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CN-122005948-A - Anticoagulation coating and preparation method thereof

CN122005948ACN 122005948 ACN122005948 ACN 122005948ACN-122005948-A

Abstract

The invention provides an anticoagulation coating which comprises anticoagulation components and a cross-linking agent, wherein the preparation method of the anticoagulation coating comprises the steps of carrying out plasma activation on the surface of a catheter, carrying out surface activation treatment on the surface of the catheter by adopting plasma, preparing an anticoagulation solution, immersing the catheter in the anticoagulation solution containing phosphorylcholine, placing the catheter at room temperature after dip-coating, then placing the catheter in a curing box for curing, and taking out the catheter after cooling to the room temperature to prepare the catheter with the anticoagulation coating of phosphorylcholine.

Inventors

  • GAO RENWEI
  • SHENG KAI
  • WANG LINGTAO

Assignees

  • 巴迪脉通医疗科技(苏州)有限公司

Dates

Publication Date
20260512
Application Date
20260213
Priority Date
20251217

Claims (8)

  1. 1. An anticoagulation coating is characterized in that the anticoagulation coating is formed by dissolving solid content of a solution consisting of an anticoagulation component and a cross-linking agent in absolute ethyl alcohol, preparing the anticoagulation solution, stirring the anticoagulation solution to be uniform, and curing the anticoagulation coating on a catheter in a heat curing mode.
  2. 2. An anticoagulant coating according to claim 1, wherein the anticoagulant component is phosphorylcholine and is used in an amount of 5% to 20% by weight of the solid content of the anticoagulant solution.
  3. 3. An anticoagulant coating according to claim 1 or 2, wherein the crosslinking agent comprises 2-hydroxyethyl methacrylate as a main component.
  4. 4. An anticoagulant coating as claimed in claim 3, wherein the cross-linking agent is used in an amount of 80% to 95% by weight of the solids content of the anticoagulant solution.
  5. 5. The preparation method of the anticoagulation coating according to any one of claims 1-4, comprising the following steps: s1, plasma activation, namely carrying out surface activation treatment on the surface of the catheter by adopting plasma for 3-8 min; S2, preparing an anticoagulation coating solution, namely slowly adding a proper amount of anticoagulation components and a crosslinking agent into absolute ethyl alcohol, fully stirring until the components and the crosslinking agent are completely clarified and dissolved, standing for 4 hours, and defoaming to obtain the anticoagulation solution after completion; And S3, preparing an anticoagulation coating on the surface, namely immersing the catheter in the anticoagulation solution, slowly pulling out the solution after immersing, then placing the catheter in a curing box for curing, and cooling to room temperature to prepare the catheter with the anticoagulation coating of phosphorylcholine.
  6. 6. The method of preparing an anticoagulant coating according to claim 5, wherein the time of the sufficient reaction in the step S2 is 30S-600S, the solution is slowly pulled out at a speed of 10mm/S, and the solution is placed in a constant temperature and humidity heat curing box at 90 ℃ and 60% RH for curing at a rotational speed of 4r/min for 2h-4 h.
  7. 7. The method of claim 6, wherein the soaking time in the step S3 is 10S-60S, and the solution is slowly pulled out at a speed of 3 mm/S.
  8. 8. The method of claim 7, wherein the curing in step S3 is performed by placing the catheter in a constant temperature and humidity heat curing box at 90 ℃ and 20% RH, and curing at a rotational speed of 4r/min for 2-5 h.

Description

Anticoagulation coating and preparation method thereof Technical Field The invention relates to the technical field of surface coating of central venous catheter medical instruments, in particular to an anticoagulation coating and a preparation method of the anticoagulation coating. Background The central venous catheter is a common vascular access, and is a catheter which is placed through internal jugular vein, subclavian vein and femoral vein, and the tip of the catheter is positioned in the superior vena cava or inferior vena cava, and can be used for infusing medicines, liquids, nutrition and the like. The central venous catheter is in direct contact with blood in clinical use, and the material of the central venous catheter needs to have better blood compatibility. The central venous catheter is mainly made of polyurethane or silicone rubber, is usually punctured and reserved in subclavian vein, femoral vein and internal jugular vein, and is used for the treatment of operation or critical patients. The medicine can be used as a long-term parenteral nutrition administration way for patients with malnutrition, can maintain blood pressure by a large amount of rapid intravenous infusion through a central venous catheter when the bleeding amount is large in a large-scale operation, is often used as a vascular access for hemodialysis, and can be used for preventing phlebitis by infusing tumor chemotherapy medicines through the central venous catheter. Central venous catheters are divided into a variety of models including single, dual, triple lumen central venous catheters and the like. In clinic, departments such as emergency department, ICU ward, anesthesia department, hemodialysis room and the like are more commonly used, and the application is wider. The central venous catheter is left in the blood vessel of a human body for a long time, and an active anticoagulation mode is mainly adopted to prevent proteins, platelets and the like in blood from being adsorbed on the surface of the catheter so as to prevent complications such as venous thrombosis, fibrin sheath and the like from occurring during implantation of the central venous catheter. Central venous catheters are an important adjuvant therapeutic material in medical clinic, and direct contact of the product with blood during surgery and therapy may also cause changes in the host's blood mechanism, which may lead to coagulation or thrombosis, causing surgical risks. Active anticoagulation generally uses a heparin coating, the principle of which is to rapidly inactivate coagulation factors flowing through the surface of a catheter by activating antithrombin in blood. After the inactivation reaction is completed, the complex formed by the coagulation factor and the antithrombin can be dissociated from heparin, and heparin molecules are kept unchanged, so that the antithrombin can be continuously activated, and the anticoagulation effect is realized. However, such anticoagulation coating may generate antibodies against the "heparin-platelet factor 4 (PF 4)" complex from the immune system after heparin is applied to a part of patients, the antibodies bind to platelets, which activate and allow the platelets to be removed, resulting in a significant decrease in platelet count, the activated platelets may also form thrombus in blood vessels, causing serious thrombotic events such as limb ischemia, pulmonary embolism, myocardial infarction, etc., and heparin coating may affect healing of wounds generated during catheterization when the patient's own coagulation function is insufficient, resulting in an increased bleeding risk. Disclosure of Invention The invention aims to overcome the defects of the prior art and provides a preparation method of an anticoagulation coating, which comprises an anticoagulation component and a cross-linking agent, wherein the anticoagulation coating is prepared by dissolving absolute ethyl alcohol into anticoagulation coating liquid, stirring the anticoagulation coating liquid to be uniform, and curing the anticoagulation coating on a catheter in a heat curing mode, so that an anti-adhesion and anti-activation biological interface is constructed on the surface of the catheter, and the start and amplification of a coagulation reaction are prevented from the source. In order to achieve the above object, the present invention provides an anticoagulant coating comprising an anticoagulant component and a crosslinking agent, dissolved and stirred to uniformity by absolute ethyl alcohol, and cured on a catheter by a heat curing method to form the anticoagulant coating. The anticoagulation component and the cross-linking agent are dissolved by absolute ethyl alcohol to prepare anticoagulation coating liquid with the solid content of 10-20wt%; the anticoagulation component is phosphorylcholine, and the use amount is 5-20wt% of the solid content of the anticoagulation solution; The usage amount of the cross-linking agent is 80-95 wt% o