CN-122005885-A - Self-adaptive spectrum sterilization and drug effect maintenance system

CN122005885ACN 122005885 ACN122005885 ACN 122005885ACN-122005885-A

Abstract

The invention belongs to the crossing field of biological medicine and photoelectron technology, in particular relates to a self-adaptive spectrum sterilization and drug effect maintenance system, and aims to solve the technical problem that the traditional sterilization technology realizes efficient microorganism inactivation and simultaneously easily damages active ingredients. The system comprises a spectrum generation, multi-mode sensing, dynamic regulation and control and closed-loop execution module, wherein a double-target optimization model is constructed by collecting multi-dimensional data such as microbial fluorescence, raman fingerprints, temperature, light transmittance and the like in real time, spectrum proportion and output parameters are adjusted on line, and sterilization efficiency and efficacy are cooperatively optimized. The method adopts pre-scanning to identify the living bacteria area and implements selective irradiation, and combines dynamic weight adjustment and compensatory protection measures to realize self-adaptive closed-loop control of the treatment process. The system has the characteristics of high precision, low damage, energy conservation and safety, and is suitable for light control treatment of high value-added products such as medicines, health products and the like.

Inventors

QIAN JINJING
Zhi Niya
SHEN XIAOHUA
CHEN XIAOYAN

Assignees

杭州市五云山医院(杭州市健康促进研究院)

Dates

Publication Date: 20260512
Application Date: 20260120

Claims (10)

1. An adaptive spectrum sterilization and pharmacodynamic maintenance system, comprising: The spectrum generation module is used for generating a programmable broad-spectrum composite optical radiation field; The multi-mode sensing module is used for synchronously collecting a microbial fluorescence characteristic signal of a sample and a Raman fingerprint of a target compound in the processing process; The dynamic regulation and control module is used for receiving the signals from the multi-mode sensing module and calculating the optimal spectrum ratio in the next time period based on a preset double-target optimization model, wherein the double-target optimization model keeps a double-optimization target with sterilization efficiency and medicinal components, and the weight coefficient of the double-target optimization model dynamically evolves according to the processing process; The closed-loop execution module is used for converting the instruction output by the dynamic regulation and control module into a specific control signal for the spectrum generation module and completing full-link response from data acquisition, analysis decision and execution adjustment in each control period.
2. The self-adaptive spectrum sterilization and drug effect maintenance system according to claim 1, wherein the multi-mode sensing module is further used for collecting local temperature distribution data and medium transmittance change curves, and all sensing probes are integrated in the processing cavity and have a self-cleaning function.
3. An adaptive spectral sterilization and pharmacodynamic maintenance system according to claim 2 wherein the acquisition of the fluorescent signature of the microorganism relies on endogenous coenzyme fluorescence enhancement techniques, wherein a low intensity excitation pulse is emitted to induce the microorganism to produce a characteristic fluorescent response and capture a spatially distributed image thereof prior to application of the main sterilization spectrum, the information obtained being used to guide spatially selective irradiation during the main treatment stage.
4. The self-adaptive spectrum sterilization and pharmacodynamic maintenance system according to claim 3, wherein the dynamic regulation module is internally provided with an updatable Raman database, standard spectrum characteristics of a plurality of medicinal components and corresponding photodamage threshold parameters are stored, and when specific Raman peak intensity attenuation exceeding a preset warning value is monitored, the dynamic regulation module starts a protection mechanism, reduces the output duty ratio of a relevant wavelength interval and starts compensatory auxiliary measures.
5. The adaptive spectral sterilization and pharmacodynamic maintenance system according to claim 4, wherein the compensatory assistance includes local injection of inert gas to the treatment area to form a transient optical barrier, activation of a micro-thermoelectric refrigeration unit for point-to-point cooling, or introduction of an anti-phase interference beam to counteract excessive energy deposition.
6. The self-adaptive spectrum sterilization and drug effect maintenance system according to claim 5, wherein the solid-state light emitting units in the spectrum generation module are distributed according to wavelength groups, a thermal isolation structure is arranged between each group, an independent heat dissipation channel is arranged between each group, and the light source driving circuit supports a digital pulse width modulation and analog current adjustment dual mode.
7. The self-adaptive spectrum sterilization and pharmacodynamic maintenance system according to claim 6, wherein the embedded algorithm engine in the dynamic regulation module adopts a heterogeneous computing architecture, and comprises a special digital signal processor and a reconfigurable logic array, and when the system is started, a processing protocol template for the current sample type is automatically loaded, and the processing protocol template is obtained by training historical successful cases.
8. The self-adaptive spectrum sterilization and drug effect maintenance system according to claim 7, wherein the generation of the processing protocol template is based on a large-scale offline training process, a training set is constructed by combining real experimental data with physical simulation, a reverse mapping relation of reversely pushing an optimal input path from a desired output is established through supervised learning, and the obtained model is compressed and then solidified in a local memory.
9. The system of claim 8, wherein the closed loop execution module has a control period of millisecond level, wherein the system evaluates the deviation of the current state from the expected path in each cycle, and wherein the adaptive calibration procedure is triggered if the plurality of consecutive samples deviate from the reference trajectory by more than a tolerance band, wherein the tolerance band width dynamically varies according to the processing stage.
10. An adaptive spectrum sterilization and pharmacodynamic maintenance system according to claim 9 wherein the adaptive correction procedure is implemented by adjusting the update step size and direction of the control parameters, the system automatically decreasing the update step size and enhancing the response sensitivity to negative feedback signals when a sustained deviation is detected.

Description

Self-adaptive spectrum sterilization and drug effect maintenance system Technical Field The invention belongs to the crossing field of biological medicine and photoelectron technology, and in particular relates to a self-adaptive spectrum sterilization and drug effect maintenance system. Background The spectrum technology is increasingly widely applied in the fields of modern medical treatment and biosafety, and the core principle is to inactivate microorganisms or regulate biological tissues by utilizing electromagnetic radiation in a specific wavelength range. With the development of optical engineering, sensor technology and automation control, spectrum-based processing approaches have gradually moved from laboratory research to clinical and industrial settings, covering multiple directions of air disinfection, surface sterilization, wound treatment, etc. The key point of the technology is that optimal spectrum parameters are selected according to biological characteristics of a target object so as to realize efficient and safe action and effects. The self-adaptive spectrum processing system is used as an intelligent evolution direction of a spectrum technology, and aims to dynamically adjust the intensity, wavelength combination and time sequence mode of an output spectrum by sensing the environment or the object state in real time, so that the accuracy and adaptability of a processing process are improved. Such systems typically integrate a multi-channel light source module, an environment-aware unit, and a feedback control algorithm, desirably maintaining optimal performance in complex and diverse application scenarios. The basic objective is to avoid unnecessary photodamage to the surrounding environment or sensitive tissue while ensuring sterilization efficacy. In the prior art, although the spectrum sterilization function under fixed parameters is realized, a plurality of limitations are exposed in practical application, namely the lack of the capability of identifying pathogen types, concentration and environmental media (such as humidity and shielding), so that spectrum output cannot be optimized as required, the system response is lagged under the multi-source interference factors, the stable sterilization efficiency is difficult to maintain, meanwhile, the existing device generally ignores the cooperative requirements of the subsequent efficacy maintenance links, cannot construct a continuous intervention mechanism from sterilization to restoration, and in addition, the problems that the system is high in energy consumption, the service life is limited by light source aging and the like are not effectively solved. These problems are particularly prominent in medical environments requiring long-term operation and high reliability guarantee, and severely restrict the deep application of spectroscopic techniques in dynamic scenes. Therefore, there is a need for an adaptive spectrum sterilization and pharmacodynamic maintenance system with environmental awareness, intelligent decision-making and multi-stage synergy. Disclosure of Invention The invention aims to provide a self-adaptive spectrum sterilization and drug effect maintenance system, which solves the technical contradiction existing in the traditional sterilization technology when complex samples with the requirements of microorganism control and active ingredient protection are treated. In the prior art, although the chemical sterilization method has higher efficiency, residues are easy to introduce and biologically active substances are easy to destroy, and the physical sterilization method such as high temperature or irradiation often causes the degradation of heat-sensitive or photosensitive active ingredients due to the unadjustable action intensity. The existing equipment mostly adopts a fixed parameter operation mode, and cannot dynamically optimize the treatment strategy according to the real-time state of the material to be treated, so that the cooperative optimization between sterilization thoroughness and component retention degree is difficult to realize. In addition, the conventional monitoring means lags behind the actual reaction process, and lacks in-situ and on-line feedback capability on key process parameters, so that insufficient control accuracy is caused. The technical scheme of the invention is that the device comprises a spectrum generation module, a multi-mode sensing module, a dynamic regulation and control module and a closed-loop execution module. The spectrum generation module is used for generating a programmable broad-spectrum composite optical radiation field, the output spectrum range of the spectrum generation module covers the ultraviolet C wave band to the near infrared region, the light source array is composed of a plurality of groups of solid-state light emitting units, and each unit is independently driven and supports nanosecond pulse modulation and continuous wave output switching. The multi-mode s