CN-122005909-A - Intelligent response type bear gall powder-based bioactive ceramic hydrogel wound repair system

Abstract

The invention discloses an intelligent response type bear gall powder-based bioactive ceramic hydrogel wound repair system, belongs to the technical field of biomedical materials, and solves the problems of uncontrollable function cutting and release and unreasonable interface combination of the existing wound dressing; the intelligent switch has the advantages that the coordination bond formed by the active groups of the bear gall powder and the metal ions released by the ceramics is used as the intelligent switch, the change of pH/ROS of wound surfaces can be responded, the antibacterial ions and the anti-inflammatory components are accurately controlled and released, meanwhile, the bond realizes the stable and dynamic compounding of the ceramics and gel, the intelligent response, the multi-element biological activity and the organic unification of a stable structure are realized, the antibacterial, anti-inflammatory and repair promotion can be cooperated, and the wound healing quality is improved.

Inventors

• DONG ZHIHONG
• WAN DAN
• ZENG ZHEN

Assignees

• 四川亿诺森生物科技有限公司

Dates

Publication Date

20260512

Application Date

20260416

Claims (8)

1. 1. An intelligent responsive type bear gall powder-based bioactive ceramic hydrogel wound repair system, which is characterized by comprising: A pH-responsive and/or active oxygen-responsive hydrogel matrix; Bioactive ceramic particles dispersed in the hydrogel matrix; bear gall powder or active extract thereof loaded on the bioactive ceramic particles; wherein the bioactive ceramic particles are connected with the hydrogel matrix through dynamic coordination bonds formed between active groups in the bear gall powder or active extracts thereof and metal ions from the bioactive ceramic particles.
2. 2. The wound repair system of claim 1, wherein the smart responsive hydrogel matrix is a dual-network hydrogel comprising a first network formed by chemical crosslinking and a second network formed by physical crosslinking or photocrosslinking.
3. 3. The wound repair system of claim 1, wherein the bioactive ceramic particles are mesoporous structured bioactive glass or bioactive ceramic particles having a composition of SiO 2 , caO, and CuO or ZnO.
4. 4. The wound repair system of claim 3, wherein the surface of the bioactive ceramic particles is modified with a metal-organic framework material, the metal nodes of the metal-organic framework material comprising Cu 2+ or Zn 2+ .
5. 5. The wound repair system of claim 1, wherein the dynamic coordination bond is reversible in a wound microenvironment at a pH of 5.5 to 7.4 and an active oxygen concentration of 100 μιη.
6. 6. The wound repair system of claim 1, wherein the active groups in the bear gall powder or active extract thereof comprise hydroxyl groups and sulfonic acid groups.
7. 7. A method of preparing the intelligent responsive bear gall powder-based bioactive ceramic hydrogel wound repair system of claim 1, comprising the steps of: s1, providing bioactive ceramic particles loaded with bear gall powder or active extract thereof; S2, mixing the bioactive ceramic particles obtained in the step S1 with a precursor solution of the intelligent response type hydrogel to form a uniform mixed solution; s3, enabling the hydrogel precursors in the mixed solution to undergo a crosslinking reaction to form an intelligent response type hydrogel matrix wrapping the bioactive ceramic particles; And S4, placing the hydrogel composite material obtained in the step S3 in an ion buffer solution containing Ca 2+ and/or Cu 2+ for incubation, so that the dynamic coordination bond is formed between the bioactive ceramic particles and the intelligent response type hydrogel matrix, and the wound repair system is obtained.
8. 8. Use of the intelligent responsive bear gall powder-based bioactive ceramic hydrogel wound repair system of claim 1 in the manufacture of a medical device or dressing for promoting wound healing, inhibiting wound infection or reducing scar formation.

Description

Intelligent response type bear gall powder-based bioactive ceramic hydrogel wound repair system Technical Field The invention relates to the technical field of biomedical materials, in particular to an intelligent response type bear gall powder-based bioactive ceramic hydrogel wound repair system. Background In the field of wound dressing, the combination of environmental responsiveness, long-acting bioactivity and stable material structure is a key for improving the repairing effect, and is also a prominent challenge for current material design. The prior art generally combines a smart response carrier, a bioactive component and a mechanical support matrix as independent modules, which results in a material system with obvious disadvantages in terms of functional synergy and structural integration, and is specifically embodied in the following aspects: The intelligent response type hydrogel, such as pH response and ROS response, can sense the change of the microenvironment of the wound surface and make physical or chemical response, so as to provide possibility for realizing controlled release of the medicine, but the innovation point of the material is often concentrated on a response mechanism, a gel network is usually composed of synthetic or natural polymers, the inherent biological activity of the material is limited, the gel network is usually used as an inert medicine carrier, the repairing effect is highly dependent on the loaded external medicine, when multiple repairing functions such as antibiosis, anti-inflammation, cell migration promotion and the like are required to be realized, multiple medicines are required to be loaded, the complexity and uncontrollability of a formula are increased, and the synergy and long-acting effect of functional components are difficult to realize; Components with definite biological activity, such as bioactive ceramics for releasing antibacterial/promoting bone ions, and traditional Chinese medicine active ingredients with pharmacological actions such as anti-inflammatory and antioxidant, such as bear gall powder, have been proved to be beneficial to wound repair, however, the prior art mostly uses the components as simple functional fillers or additives, and introduces the components into a dressing matrix through a physical blending or adsorption mode, so that the mode has obvious defects that the active components and a base material are combined mainly through weak physical action, are easy to quickly lose under the flushing of body fluid, the release behavior is passive and uncontrollable, and cannot be matched with the dynamic process of wound healing, and meanwhile, the simple mixing is difficult to realize the synergy of different active components on release kinetics; In order to combine the advantages of different materials, composite materials are widely studied, but traditional methods, such as using chemical coupling agents to establish firm static covalent bond connection among components, the connection mode enhances mechanical stability, but leads to interface rigidity and irreversibility, and in dynamically changing wound microenvironment, the static combination cannot respond to environmental signals, such as reversible adjustment or reconstruction of pH and ROS, and limits the self-adaption capability of the materials and the intelligent release potential of active ingredients; it is particularly notable that, for active substances such as bear gall powder, which are traditional Chinese medicines, the active substances are almost completely regarded as drug-loaded objects in the prior art, the value is only in pharmacological activity, however, the value of active groups such as hydroxyl groups and sulfonic acid groups which are possibly involved in constructing a material network and are contained in the molecular structure is ignored, so that the combination of the active substances and other material components such as inorganic ceramics and polymer chains stays at a physical level, and a stable and functionally integrated structure cannot be formed on a molecular scale. In summary, the core defect existing in the prior art is that the cleavage and mechanical superposition of the functional module, the intelligent response carrier, the bioactive component and the stable composite interface are not organically unified through a design concept, so that the material has responsiveness but insufficient self-activity, or the material is rich in activity but releases coarsely and cannot be intelligently regulated, and the dynamic response capability of the environment is sacrificed for stable composite, so that a new material construction strategy is urgently needed in the field, and the three of the intelligent responsiveness, the multiple bioactivity and the dynamic stable interface are combined into a synergistic system, thereby realizing more accurate, more efficient and more comprehensive promotion of the wound healing process. Disclosure of