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CN-122006098-A - Application of high-dielectric composite material in patch electrode for tumor electric field treatment

CN122006098ACN 122006098 ACN122006098 ACN 122006098ACN-122006098-A

Abstract

The invention discloses application of a high-dielectric composite material in a patch electrode for tumor electric field treatment, and relates to the technical field of medical appliances. The high-dielectric composite material comprises a conductive three-dimensional framework layer, a high-dielectric inorganic shell layer and a flexible interface layer, wherein the high-dielectric inorganic shell layer is coated on the surface of the conductive three-dimensional framework layer, and the flexible interface layer is filled in the conductive three-dimensional framework layer and the high-dielectric inorganic shell layer. The composite material has the characteristics of high dielectric property, low loss and good heat dissipation, is applied to a flexible patch electrode of 100-500 kHz medium-frequency alternating electric field body surface capacitive coupling, can obviously improve the in-vivo electric field strength and depth coverage on the premise of not improving the output voltage of equipment, and simultaneously reduces power consumption and skin adverse reaction.

Inventors

  • WANG XINDONG
  • HUANG YAHUI

Assignees

  • 中山大学孙逸仙纪念医院

Dates

Publication Date
20260512
Application Date
20251230

Claims (10)

  1. 1. The application of the high-dielectric composite material in the patch electrode for tumor electric field treatment is characterized in that the high-dielectric composite material comprises a conductive three-dimensional framework layer, a high-dielectric inorganic shell layer and a flexible interface layer, wherein the high-dielectric inorganic shell layer is coated on the surface of the conductive three-dimensional framework layer, and the flexible interface layer is filled in the conductive three-dimensional framework layer and the high-dielectric inorganic shell layer.
  2. 2. The use according to claim 1, wherein the material of the conductive three-dimensional framework layer is selected from the group consisting of Ni, ni-Cr alloys, ni-Co alloys, cu-Ni alloys, ti, ta, mo, W, stainless steel, ni-Mo, ni-W and mixed-base foam or metal fiber materials thereof; or, the material of the conductive three-dimensional framework layer is selected from nickel-titanium alloy, titanium-molybdenum alloy, tantalum-niobium alloy metal fabric, woven mesh, knitted mesh or fiber felt.
  3. 3. The use according to claim 1, wherein the electrically conductive three-dimensional skeleton layer has an open porosity of 70-99%, an average pore size of 30-1500 μm and a thickness of 5-3000 μm.
  4. 4. The use of claim 1, wherein the material of the high dielectric inorganic shell comprises at least one of ferroelectric/relaxor ferroelectric, giant dielectric materials.
  5. 5. The use according to claim 4, wherein the ferroelectric/relaxor ferroelectric comprises at least one of BaTiO 3 and its modified solid solution material, lead-containing material, bismuth-containing ferroelectric material; and/or the giant dielectric material comprises at least one of CaCu 3 Ti 4 O 12 、SrCu 3 Ti 4 O 12 、La 0.5 Ba 0.5 TiO 3 .
  6. 6. The use according to claim 1, wherein the high dielectric inorganic shell layer has a thickness of 5-300 μm.
  7. 7. The use of claim 1, wherein the material of the flexible interface layer comprises at least one of PDMS silicone, polyurethane elastomers, epoxy and polyetheramine cure systems, acrylics, polyesters, multi-block copolymers, polyetheresters, polyimides, polyvinylidene fluoride, polyetheretherketones, polyethersulfones.
  8. 8. The use according to claim 1, wherein the mass ratio of the conductive three-dimensional framework layer, the high dielectric inorganic shell layer and the flexible interface layer is (1-5): (6-14): (3-10); Or the mass ratio of the conductive three-dimensional framework layer to the high-dielectric inorganic shell layer to the flexible interface layer is (1-5): 4-10): 5-12; or the mass ratio of the conductive three-dimensional framework layer to the high-dielectric inorganic shell layer to the flexible interface layer is (1-6): 2-8): 8-14.
  9. 9. The use according to claim 1, wherein the method of preparing the high dielectric composite material comprises the steps of: (1) Adding the high-dielectric inorganic shell material into an organic solvent, stirring for 3-4 h, then carrying out ultrasonic treatment for 20-30 min, and uniformly dispersing to obtain a mixed solution; (2) Carrying out electrophoretic deposition by using a direct current power supply, wherein a platinum sheet is used as an anode, a conductive three-dimensional framework layer is used as a cathode, the distance between the conductive three-dimensional framework layer and the platinum sheet is 10-25 mm, and the deposition is carried out under 40V voltage, wherein the deposition time is set to be 8-10 min of single-sided electroplating, and the front side and the back side are respectively electroplated once; (3) Sintering at 1000-1300 ℃ for 1-2 h under a protective atmosphere, and cooling to obtain the composite material with the high-dielectric inorganic shell layer coating the conductive three-dimensional framework layer; (4) And injecting the material of the flexible interface layer into pores in the composite material of the high-dielectric inorganic shell layer coated conductive three-dimensional framework layer, thus obtaining the high-dielectric composite material.
  10. 10. A patch electrode for tumor electric field therapy, made of the high dielectric composite material of any one of claims 1-9.

Description

Application of high-dielectric composite material in patch electrode for tumor electric field treatment Technical Field The invention relates to the technical field of medical equipment, in particular to application of a high-dielectric composite material in a patch electrode for tumor electric field treatment. Background Tumor electric field therapy is a therapy which uses low-intensity, medium (100-500 KHz) frequency, alternating electric field to act on human tissue, and interfere with the mitotic process of cells, so as to inhibit and destroy rapidly proliferating cells, and is mainly used for tumor therapy. Such treatment of tumors is known as alternating electric field therapy or Tumor TREATING FIELDS (TTFields, hereinafter abbreviated as TTF) abroad, and is a technology developed after year 2000, and TTF treatment of brain glioma in 2011 was approved by the us FDA, and related therapeutic equipment in 2018 is marketed in hong kong in china. TTF treatment of malignant pleural mesothelioma in 2019 was also FDA approved. Up to the present, the three-stage clinical test results of various tumors are good, and the method is a tumor treatment technology with relatively good prospect. The existing TTF equipment mostly adopts hard ceramic electrode plates with smaller size, and the effective coupling area is reduced, the interface air gap is increased due to the fact that the tilted edges, hollows and stress concentration exist on the curved surface of a human body, so that the equivalent coupling capacitance is reduced comprehensively, and under the condition that the port voltage is limited, the electric field intensity and the energy coupling efficiency in tissues are limited. Moreover, the heavy and airtight properties of the hard ceramic electrode sheet also easily cause skin irritation and inflammation, affecting long-term compliance of >18 hours/day. Disclosure of Invention The invention aims to overcome the defects of the prior art and provide the application of the high-dielectric composite material in the patch electrode for tumor electric field treatment. The composite material has the characteristics of high dielectric property, low loss and good heat dissipation, is applied to a flexible patch electrode of 100-500 kHz medium-frequency alternating electric field body surface capacitive coupling, can obviously improve the in-vivo electric field strength and depth coverage on the premise of not improving the output voltage of equipment, and simultaneously reduces power consumption and skin adverse reaction. In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: in a first aspect, the invention provides an application of a high-dielectric composite material in a patch electrode for tumor electric field therapy, wherein the high-dielectric composite material comprises a conductive three-dimensional framework layer, a high-dielectric inorganic shell layer and a flexible interface layer, the high-dielectric inorganic shell layer is coated on the surface of the conductive three-dimensional framework layer, and the flexible interface layer is filled in the conductive three-dimensional framework layer and the high-dielectric inorganic shell layer. Tumors treated in the tumor electric field therapy of the present invention include, but are not limited to: (1) Central nervous system, glioblastoma multiforme (GBM), anaplastic astrocytomas, oligodendrogliomas, brain metastases (primary metastases to the brain, including lung/breast, etc.); (2) Chest, malignant pleural mesothelioma, lung cancer; (3) Digestive system including pancreatic cancer, liver cancer, biliary tract cancer, gastric cancer, esophageal cancer, and colorectal cancer; (4) Urinary and reproductive, kidney cell carcinoma, bladder carcinoma, prostate carcinoma, ovarian carcinoma, endometrial carcinoma, cervical carcinoma; (5) Breast and endocrine, breast cancer, thyroid cancer; (6) Head and neck skin soft tissue, head and neck squamous carcinoma, soft tissue sarcoma, melanoma; (7) Bone and metastasis, bone tumor, bone metastasis; (8) Paediatric solid tumor, medulloblastoma, neuroblastoma and rhabdomyosarcoma. Such tumors include both tumors in humans and various solid tumors in pets. Preferably, the material of the conductive three-dimensional skeleton layer may be selected from Ni, ni-Cr alloy, ni-Co alloy, cu-Ni alloy, ti, ta, mo, W, stainless steel (Fe-Cr-Ni system), ni-Mo, ni-W and their mixed base foam or metal fiber material, or metal fabric, woven mesh, knitted mesh or fiber felt selected from nickel-titanium alloy, titanium-molybdenum alloy, tantalum-niobium alloy. Because the melting point of the materials is very high, the framework can be kept stable during sintering. Preferably, the conductive three-dimensional skeleton layer is a three-dimensional conductive skeleton communicated with the open pores, the open pore ratio is 70-99%, the average pore diameter is 30-1500 mu m, and the thickn