CN-122005922-A - Porous polyester microsphere filler for improving external nose volume and morphology

CN122005922ACN 122005922 ACN122005922 ACN 122005922ACN-122005922-A

Abstract

The invention belongs to the technical field of biomedical materials, and in particular relates to a porous polyester microsphere filler for improving the volume and shape of an external nose, which comprises the following components: degradable polyester polymer microspheres with porous structures; the porous structure is a penetrating porous structure, and the porosity is 50% -90%; the particle size of the polymer microsphere is 100-500 mu m, and the polymer microsphere accounts for 1-60% of the mass of the filler; and, thickeners, excipients, carriers, pharmaceuticals and nutritional ingredients; the porous microsphere filler has a rich microscopic hole structure, is beneficial to fixing on the nose of a human body, and avoids exposure and infection by external force; meanwhile, the porous microspheres in the porous polyester microsphere filler have a penetrating through hole structure which is beneficial to cell entry, provides a large volume and a large surface area for transporting nutrient substances and removing wastes, finally leads to cell attachment, proliferation and differentiation, finally forms a regenerated collagen reticular structure and achieves a more natural repairing effect.

Inventors

YANG YI
LIU PEIMING
SI BO
GAO JIANJIE

Assignees

常州药物研究所有限公司

Dates

Publication Date: 20260512
Application Date: 20260228

Claims (8)

1. A porous polyester microsphere filler comprising: Degradable polyester polymer microspheres with porous structures; the porous structure is a penetrating porous structure, and the porosity is 50% -90%; the particle size of the polymer microsphere is 100-500 mu m, and the polymer microsphere accounts for 1-60% of the mass of the filler; and, thickeners, excipients, carriers, pharmaceuticals and nutritional ingredients.
2. The porous polyester microsphere filler according to claim 1, wherein the porous polyester microsphere filler is a polymer, The degradable polyester comprises one or more of polylactic acid, polycaprolactone, polyglycolic acid, polydioxanone, polyhydroxyalkanoate, polybutylene succinate, polylactic acid-glycolic acid copolymer, polylactic acid-ethylene glycol copolymer, poly L-lactide-caprolactone copolymer and/or copolymer of two or more different types of polymers, including polylactic acid-polycaprolactone copolymer and polylactic acid-polycaprolactone-polyethylene glycol copolymer; the molecular weight of the degradable polyester is 10000-500000.
3. The porous polyester microsphere filler according to claim 1, wherein the porous polyester microsphere filler is a polymer, The thickener comprises at least one of natural polymer thickener and cellulose thickener; the natural polymer thickener comprises any one or a combination of more of hyaluronic acid and salt form, soluble starch, acacia, pectin, agar, gelatin and trehalose; the cellulose thickener comprises any one or a combination of more of carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose and methyl cellulose.
4. The porous polyester microsphere filler according to claim 1, wherein the porous polyester microsphere filler is a polymer, The excipient comprises any one or more of mannitol, glucose, dextran and sorbitol; The carrier comprises any one or a combination of a plurality of sodium hyaluronate, sodium carboxymethylcellulose, collagen, silk fibroin, mussel protein and agarose gel; The medicine comprises any one or a combination of a plurality of lidocaine, procaine, tetracaine, ropivacaine, bupivacaine, tranexamic acid, chondroitin sulfate, vancomycin, gentamicin, tobramycin, bone morphogenetic protein and bisphosphate; the nutritional ingredients comprise any one or more of amino acid, nicotinamide adenine dinucleotide, polypeptide, protein, polysaccharide, polyalcohol, vitamin and lipid.
5. The porous polyester microsphere filler according to claim 1, wherein the porous polyester microsphere filler is a polymer, The dosage form of the porous polyester microsphere filler is freeze-dried powder, and the porous polyester microsphere filler is freeze-dried powder.
6. The porous polyester microsphere filler according to claim 1, wherein the porous polyester microsphere filler is a polymer, The porous polyester microsphere filler is in a pre-filled syringe dosage form, is encapsulated in the syringe, and is matched with the pre-filled syringe and a disposable sterile injection needle.
7. A method for preparing the porous polyester microsphere filler according to claim 1, comprising the steps of: mixing porous microspheres with degradable polyester to obtain degradable polyester polymer microspheres with porous structures; And uniformly stirring and mixing the degradable polyester polymer microsphere with the porous structure, a thickening agent, an excipient, a carrier, medicaments and nutritional ingredients in an aqueous solution to obtain the porous polyester microsphere filler.
8. Use of the porous polyester microsphere filler according to claim 1 in the field of orthopedics.

Description

Porous polyester microsphere filler for improving external nose volume and morphology Technical Field The invention belongs to the technical field of biomedical materials, and particularly relates to a porous polyester microsphere filler for improving the volume and shape of an external nose. Background Nose plastic surgery is a procedure that changes the nose height and shape by implanting appropriate materials to coordinate with other parts of the face, and is the most common procedure in the field of plastic surgery. Nose is a key component of facial aesthetics, and lacks a stereoscopic impression if there are manifestations of hypertrophy of nose, roundish, flat nose root, low nose bridge, etc. The nose shaping product used clinically at present has the defects that ① parts of materials are harder, poor biocompatibility leads to poor binding property with human tissues, materials made of ② dies are relatively fixed in shape and model, the nose shaping product is not necessarily suitable for different nose shapes of all people, the temporary adjustment binding property is poor in clinical use, ③ traditional nose silicon rubber filling materials are inert materials and are of solid structures, firm biological fixation cannot be formed between the materials and surrounding tissues, dislocation easily occurs in a human body for a long time, ④ porous expanded polytetrafluoroethylene has a larger probability of being polluted by bacteria if the engraving time is longer in operation, the gas in an inner pore canal is easy to cause infection, the shape or the size is not proper, tissue tension is excessively large or an invalid cavity is formed after implantation, blood accumulation and liquid accumulation are easy to create conditions for bacterial growth, ⑤ is transplanted by using ear cartilage or rib cartilage of a patient, the biological compatibility is excellent, the effect is natural, but the operation wound is large, complications can occur in a supply area, the cartilage engraving technology is high, mass production is difficult, and the filling materials ⑥ are difficult to inject, such as uric acid, the time is short, the shape of the human body is required to be degraded, and the shape of the human body is required to be changed after the human body is degraded, and the repairing effect of the nose shaping material is not changed periodically. In the above technical route, the injection filler product has the defect of short maintenance time, but the injection nose shaping product is more popular for consumers, so how to improve the maintenance time of the injection filler product is a technical problem to be solved in the field. It should be noted that the above information disclosed in this background section is only for understanding the background of the inventive concept and therefore the above description is not to be construed as constituting prior art information. Disclosure of Invention Embodiments of the present disclosure provide at least one porous polyester microsphere filler for improving the external nasal volume and morphology. In a first aspect, the embodiment of the disclosure provides a porous polyester microsphere filler, which comprises a degradable polyester polymer microsphere with a porous structure, wherein the porous structure is a penetrating porous structure, the porosity is 50% -90%, the particle size of the polymer microsphere is 100-500 μm, the polymer microsphere accounts for 1-60% of the filler by mass, and a thickener, an excipient, a carrier, medicines and nutritional ingredients. In an alternative embodiment, the degradable polyester comprises one or more of polylactic acid, polycaprolactone, polyglycolic acid, polydioxanone, polyhydroxyalkanoate, polybutylene succinate, polylactic acid-glycolic acid copolymer, polylactic acid-ethylene glycol copolymer, poly L-lactide-caprolactone copolymer and/or copolymer of two or more different types of polymers, wherein the molecular weight of the degradable polyester is 10000-500000. In an alternative embodiment, the thickener comprises at least one of natural polymer thickener and cellulose thickener, wherein the natural polymer thickener comprises hyaluronic acid and any one or more of salt form, soluble starch, acacia, pectin, agar, gelatin and trehalose, and the cellulose thickener comprises any one or more of carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose and methyl cellulose. In an alternative embodiment, the excipient comprises any one or more of mannitol, glucose, dextran, sorbitol. In an alternative embodiment, the carrier comprises any one or a combination of several of sodium hyaluronate, sodium carboxymethylcellulose, collagen, silk fibroin, mussel protein, agarose gel. In an alternative embodiment, the drug comprises any one or more of lidocaine, procaine, tetracaine, ropivacaine, bupivacaine, tranexamic acid, chondroitin sulfate, vancomycin, gentamicin, tobramycin, bone morphoge