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CN-122006091-A - Sound field driving microsphere lung targeting drug delivery device

CN122006091ACN 122006091 ACN122006091 ACN 122006091ACN-122006091-A

Abstract

The invention discloses a sound field driven microsphere lung targeting drug delivery device, belonging to the technical field of lung targeting drug delivery; the invention comprises a sound field generation module, a microsphere storage and administration module, a targeting regulation module and a temperature control protection module, wherein the sound field generation module can output graded sound fields with adjustable gradients, so that the segmented driving of the drug microspheres from an air passage inlet to a lesion area is realized, the microsphere deposition deviation caused by a single sound field is avoided, the drug microspheres with lung targeting ligands and mucus penetrating units are decorated on the surface in the microsphere storage and administration module, the accurate anchoring is realized by matching with the sound field driving, the targeting regulation module dynamically regulates the frequency, the intensity and the action time of the sound field by collecting lung lesion position signals in real time, and the accurate administration of the lesion area is realized.

Inventors

  • WENG WENHUI
  • FANG RUI

Assignees

  • 福州大学附属省立医院

Dates

Publication Date
20260512
Application Date
20260326

Claims (10)

  1. 1. A sound field driven microsphere lung targeting drug delivery device is characterized by comprising a sound field generation module (1), a microsphere storage drug delivery module (2), a targeting regulation module (3) and a temperature control protection module (4), wherein the sound field generation module (1) is of a hierarchical sound field structure and comprises a low-frequency sound field generator (11) and a high-frequency sound field generator (12), a gradient adjustable hierarchical sound field can be output to realize segmented driving of drug microspheres from an airway inlet to a lung lesion area, the microsphere storage drug delivery module (2) is internally provided with drug microspheres (21) with lung targeting ligands and mucus penetrating units, the lung targeting ligands are lung epithelial cell specific binding ligands, the mucus penetrating units are hydrophilic polymer modification layers, the targeting regulation module (3) comprises a lesion position detector (31), a signal processor (32) and a parameter regulation and control unit (33), lesion position signals can be acquired in real time, the frequency, the intensity and the acting time of the sound field generation module (1) can be dynamically adjusted, and the temperature control module (4) can maintain a safe temperature controller (41) in a safe and temperature protection area.
  2. 2. The sound field driven microsphere lung targeting drug delivery device according to claim 1, wherein the frequency range of the low frequency sound field generator (11) is 10-50kHz, the intensity is 0.1-0.5W/cm2, the low frequency sound field generator is used for driving the drug microsphere (21) to penetrate through lung mucus layers, the frequency range of the high frequency sound field generator (12) is 100-500kHz, the intensity is 0.05-0.2W/cm2, the low frequency sound field generator is used for accurately pushing the drug microsphere (21) to a lesion area, and the action range of the high frequency sound field can be focused and adjusted through the parameter adjusting and controlling unit (33).
  3. 3. The sound field driven microsphere lung targeting drug delivery device according to claim 1, wherein the particle size of the drug microsphere (21) is 1-5 μm, the surface modified lung targeting ligand is an alveolar epithelial cell surface receptor specific antibody, the mucus penetrating unit is a polyethylene glycol (PEG) modified layer, the drug microsphere (21) internally wraps the lung therapeutic drug, and the microsphere shell is an ultrasonic response material, so that the drug can be slowly released under the action of a graded sound field.
  4. 4. The sound field driven microsphere lung targeting drug delivery device according to claim 1, wherein the lesion position detector (31) is a portable lung ultrasound detector, position coordinates and lesion range signals of a lung lesion area can be acquired in real time, the acquired signals are converted into electric signals by the signal processor (32) and transmitted to the parameter regulating and controlling unit (33), and automatic regulation of sound field parameters is realized, and the regulation response time is less than or equal to 0.5s.
  5. 5. The sound field driven microsphere lung targeting drug delivery device according to claim 1, wherein the sound field generating module (1) further comprises a sound field conduction probe (13), the sound field conduction probe (13) is of an arc structure, is attached to the face and neck contours of a human body, can conduct a graded sound field to the entrance of an air passage in a directional manner, reduces the energy loss of the sound field, and the surface of the sound field conduction probe (13) is provided with a biocompatible coating.
  6. 6. The sound field driven microsphere lung targeting drug delivery device according to claim 5, wherein a temperature sensor (41) of the temperature control protection module (4) is arranged at the sound field conduction probe (13) and can monitor the lung airway surface temperature in real time, the monitoring range is 36-40 ℃, and when the temperature exceeds 37.5 ℃, the temperature controller (42) automatically reduces the sound field intensity until the temperature is restored to a safe range.
  7. 7. The sound field driven microsphere lung targeting drug delivery device according to claim 1, wherein the microsphere storage drug delivery module (2) further comprises a quantitative drug delivery valve (22) and a microsphere delivery pipe (23), the quantitative drug delivery valve (22) can accurately control the quantity of microspheres which are delivered once, the control precision is +/-5%, an outlet of the microsphere delivery pipe (23) is connected with a mask, and an anti-adhesion coating is arranged on the inner wall of the delivery pipe to avoid adhesion and blockage of the drug microspheres (21).
  8. 8. The sound field driven microsphere lung targeting drug delivery device according to claim 1, wherein the targeting control module (3) further comprises a man-machine interaction interface (34) capable of manually setting sound field parameters, drug delivery dosage and drug delivery time, and displaying lesion positions, sound field parameters and temperature data in real time, so that an operator can monitor the device conveniently.
  9. 9. The sound field driven microsphere lung targeting drug delivery device according to claim 1, wherein the temperature controller (42) adopts a semiconductor temperature control technology, the temperature control precision is +/-0.1 ℃, and the temperature controller can be adjusted in real time according to the feedback signal of the temperature sensor (41) so as to avoid lung tissue damage caused by sound field action.
  10. 10. The sound field driven microsphere lung targeting drug delivery device according to any one of claims 1-9, wherein the drug delivery device is of a portable structure, has a weight of less than or equal to 500g, can be powered by a rechargeable battery (5), has a duration of more than or equal to 4 hours, and is suitable for clinical bedside drug delivery and home long-term care drug delivery.

Description

Sound field driving microsphere lung targeting drug delivery device Technical Field The invention relates to the technical field of lung targeting drug delivery, in particular to a sound field driven microsphere lung targeting drug delivery device. Background Pulmonary diseases are a disease with high incidence and great treatment difficulty, and traditional pulmonary administration modes mainly comprise oral administration, intravenous injection administration and conventional inhalation administration. The conventional inhalation administration (such as aerosol inhalation) can directly send the medicine into the airway, but has the defects of low targeting precision, easiness in clearing the medicine by the mucociliary of the lung, insufficient administration depth and the like, the medicine cannot be accurately delivered to the deep lesion area of the lung, and the medicine microspheres are easily deposited on the surface of the airway, so that the treatment effect is poor. With the development of sound field driving technology, some sound field driven pulmonary drug delivery devices are presented in the prior art, and the core principle of the device is to drive drug microspheres into the lungs by using the mechanical effect of an ultrasonic sound field. However, the existing sound field driven drug delivery device still has obvious technical defects: 1. The single-frequency sound field driving is adopted, and driving parameters cannot be dynamically adjusted according to physiological structures (such as airway mucus layer and alveolus region) of different regions of the lung, so that the drug microspheres are difficult to penetrate through mucus barriers and are easy to deposit in non-pathological regions; 2. The drug microsphere and the sound field drive lack of cooperative adaptation, the microsphere surface is not subjected to targeted modification, the accurate anchoring of a lesion area can not be realized, and the drug microsphere is easy to be cleared by immune cells of the lung; 3. The lack of an effective targeting regulation mechanism can not adjust the action range and intensity of a sound field in real time according to the lesion position, so that the targeting precision is low; 4. Local overheating is easy to generate in the sound field action process, normal tissues of the lung can be damaged, and effective temperature control protection measures are lacked. The Chinese patent with publication number of CN121466431A discloses an atomizing drug delivery device for targeted pulmonary delivery of icariin, which adopts air flow driving to realize screening and delivery of drug particles, but the device is not driven by an acoustic field, can not break through a pulmonary mucus barrier, is difficult to realize accurate drug delivery in deep lesion areas due to the fact that targeting precision depends on air flow screening, and further researches adopt an ultrasonic acoustic field to drive drug microspheres, but only adopts a single-frequency acoustic field, and the microspheres are not subjected to mucus penetration and targeting modification, so that the problem of low drug delivery efficiency and poor targeting property exists. Therefore, research and development of a sound field driven microsphere lung targeting drug delivery device which can break through the lung mucus barrier, realize accurate targeting of a lesion area and have a safety protection function becomes an urgent need in the current lung drug delivery technical field. Disclosure of Invention In order to solve the technical problems, the technical scheme provided by the invention is as follows: The sound field driven microsphere lung targeting drug delivery device comprises a sound field generation module, a microsphere storage drug delivery module, a targeting regulation module and a temperature control protection module, wherein the sound field generation module is of a hierarchical sound field structure and comprises a low-frequency sound field generator and a high-frequency sound field generator, the hierarchical sound field with adjustable gradients can be output to realize segmented driving of drug microspheres from an airway inlet to a lung lesion area, the microsphere storage drug delivery module is internally provided with drug microspheres with lung targeting ligands and mucus penetrating units, the lung targeting ligands are lung epithelial cell specific binding ligands, the mucus penetrating units are hydrophilic macromolecule modifying layers, the targeting regulation module comprises a lesion position detector, a signal processor and a parameter regulation unit, the lung lesion position signals can be collected in real time, the frequency, the intensity and the acting time of the sound field generation module can be dynamically adjusted, the temperature control protection module comprises a temperature sensor and a temperature controller, and the temperature of the action area can be monitored in real time and