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CN-122006101-A - Device and method for deep scalp electrical delivery

CN122006101ACN 122006101 ACN122006101 ACN 122006101ACN-122006101-A

Abstract

The invention relates to the technical field of transdermal drug delivery, in particular to a device and a method for scalp deep electric delivery. The device comprises an electric signal generator for generating pulse voltage, a main control module electrically connected with the electric signal generator, and a comb-shaped shell, wherein the electric signal generator and the main control module are integrated in the comb-shaped shell. The device further comprises a plurality of first electrodes, a plurality of second electrodes and a medicine supply module, wherein the first electrodes and the second electrodes are electrically connected with the electric signal generator and used for forming a directional electric field, the first electrodes and the second electrodes are arranged on the comb-shaped shell according to a preset arrangement rule, and the length of the first electrodes is longer than that of the second electrodes. The comb-shaped shell comprises a comb handle and a comb body connected to one end of the comb handle. Wherein the main control module is configured to control the electric signal generator to generate corresponding pulse voltages when receiving the trigger signal so as to apply a directional electric field to the target area through the first electrode and the second electrode to deliver the medicine to the deep hair follicle of the head.

Inventors

  • CHANG LINGQIAN
  • LIU FENG
  • DONG ZAIZAI
  • YAO FUQI
  • Tong Yihang

Assignees

  • 北京航空航天大学

Dates

Publication Date
20260512
Application Date
20260323

Claims (10)

  1. 1. A device for deep electrical delivery of the scalp, characterized by comprising an electrical signal generator for generating a pulsed voltage, a main control module electrically connected to the electrical signal generator, and a comb-shaped housing (1), the electrical signal generator and the main control module being integrated within the comb-shaped housing (1); The device further comprises a plurality of first electrodes (3) and a plurality of second electrodes (4) which are electrically connected with the electric signal generator and used for forming a directional electric field, and a medicine supply module, wherein the plurality of first electrodes (3) and the plurality of second electrodes (4) are arranged on the comb-shaped shell (1) according to a preset arrangement rule, the length L1 of the first electrodes (3) is larger than the length L2 of the second electrodes (4), the comb-shaped shell (1) comprises a comb handle (2) and a comb body (5) connected to one end of the comb handle (2), The main control module is configured to control the electric signal generator to generate corresponding pulse voltages when receiving a trigger signal so as to apply a directional electric field to a target area through the first electrode (3) and the second electrode (4) to deliver medicines to the deep hair follicles of the head.
  2. 2. The device for deep electrical delivery of scalp according to claim 1, wherein the preset arrangement rules comprise a two-dimensional planar layout rule and a three-dimensional stereoscopic layout rule, wherein, The two-dimensional plane layout rule comprises that a plurality of first electrodes (3) and a plurality of second electrodes (4) are alternately arranged along the length direction of the comb body (5) to be used as a row of comb teeth connected with the comb body (5); The three-dimensional layout rule comprises: The first electrodes (3) and the second electrodes (4) are respectively positioned on at least two planes which are parallel to each other and serve as at least two rows of comb teeth connected with the comb body (5); or at least two rows of comb teeth connected with the comb body (5), wherein a plurality of first electrodes (3) and a plurality of second electrodes (4) in each row of comb teeth are alternately arranged along the length direction of the comb body (5); Or a plurality of first electrodes (3) and a plurality of second electrodes (4) are respectively arranged on a plurality of mounting surfaces which are arranged around the circumference of the comb body at intervals, so that the plurality of first electrodes (3) and the plurality of second electrodes (4) are respectively arranged on two adjacent mounting surfaces as a plurality of rows of comb teeth which are arranged around the circumference of the comb body (5) at intervals; Or a plurality of the first electrodes (3) and a plurality of the second electrodes (4) are respectively arranged on a plurality of mounting surfaces which are arranged around the comb body (5) at intervals, so that the plurality of the first electrodes (3) and the plurality of the second electrodes (4) are used as a plurality of rows of comb teeth which are arranged around the comb body (5) at intervals in the circumferential direction, and the plurality of the first electrodes (3) and the plurality of the second electrodes (4) are alternately arranged on each mounting surface.
  3. 3. A device for deep electrical delivery of the scalp according to claim 2, characterized in that the second electrode (4) comprises a second conductive element (404) extending in the axial direction of the comb teeth, and in that the drug delivery module comprises, correspondingly, a drug reservoir (402) built into the second electrode (4); The second conductive element (404) is arranged in the medicine storage cabin (402) and can reciprocate along the axial direction of the medicine storage cabin (402), the tail end of the second conductive element (404) is provided with a conductive blocking piece (403), and the tail end of the second conductive element (404) is provided with an elastic resetting piece (401); When no external acting force exists, under the action of the elastic reset piece (401), the blocking piece (403) at the tail end of the second conductive element (404) blocks the outlet of the medicine storage cabin (402); when the end of the first electrode (3) and the blocking piece (403) of the second electrode (4) act on the head, the blocking piece (403) is separated from the outlet of the medicine storage cabin (402) under the action of extrusion of the head, so that medicine liquid can flow out from the outlet and permeate under the action of a directional electric field formed between the first electrode (3) and the second electrode (4).
  4. 4. A device for deep electrical delivery of the scalp according to claim 1 characterized in that the medicated module comprises a drug coating applied on the contact surface of the end of the second electrode (4) with the skin.
  5. 5. A device for deep electrical delivery of the scalp according to any one of claims 1 to 4, characterized in that the difference between the length L1 of the first electrode (3) and the length L2 of the second electrode (4) is greater than 0mm and less than 2mm.
  6. 6. A device for deep electrical delivery of the scalp according to claim 5 characterized in that the spacing L3 between the first electrode (3) and the second electrode (4) is greater than 0mm and less than 14mm.
  7. 7. A device for deep electric delivery of scalp according to claim 3, characterized in that a first limiting member (405) is fixedly arranged in the medicine storage cabin (402), a second limiting member (406) is detachably arranged at the outlet of the medicine storage cabin (402), two ends of the elastic reset member (401) respectively lean against the first limiting member (405) and the second limiting member (406), and the second conductive element (404) penetrates through the first limiting member (405) and can reciprocate relative to the first limiting member (405) along the axial direction of the medicine storage cabin (402); Wherein, the second limiting piece (406) is provided with a through hole matched with the plugging piece (403).
  8. 8. The device for deep electrical delivery of the scalp according to claim 7 wherein the second limiter (406) is funnel-shaped.
  9. 9. A method for scalp deep electrical delivery, characterized in that it is implemented based on a device for scalp deep electrical delivery according to any one of claims 1 to 8, comprising the steps of: s1, configuring equipment parameters, wherein the equipment parameters comprise pulse voltage values; and S2, when a trigger signal is received, controlling an electric signal generator in the device to generate and send corresponding pulse voltages to a first electrode (3) and a second electrode (4) in the device according to the preset pulse voltage value, and forming a directional electric field on the head through the first electrode (3) and the second electrode (4) so as to open a channel and simultaneously convey medicine to the deep part of a hair follicle of the head.
  10. 10. A method for scalp deep electrical delivery, characterized in that it is implemented based on a device for scalp deep electrical delivery according to any one of claims 1 to 8, comprising the following steps: s1, configuring equipment parameters, wherein the equipment parameters comprise a working mode, and the working mode comprises an electric stimulation mode, a medicine electric delivery mode and a mixed mode; S2, when a trigger signal is received, the current working mode is identified, and the step S3 is executed if the trigger signal is in an electric stimulation mode, the step S4 is executed if the trigger signal is in a medicine electric delivery mode, and the step S5 is executed if the trigger signal is in a mixed mode; S3, controlling an electric signal generator in the device to generate and send corresponding pulse voltages to a first electrode (3) and a second electrode (4) in the device according to a first preset pulse voltage value, and forming a directional electric field on the head through the first electrode (3) and the second electrode (4) so as to perform electric stimulation; s4, controlling an electric signal generator in the device to generate and send corresponding pulse voltages to a first electrode (3) and a second electrode (4) in the device according to a second preset pulse voltage value, and forming a directional electric field on the head through the first electrode (3) and the second electrode (4) so as to convey medicine to the deep hair follicle of the head while opening a channel; s5, according to a preset interval time T, an electric stimulation mode and a medicine electric delivery mode are started in sequence, so that the channel is opened firstly through the electric stimulation mode, and then the medicine is delivered efficiently through the opened channel through the medicine electric delivery mode.

Description

Device and method for deep scalp electrical delivery Technical Field The invention relates to the technical field of transdermal drug delivery, in particular to a device and a method for scalp deep electric delivery. Background Androgenic alopecia (Androgenetic Alopecia, AGA) is a common chronic progressive hair loss disorder, the pathological mechanism of which is mainly related to genetic susceptibility and toxic effects of androgens (particularly dihydrotestosterone) on hair follicles, leading to progressive miniaturization of hair follicles, shortening of anagen phase, and finally, thinning and even baldness of hair. Effective AGA treatment relies on the precise delivery of active agents or biological factors to the deep hair follicle, particularly the key targets of papilla cells, to inhibit the androgen signaling pathway, reverse hair follicle atrophy and promote hair growth. Therefore, whether the drug can efficiently penetrate the scalp barrier and concentrate in the deep tissue of hair follicle is a central factor determining success or failure of treatment. The currently mainstream AGA treatment means in clinic mainly comprise oral medicines and topical preparations. Oral 5 alpha-reductase inhibitors (e.g., finasteride) can exert therapeutic effects by systematically reducing the in vivo dihydrotestosterone levels, but due to their lack of local targeting, systemic adverse reactions such as hyposexuality, erectile dysfunction, etc. are often associated, some patients reject long-term administration due to worry side effects, and rebound of therapeutic effects is likely to occur after withdrawal. In contrast, topical vasodilators (such as minoxidil) are widely used for their convenience and safety, but rely on passive diffusion mechanisms, which are limited by the natural barrier effect of the scalp stratum corneum and physical obstruction of drug distribution by dense hair, resulting in difficulty in effective penetration of the drug into the deep hair follicle. The medicine liquid is remained on the surface of the skin or is adhered to the hair shaft, so that the bioavailability is low, the individual difference of the curative effect is large, the effect is slow, and the stable and efficient treatment requirement is difficult to meet. To overcome the above limitations, a variety of new transdermal delivery technologies have emerged in recent years, typified by microneedle-type devices. The micro-needle can remarkably improve the drug permeation efficiency by forming a micron-sized channel in the stratum corneum, and has good hair follicle targeting potential under laboratory conditions. However, the technology is a minimally invasive or invasive method essentially, and obvious short plates exist in practical application, namely, on one hand, repeated puncture can cause pain, red swelling, bleeding and even secondary infection, patient tolerance is poor, and on the other hand, in a hair coverage area, a microneedle patch is difficult to closely adhere to scalp, and medicine leakage or uneven distribution is caused due to insufficient tightness, so that delivery efficiency is seriously affected. More importantly, AGA is a chronic disease requiring long-term management, and a treatment scheme is required to have high daily operability and comfort, while the existing microneedle devices are generally complicated in operation and strong in discomfort, and are difficult to support daily, large-area and long-term home use. Based on this, there have been studies on attempts to apply physical permeation-promoting techniques (such as iontophoresis and magnetotherapy) to topical administration. For example, the invention patent with application publication number CN116764090A discloses a physiotherapy method and system for introducing medicine ions into an absorption head film, comprising the following steps of coating an absorption head film on scalp, ionizing medicine by a medicine ionization module, introducing medicine ions into the head film, and promoting medicine absorption in scalp by electric ion introduction. Although the method uses ionization treatment to administer medicine, then a separate scalp film, namely a medicine carrier, is required to be covered on the scalp, and the hair is required to be removed in advance to eliminate the physical interference of the scalp, so that the user product has larger psychological resistance, namely the user experience is reduced, and the coordination degree is low. For another example, the invention patent with publication number CN1178103A provides a multifunctional massage comb, which integrates magnetic therapy, pulse electrotherapy, medical therapy, far infrared physiotherapy and vibration massage. The comb is internally provided with a battery and an electronic circuit to generate electric pulse, is provided with a medicine bag and a duct which can magnetize medicines, adopts a volatile structure similar to a medicine pillow to release medicines at t