CN-122005960-A - Medicine-carrying acupuncture needle and preparation method and application thereof

Abstract

The application relates to a medicine-carrying acupuncture needle in the technical field of Chinese and Western medicine combined treatment, and a preparation method and application thereof, wherein the medicine-carrying acupuncture needle comprises a needle body, and the surface of the needle body is subjected to glow discharge treatment; the liquid medicine carrying gel is at least uniformly coated on the surface near the tip of the needle body and is solidified and attached on the surface of the needle body, and the liquid medicine carrying gel comprises uniformly mixed double-network hydrogel, conductive polymer and medicine molecules. The medicine-carrying acupuncture needle disclosed by the application utilizes glow discharge treatment on the surface of the needle body, and by constructing a multifunctional hydrogel medicine-carrying coating, the icariin active ingredients are organically combined with the acupuncture needle, so that an accurate treatment mode of needle medicine synergy is realized; the medicine carrying acupuncture needle system has the characteristics of high medicine loading rate, controllable release and the like, can realize intelligent medicine administration under the condition of electric stimulation, can obviously promote the repair of achilles tendon tissues and inhibit inflammatory reaction, has better curative effect than a single treatment mode, and provides a safe and effective innovative treatment scheme for the damage of a motor system.

Inventors

• HUANG HONGJIE
• LIU YANG
• WU YANG
• XING SIMIN
• ZHENG ZITIAN

Assignees

• 北京大学第三医院（北京大学第三临床医学院）
• 清华大学

Dates

Publication Date

20260512

Application Date

20251226

Claims (10)

1. 1. A drug-loaded acupuncture needle, comprising: The surface of the needle body is subjected to glow discharge treatment; the liquid medicine carrying gel is at least uniformly coated on the surface near the tip of the needle body and is solidified and attached to the surface of the needle body; The aqueous carrier gel comprises a uniformly mixed double-network hydrogel, a conductive polymer and drug molecules.
2. 2. The drug-loaded acupuncture needle according to claim 1, wherein the double-network hydrogel is constructed by carboxymethyl chitosan-glucolactone and methacryloyl silk fibroin.
3. 3. The drug-loaded acupuncture needle according to claim 1, wherein the conductive polymer component is PEDOT: PSS.
4. 4. The drug-loaded acupuncture needle according to claim 1, wherein the drug molecule is icariin.
5. 5. A method for preparing the drug-loaded acupuncture needle according to any one of claims 1 to 4, comprising the steps of: preparing a needle body, and performing glow discharge treatment on the needle body; Uniformly mixing the double-network hydrogel, the conductive polymer and the drug molecules to obtain a carrier hydrogel; And uniformly coating the medicine-carrying gel on the surface of the needle body subjected to glow discharge treatment, and fixing and combining to obtain the medicine-carrying acupuncture needle.
6. 6. The method according to claim 5, wherein the needle is alkali washed before the glow discharge treatment.
7. 7. The method according to claim 5, wherein the glow discharge treatment has a parameter of air pressure 0.36 mbar~0.42 mbar, a discharge current of 10 mA to 20 mA and a discharge time of 20 s to 90 s.
8. 8. The method of claim 5, wherein the preparation of the hydrogel comprises the steps of: Dissolving carboxymethyl chitosan in ammonia water and calcium hydroxide solution, and stirring to obtain carboxymethyl chitosan solution; mixing glucono-delta-lactone with the carboxymethyl chitosan solution, and stirring until the system becomes transparent gel-like to obtain a first gel solution; Adding icariin into a dispersion liquid of poly (3, 4-ethylenedioxythiophene) and polystyrene sulfonate, and carrying out ultrasonic dispersion treatment to obtain a mixed solution; adding the methacryloyl silk fibroin into the mixed solution, and stirring until the methacryloyl silk fibroin is completely dissolved to obtain a second gel solution; mixing the first gel solution and the second gel solution, adding the photoinitiator, and uniformly stirring to obtain the aqueous gel.
9. 9. The method of claim 8, wherein the fixed combination of the needle after the application of the carrier hydrogel comprises the steps of: irradiating the needle body by using an ultraviolet lamp, and drying the needle body after the surface of the needle body is solidified.
10. 10. Use of a drug-loaded needle according to any one of claims 1 to 4 or a drug-loaded needle according to any one of claims 5 to 9 in the manufacture of a medical device for treating achilles tendinea.

Description

Medicine-carrying acupuncture needle and preparation method and application thereof Technical Field The application relates to the technical field of combined treatment of traditional Chinese and western medicine, in particular to a medicine-carrying acupuncture needle and a preparation method and application thereof. Background Tendinosis is a multi-factor degenerative disease of tendons, and the main pathological characteristics are degeneration of tendon tissues and unbalance of extracellular matrix metabolism. Achilles tendinitis is a common movement system disease, and when the achilles tendinitis is subjected to excessive pressure in a short time, strain, contusion or tearing may occur, so that aseptic achilles tendinitis occurs. Achilles tendinitis has a high incidence in frequent sports people, especially athletes, with an incidence of about 5.6%. At present, the traditional rehabilitation treatment and operation for relieving pain, reducing local inflammation and the like are mainly used clinically, but the traditional rehabilitation treatment and operation have slow effect, are difficult to cure and have higher recurrence rate. The acupuncture needle is used as a core tool for acupuncture treatment, the shape and the material of the acupuncture needle are carefully designed, the human body acupuncture point can be accurately stimulated, the qi and blood operation can be regulated, and the aim of treating diseases is fulfilled, however, the traditional acupuncture needle only has a physical stimulation function, and although the traditional acupuncture needle can be functionally modified by coating medicine-carrying gel on the surface of the acupuncture needle, the problems that the medicine-carrying gel has low medicine carrying capacity, the hydrogel is easy to fall off from the acupuncture needle, the controllable release function is lacking and the like exist, so that the treatment effect on tendon degenerative diseases such as achilles tendinitis is very limited. Disclosure of Invention The invention aims to provide a medicine-carrying acupuncture needle, a preparation method and application thereof, and aims to solve at least one technical problem. In order to achieve the aim, the invention provides a medicine-carrying acupuncture needle which comprises a needle body, a medicine-carrying gel and a medicine-carrying gel, wherein the surface of the needle body is subjected to glow discharge treatment, the medicine-carrying gel is at least uniformly coated on the surface near the tip of the needle body and is solidified and attached to the surface of the needle body, and the medicine-carrying gel comprises uniformly mixed double-network hydrogel, conductive polymer and medicine molecules. In some embodiments of the invention, the dual network hydrogel is constructed using carboxymethyl chitosan-glucolactone with methacryloylated silk fibroin. In some embodiments of the invention, the conductive polymer component is PEDOT: PSS. In some embodiments of the invention, the drug molecule is icariin. The invention further provides a preparation method of the medicine-carrying acupuncture needle, which comprises the steps of preparing a needle body, carrying out glow discharge treatment on the needle body, uniformly mixing the double-network hydrogel, the conductive polymer and the medicine molecules to obtain medicine-carrying gel, uniformly coating the medicine-carrying gel on the surface of the needle body subjected to glow discharge treatment, and fixedly combining to obtain the medicine-carrying acupuncture needle. In some embodiments of the invention, the needle is alkali washed prior to glow discharge treatment of the needle. In some embodiments of the invention, the parameters of the glow discharge treatment are that the air pressure is 0.36 mbar~0.42 mbar, the discharge current is 10 mA-20 mA, and the time is 20 s-90 s. In some embodiments of the invention, the preparation of the aqueous carrier gel comprises the steps of dissolving carboxymethyl chitosan in ammonia water and calcium hydroxide solution, stirring to obtain carboxymethyl chitosan solution, mixing glucono-delta-lactone with the carboxymethyl chitosan solution, stirring until the system becomes transparent gel, obtaining a first gel solution, adding icariin into a dispersion liquid of poly (3, 4-ethylenedioxythiophene) polystyrene sulfonate, carrying out ultrasonic dispersion treatment to obtain a mixed solution, adding methacryloylated silk fibroin into the mixed solution, stirring until the mixed solution is completely dissolved to obtain a second gel solution, mixing the first gel solution and the second gel solution, adding a photoinitiator, and stirring uniformly to obtain the aqueous carrier gel. In some embodiments of the invention, the fixed combination of the needle body after the application of the liquid carrier gel comprises the steps of irradiating the needle body by using an ultraviolet lamp, and drying the needle bod