CN-122005946-A - Preparation method of high-temperature-resistant antibacterial sputum suction catheter

Abstract

The invention provides a preparation method of a high-temperature-resistant antibacterial sputum suction catheter, and belongs to the technical field of medical appliances. The preparation method comprises the following steps of treating quaternary ammonium salt chitosan by using chitosan enzyme to obtain modified chitosan, reacting polytetrahydrofuran, polyethylene glycol and diisocyanate to obtain prepolymer, reacting the prepolymer, dimethylolpropionic acid and the modified chitosan to obtain polyurethane prepolymer, mixing modified silane and the polyurethane prepolymer to obtain a mixture, and extruding and molding the mixture to obtain the high-temperature-resistant antibacterial sputum suction catheter. In addition, the quaternary ammonium salt structure in resveratrol and modified chitosan can jointly destroy the metabolism of bacteria to achieve good antibacterial effect, and the combined non-antibiotic antibacterial strategy can delay the generation of drug-resistant bacteria.

Inventors

• ZHUANG KAIYUAN

Assignees

• 江苏康百年医疗科技有限公司

Dates

Publication Date

20260512

Application Date

20250416

Claims (5)

1. 1. The preparation method of the high-temperature-resistant antibacterial sputum suction catheter is characterized by comprising the following steps of: The quaternary ammonium salt chitosan is treated by chitosan enzyme to obtain modified chitosan, polytetrahydrofuran, polyethylene glycol and diisocyanate react to obtain prepolymer, the prepolymer, dimethylolpropionic acid and the modified chitosan react to obtain polyurethane prepolymer, the modified silane and the polyurethane prepolymer are mixed to obtain a mixture, and the mixture is extruded and molded to obtain the high-temperature-resistant antibacterial sputum suction catheter; The preparation method of the modified silane comprises the following steps: The hydroxypropyl-beta-cyclodextrin reacts with resveratrol to obtain modified resveratrol, 3-mercaptopropyl trimethoxy silane, itaconic acid and an initiator react to obtain carboxylated silane, and the modified resveratrol and the carboxylated silane are mixed and then subjected to acid treatment and alkali treatment in sequence to obtain modified silane; The weight ratio of the modified resveratrol to the carboxylated silane is 1-3:9-11; The initiator is benzoin diethyl ether; The diisocyanate includes hexamethylene diisocyanate or isophorone diisocyanate.
2. 2. The method for preparing the high-temperature-resistant antibacterial sputum suction catheter according to claim 1, wherein the reaction conditions of the hydroxypropyl-beta-cyclodextrin and the resveratrol comprise the reaction temperature of 55-60 ℃ and the reaction time of 8-12 h.
3. 3. The method for preparing the high-temperature-resistant antibacterial sputum aspirator catheter according to claim 1, wherein the reaction condition of the 3-mercaptopropyl trimethoxysilane, the itaconic acid and the initiator is that 365nm ultraviolet light is used for irradiation treatment for 30-60 min.
4. 4. The method for preparing the high-temperature-resistant antibacterial sputum aspirator catheter according to claim 1, wherein the reaction conditions of the prepolymer, the dimethylolpropionic acid and the modified chitosan comprise a reaction temperature of 55-65 ℃ and a reaction time of 4-6 hours.
5. 5. The method for preparing the high-temperature-resistant antibacterial sputum aspirator catheter according to claim 1, wherein the mixing condition of the modified silane and the polyurethane prepolymer comprises the mixing temperature of 180-190 ℃ and the mixing time of 15-25 min.

Description

Preparation method of high-temperature-resistant antibacterial sputum suction catheter The application discloses a high-temperature-resistant antibacterial sputum suction catheter and a preparation method thereof, which are filed in 2025, 04 and 16 days, and have the application number 202510476791.3. Technical Field The invention relates to the technical field of medical instruments, in particular to a preparation method of a high-temperature-resistant antibacterial sputum suction catheter. Background The sputum suction catheter is a vital medical instrument in clinical respiratory tract care, and is mainly used for clearing sputum and secretion in respiratory tracts of patients, maintaining the respiratory tracts unobstructed, and preventing complications such as pulmonary infection. In departments such as intensive care units and respiratory medicine, sputum aspiration is very frequent, and the effect directly influences the respiratory function recovery and the overall rehabilitation process of patients. However, the sputum suction catheter used in clinic at present has a plurality of problems, which severely restrict the use effect and safety. At present, the main stream sputum suction catheter in the market mostly adopts common silica gel or PVC materials, and the materials are easy to soften, deform and even destroy the structure in the high-temperature and high-pressure sterilization process, so that the lumen collapse, the surface roughness or the pore diameter change are caused, the sputum suction efficiency is obviously reduced, and the damage risk of patients is increased. Meanwhile, the existing antibacterial technology, such as silver nanoparticle coating and hydrophilic polymer layer, has the problems of degradation, agglomeration or interfacial peeling at high temperature, and the antibacterial function is uncontrollably attenuated. Although the traditional ethylene oxide sterilization can avoid high-temperature damage, the residual toxicity and penetrability are insufficient, so that the sterilization requirement of a complex catheter structure is difficult to meet, the risk of related infection of the catheter is high, and the development of a novel catheter material with high-temperature resistance and long-acting antibacterial performance is needed. Chinese patent CN 111423693B discloses a PEEk-based medical tubing and a preparation method and application thereof, wherein PEEK, PEI, PPSU is dried to remove water, raw materials are weighed according to a formula, and after being uniformly mixed, the raw materials are melt blended, extruded and granulated in a double-screw extruder, and extruded in a single-screw extruder to produce the PEEk-based medical tubing, the prepared PEEk-based medical tubing has good high temperature resistance, but the invention does not relate to the antibacterial effect. Therefore, providing a novel catheter material with high temperature resistance and good antibacterial performance is an important problem to be solved in the field. Disclosure of Invention In order to solve the problems in the prior art, the invention provides a preparation method of a high-temperature-resistant antibacterial sputum suction catheter, and specifically, the technical scheme of the invention comprises the following steps: A method for preparing a high-temperature-resistant antibacterial sputum suction catheter, which comprises the following steps: The quaternary ammonium salt chitosan is treated by chitosan enzyme to obtain modified chitosan, polytetrahydrofuran, polyethylene glycol and diisocyanate react to obtain prepolymer, the prepolymer, dimethylolpropionic acid and the modified chitosan react to obtain polyurethane prepolymer, the modified silane and the polyurethane prepolymer are mixed to obtain mixture, and the mixture is extruded and molded to obtain the high-temperature-resistant antibacterial sputum suction catheter. Further, the preparation method of the modified silane comprises the following steps: the hydroxypropyl-beta-cyclodextrin reacts with resveratrol to obtain modified resveratrol, 3-mercaptopropyl trimethoxy silane, itaconic acid reacts with an initiator to obtain carboxylated silane, and the modified resveratrol and the carboxylated silane are mixed and then subjected to acid treatment and alkali treatment in sequence to obtain modified silane. Further, the weight ratio of the hydroxypropyl-beta-cyclodextrin to the resveratrol is 2-3:1.5-2.5. Further, the reaction conditions of the hydroxypropyl-beta-cyclodextrin and the resveratrol comprise the reaction temperature of 55-60 ℃ and the reaction time of 8-12 hours. Further, the weight ratio of the 3-mercaptopropyl trimethoxy silane to the itaconic acid to the initiator is 19-22:12-14:0.13-0.15. Further, the initiator is benzoin diethyl ether. Further, the reaction condition of the 3-mercaptopropyl trimethoxy silane, the itaconic acid and the initiator is that 365nm ultraviolet light is used for irradiation