CN-122006031-A - Breathing trigger microgrid atomizer based on thermocouple sensor

CN122006031ACN 122006031 ACN122006031 ACN 122006031ACN-122006031-A

Abstract

The invention relates to the technical field of micro-grid atomizers, and discloses a respiration triggering micro-grid atomizer based on a thermocouple sensor, wherein the device comprises a three-way pipe second port and a third port; the respiratory sensing module is provided with a differential sensing array on a flexible circuit board, the sensing unit at least comprises a thermocouple sensor, the atomization module integrates an impedance measuring circuit and a driving circuit on the flexible circuit board to multiplex the micro-grid transducer to sense the state of the micro-grid transducer, the controller carries out weighted fusion on sensing unit signals in the differential sensing array and predicts the starting moment of inspiration, a pre-trigger instruction is sent out at the end of expiration to drive the transducer to pre-charge atomized liquid medicine with low power, impedance characteristics are synchronously collected to obtain the micro-grid efficiency value, the inspiration phase carries out compensation correction on driving power according to the real-time flow ratio and the efficiency value, and the expiration phase applies reverse pulse to clean the micro-grid and records the effect to predict the subsequent cleaning time. And closed-loop control of respiratory phase prediction triggering, phased scheduling and efficiency self-calibration is realized.

Inventors

ZHENG XIAOLIN
LIN XIAOLIANG
LIN YUNIAN
YAN LINYONG
LIU JIANFEI
HE XUELI

Assignees

厦门小羽人科技有限公司

Dates

Publication Date: 20260512
Application Date: 20260413

Claims (10)

1. The respiratory triggering micro-grid atomizer based on the thermocouple sensor is characterized by comprising a three-way pipe, a respiratory sensing module, an atomization module and a controller; the three-way pipe is provided with a first port, a second port and a third port, the first port is used for being connected with the airway of a patient, the third port is used for being connected with a breathing machine loop, and the second port is communicated with the atomization module; the atomization module comprises a micro-grid transducer arranged at the end part of the second port, a micro-grid atomization sheet arranged in the micro-grid transducer and a liquid medicine cup arranged above the micro-grid transducer; The respiration sensing module comprises a flexible circuit board and a differential sensing array arranged on the flexible circuit board, wherein the differential sensing array comprises a plurality of sensing units which are distributed at intervals along the direction of a three-way pipe airflow channel, and the sensing units at least comprise thermocouple sensors; the atomization module comprises a micro-grid transducer and a driving circuit integrated on the flexible circuit board, wherein an impedance measurement circuit is arranged in the driving circuit and is electrically connected with the micro-grid transducer; The controller is respectively and electrically connected with the respiration sensing module and the atomization module and is used for carrying out weighted fusion processing on signals output by the sensing units in the differential sensing array to obtain respiration phase signals of the patient; Comparing and analyzing the respiratory phase signal of the current respiratory cycle with the respiratory phase signal of the historical respiratory cycle to obtain a respiratory frequency information set, predicting the next inspiration starting moment according to the respiratory frequency information set, and sending a pre-trigger instruction to the atomization module at the final stage of the current respiratory phase; Responding to the pre-triggering instruction, driving the micro-grid transducer in a low-power pulse mode, and pre-filling atomized liquid medicine in the inner cavity of the three-way pipe; Carrying out fusion processing on the resonant frequency offset, the impedance modulus value variation and the phase angle drift of the micro-grid transducer acquired by the impedance measuring circuit to acquire a micro-grid efficiency value; During the inspiration phase, detecting the real-time inspiration flow, proportionally adjusting the driving power of the transducer and the real-time inspiration flow, and introducing the micro-grid efficiency value into compensation correction of the driving power to obtain corrected driving power so as to enable the atomized liquid medicine dose delivered by each breath to be consistent with the prescription target quantity.
2. The thermocouple sensor-based respiratory triggering microgrid atomizer according to claim 1, wherein the controller is electrically connected with the respiratory sensing module and the atomization module respectively, and is configured to perform weighted fusion processing on signals output by the sensing units in the differential sensing array, obtain respiratory phase signals of the patient, and further include: During the expiration phase, the driving phase of the energy converter is reversely adjusted, a reverse driving pulse sequence is applied to the micro-grid energy converter, so that the micro-grid generates vibration with the opposite direction to the vibration direction of the energy converter when atomized liquid medicine is generated, the deposition of the micro-grid wall is peeled to the liquid medicine cup side, and the effective aperture of the micro-grid is recovered; After the back driving pulse is executed, the resonance frequency offset, the impedance module value variation and the phase angle shift of the micro-grid transducer are acquired again through the impedance measuring circuit, the micro-grid efficiency value after cleaning is obtained, and the micro-grid efficiency values before and after cleaning are compared and recorded so as to predict the subsequent cleaning triggering time.
3. The thermocouple sensor-based respiratory triggering microgrid atomizer according to claim 1, wherein the controller is electrically connected with the respiratory sensing module and the atomization module respectively, and is configured to perform weighted fusion processing on signals output by the sensing units in the differential sensing array, obtain respiratory phase signals of the patient, and further include: Extracting a low-frequency modulation component generated by airflow modulation from an output signal of the impedance measurement circuit, performing multipath comparison and verification on the low-frequency modulation component and a signal of a thermocouple sensor in the differential sensing array, and performing cross verification on a respiratory phase signal to obtain a respiratory phase signal after verification.
4. The thermocouple sensor-based breath-triggered microgrid nebulizer of claim 1, wherein the sensing units in the differential sensing array further comprise a humidity sensor and a carbon dioxide sensor; Detecting the signal arrival time of a sensing unit in the differential sensing array in the direction of an airflow channel, extracting the signal arrival time difference between a humidity sensor and a carbon dioxide sensor and between the humidity sensor and a thermocouple sensor, acquiring an airflow time sequence gradient, and using the airflow time sequence gradient and a weighted fusion processing result together to predict the starting time of inhalation.
5. The respiratory triggering microgrid atomizer based on the thermocouple sensor according to claim 1, wherein the impedance measurement circuit and the driving circuit multiplex wiring on the flexible circuit board, and the microgrid transducer is driven by low power pulses to complete the period of atomized liquid medicine pre-charging, and the impedance measurement circuit synchronously collects the resonant frequency offset, the impedance module value change and the phase angle shift of the transducer under the excitation of the low power pulses to obtain the microgrid efficiency value.
6. The thermocouple sensor-based breath-triggered microgrid nebulizer of claim 4, wherein using the airflow timing gradient in conjunction with a weighted fusion process result for predicting inspiration onset time further comprises: When the signals output by the sensing units in the differential sensing array are subjected to weighted fusion processing, the historical misjudgment rate of the sensing units in the differential sensing array is counted, the weight corresponding to the sensing unit with the lower misjudgment rate is set to be a larger value, the weight corresponding to the sensing unit with the higher misjudgment rate is set to be a smaller value, the sensing unit weight in the differential sensing array is dynamically adjusted, the adjusted weight and the corresponding sensing unit signal are subjected to weighted summation, a respiratory phase comprehensive signal is obtained, and the comprehensive signal is compared with a preset inhalation threshold value to obtain a respiratory phase signal.
7. The thermocouple sensor-based respiratory trigger microgrid nebulizer of claim 1, wherein comparing the respiratory phase signal of the current respiratory cycle with the respiratory phase signal of the historical respiratory cycle to obtain a respiratory frequency information set, predicting a next inspiration starting time according to the respiratory frequency information set, and sending a pre-trigger instruction to the nebulizing module at the end of the current respiratory phase further comprises: the method comprises the steps of storing inspiration starting moments of N previous respiratory cycles through a controller, carrying out sliding average value calculation on the N inspiration starting moments to obtain the next inspiration starting prediction moment, carrying out self-adaptive adjustment on an N value according to the fluctuation degree of respiratory frequency of a patient by the controller, taking a larger value when the respiratory frequency is stable and taking a smaller value when the respiratory frequency is large, sending a pre-trigger instruction to an atomization module before the prediction moment, and carrying out self-adaptive adjustment on the advance according to the current respiratory rhythm of the patient.
8. The thermocouple sensor-based respiratory-triggered microgrid nebulizer of claim 1, wherein said driving the microgrid transducer in a low power pulse manner responsive to said pre-trigger instruction, pre-filling the three-way tube lumen with nebulized medical fluid further comprises: The method comprises the steps of setting a target dose required to be complemented by a difference between a prescription target quantity and a delivered dose in an atomized liquid medicine pre-filling stage as a target dose required to be complemented by the inhalation phase during the inhalation phase through a controller, setting driving power of a transducer and real-time inhalation flow into a proportional relation, setting driving power and a micro-grid efficiency value into an inverse compensation relation, and when the micro-grid efficiency value is reduced, driving power is increased in a same-ratio mode so that the total delivered atomized liquid medicine in the inhalation phase accords with the target dose.
9. The respiratory triggering microgrid atomizer based on a thermocouple sensor according to claim 2, wherein the fusion processing of the resonant frequency offset, the impedance modulus value variation and the phase angle drift of the microgrid transducer acquired by the impedance measurement circuit, the obtaining of the microgrid efficiency value further comprises: Calculating the difference value of the efficiency values of the micro-grid before and after cleaning through a controller to obtain a single cleaning efficiency recovery amount, counting the time interval of the efficiency value before the cleaning until the past time is reduced to a cleaning trigger threshold value to obtain an efficiency decay time rule, comprehensively analyzing the cleaning efficiency recovery amount and the efficiency decay time rule, and predicting the subsequent cleaning trigger time to obtain a self-adaptive cleaning period.
10. The thermocouple sensor based breath triggered microgrid nebulizer of any one of claims 1 to 9, wherein the controller comprises: The sensing fusion unit is used for collecting signals of the sensing units in the differential sensing array, and carrying out weighted fusion processing on the collected multipath signals to obtain respiratory phase signals of the patient; The phase prediction unit is used for periodically storing the respiratory phase signals output by the sensing fusion unit, comparing and analyzing the current respiratory cycle data with the historical respiratory cycle data, predicting the next inspiration starting moment, and generating a pre-trigger instruction at the end of the expiration phase; The device comprises a phase prediction unit, a drive scheduling unit, a real-time inhalation flow rate detection unit, a phase prediction unit, a phase adjustment unit and a control unit, wherein the phase prediction unit is used for receiving a pre-trigger instruction of the phase prediction unit, driving a transducer in a low-power pulse mode at the end of expiration to finish atomized liquid medicine pre-charge; The efficiency compensation unit is used for carrying out fusion processing on the resonance frequency offset, the impedance module value variation and the phase angle offset acquired by the impedance measurement circuit to acquire a micro-grid efficiency value, inputting the micro-grid efficiency value into the driving scheduling unit, and carrying out compensation correction on the driving power to acquire corrected driving power; and the cleaning management unit is used for applying a reverse driving pulse to the transducer during the expiration phase, stripping the micro-mesh wall sediment to the side of the liquid medicine cup, comparing and recording the micro-mesh efficiency values before and after cleaning, and predicting the subsequent cleaning trigger time.

Description

Breathing trigger microgrid atomizer based on thermocouple sensor Technical Field The invention relates to the technical field of micro-grid atomizers, in particular to a breath triggering micro-grid atomizer based on a thermocouple sensor. Background Nebulized inhaled administration is an important treatment for mechanically ventilated patients. The existing atomizer is generally composed of an atomization module, a controller and a connecting pipeline, and is matched with a breathing machine loop to be used, so that liquid medicine is converted into atomized liquid medicine and then is sent to the lung of a patient along with air flow. In the aspect of trigger sensing, the common atomizer has inherent trigger delay, is easily interfered by body temperature and environmental temperature fluctuation to generate false trigger, causes the atomization opportunity to deviate from the actual inhalation phase, causes the waste of part of liquid medicine in exhalation phase, and in the aspect of drive control, the conventional atomizer only realizes simple switch, continuously atomizes with fixed power in the whole inhalation process, when the flow rate at the tail stage of inspiration is reduced, the concentration of atomized liquid medicine is suddenly increased, the lung deposition is uneven, the effective deep lung deposition rate is low, meanwhile, medicines are remained on the micro-mesh wall to gradually deposit and crystallize, so that the effective aperture is reduced, the atomization efficiency is continuously reduced, the existing equipment has no sensing capability, and has no dose compensation mechanism, so that the actual delivered dose is systematically lower along with the prolonged use time. Therefore, under the condition that the three links of triggering sensing, driving control and micro-grid maintenance have obvious defects, the atomized liquid medicine dose actually obtained by the patient in each breath cannot be consistent with the prescription target quantity, and the clinical accurate administration requirement is difficult to meet. Disclosure of Invention The invention provides a respiratory triggering micro-grid atomizer based on a thermocouple sensor, which aims to solve the problems that an atomized liquid medicine dosage obtained by each breath of a patient has an error with a target dosage and the dosing precision is poor. In order to solve the technical problems, the technical scheme of the invention is as follows: In a first aspect, a respiratory triggering micro-grid atomizer based on a thermocouple sensor comprises a three-way pipe, a respiratory sensing module, an atomization module and a controller; the three-way pipe is provided with a first port, a second port and a third port, the first port is used for being connected with the airway of a patient, the third port is used for being connected with a breathing machine loop, and the second port is communicated with the atomization module; the atomization module comprises a micro-grid transducer arranged at the end part of the second port, a micro-grid atomization sheet arranged in the micro-grid transducer and a liquid medicine cup arranged above the micro-grid transducer; The respiration sensing module comprises a flexible circuit board and a differential sensing array arranged on the flexible circuit board, wherein the differential sensing array comprises a plurality of sensing units which are distributed at intervals along the direction of a three-way pipe airflow channel, and the sensing units at least comprise thermocouple sensors; the atomization module comprises a micro-grid transducer and a driving circuit integrated on the flexible circuit board, wherein an impedance measurement circuit is arranged in the driving circuit and is electrically connected with the micro-grid transducer; The controller is respectively and electrically connected with the respiration sensing module and the atomization module and is used for carrying out weighted fusion processing on signals output by the sensing units in the differential sensing array to obtain respiration phase signals of the patient; Comparing and analyzing the respiratory phase signal of the current respiratory cycle with the respiratory phase signal of the historical respiratory cycle to obtain a respiratory frequency information set, predicting the next inspiration starting moment according to the respiratory frequency information set, and sending a pre-trigger instruction to the atomization module at the final stage of the current respiratory phase; Responding to the pre-triggering instruction, driving the micro-grid transducer in a low-power pulse mode, and pre-filling atomized liquid medicine in the inner cavity of the three-way pipe; Carrying out fusion processing on the resonant frequency offset, the impedance modulus value variation and the phase angle drift of the micro-grid transducer acquired by the impedance measuring circuit to acquire a micro-grid efficiency v