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CN-122005914-A - Medical high-strength low-modulus antibacterial porous implant with negative poisson ratio and preparation method thereof

CN122005914ACN 122005914 ACN122005914 ACN 122005914ACN-122005914-A

Abstract

The invention relates to the technical field of medical biological implant materials, and discloses a negative poisson ratio high-strength low-modulus antibacterial porous implant and a preparation method thereof. The method comprises the steps of mixing Ti6Al4V with Cu powder, drying in vacuum, introducing a porous model into printing equipment, melting the mixed powder by using a laser powder bed fusion technology to print a sample, and carrying out ultrasonic cleaning and drying on the sample to obtain a finished product. The implant is of a concave hexagonal honeycomb negative poisson ratio structure, has high yield strength and low elastic modulus, is matched with human bones, and avoids stress shielding. The copper component incorporated imparts broad-spectrum antimicrobial properties. The additive manufacturing ensures the accurate formation of a complex porous structure, promotes the ingrowth of bone tissue, reduces the operation difficulty and improves the long-term safety.

Inventors

  • HE ZHENGYUAN
  • MEI CHENGGUO
  • LI ZONGHAO
  • CHEN NING
  • YANG YU

Assignees

  • 昆明理工大学

Dates

Publication Date
20260512
Application Date
20260310

Claims (8)

  1. 1. The preparation method of the medical high-strength low-modulus antibacterial porous implant with the negative poisson ratio is characterized by comprising the following steps of: s1, mixing Ti6Al4V alloy powder with Cu powder, and then carrying out vacuum drying to obtain mixed powder; s2, introducing the porous structure model into printing equipment, placing mixed powder into a powder supply bin of the printing equipment, and performing laser melting printing by a laser powder bed fusion technology to obtain a porous implant sample; and S3, sequentially carrying out ultrasonic cleaning and drying on the porous implant sample to obtain the medical high-strength low-modulus antibacterial porous implant with the negative poisson ratio.
  2. 2. The method for preparing the medical high-strength low-modulus antibacterial porous implant with the negative poisson ratio according to claim 1, wherein in the S1, the granularity of the Ti6Al4V alloy powder and the granularity of the Cu powder are 15-53 μm.
  3. 3. The preparation method of the medical high-strength low-modulus antibacterial porous implant with the negative poisson ratio according to claim 2, wherein in the S1, the mass ratio of Ti6Al4V alloy powder to Cu powder is 90-99:1-10.
  4. 4. The method for preparing the medical high-strength low-modulus antibacterial porous implant with the negative poisson ratio according to claim 3, wherein in the step S1, the temperature of vacuum drying is 80-100 ℃, and the time of vacuum drying is 6-24 hours.
  5. 5. The method for preparing the medical high-strength low-modulus antibacterial porous implant with the negative poisson ratio according to any one of claims 1 to 4, wherein in the step S2, the laser powder bed fusion technology has the parameters of 110 to 150W of laser power, 1100 to 1400mm/S of scanning speed, 40 to 60 μm of scanning interval, 20 to 40 μm of powder spreading thickness and 40 to 70 μm of light spot diameter.
  6. 6. The method for preparing a medical high-strength low-modulus antibacterial porous implant with negative poisson' S ratio according to claim 5, wherein in S2, the porous structure model is designed by three-dimensional modeling software.
  7. 7. The method for preparing the medical high-strength low-modulus antibacterial porous implant with the negative poisson ratio according to claim 2, 3, 4 or 6, wherein the ultrasonic cleaning is performed for 3-5 times in the step S3.
  8. 8. The negative poisson ratio medical high-strength low-modulus antibacterial porous implant prepared by the method for preparing the negative poisson ratio medical high-strength low-modulus antibacterial porous implant of any one of claims 1 to 7.

Description

Medical high-strength low-modulus antibacterial porous implant with negative poisson ratio and preparation method thereof Technical Field The invention relates to the technical field of medical biological implant materials, in particular to a medical high-strength low-modulus antibacterial porous implant with negative poisson ratio and a preparation method thereof. Background The Ti6Al4V (TC 4) alloy is widely applied to orthopaedics and dental implants due to low density, high specific strength and corrosion resistance, and can be well compatible with human tissues. However, the elastic modulus (110 GPa) of the traditional Ti6Al4V alloy implant is obviously higher than the elastic modulus range (0.5-30 GPa) of human bones, so that stress shielding is generated, and surrounding bone tissues are weakened, and bone regeneration is affected. The porous structure can regulate and control the elastic modulus and the porosity, so that the porous structure is closer to human bones, the stress shielding effect is reduced, and the bone regeneration is promoted. In one aspect, the porous structure of the porous Ti6Al4V alloy provides a microenvironment suitable for bone cell growth, enhancing osseointegration capability. On the other hand, the porous Ti6Al4V alloy reduces the generation of stress shielding, improves the success rate of implantation operation and reduces the pain of patients. In addition, the Ti6Al4V alloy itself does not have antibacterial properties, and implantation may fail due to inflammatory reaction, bacterial infection, etc. after implantation into the human body. A small amount of antibacterial elements such as Au, cu and the like are added into the Ti6Al4V alloy to obtain antibacterial capability. The antibacterial capability of the Ti6Al4V alloy can be obviously improved by adding a small amount of Cu (5 wt%) and the infection risk is reduced. In addition, the Cu element is also helpful for enhancing the adhesion and differentiation of bone cells, promoting the osseointegration and improving the long-term effect of the implant. However, the conventional preparation method is difficult to prepare a complex porous structure, so how to prepare a high-strength low-modulus antibacterial porous implant is a problem to be solved by those skilled in the art. Disclosure of Invention The invention aims to solve the technical problems that the elastic modulus of the traditional Ti6Al4V alloy is higher than that of human bone, the stress shielding effect exists, and the Ti6Al4V alloy has no antibacterial property. In order to achieve the above object, the present invention provides the following technical solutions: the invention provides a preparation method of a medical high-strength low-modulus antibacterial porous implant with negative poisson ratio, which comprises the following steps: s1, mixing Ti6Al4V alloy powder with Cu powder, and then carrying out vacuum drying to obtain mixed powder; s2, introducing the porous structure model into printing equipment, placing mixed powder into a powder supply bin of the printing equipment, and performing laser melting printing by a laser powder bed fusion technology to obtain a porous implant sample; and S3, sequentially carrying out ultrasonic cleaning and drying on the porous implant sample to obtain the medical high-strength low-modulus antibacterial porous implant with the negative poisson ratio. In the S1, the grain sizes of the Ti6Al4V alloy powder and the Cu powder are 15-53 μm. Further, in the S1, the mass ratio of the Ti6Al4V alloy powder to the Cu powder is 90-99:1-10. Further, in the step S1, the temperature of vacuum drying is 80-100 ℃, and the time of vacuum drying is 6-24 hours. In the S2, the laser powder bed fusion technology has the parameters of 110-150W of laser power, 1100-1400 mm/S of scanning speed, 40-60 μm of scanning interval, 20-40 μm of powder spreading thickness and 40-70 μm of light spot diameter. Further, in S2, the porous structure model is designed by three-dimensional modeling software. Further, in the step S3, the number of times of ultrasonic cleaning is 3 to 5. The invention also provides the medical high-strength low-modulus antibacterial porous implant with negative poisson ratio prepared by the preparation method of the medical high-strength low-modulus antibacterial porous implant with negative poisson ratio. Compared with the prior art, the invention has the following beneficial effects: 1. According to the porous structure design with negative Poisson's ratio, the laser powder bed melting technology is combined to carry out forming processing on Ti6Al4V alloy and Cu mixed powder, so that the elastic modulus of the prepared bearing bone implant is accurately matched with that of human bones (0-30 GPa), compared with a compact Ti6Al4V alloy implant, the stress shielding defect caused by the fact that the elastic modulus (110 Pa) of the existing compact Ti6Al4V alloy is higher than that of the human bones is effectivel