Search

CN-122005947-A - Antibacterial polyurethane medical catheter material and preparation method thereof

CN122005947ACN 122005947 ACN122005947 ACN 122005947ACN-122005947-A

Abstract

The invention discloses an antibacterial polyurethane medical catheter material and a preparation method thereof, and relates to the technical field of polyurethane materials. The invention relates to an antibacterial polyurethane medical catheter material, which is prepared by reacting genistein and zinc acetate to prepare a genistein complex, treating boron nitride with sodium hydroxide and kh550 in sequence to prepare amino boron nitride, reacting amino boron nitride with a phosphorus-containing flame retardant to prepare functional boron nitride, reacting 2-amino-2-methyl-1, 3-propanediol with 4-pyridylaldehyde and 1-bromohexane in sequence to prepare a pyridinium monomer, polymerizing polytetrahydrofuran and diphenylmethane diisocyanate, and chain-extending the pyridinium monomer to prepare polyurethane, and uniformly mixing the polyurethane, the genistein complex and the functional boron nitride to prepare the antibacterial polyurethane medical catheter material.

Inventors

  • LIU DONGYA

Assignees

  • 济宁医学院

Dates

Publication Date
20260512
Application Date
20260204

Claims (9)

  1. 1. The antibacterial polyurethane medical catheter material is characterized in that the antibacterial polyurethane medical catheter material is prepared by uniformly mixing 70-80 parts of polyurethane, 6-7 parts of genistein complex and 3.5-4.5 parts of functionalized boron nitride; The polyurethane is prepared by polymerizing polytetrahydrofuran and diphenylmethane diisocyanate and chain-extending with pyridinium monomers; the genistein complex is prepared by reacting genistein and zinc acetate; the functionalized boron nitride is prepared by reacting an amino boron nitride and a phosphorus-containing flame retardant.
  2. 2. The antibacterial polyurethane medical catheter material according to claim 1, wherein the pyridinium monomer is prepared by sequentially reacting 2-amino-2-methyl-1, 3-propanediol with 4-pyridylaldehyde and 1-bromohexane.
  3. 3. The antibacterial polyurethane medical catheter material according to claim 1, wherein the aminated boron nitride is prepared by sequentially treating boron nitride with sodium hydroxide and gamma-aminopropyl triethoxysilane.
  4. 4. The antibacterial polyurethane medical catheter material according to claim 1, wherein the phosphorus-containing flame retardant is prepared by reacting pentaerythritol phosphate and methacryloxyethyl isocyanate.
  5. 5. The preparation method of the antibacterial polyurethane medical catheter material is characterized by comprising the following steps of: S1, uniformly mixing genistein and absolute ethyl alcohol, stirring for 2-3 hours at 50-60 ℃, regulating the pH value to 7.5-8.5 by using triethylamine, continuously stirring for 5-10 minutes, adding zinc acetate with the molar quantity of 0.5 times of that of the genistein, stirring and reacting for 7-9 hours at 55-65 ℃, cooling to room temperature, centrifuging, washing and drying to obtain a genistein complex; S2, uniformly mixing pentaerythritol phosphate, dibutyl tin dilaurate, hydroquinone and tetrahydrofuran, stirring at room temperature for 20-30min, heating to 40-50 ℃, adding the equal molar amount of methacryloyloxyethyl isocyanate of the pentaerythritol phosphate at uniform speed within 1h, continuously stirring for reacting for 3-4h, and performing reduced pressure rotary evaporation to obtain the phosphorus-containing flame retardant; S3, uniformly mixing (3-4): (0.06-0.08): (30-40) of amino boron nitride, phosphorus-containing flame retardant, sodium ethoxide and N, N-dimethylformamide according to the mass ratio of 1 (3-4), stirring and reacting for 8-10 hours at 60-70 ℃, filtering, washing and drying to obtain the functional boron nitride; s4, adding 2-amino-2-methyl-1, 3-propanediol and 4-pyridine formaldehyde into N, N-dimethylformamide with the mass of 22-24 times of that of the 4-pyridine formaldehyde according to the mol ratio of 1:1, stirring and reacting for 6-8 hours at 60-70 ℃, adding 1-bromohexane with the same mol amount of 4-pyridine formaldehyde, continuing stirring and reacting for 24-30 hours, and drying to obtain pyridine salt monomers; s5, uniformly mixing a pyridinium monomer and N, N-dimethylformamide to prepare a chain extender solution, mixing polytetrahydrofuran and diphenylmethane diisocyanate, adding dibutyltin dilaurate with the mass of 0.002-0.004 times that of polytetrahydrofuran, stirring and reacting for 90-110min at 70-80 ℃, adding the chain extender solution, heating to 75-85 ℃, continuing stirring and reacting for 90-110min, and drying to prepare polyurethane; And S6, adding 70-80 parts of polyurethane, 6-7 parts of genistein complex and 3.5-4.5 parts of functionalized boron nitride into tetrahydrofuran which is 4-5 times of the polyurethane in mass, uniformly mixing, performing ultrasonic dispersion for 3-4 hours, stirring for 10-12 hours at 400-500 r/min, and drying to obtain the antibacterial polyurethane medical catheter material.
  6. 6. The method for preparing an antibacterial polyurethane medical catheter material according to claim 5, wherein the chemical reaction formula of the phosphorus-containing flame retardant in the step S2 is: 。
  7. 7. The preparation method of the antibacterial polyurethane medical catheter material according to claim 5, which is characterized in that the preparation method of the amino boron nitride in the step S3 comprises the steps of uniformly mixing gamma-aminopropyl triethoxysilane and an 80wt% ethanol aqueous solution according to the mass ratio of 1 (50-60), stirring for 1-2h at 60-70 ℃, adding pretreated boron nitride with the mass 2-3 times of that of the gamma-aminopropyl triethoxysilane, continuing stirring for reacting for 5-7h, filtering, washing and drying to obtain the amino boron nitride.
  8. 8. The preparation method of the antibacterial polyurethane medical catheter material according to claim 7, which is characterized in that the preparation method of the pretreated boron nitride comprises the steps of uniformly mixing boron nitride and 7wt% of sodium hydroxide aqueous solution according to the mass ratio of 1 (40-50), stirring for 6-8 hours at 80-90 ℃, filtering, washing and drying to obtain the pretreated boron nitride.
  9. 9. The method for preparing the antibacterial polyurethane medical catheter material according to claim 5, wherein the molar ratio of polytetrahydrofuran, pyridinium monomer and diphenylmethane diisocyanate in the step S5 is (10-12): 7-8): 16-18.

Description

Antibacterial polyurethane medical catheter material and preparation method thereof Technical Field The invention relates to the technical field of polyurethane materials, in particular to an antibacterial polyurethane medical catheter material and a preparation method thereof. Background In a hospital setting, patients are also alerted to the threat of nosocomial infections in addition to being at risk for microbial infections. Pathogens are transmitted in medical facilities through a variety of channels, such as medical instruments that are not thoroughly sterilized, unclean hands of medical personnel, and contaminated surfaces of objects in the lesion. Such infections obtained during medical procedures are typical iatrogenic health problems, and serious consequences include various adverse clinical outcomes such as impeded treatment progression, exacerbation of the condition, and increased patient suffering. Medical devices such as catheters are tubular medical devices made of flexible materials such as silicone, polyurethane, PVC, etc. for delivering liquids, gases, drugs or performing medical procedures. Medical catheters have become an integral part of modern medicine, greatly improving the level of disease prevention and treatment. However, these devices may also become a hotbed for microorganism attachment, causing bacterial infections, affecting health of medical personnel and patients. Therefore, it is necessary to invent a medical catheter material with excellent antibacterial performance, which actively inhibits the colonization and propagation of bacteria on the surface of a catheter and remarkably reduces the infection risk. On the other hand, polyurethane catheter is widely used medical catheter material by virtue of excellent biocompatibility and flexibility, high strength and durability, corrosion resistance and insulation, but the polyurethane material has the problems of low limiting oxygen index and easy combustion, and potential safety hazards exist in the storage, transportation and use of the material, so that the polyurethane medical catheter material is subjected to antibacterial and flame retardant dual improvement, and the use safety of the catheter is further enhanced. Disclosure of Invention The invention aims to provide an antibacterial polyurethane medical catheter material and a preparation method thereof, which are used for solving the problems in the prior art. An antibacterial polyurethane medical catheter material is prepared by uniformly mixing 70-80 parts of polyurethane, 6-7 parts of genistein complex and 3.5-4.5 parts of functionalized boron nitride; The polyurethane is prepared by polymerizing polytetrahydrofuran and diphenylmethane diisocyanate and chain-extending with pyridinium monomers; the genistein complex is prepared by reacting genistein and zinc acetate; the functionalized boron nitride is prepared by reacting an amino boron nitride and a phosphorus-containing flame retardant. Further, the pyridinium monomer is prepared by sequentially reacting 2-amino-2-methyl-1, 3-propanediol with 4-pyridylaldehyde and 1-bromohexane. Further, the aminated boron nitride is prepared by sequentially treating boron nitride with sodium hydroxide and gamma-aminopropyl triethoxysilane. Further, the phosphorus-containing flame retardant is prepared by reacting pentaerythritol phosphate and methacryloyloxyethyl isocyanate. The preparation method of the antibacterial polyurethane medical catheter material comprises the following steps: S1, uniformly mixing genistein and absolute ethyl alcohol according to the mass ratio of 1 (80-100), stirring for 2-3h at 50-60 ℃, regulating the pH value to 7.5-8.5 by using triethylamine, continuously stirring for 5-10min, adding zinc acetate with the molar quantity of 0.5 times of that of the genistein, stirring for reacting for 7-9h at 55-65 ℃, cooling to room temperature, centrifuging, washing by using ethanol water solution with the volume ratio of 1:1, and vacuum drying for 18-22h at 50-60 ℃ to obtain a genistein complex; S2, uniformly mixing pentaerythritol phosphate, dibutyl tin dilaurate, hydroquinone and tetrahydrofuran (0.001-0.002): (0.004-0.005): (30-40) according to the mass ratio of 1 (0.001-0.002), stirring at room temperature for 20-30min, heating to 40-50 ℃, adding methacryloyloxyethyl isocyanate with equal molar weight of pentaerythritol phosphate at uniform speed within 1h, continuing stirring for reacting for 3-4h, and performing reduced pressure rotary evaporation to obtain a phosphorus-containing flame retardant; S3, uniformly mixing (3-4) of (0.06-0.08) of (30-40) of (1) aminated boron nitride, a phosphorus-containing flame retardant, sodium ethoxide and N, N-dimethylformamide according to the mass ratio, stirring and reacting for 8-10 hours at 60-70 ℃, filtering, washing with an ethanol aqueous solution with the volume ratio of 1:1, and vacuum drying for 20-24 hours at 70-80 ℃ to obtain the functionalized boron nitride; S4, a