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CN-122005902-A - Medical antibacterial and anti-inflammatory sodium hyaluronate dressing and preparation method thereof

CN122005902ACN 122005902 ACN122005902 ACN 122005902ACN-122005902-A

Abstract

The invention belongs to the technical field of dressing, and in particular relates to a medical antibacterial and anti-inflammatory sodium hyaluronate dressing and a preparation method thereof. The sodium hyaluronate dressing comprises, by mass, 3-5% of sodium hyaluronate, 1.5-3% of polyvinyl alcohol, 1.5-2% of modified silicon nitride, 0.3-0.5% of a ricepaper pith extract, 0.4-0.7% of carbomer, 1-2% of sodium alginate and the balance of deionized water. The dressing can effectively improve the antibacterial and anti-inflammatory effects of the dressing, prevent wound infection and promote wound healing.

Inventors

  • LI SHAOQING
  • GU ZICHEN
  • AN NA
  • XU HONGYU
  • LI CUIYUN
  • YAN CUIPING
  • ZHAO JUNKUI
  • LIN YUXIA

Assignees

  • 河南中科生物新材料有限公司

Dates

Publication Date
20260512
Application Date
20260212

Claims (10)

  1. 1. The medical antibacterial and anti-inflammatory sodium hyaluronate dressing is characterized by comprising, by mass, 3-5% of sodium hyaluronate, 1.5-3% of polyvinyl alcohol, 1.5-2% of modified silicon nitride, 0.3-0.5% of ricepaper pith fruit extract, 0.4-0.7% of carbomer, 1-2% of sodium alginate and the balance of deionized water; the preparation process of the modified silicon nitride comprises the following steps: (a) Activating silicon nitride particles, adding the activated silicon nitride particles into an ethanol water solution, adding gamma-glycidol ether oxypropyl trimethoxy silane, heating for reaction, and filtering, washing and drying the silicon nitride particles after the reaction is finished to obtain pretreated silicon nitride particles; (b) Adding the pretreated silicon nitride particles and L-tyrosine methyl ester obtained in the step (a) into an ethanol water solution, stirring for reaction, filtering, drying and collecting a product after the reaction is completed; (c) And (3) adding the product obtained in the step (b) into N, N-dimethylformamide, adding itaconic anhydride and potassium carbonate, heating, filtering, washing and drying after the reaction is finished, and thus obtaining the modified silicon nitride.
  2. 2. The medical antibacterial and anti-inflammatory sodium hyaluronate dressing according to claim 1, wherein in the step (a), the mass ratio of the silicon nitride particles, the gamma-glycidoxypropyl trimethoxysilane and the ethanol aqueous solution is 1 (0.3-0.5): 12-16%, and the concentration of the ethanol aqueous solution is 85-90wt%.
  3. 3. The medical bacteriostatic anti-inflammatory sodium hyaluronate dressing according to claim 2, wherein the silicon nitride particles have a volume particle diameter Dv50 of 500-1000nm.
  4. 4. The medical antibacterial and anti-inflammatory sodium hyaluronate dressing according to claim 1, wherein the activation treatment in the step (a) is performed at a temperature of 120-130 ℃ for 2-3 hours, and the heating reaction is performed at a temperature of 60-70 ℃ for 6-8 hours.
  5. 5. The medical antibacterial and anti-inflammatory sodium hyaluronate dressing according to claim 1, wherein the mass ratio of the pretreated silicon nitride particles, the L-tyrosine methyl ester and the ethanol aqueous solution in the step (b) is 1 (2-3) (32-36), and the concentration of the ethanol aqueous solution is 50wt%.
  6. 6. The medical bacteriostatic anti-inflammatory sodium hyaluronate dressing according to claim 1, wherein the stirring reaction in step (b) is performed at a temperature of 40-50 ℃ for a period of 8-12 hours.
  7. 7. The medical antibacterial and anti-inflammatory sodium hyaluronate dressing according to claim 1, wherein the mass ratio of the product, itaconic anhydride and potassium carbonate in the step (C) is 1 (1-1.15): 1.8-2), the heating temperature is 50-60 ℃ and the time is 3-5h.
  8. 8. The medical antibacterial and anti-inflammatory sodium hyaluronate dressing according to claim 1, wherein the molecular weight of the sodium hyaluronate is 10-30kDa, the polyvinyl alcohol is polyvinyl alcohol 1788, the molecular weight is 75-80kDa, the polymerization degree is 1700, and the alcoholysis degree is 87-89%.
  9. 9. A method for preparing a medical bacteriostatic anti-inflammatory sodium hyaluronate dressing according to any one of claims 1-8, which is characterized by comprising the following steps: S1, weighing the raw materials according to the mass percentage, adding carbomer into one half of deionized water, and uniformly mixing to obtain carbomer solution; s2, adding modified silicon nitride, the ricepaper pith extract, sodium hyaluronate, sodium alginate and polyvinyl alcohol into the rest deionized water, and uniformly mixing to obtain a mixed solution; And S3, adding the carbomer solution of S1 into the mixed solution of S2, stirring uniformly, and then irradiating.
  10. 10. The method for preparing the medical antibacterial and anti-inflammatory sodium hyaluronate dressing according to claim 9, wherein the irradiation time is 5-8min.

Description

Medical antibacterial and anti-inflammatory sodium hyaluronate dressing and preparation method thereof Technical Field The invention belongs to the technical field of dressing, and in particular relates to a medical antibacterial and anti-inflammatory sodium hyaluronate dressing and a preparation method thereof. Background In clinical medicine and daily care, wound management is a core link. The ideal wound dressing not only can passively cover the wound surface, but also actively builds a microenvironment beneficial to healing, thereby effectively resisting infection and accelerating tissue repair. Traditional dressing such as gauze is easy to adhere to new granulation tissue, causes secondary damage during replacement and has poor moisture retention, so that the requirements of modern medical treatment on efficient healing are difficult to meet. Therefore, the development of novel functional dressings with excellent biological functions and good use experience becomes a research hotspot in the current biomaterial field. Among the numerous biological materials, sodium hyaluronate is favored for its excellent biocompatibility and moisture retention. It is an important component of extracellular matrix of human body, and can obviously regulate wound surface humidity and promote cell migration and proliferation so as to accelerate wound healing. However, a single sodium hyaluronate gel has the defects of insufficient mechanical properties, such as low mechanical strength, easiness in degradation and poor formability, is difficult to be used as a dressing independently, and does not have remarkable antibacterial capability. Excessive swelling caused by wound exudate accumulation may even lead to disintegration of the gel structure, instead providing a warm bed for bacterial growth. Therefore, by the composite modification strategy, the mechanical strength of the sodium hyaluronate is enhanced and the strong antibacterial capability is endowed while the healing promotion advantage of the sodium hyaluronate is maintained, so that the sodium hyaluronate is a key for breaking through the application bottleneck of the sodium hyaluronate. Based on the above, the invention provides a medical antibacterial and anti-inflammatory sodium hyaluronate dressing. Disclosure of Invention In order to overcome the defects of the prior art, the first aim of the invention is to provide a medical antibacterial and anti-inflammatory sodium hyaluronate dressing which has excellent antibacterial, mechanical and wound healing promoting performances. The second aim of the invention is to provide a preparation method of medical antibacterial and anti-inflammatory sodium hyaluronate dressing, which is simple to prepare. In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: The medical antibacterial and anti-inflammatory sodium hyaluronate dressing comprises, by mass, 3-5% of sodium hyaluronate, 1.5-3% of polyvinyl alcohol, 1.5-2% of modified silicon nitride, 0.3-0.5% of ricepaper pith extract, 0.4-0.7% of carbomer, 1-2% of sodium alginate and the balance of deionized water; the preparation process of the modified silicon nitride comprises the following steps: (a) Activating silicon nitride particles, adding the activated silicon nitride particles into an ethanol water solution, adding gamma-glycidol ether oxypropyl trimethoxy silane, heating for reaction, and filtering, washing and drying the silicon nitride particles after the reaction is finished to obtain pretreated silicon nitride particles; (b) Adding the pretreated silicon nitride particles and L-tyrosine methyl ester obtained in the step (a) into an ethanol water solution, stirring for reaction, filtering, drying and collecting a product after the reaction is completed; (c) And (3) adding the product obtained in the step (b) into N, N-dimethylformamide, adding itaconic anhydride and potassium carbonate, heating, filtering, washing and drying after the reaction is finished, and thus obtaining the modified silicon nitride. The silicon nitride particles have good biological safety and antibacterial activity, but are easy to agglomerate in the dressing, and the surface is hydrophobic to influence the application effect. Therefore, the silicon nitride particles are modified by the silane coupling agent, epoxy groups are introduced to the surfaces of the silicon nitride particles, and then the epoxy groups are utilized to react with amino groups on the L-tyrosine methyl ester with good biological activity, so that the irritation of the dressing to wounds can be reduced, the aggravation of inflammatory reaction is avoided, the unreacted amino groups or phenolic hydroxyl groups on the L-tyrosine methyl ester react with itaconic anhydride, and the itaconic acid and the silicon nitride particles act synergistically to play a role in bacteriostasis. The modified silicon nitride surface has rich carboxyl, phenolic hydroxyl and other polar groups,