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CN-122006007-A - Drug administration control method and system of postoperative analgesic pump

CN122006007ACN 122006007 ACN122006007 ACN 122006007ACN-122006007-A

Abstract

The invention relates to the technical field of automatic drug delivery control, in particular to a drug delivery control method and system of a postoperative analgesic pump, comprising the following steps: the method comprises the steps of obtaining a respiratory frequency and pressing behavior sequence of a patient, identifying fluctuation trend and request growth, judging synchronous response time period, adjusting infusion rhythm and dosage, analyzing pressure curve characteristic identification abnormal operation, and performing emergency infusion in combination with signal linkage to generate a dynamic drug administration control instruction. According to the invention, the continuous respiratory frequency variation trend of the patient is acquired, the breathing extremum is combined to judge and generate the severe fluctuation mark, the time sequence variation trend analysis of the patient request behavior is matched to form the linkage time period mark, the basic infusion frequency and the dosage are adjusted in real time to fit the actual analgesia requirement, the intelligent recognition and quick response mechanism under the condition of leading the physiological state is realized, the adaptability, the safety and the timeliness of the analgesia process are enhanced, and the problems of control lag and judging blind areas under the fixed parameter mode are effectively alleviated.

Inventors

  • LIANG JINMEI
  • YANG LI
  • SHEN HAO
  • QIAO NA
  • LIU XIAOLEI

Assignees

  • 中国人民解放军总医院

Dates

Publication Date
20260512
Application Date
20260204

Claims (10)

  1. 1. A method for controlling the administration of a surgical postoperative analgesic pump comprising the steps of: S1, acquiring a continuous respiratory frequency sequence of a patient in a postoperative analgesia management scene, dividing according to a complete respiratory cycle, extracting trough and peak values in the cycle, comparing and judging the peak values of the real-time cycle with respiratory extremum values of an anesthesia stage, and generating a respiratory fluctuation trigger mark; S2, invoking the breathing fluctuation trigger mark, acquiring a time distribution sequence of a patient medication request pressing action, dividing a unified sliding time window, counting the number of requests in a real-time window and a previous window, and generating a burst request linkage time period mark; S3, marking the burst request linkage time period, acquiring a continuous infusion time point and an infusion dose recorded in a basic infusion behavior of the postoperative analgesic pump, counting basic infusion times in the marked linkage time period, and generating a basic administration rhythm adjustment result; And S4, acquiring a high-frequency pressure waveform generated by pressing each time of a patient in the using process of the analgesic pump through the basic administration rhythm adjustment result, extracting a complete pressure curve from the initial pressing to the release end point, executing inflection point number identification and rebound change trend judgment, and carrying out parallel sequencing comparison on a real-time curve and a preamble tertiary curve to generate an autonomous operation identification mark.
  2. 2. The method according to claim 1, wherein the respiratory fluctuation trigger mark comprises an amplitude change direction trend mark, a period peak out-of-range judgment result and a stimulus response time point mark, the burst request linkage period mark comprises a request increasing trend, a respiratory fluctuation quantity rising trend and a request and fluctuation synchronization relation, the basic administration rhythm adjustment result comprises a start interval time update, a continuous infusion frequency adjustment and each infusion dose correction, and the autonomous operation identification mark comprises an inflection point distribution deviation, a rebound section structure abnormality and a pressurizing behavior abnormality mark.
  3. 3. The method for controlling the administration of a surgical postoperative analgesic pump according to claim 1, wherein the specific steps of S1 are: s101, acquiring a continuous respiratory frequency sequence of a patient in a postoperative analgesia management scene, splitting a continuous time period in the continuous respiratory frequency sequence of the patient, analyzing respiratory waveform data frames in a period according to periodic fluctuation of inhalation and exhalation phases in a complete respiratory period, extracting trough and peak values of waveforms in the period, and recording time indexes and amplitude values respectively to generate a respiratory period extremum sequence group; S102, based on the respiratory cycle extremum sequence group, judging the numerical direction of an amplitude difference sequence formed by peaks and troughs of adjacent three continuous respiratory cycles, constructing three cycle direction state groups according to whether the amplitude change directions between two adjacent cycles are consistent, if the amplitude change directions of the continuous three cycles are consistent, marking the three cycle direction state groups as forward fluctuation trend states, otherwise marking the three cycle direction state groups as non-forward trend states, and generating a cycle amplitude trend marking set; And S103, calling the periodic amplitude trend marking set, searching a corresponding periodic peak value data item according to a time point marked as a forward fluctuation trend, comparing the periodic peak value data item with a respiratory peak value limit range recorded during an anesthesia stage in a postoperative analgesia scene, and if the periodic peak value amplitude exceeds the upper limit of the respiratory extremum of the anesthesia stage, recording the time point and carrying out trigger state assignment processing to obtain a respiratory fluctuation trigger mark.
  4. 4. The method for controlling the administration of a postoperative analgesic pump as claimed in claim 3, wherein the specific step of S2 is: S201, invoking the breathing fluctuation trigger mark, obtaining a time distribution sequence of a patient medication request pressing action, dividing the time distribution sequence into continuous sliding time windows according to fixed step length, counting the medication request times in the time windows, and generating a sliding window request quantity set; S202, based on the sliding window request quantity set, carrying out quantity value difference judgment on the request quantity in two adjacent continuous time windows, if the request quantity of the next window is larger than the request quantity of the previous window, marking the time window as an incremental state, carrying out synchronous window division and quantity statistics on the respiration fluctuation triggering mark on the same time axis, judging whether the fluctuation triggering quantity in the window is increased compared with the previous window, and if both items are in the incremental state, marking the window as a linkage state, and generating a linkage state window marking sequence; s203, according to the time window marked as the linkage state in the linkage state window marking sequence, identifying the linkage start-stop time range corresponding to the time period, giving a burst request synchronous response attribute, completing marking operation on the linkage state window, and obtaining the burst request linkage time period mark.
  5. 5. The method for controlling the administration of a surgical post-operative analgesic pump of claim 4 wherein the specific step of S3 is: S301, calling the burst request linkage time period mark, acquiring continuous infusion time points and corresponding infusion dosage information recorded in basic infusion behaviors of the postoperative analgesic pump, searching whether the basic infusion time points fall into a range in a linkage time period range, counting basic infusion times in the linkage time period, and generating a basic infusion statistical table in the linkage time period; S302, calculating the ratio of the basic infusion times in the linkage period to the medication request quantity in the corresponding period according to the basic infusion statistical table in the linkage period, judging the time sequence coincidence proportion between the basic infusion rhythm and the patient request behavior, and marking the time sequence mismatch state if the coincidence proportion is lower than a preset behavior matching ratio threshold value, so as to generate a basic infusion rhythm mismatch identification set; S303, extracting the initial interval time and continuous infusion frequency of real-time basic infusion by adopting the time period marked as the time sequence mismatch state in the basic infusion rhythm mismatch mark set, respectively comparing the initial interval time and the continuous infusion frequency with a behavior matching reference configuration parameter set, updating the initial interval time and frequency parameters, and reallocating the infusion dosage of each time according to the updated frequency to obtain a basic administration rhythm adjustment result.
  6. 6. The method for controlling the administration of a surgical post-operative analgesic pump of claim 5 wherein the specific step of S4 is: S401, acquiring a high-frequency pressure waveform sequence generated by each pressing action of a patient in the using process of the analgesic pump through the basic administration rhythm adjustment result, extracting a corresponding complete pressure curve from a pressing starting point to a releasing end point, identifying derivative change points which are positively rotated negatively or negatively rotated positively in the curve, counting the number and the positions of the derivative change points, and generating a pressing pressure curve inflection point characteristic set; S402, calling the inflection point characteristic group of the pressing pressure curve, searching the adjacent data of the previous three pressing pressure curves, extracting a derivative direction sequence and an inflection point index sequence of a rebound section in each curve after time sequence arrangement, correspondingly comparing the number of inflection points and the change trend of the rebound section of a real-time curve with a precursor tertiary curve, recording the differential distribution of structural characteristics, and generating a real-time curve structure deviation data table; S403, judging whether the real-time pressing curve has inflection point quantity reduction, rebound segment deletion or position deviation abnormal state according to the structural feature difference recorded in the real-time curve structure deviation data table, if so, setting an abnormal identification state for the pressing behavior, and giving an autonomous operation attribute to obtain an autonomous operation identification mark.
  7. 7. The method according to claim 6, wherein whether or not there is an abnormal decrease in the number of inflection points of the real-time compression curve is determined based on the inflection point feature set extracted from the real-time compression curve; if the number of inflection points of the real-time pressing pressure curve is reduced, checking whether a rebound segment of the real-time pressing pressure curve is missing or whether a derivative direction sequence of the rebound segment deviates from a normal trend; if the rebound segment of the real-time pressing pressure curve is missing or the derivative direction sequence of the rebound segment is deviated, setting an abnormal identification state for the pressing behavior, and marking the pressing behavior as having an autonomous operation attribute; The judging process specifically comprises the steps of identifying a complete pressure curve corresponding to each pressing action in the extracted real-time curve, extracting a rebound section in the pressure curve, comparing the variation trend of the derivative direction of the rebound section with the variation trend in the adjacent previous curves, and judging an abnormal state if the variation of the trend exceeds a preset threshold value.
  8. 8. The method for controlling the administration of a surgical post-operative analgesic pump of claim 1 further comprising the step S5 of: s5, judging whether the automatic operation identification mark and the breathing fluctuation triggering mark are activated at the time node or not by utilizing the automatic operation identification mark and the breathing fluctuation triggering mark, if the automatic operation identification mark and the breathing fluctuation triggering mark are in a marked state, responding and releasing emergency infusion actions by a burst control channel of an analgesic pump, calling updated basic infusion parameters to execute continuous control, constructing a dual-channel linkage path with breathing fluctuation and a pressing signal as main factors, and generating a dynamic drug administration control instruction; the dynamic drug delivery control instruction comprises emergency infusion action trigger, basic infusion parameters and a double-channel linkage path.
  9. 9. The method for controlling the administration of a surgical post-operative analgesic pump of claim 8 wherein the specific step of S5 is: S501, comparing time indexes of the activation states of the two types of marks on the same time node by utilizing the autonomous operation identification mark and the breathing fluctuation trigger mark, judging whether a joint mark condition with time coincidence exists, recording a corresponding time index if the autonomous operation identification mark and the breathing fluctuation trigger mark are in the mark state in the same time node, setting the corresponding time index as a linkage trigger time point, and generating an identification linkage activation time set; S502, according to the linkage trigger time point in the identification linkage activation time set, a burst control channel of the analgesic pump invokes a related channel response mechanism, the emergency infusion action is released corresponding to the activation state, the updated basic infusion parameter set is invoked, continuous dose control operation is continuously executed, and a dual-channel control execution set is generated; S503, calling the emergency channel response and basic channel continuous control configuration recorded in the dual-channel control execution set, carrying out channel state fusion according to the time priority of the breathing fluctuation signal and the autonomous pressing signal, constructing a linkage output control path with the breathing fluctuation signal and the pressing signal as core driving factors, and generating a dynamic drug administration control instruction.
  10. 10. A medication administration control system for a surgical post-operative analgesic pump, the system for implementing a medication administration control method for a surgical post-operative analgesic pump as claimed in any one of claims 1 to 9, the system comprising: The respiratory fluctuation identification module acquires a continuous respiratory frequency sequence of a patient in a postoperative analgesia management scene, extracts peak values and trough values in a segmented mode according to a complete respiratory cycle, acquires cycle amplitude differences and forms an amplitude change set of three adjacent cycles, calls the three amplitude differences and compares whether the change directions are consistent or not, marks the three amplitude differences as trend segments if the three amplitude differences are in the unified direction, compares the cycle peak values with the upper limit of respiratory peak values recorded in an anesthesia stage, and generates respiratory fluctuation trigger marks; The request behavior monitoring module collects the record of the pressing behavior of the patient on the analgesic pump according to the respiratory fluctuation trigger mark, constructs a request distribution sequence according to time sequence, divides the number of requests in a long-time window statistical window, and generates a burst request linkage time period mark; The rhythm adjustment module searches a basic infusion time sequence and an infusion dosage record of the analgesic pump based on the burst request linkage time period mark, counts the occurrence times of basic infusion behaviors in a interval, calculates the superposition proportion of the basic infusion behaviors on a time axis, adjusts basic infusion setting parameters if the proportion is low, shortens basic infusion interval time and generates a basic administration rhythm adjustment result; The autonomous operation recognition module invokes the basic administration rhythm adjustment result, acquires pressure waveform data when a patient operates an analgesic pump button, recognizes a complete pressing curve, extracts inflection point distribution and rebound segment forms, compares a real-time curve with a previous three-time recorded curve in parallel, judges whether abnormal deviation or structural deletion exists between the inflection point position and rebound trend, and generates an autonomous operation recognition mark; And the dynamic drug delivery linkage module compares whether the mark positions on the time axis are activated at the same time according to the autonomous operation identification mark and the breathing fluctuation trigger mark, and if so, invokes an emergency infusion control path, executes basic infusion adjustment, executes continuous infusion operation on the channel and generates a dynamic drug delivery control instruction.

Description

Drug administration control method and system of postoperative analgesic pump Technical Field The invention relates to the technical field of automatic drug delivery control, in particular to a drug delivery control method and system of a postoperative analgesic pump. Background The technical field of automatic drug administration control relates to the realization of quantitative, timed or on-demand drug administration by carrying out automatic management on the drug infusion process, and is widely applied to clinical scenes such as postoperative analgesia, intensive care, chronic disease management and the like. The technical field mainly comprises core matters such as a liquid medicine conveying device, a flow regulation mechanism, a patient self-control interface, a feedback signal acquisition device, a control algorithm and the like. The automatic drug administration control technology realizes dynamic adjustment of the infusion rate by comparing the physiological parameters acquired by the sensor with preset drug administration parameters so as to improve the curative effect and safety of the drug. The technical development of the field is concentrated on continuous optimization of hardware stability, control precision, human-computer interaction experience and clinical suitability. The administration control method of the traditional postoperative analgesic pump refers to continuous or intermittent infusion of analgesic drugs into a body through the analgesic pump after operation of a patient so as to relieve discomfort of postoperative pain. The method adopts a mode of combining continuous infusion with preset speed and self-controlled administration of patients to realize analgesia control. In the traditional way, the analgesic pump is generally composed of a programmable infusion pump, a medicine storage bag and an infusion pipeline, and depends on the medical staff to set the basic infusion rate and the single self-control dosage, and part of the device can be configured with locking time to prevent excessive medicine. The administration control is mainly based on time intervals and dose limiting setting parameters, does not have the capability of adjusting according to the real-time state change of a patient, and is mainly completed by driving the infusion of liquid medicine through a mechanical key, an electric push or an elastic pump. In the prior art, the control mode of the postoperative analgesic pump depends on fixed time intervals and dosage parameters, the instant physiological state change of a patient cannot be perceived, the drug infusion lacks dynamic response capability, the basic infusion rate and the pain change of the patient are disjointed, the pain relieving effect is insufficient or the risk of drug accumulation is easy to occur, the patient self-control behavior is only based on mechanical pressing operation, an intelligent recognition mechanism is not provided, whether the patient self-control behavior is driven by real pain cannot be judged, if invalid or abnormal pressing occurs, the pain relieving evaluation and the drug use strategy are interfered, the infusion is still performed according to preset dosage when frequent requests but no actual demands exist, the potential risk of excessive drug is increased, the system lacks the capability of judging cooperatively based on physiological fluctuation and behavior signals, and the sudden demands are difficult to respond timely and effectively. Disclosure of Invention In order to solve the technical problems in the prior art, the embodiment of the invention provides a drug administration control method of a postoperative analgesic pump, which comprises the following steps: S1, acquiring a continuous respiratory frequency sequence of a patient in a postoperative analgesia management scene, dividing according to a complete respiratory cycle, extracting trough and peak values in the cycle, comparing and judging the peak values of the real-time cycle with respiratory extremum values of an anesthesia stage, and generating a respiratory fluctuation trigger mark; S2, invoking the breathing fluctuation trigger mark, acquiring a time distribution sequence of a patient medication request pressing action, dividing a unified sliding time window, counting the number of requests in a real-time window and a previous window, and generating a burst request linkage time period mark; S3, marking the burst request linkage time period, acquiring a continuous infusion time point and an infusion dose recorded in a basic infusion behavior of the postoperative analgesic pump, counting basic infusion times in the marked linkage time period, and generating a basic administration rhythm adjustment result; And S4, acquiring a high-frequency pressure waveform generated by pressing each time of a patient in the using process of the analgesic pump through the basic administration rhythm adjustment result, extracting a complete pressure curve from the initia