CN-122006103-A - Nerve stimulator for diaphragm regulation and control assisted respiration

CN122006103ACN 122006103 ACN122006103 ACN 122006103ACN-122006103-A

Abstract

The invention discloses a nerve stimulator for diaphragm regulation and control assisted respiration, and particularly relates to the technical field of integrated circuits, which comprises an FPGA (field programmable gate array), a low-voltage part, a high-voltage part, a first electrode, a second electrode, a reference voltage source module and biological nerves; the low-voltage part comprises a time sequence control module, a current generation module, a low-voltage power supply voltage and ground. Compared with the traditional scheme of breathing by passively sucking gas and exhausting gas, the invention can lead the organism to breathe through the muscles of the organism, has smaller integrated structure volume and convenient carrying, can lead the organism to breathe controllably, can combine breathing and sucking with different lengths according to the requirements, can avoid irreversible damage of intubation operation to the organism caused by the traditional breathing machine, and has better use effect.

Inventors

TIAN XUE
LIU XU
ZHOU JIAN
LU ZEYU
WU ZIYUE
ZHONG MINGHAO
DING WEISI

Assignees

北京大学人民医院
北京工业大学

Dates

Publication Date: 20260512
Application Date: 20251212

Claims (8)

1. A nerve stimulator for diaphragm regulation and control assisted respiration, which is characterized by comprising an FPGA (100), a low-voltage part (116), a high-voltage part (117), an electrode I (105), an electrode II (106) and a reference voltage source module (104); The low-voltage part (116) comprises a time sequence control module (101) and a current generation module (102), wherein the time sequence control module (101) and the current generation module (102) are connected with a low-voltage power supply voltage (112) and a ground (115), and the FPGA (100) is connected with the time sequence control module (101) and the current generation module (102); The high-voltage part (117) comprises a high-voltage output module (103) and a high-voltage power supply voltage (113), the high-voltage output module (103) is connected with the biological nerve (107) through an electrode I (105), the high-voltage output module (103) provides current input to the biological nerve (107) through the electrode I (105), the reference voltage power supply module (104) is connected with the biological nerve (107) through an electrode II (106), and the reference voltage power supply module (104) provides reference voltage (114) to the biological nerve (107) through an electrode II (106); The timing control module (101) provides a control signal for the high-voltage output module (103), the current generation module (102) provides a controllable current for the high-voltage output module (103), the electrode one (105) and the electrode two (106) provide a stimulating current for the biological nerve (107), and a conductive path (108) is formed by connection between the electrode one (105) and the electrode two (106) and the biological nerve (107).
2. A neurostimulator for diaphragm regulated assisted respiration according to claim 1, characterized in that the high voltage output module (103) is connected with the current generation module (102) and the time sequence control module (101) respectively, the high voltage output module (103) is connected with the electrode one (105) and the ground (115) respectively, and the reference voltage source module (104) is connected with the electrode two (106), the reference voltage (114) and the ground (115) respectively.
3. A neurostimulator for diaphragm regulated assisted respiration according to claim 2, characterized in that the first (105) and second (106) electrodes consist of an electrode portion (110) and a bare electrode portion (111) which are wrapped with an insulating material; For the biological nerve (107) part connected with the exposed electrode part (111) of the electrode I (105), the voltage state of the high-voltage power supply voltage (113) or the ground (115) is represented; For the portion of the biological nerve (107) connected to the exposed electrode portion (111) of electrode two (106), the voltage state of the reference voltage (114) is represented.
4. A neural stimulator for diaphragm regulated assisted respiration according to claim 3, characterized in that the portion of the biological nerve (107) connected to electrode one (105) and electrode two (106) has two opposite voltage states such that two opposite currents, called cathodal stimulation and anodal stimulation, respectively, are present on the conductive path (108) on the biological nerve (107).
5. A neurostimulator for diaphragm regulated assisted respiration according to claim 4, characterized in that the electrode portion (110) surrounded by insulating material prevents the electrodes one (105) and two (106) from delivering a stimulating current to the unrelated biological tissue when stimulated, and the exposed electrode portion (111) enables the electrodes one (105) and two (106) to stimulate the corresponding biological nerve (107) in a targeted manner when stimulated.
6. The neural stimulator for diaphragm regulated assisted respiration according to claim 4, wherein the FPGA (100) is configured to input a control signal, wherein the current generating module (102) receives the control signal generated by the FPGA (100) to generate the adjustable cathode and anode stimulation current to the high voltage output module (103), and the timing control module (101) receives the control signal generated by the FPGA (100) to control the on and off of the high voltage output module (103) to control when the cathode and anode stimulation is generated.
7. A neural stimulator for diaphragm regulated assisted respiration according to claim 6, characterized in that the exposed electrode portion (111) and the exposed electrode portion (111) form a "U" or "fishhook" structure.
8. A neurostimulator for diaphragm regulated assisted respiration according to claim 1, characterized in that said biological nerve (107) is used for dominating the breathing behaviour of an organism, by precisely regulating the contraction and relaxation of the organism's pulmonary muscles, to inhale and exhale the gas, effecting a gas exchange; Providing cathodic and anodic current stimulation to the biological nerve (107) between the high voltage output module (103) and the reference voltage source module (104) through two opposite voltage drops on a conductive path (108) on the biological nerve (107), namely, causing action potential of the biological nerve (107) to cause contraction of pulmonary muscles, allowing the lungs of an organism to inhale air, and keeping the voltage state on the biological nerve (107) unchanged through an opposite current; During the remaining time of a stimulation phase, the high voltage output module (103) stops outputting current, no current exists in the conductive path (108) on the biological nerve (107), the biological nerve (107) does not reach action potential, the lung muscles of the organism relax, and the lung discharges gas.

Description

Nerve stimulator for diaphragm regulation and control assisted respiration Technical Field The invention relates to the technical field of integrated circuits, in particular to a neural stimulator for diaphragm regulation and control assisted respiration. Background In recent decades, ventilators have become a widely used medical device that helps patients to exchange air. However, the existing traditional breathing machine has the defects of overlarge volume, portability, possibly need intubation operation, easy irreversible damage to organisms, and passive breathing of patients, and not breathing through the original lung muscles of the patients, and the like, so that a convenient and fast technical scheme for enabling the organisms to breathe controllably and spontaneously is needed to be designed for the traditional breathing scheme, and the technical scheme for sucking gas and exhausting gas is not carried out passively. Disclosure of Invention The invention aims to provide a neural stimulator for diaphragm regulation and control assisted respiration, which enables a living body to generate expected spontaneous respiratory behaviors after receiving a set stimulation waveform so as to solve the defects in the technology. In order to achieve the aim, the invention provides the following technical scheme that the neural stimulator for diaphragm regulation and control assisted respiration comprises an FPGA, a low-voltage part, a high-voltage part, a first electrode, a second electrode and a reference voltage source module; the low-voltage part comprises a time sequence control module and a current generation module, wherein the time sequence control module and the current generation module are both connected with the voltage of the low-voltage power supply and the ground; The high-voltage part comprises a high-voltage output module and a high-voltage power supply voltage, the high-voltage output module is connected with the biological nerve through an electrode I, the high-voltage output module provides current input for the biological nerve through the electrode I, the reference voltage power supply module is connected with the biological nerve through an electrode II, and the reference voltage power supply module provides reference voltage for the biological nerve through the electrode II; The time sequence control module provides control signals for the high-voltage output module, the current generation module provides controllable current for the high-voltage output module, the first electrode and the second electrode provide stimulation current for biological nerves, and a conductive path is formed by connection between the first electrode and the second electrode and the biological nerves. Preferably, the high-voltage output module is respectively connected with the current generation module and the time sequence control module, the high-voltage output module is respectively connected with the electrode I and the ground, and the reference voltage source module is respectively connected with the electrode II, the reference voltage and the ground. Preferably, the first electrode and the second electrode are formed by an electrode part wrapped by an insulating material and a bare electrode part; for the biological nerve part connected with the exposed electrode part of the electrode I, the high-voltage power supply voltage or the voltage state of the ground is represented; for the biological nerve part connected with the exposed electrode part of the electrode II, the voltage state of the reference voltage is shown. Preferably, the portions of the biological nerve connected to the first electrode and the second electrode have two opposite voltage conditions such that two opposite currents, called cathodal and anodal stimulation, respectively, are present in the conductive paths on the biological nerve. Preferably, the electrode part wrapped by the insulating material prevents the electrode one and the electrode two from transmitting the stimulating current to irrelevant biological tissues when stimulating, and the exposed electrode part enables the electrode one and the electrode two to stimulate corresponding biological nerves in a targeted way when stimulating. Preferably, the FPGA is configured to input a control signal, wherein the current generating module receives the control signal generated by the FPGA to generate the adjustable cathode and anode stimulation currents to the high voltage output module, and the timing control module receives the control signal generated by the FPGA to control on and off of the high voltage output module, so as to control when the cathode and anode stimulation is generated. Preferably, the exposed electrode portion and the exposed electrode portion form a "U" or "fishhook" type structure. Preferably, the biological nerve is used for leading the respiratory behavior of an organism, and the contraction and the relaxation of the lung muscles of the organism are accura