CN-122006016-A - Disposable grinding injection device for parathyroid gland autogenous transplantation

Abstract

The invention discloses a disposable grinding injection device for parathyroid autogenous transplantation, which comprises a cylinder body, wherein the rear end of the cylinder body is opened, a luer connector and a needle head are sequentially arranged at the front end of the cylinder body, a double-layer plane grinding net is arranged at the rear end of the cylinder body, the mesh aperture of a first grinding net is 1.0-1.5mm, the mesh aperture of a second grinding net is 0.5-0.8mm, the two layers of grinding nets keep a vertical distance of 2-3mm, the mesh patterns of the two layers of grinding nets are rotationally misplaced at an angle of 30-45 degrees, a cylindrical push rod is in sealing loose fit with the inner cavity of the cylinder body, the cylindrical push rod is arranged in the cylinder body and is arranged at the rear end of the double-layer plane grinding net, and when being pushed, tissues are pushed to move towards the net, negative pressure is generated when the push rod is pulled back, and liquid suction is realized. The invention realizes standardized control of the tissue particle size, shortens the operation time to 2-3 minutes, reduces the tissue exposure link, reduces the pollution risk, adopts a grinding mechanism with shearing force as a main component, improves the cell survival rate, realizes the integration of grinding and injection, and eliminates the intermediate transfer link.

Inventors

• Qiu Wangwang
• YANG ZHILI
• FAN YOUBEN
• YAN TING
• HU JUNDA

Assignees

• 上海市第六人民医院

Dates

Publication Date

20260512

Application Date

20260311

Claims (10)

1. 1. The disposable grinding injection device for parathyroid autograft is characterized by comprising the following components: the rear end of the cylinder body is opened, and the front end of the cylinder body is sequentially provided with a luer connector and a needle head, so that a tissue grinding space is provided; The double-layer plane grinding net is arranged at the front end of the barrel body and is 5-8mm away from the luer joint and consists of two layers of parallel grinding net sheets, wherein the mesh aperture of the first grinding net sheet is 1.0-1.5mm, the mesh aperture of the second grinding net sheet is 0.5-0.8mm, the two layers of grinding net sheets keep a vertical distance of 2-3mm, and the mesh patterns of the two layers of grinding net sheets are rotationally staggered at an angle of 30-45 degrees; The cylindrical push rod is in sealing loose fit with the inner cavity of the cylinder body and is arranged at the rear end of the second grinding net sheet in the cylinder body, and when the push rod is pushed, the tissue is pushed to move towards the net sheet, and when the push rod is pulled back, negative pressure is generated, so that liquid suction is realized.
2. 2. The disposable grinding and injecting device for parathyroid autograft according to claim 1, wherein the two grinding meshes are reliably connected with the cylinder body by adopting a buckling mode respectively.
3. 3. The disposable grinding and injecting device for parathyroid autograft according to claim 1, wherein the front end of the push rod is conical, the first grinding net sheet is fixedly connected with the conical top of the push rod, and the first grinding net sheet and the push rod move synchronously.
4. 4. The disposable grinding and injecting device for parathyroid autograft according to claim 2 or 3, wherein the mesh diameter of the first grinding net sheet is 1.2mm, the thickness is 0.3-0.5mm, the mesh diameter of the second grinding net sheet is 0.6mm, the thickness is 0.3-0.5mm, the holes of any grinding net sheet are in regular circular or hexagonal arrangement, and the hole edges are polished.
5. 5. The disposable grinding and injecting device for parathyroid autograft according to claim 2 or 3, wherein the mesh diameter of the first grinding net sheet is 1.5mm, the thickness is 0.3-0.5mm, the mesh diameter of the second grinding net sheet is 0.8mm, the thickness is 0.3-0.5mm, the holes of any grinding net sheet are in regular circular or hexagonal arrangement, and the hole edges are polished.
6. 6. The disposable grinding and injecting device for parathyroid autograft according to claim 1, wherein the end surface of the push rod is uniformly provided with a tissue pushing structure.
7. 7. The disposable grinding and injection device for parathyroid autograft according to claim 6, wherein the tissue pushing structure comprises 10-20 hemispherical or conical convex arrays with a diameter of 2-3mm and a height of 1-2 mm.
8. 8. The disposable grinding and injecting device for parathyroid autograft according to claim 6, wherein said tissue pushing structure is a cone structure having spiral lines.
9. 9. The disposable grinding injection device for parathyroid autograft according to claim 1, wherein the transparency of the cylinder is more than or equal to 90%, the grinding net sheet is made of medical stainless steel 316L or high-strength polyether-ether-ketone, and the front end of the cylinder is connected with a luer joint and is arranged in a conical shape.
10. 10. The disposable grinding and injecting device for parathyroid autograft according to claim 1, wherein a rotary handle is arranged at the rear end of the push rod, and anti-slip lines are arranged on the surface of the handle.

Description

Disposable grinding injection device for parathyroid gland autogenous transplantation Technical Field The invention relates to the technical field of biological tissue treatment, in particular to a disposable grinding injection device for parathyroid autograft. Background Parathyroid autograft is a common procedure in thyroidectomy, parathyroid adenomatoctomy, and other procedures for maintaining normal parathyroid function in patients after surgery. Parathyroid tissue reduction treatment in parathyroid autograft surgery is an important factor affecting the effect of the surgery. The parathyroid tissue reduction treatment method commonly adopted clinically at present is a manual cutting method, and the specific operation process comprises the following steps: Ischemic parathyroid tissue (typically 1 gland, individual weights about 30-50 mg) was placed in sterile stainless steel plates during surgery and kept moist with the addition of a small amount of physiological saline. The operator repeatedly cuts the tissue in the petri dish using an ophthalmic scissors, a tissue scissors or a surgical blade, and chops it into tissue pieces of about 3mm3 size. The entire morcellation process typically takes 5-10 minutes during which the tissue is exposed to air, with the operator constantly adjusting the cutting angle and force. After the completion of the morcellation, the clamped tissue fragments are transferred to a pre-incised implantation site using forceps, vascular clamps, or the like. The existing manual shredding method has the following remarkable problems: First, tissue grain size is severely heterogeneous, manual cutting is entirely dependent on the experience and skill of the operator, and lacks standardized size control means. The size of the minced tissue varies from 0.2mm to 3mm, with significant differences. Large particles (> 2 mm) are difficult to permeate into the center of tissue due to overlarge volume, so that ischemia necrosis and endocrine function loss are caused in the center area, and too small particles (< 0.3 mm) are excessive in mechanical injury, high in cell membrane rupture rate and low in survival rate. According to literature reports, the uneven particle size is one of the main reasons for the fluctuation of the success rate of the autograft, and the success rate is greatly different from 40% to 85%. Second, the procedure is time consuming and highly dependent on the operator experience, with manual shredding typically taking 5-10 minutes, which can be longer for underexperienced young doctors. In the cutting process, the operator is required to repeatedly adjust the angle of the blade and control the cutting force, the whole process lacks objective standards, and the quality control is difficult. Furthermore, studies have shown that the viability of parathyroid cells after manual chopping decreases with increasing cutting time. And again, the risk of pollution is high, the loss of cell activity is large, tissues are repeatedly cut in an open container (a culture dish), the exposure time is as long as 5-10 minutes, and the risks of bacterial pollution and air particulate matter mixing are increased. Air flow in the operating room, operator respiration, and microorganisms on the surfaces of the instruments can all become sources of contamination. The process of aspiration of tissue from the dish and re-transfer to the syringe increases the chances of multiple contacts and exposures, further increasing the risk of infection. In addition, repeated cutting of the surgical blade or scissors produces a mixed action of the pressing force and the shearing force on the tissue, but the pressing force is dominant. Such blunt mechanical injury can lead to massive cell membrane rupture, leakage of cell contents, and reduced cell viability and functional recovery after transplantation. Finally, the transferring link is complicated, namely the minced tissues need to be sucked from the culture dish by a syringe, and the needle heads are easy to be blocked or left on the container wall in the sucking process due to different sizes of tissue blocks, so that the tissue waste is caused. After the suction, the content is required to be transferred to another syringe, and the repeated transfer is complex in operation, so that the pollution opportunity and the tissue loss are increased. Therefore, developing a disposable grinding injection device that overcomes the above problems is an industry challenge that is highly sought to be solved. Disclosure of Invention Aiming at the problems existing in the prior art, the invention aims to provide a disposable grinding injection device for parathyroid autograft, which is used for realizing standardized control of tissue particle size, ensuring that the final particle size is uniform and consistent within the range of 0.4-0.6mm, shortening the operation time to 2-3 minutes, reducing the dependence on experience of operators, reducing tissue exposure links, reduc