CN-122005897-A - Photothermal antibacterial surgical suture and preparation method thereof

Abstract

A photo-thermal antibacterial surgical suture and a preparation method thereof, wherein the photo-thermal antibacterial surgical suture comprises an inorganic-organic hybrid suture with piezoelectric property and photo-thermal property, the inorganic-organic hybrid suture comprises an organic piezoelectric polymer loaded with photo-thermal nano composite particles, and the photo-thermal nano composite particles comprise silicate clay with a surface modified with CuS nano particles. The photothermal antibacterial surgical suture uses an electric signal to compensate an endogenous electric field of a damaged wound part, promotes the transition of inflammation in the wound under the irradiation of near infrared light, improves the collagen arrangement, adjusts the collagen remodeling, enables the wound tissue to heal in a regeneration mode rather than a scar mode, realizes the effect of inhibiting/improving scar generation, and effectively improves the mechanical property of the incision tissue.

Inventors

• WU JIANG
• HE HUACHENG
• LUO YUTING
• LI XIAOKUN
• CUI YANNA

Assignees

• 温州医科大学

Dates

Publication Date

20260512

Application Date

20260410

Claims (10)

1. 1. A photothermal antimicrobial surgical suture comprising an inorganic-organic hybrid suture having piezoelectric properties and photothermal properties, the inorganic-organic hybrid suture comprising an organic piezoelectric polymer loaded with photothermal nanocomposite particles comprising silicate clay surface-modified with CuS nanoparticles.
2. 2. The photothermal antimicrobial surgical suture according to claim 1, wherein the photothermal conversion efficiency of the photothermal nanocomposite particles is not less than 30%.
3. 3. The photothermal antimicrobial surgical suture according to claim 1, wherein the CuS nanoparticle has a particle size of less than 100nm and the silicate clay has a particle size of 200-3000 nm.
4. 4. The photothermal antimicrobial surgical suture according to claim 1, wherein the ratio of the charged mass of the photothermal nanocomposite particles to the organic piezoelectric polymer in the inorganic-organic hybrid suture is 1:10.
5. 5. The photothermal antimicrobial surgical suture according to claim 1, wherein the silicate clay comprises one or more of halloysite, hectorite, montmorillonite, and attapulgite.
6. 6. The photothermal antimicrobial surgical suture of claim 1, wherein the silicate clay is an acidified silicate clay.
7. 7. The photothermal antimicrobial surgical suture according to claim 1, wherein the inorganic-organic hybrid suture is a surgical suture that reduces skin fibrosis or scarring in skin wound healing, or wherein the inorganic-organic hybrid suture is a surgical suture that promotes healing of infected wounds.
8. 8. A method of preparing a photothermal antimicrobial surgical suture according to any one of claims 1-7, wherein the method of preparing comprises the steps of: modifying CuS nano particles on the surface of silicate clay to prepare the photothermal nano composite particles; And (2) uniformly dispersing the photo-thermal nano composite particles in an electrospinning liquid containing an organic piezoelectric polymer, and preparing the inorganic-organic hybrid suture line under the action of high-voltage polarization of electrospinning.
9. 9. The method of preparing a photothermal antimicrobial surgical suture according to claim 8, wherein the step (1) further comprises acidifying silicate clay, and preparing the photothermal nanocomposite particles by coprecipitation of the acidified natural silicate clay and the CuS nanoparticle.
10. 10. The method for preparing a photothermal antimicrobial surgical suture according to claim 8, wherein the parameters of the electrostatic spinning in the step (2) are 20 KV voltage, 0.0030 mm/s push speed, 12 cm receiving distance, 150 rpm receiver rotation speed and 20-40 min spinning time.

Description

Photothermal antibacterial surgical suture and preparation method thereof Technical Field The invention relates to the technical field of medical surgical sutures, in particular to a photothermal antibacterial surgical suture and a preparation method thereof. Background Medical surgical sutures are an important component of wound closure and surgical repair, playing an indispensable role in modern healthcare systems. By securing the wound edges together, the surgical suture reduces the risk of dehiscence of the wound, reduces the tension in the wound bed, and creates an environment conducive to tissue regeneration. Postsurgical scarring is a common problem in surgery and scar tissue can not only lead to skin dysfunction and damage, but also affect the mental health of humans. Pathological scars can also be formed in severe cases, and lesions, itching, burning, lesions and the like are caused. Common surgical sutures in surgery are often made of natural materials (e.g., silk) or synthetic polymers (e.g., polypropylene), which have reliable tensile strength, good compatibility, and provide reliable support for the wound. However, the above surgical suture lacks active regulatory capability for common complications of wounds, such as surgical site infection, scar regeneration, and the like. Therefore, the development of the multifunctional surgical suture for promoting wound healing, effectively resisting postoperative infection and improving or inhibiting scar formation has important significance. Disclosure of Invention The invention provides a photothermal antibacterial surgical suture, which is prepared by an electrostatic spinning method and has the advantages of photothermal antibacterial property, piezoelectric property and effective scar formation inhibition, and the passive healing promotion of the traditional suture is converted into the active healing promotion of in-situ electrical stimulation. The photothermal antibacterial surgical suture provided by the invention has the effects of promoting wound healing, reducing inflammatory reaction, improving collagen fiber arrangement and further reducing scar formation. The invention provides a photothermal antibacterial surgical suture, which comprises an inorganic-organic hybrid suture (CuS-clay suture) with piezoelectric property and photothermal property, wherein the inorganic-organic hybrid suture comprises an organic piezoelectric polymer loaded with photothermal nano composite particles (CuS-clay particles), and the photothermal nano composite particles comprise silicate clay (clay) with a surface modified with CuS nano particles. Preferably, the photo-thermal conversion efficiency of the photo-thermal nanocomposite particles is not less than 30%. Specifically, the feeding mass ratio of the CuS nano particles to the acidified silicate clay in the photo-thermal nano composite particles is 1:2. Preferably, the particle size of the silicate clay is 200-3000 nm, and the particle size of the CuS nano-particles is less than 100 nm. Preferably, the feeding mass ratio of the photo-thermal nano composite particles to the organic piezoelectric polymer in the inorganic-organic hybrid suture line is 1:10. Preferably, the silicate clay is an acidified silicate clay. Preferably, the silicate clay may be selected from natural silicate nanomaterials. The natural silicate nanomaterial comprises one or more of Halloysite (HNT), two-dimensional layered hectorite (Lap), two-dimensional flaky montmorillonite (MMT) and fiber rod-shaped attapulgite (PGS) in a hollow tube shape. Preferably, the organic piezoelectric polymer comprises a piezoelectric biomaterial, which may be selected from polyvinylidene fluoride (PVDF). Preferably, the inorganic-organic hybrid suture is a surgical suture that reduces skin fibrosis or scarring in skin wound healing, or the inorganic-organic hybrid suture is a surgical suture that promotes healing of infected wounds. A method of preparing a photothermal antimicrobial surgical suture, the method comprising the steps of: modifying CuS nano particles on the surface of silicate clay to prepare the photothermal nano composite particles; And (2) uniformly dispersing the photo-thermal nano composite particles in an electrospinning liquid containing an organic piezoelectric polymer, and preparing the inorganic-organic hybrid suture under the action of high-voltage polarization of electrospinning. Preferably, the step (1) further comprises acidification of silicate clay, and the photo-thermal nano composite particles are prepared by coprecipitation of the acidified silicate clay and the CuS nano particles. Preferably, the parameters of the electrostatic spinning in the step (2) are needle specification 18G, voltage 20 KV, push speed 0.0030 mm/s, receiving distance 12 cm, receiver rotating speed 150 rpm and spinning time 20-40 min. The application of the photothermal antibacterial surgical suture provided by the invention in preparing a wound repair