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CN-122005894-A - Waterproof chitin nanofiber wound repair gel membrane and preparation method thereof

CN122005894ACN 122005894 ACN122005894 ACN 122005894ACN-122005894-A

Abstract

The invention discloses a waterproof chitin nanofiber wound repair gel film and a preparation method thereof, belonging to the field of wound repair gel, the steps comprise deacetylating chitin, processing the chitin into chitin nanofiber, preparing into aqueous dispersion with certain concentration, adding the polymer solution with negative charges into the aqueous dispersion solution, mixing to obtain a mixed solution, regulating and controlling the conditions of the mixed solution to promote the crosslinking of components to form gel, evaporating the water in the gel, and drying to form a film to obtain the waterproof chitin nanofiber wound repair gel film. The invention combines the strong hydrogen bond interaction among the chitin nanofibers through the specific electrostatic interaction to construct a stable three-dimensional crosslinked network structure, so that the gel forms a compact and uniform gel film in the processes of water evaporation and drying, thereby having excellent waterproof performance, and the film formed by the chitin nanofibers through the self-assembly has a porous structure with uniform pore diameters, thereby having air permeability.

Inventors

  • ZHAO YAN
  • ZHANG WENCHANG
  • YUAN WEN
  • AN GUOQING

Assignees

  • 海湾生物(广西)有限公司

Dates

Publication Date
20260512
Application Date
20260410

Claims (10)

  1. 1. A preparation method of a waterproof chitin nanofiber wound repair gel membrane is characterized by comprising the steps of performing deacetylation pretreatment on chitin, processing the chitin into chitin nanofibers, preparing aqueous dispersion of the chitin nanofibers, adding a polymer solution into the aqueous dispersion, mixing to obtain a mixed solution, regulating the mixed solution to enable components to be crosslinked to form gel, evaporating water in the gel, and drying to form a film, so that the waterproof chitin nanofiber wound repair gel membrane is obtained, wherein solute of the polymer solution is a polymer material with negative charges of dissolved polymer chains.
  2. 2. The method for preparing the waterproof chitin nanofiber wound repair gel membrane according to claim 1, wherein the high polymer material is at least one selected from hyaluronic acid, sodium alginate, carrageenan, polyacrylic acid and carbomer.
  3. 3. The method for preparing the waterproof chitin nanofiber wound repair gel membrane according to claim 1, wherein in the step of deacetylating chitin, the deacetylation degree is 20% -50%.
  4. 4. The method for preparing the waterproof chitin nanofiber wound repair gel membrane according to claim 1, wherein the diameter of the chitin nanofiber is 50 nm-200 nm.
  5. 5. The method for preparing the waterproof chitin nanofiber wound repair gel membrane according to claim 1, wherein the concentration of the chitin nanofiber in the aqueous dispersion is 0.3% -2.0%.
  6. 6. The method for preparing a waterproof chitin nanofiber wound repair gel membrane according to claim 1, wherein the mass ratio of the polymer material in the polymer solution to the chitin nanofiber in the aqueous dispersion is 2:1 to 0.2:1.
  7. 7. The method for preparing the waterproof chitin nanofiber wound repair gel membrane according to claim 1, wherein the step of adding the polymer solution into the aqueous dispersion and mixing is carried out under the mixing condition of stirring at 25-30 ℃ for 30-60 min.
  8. 8. The method for preparing the waterproof chitin nanofiber wound repair gel membrane according to claim 1, wherein the step of regulating the mixed solution to crosslink components to form gel comprises the steps of placing the mixed solution in a reaction container, regulating the pH value of a system to 5.5-7.0, controlling the environmental temperature to be 30-35 ℃, and standing for more than 1 h.
  9. 9. The method for preparing the waterproof chitin nanofiber wound repair gel membrane according to claim 1, wherein the step of evaporating water in the gel and then drying the gel to form a membrane comprises the steps of evaporating the gel to a solid content of 16.6% -67% in an environment of 25-40 ℃ and then freeze-drying the gel.
  10. 10. A waterproof chitin nanofiber wound repair gel membrane, characterized in that the membrane is prepared by the preparation method of the waterproof chitin nanofiber wound repair gel membrane according to any one of claims 1 to 9.

Description

Waterproof chitin nanofiber wound repair gel membrane and preparation method thereof Technical Field The invention relates to a waterproof chitin nanofiber wound repair gel membrane and a preparation method thereof, belonging to the field of wound repair gels. Background In the field of wound repair, the current mainstream technical schemes comprise traditional gauze dressing, hydrogel dressing, foam dressing and the like, and the schemes promote wound healing mainly by means of keeping the moist environment of the wound, absorbing exudates, preventing infection and the like. With the development of biological material technology, natural polymer materials such as chitin, hyaluronic acid and the like are widely applied to the field of wound repair, and the development trend of the current industry is to develop a wound repair material with multiple functions of water resistance, ventilation, antibiosis, healing promotion and the like. The traditional wound repair material has the defects that the traditional wound repair material has insufficient waterproof performance, such as gauze, hydrogel dressing and the like, is easy to wet after contacting water, so that the wound infection risk is increased, the wound healing process is hindered, the wound repair material with the waterproof performance partially has the air permeability, the air permeability is usually sacrificed for improving the waterproof effect, the local humidity of the wound is abnormally increased, the conditions are provided for bacteria breeding, the local inflammation reaction of the wound is easy to be initiated, meanwhile, the antibacterial effect of the traditional partial wound repair material is limited, the antibacterial spectrum is narrow, the growth and the reproduction of various pathogenic bacteria cannot be effectively inhibited, the sterile environment of the wound is difficult to be fully ensured, in addition, the traditional wound repair material can also induce the local inflammation reaction of the wound in the use process, the wound healing is further delayed, the overall repair effect of the traditional wound repair material still needs to be improved, and particularly for chronic difficult healing wounds, the traditional material is difficult to achieve the ideal repair effect, and the diversified and high-quality requirements of clinical wound repair cannot be met. Disclosure of Invention In order to overcome the defects of the prior art, the invention provides a waterproof chitin nanofiber wound repair gel membrane and a preparation method thereof, which have excellent waterproof property, air permeability, anti-inflammatory property and wound repair performance. The technical scheme adopted for solving the technical problems is as follows: the application provides a preparation method of a waterproof chitin nanofiber wound repair gel membrane, which comprises the steps of performing deacetylation pretreatment on chitin, processing the chitin into chitin nanofibers, preparing aqueous dispersion of the chitin nanofibers, adding a polymer solution into the aqueous dispersion to mix to obtain a mixed solution, regulating the mixed solution to crosslink components to form gel, evaporating water in the gel, and drying to form a film, so as to obtain the waterproof chitin nanofiber wound repair gel membrane, wherein solute of the polymer solution is a polymer material with negative charge of dissolved polymer chains. The preparation method of the waterproof chitin nanofiber wound repair gel membrane provided by the application takes chitin nanofibers and negatively charged polymer materials as core components, promotes the electrostatic action and hydrogen bonding action between the components, completes the self-assembly and film formation of the gel, and the prepared gel membrane has excellent waterproof property, air permeability, anti-inflammatory property and wound repair performance, is non-irritating, and can meet the clinical wound repair requirement. Further, the polymer material is at least one selected from hyaluronic acid, sodium alginate, carrageenan, polyacrylic acid and carbomer. Further, in the step of deacetylating the chitin, the deacetylation degree is 20% -50%, so that sufficient positive charges are provided, the electrostatic combination with the negatively charged polymer material is firm and reliable, a stable cross-linked network skeleton is formed, and meanwhile, the cross-linking reaction is prevented from being too severe. Further, the diameter of the chitin nanofiber is 50 nm-200 nm. The gel is favorable for keeping the specific high flexibility and the specific surface area of the nanofiber, compact waterproof structure can be formed by tightly stacking through hydrogen bonds, and the problem of out-of-control aggregation caused by excessive fine particles is avoided. When the nanofiber in the size range is electrostatically combined with a negatively charged polymer material, a cross-linked n