smaller than the sidewall thickness.

Description

Ultrasonic coupling bag, ultrasonic coupling agent and preparation method of ultrasonic coupling agent Technical Field The application relates to the technical field of ultrasonic couplants, in particular to an ultrasonic coupling bag, an ultrasonic couplant and a preparation method thereof. Background The ultrasonic diagnosis technology has become an indispensable imaging examination means in clinical medicine because of the advantages of noninvasive, real-time, low cost and the like. In the ultrasonic inspection process, the ultrasonic couplant plays a vital role. The basic principle is that if an air gap exists between the ultrasonic probe and the skin of the human body, the ultrasonic probe can strongly reflect at an interface and cannot effectively penetrate the skin to enter the tissue of the human body due to the extremely low acoustic impedance of the air and the huge difference of the acoustic impedance of the ultrasonic probe and the skin or soft tissue of the human body. The couplant has the functions of filling a tiny gap between the probe and the skin, exhausting air and realizing matching transition of acoustic impedance, thereby ensuring high-efficiency penetration of ultrasonic waves and obtaining clear and high-quality diagnostic images. At present, widely used ultrasound coupling media in clinic are mainly divided into two main categories. One type is a traditional couplant, which is directly smeared on the skin surface of a patient, and can be polluted by microorganisms in the use process, so that the risk of cross infection exists for the patient with skin damage, ulcer or postoperative examination. The couplant has low cost, but needs to consume a large amount of paper towels for erasure after inspection for disposable use, thereby not only causing resource waste and environmental pollution, but also increasing the workload of medical staff. Although sterile or aseptic type couplants are present on the market, the disposable nature is unchanged, and when a wound surface or a special part (such as an operation) is involved in examination, extremely high requirements are imposed on the sterility and safety of the product, and the existing aseptic gel products have limited choices and high cost. The other type is a solid or semi-solid coupling pad, with hydrogel coupling pads being more common. Such products are typically disposable and are applied directly to the surface of the patient's skin for ultrasonic investigation. Compared with the traditional gel, the partial hydrogel coupling pad has the advantages of no residue and no wiping. The thickness of the existing coupling pad is usually fixed, and cannot be adjusted in real time according to the probe depth and the focus area during the inspection process. Although studies have shown that the thickness of the coupling layer has a significant effect on the acoustic transmission efficiency, for example in certain acoustic streaming devices it is necessary to precisely optimize the thickness for optimal coupling. In addition, most of the existing coupling pads are designed to be in direct contact with the skin, and once they are used in the skin-breaking area, they are also at risk of cross-contamination, and it is difficult to thoroughly clean and sterilize for repeated use. Disclosure of Invention In order to solve the defects in the art, the application aims to provide an ultrasonic coupling bag, an ultrasonic coupling agent and a preparation method thereof. According to an aspect of the present application, there is provided an ultrasonic couplant comprising a first component and a second component; the first component is prepared from the following raw materials in parts by weight: phenyl xylylethane 90-110; 0.8-1.2 of 2, 5-diphenyl oxazole; 7-12 parts of polymethyl methacrylate; 90-110 parts of dichloromethane; span 202-3; 90-110 parts of deionized water; The second component comprises poloxamer F188 and deionized water; wherein the mass ratio of the first component of poloxamer F188 to deionized water is (2-3) 1 (4-6). According to some embodiments of the application, the first component is prepared from the following raw materials in parts by weight: phenyl xylylethane 100; 2, 5-diphenyloxazole 1; polymethyl methacrylate 9; Dichloromethane 100; span 202.5; deionized water 100; Optionally, the mass ratio of the first component to poloxamer F188 to deionized water is 2.5:1:5. According to another aspect of the present application, there is provided a method for preparing the above-mentioned ultrasonic couplant, comprising: 2, 5-diphenyl oxazole is dripped into phenyl xylylethane to prepare 2, 5-diphenyl oxazole-phenyl xylylethane solution; adding polymethyl methacrylate into dichloromethane to prepare polymethyl methacrylate solution; mixing a2, 5-diphenyl oxazole-phenyl xylylethane solution with a polymethyl methacrylate solution to form an oil phase; mixing the oil phase with an aqueous solution of span 20 to obtain a suspension,