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CN-122006113-A - Apparatus for applying electric field to subject and temperature control method thereof

CN122006113ACN 122006113 ACN122006113 ACN 122006113ACN-122006113-A

Abstract

An apparatus for applying an electric field to a subject and a temperature control method thereof are provided. The device comprises at least two pairs of electrode arrays, at least two pairs of temperature sensor arrays for acquiring temperature information corresponding to temperature signals at corresponding body parts of a subject, an alternating current signal generator for generating at least two paths of alternating current signals, at least two pairs of output terminals for outputting the alternating current signals to the electrode arrays and a signal controller. The signal controller is configured to acquire temperature information of a respective body part of the subject, and control the corresponding output terminal to stop outputting the respective one-way alternating current signal when the temperature information is greater than a temperature threshold, or control the corresponding output terminal to output the respective one-way alternating current signal when the temperature information is not greater than the temperature threshold.

Inventors

  • CHEN CHENG
  • YING JIANJUN
  • YU JING
  • ZHANG JUN

Assignees

  • 江苏海莱新创医疗科技有限公司

Dates

Publication Date
20260512
Application Date
20211224

Claims (16)

  1. 1. An apparatus for applying an electric field to a subject, comprising: At least two pairs of electrode arrays configured to be in contact with respective body parts of a subject; at least two pairs of temperature sensor arrays configured to acquire temperature information corresponding to temperature signals at respective body parts of a subject; An alternating current signal generator configured to generate at least two alternating current signals to be output to respective at least two pairs of electrode arrays to establish at least two-directional electric fields for application to respective body parts of a subject; At least two pairs of output terminals configured to be electrically connected to the AC signal generator, each pair of output terminals being further configured to output an AC signal from the AC signal generator to a pair of the electrode arrays electrically connected thereto, respectively, and A signal controller configured to acquire temperature information of each of the respective body parts of the subject, and further configured to (1) control a corresponding pair of the output terminals to stop outputting one of the alternating current signals establishing an electric field applied to the body part when the acquired temperature information of the respective body parts of the subject is greater than a temperature threshold; (2) when the acquired temperature information at the corresponding body part of the subject is not greater than the temperature threshold value, controlling the corresponding pair of output terminals to output one path of the alternating current signal for establishing the electric field applied to the body part.
  2. 2. The apparatus of claim 1, further comprising at least two pairs of switches, each of the switches being disposed between the ac signal generator and a corresponding one of the output terminals, wherein the signal controller is configured to output one of the ac electrical signals establishing an electric field applied to a corresponding body part to a pair of the output terminals electrically connected to the pair of the switches by controlling opening or closing of the corresponding pair of the switches.
  3. 3. The apparatus of claim 1, wherein the ac signal generator comprises: a DC signal source configured to generate a DC signal, and And a power converter configured to convert the direct current signal into the at least two paths of alternating current signals.
  4. 4. The apparatus of claim 3, wherein the ac signal generator further comprises: a DC signal switch electrically connected between the DC signal source and the power converter, Wherein the signal controller is configured to control the supply of the direct current signal from the direct current signal source to the power converter by controlling the direct current signal switch.
  5. 5. The apparatus of claim 3, wherein the AC signal generation further comprises a DC signal switch electrically connected between the DC signal source and the power converter, wherein the signal controller is configured to stop or continue outputting one of the AC signals establishing an electric field applied to a corresponding body part of the subject by controlling the DC signal switch to control whether the AC signal generator generates the at least two AC signals.
  6. 6. The apparatus of any one of claims 1 to 5, wherein the temperature threshold range is 37 ℃ to 41 ℃.
  7. 7. The apparatus of any one of claims 1 to 5, wherein the temperature sensor array and the electrode array are combined with each other and configured to sense temperature signals at respective body parts of a subject to provide respective said temperature information.
  8. 8. The apparatus of any one of claims 1 to 5, wherein the temperature information includes first temperature information indicating a temperature at a body part to which an electric field of one of the at least two directions is applied and second temperature information indicating a temperature at a body part to which an electric field of the other of the at least two directions is applied.
  9. 9. The apparatus of claim 8, wherein the signal controller is configured to: Acquiring the first temperature information; Comparing the first temperature information with the temperature threshold value, and When the first temperature information is larger than the temperature threshold value, controlling a corresponding pair of the output terminals to stop outputting one path of the alternating current signal for establishing a directional electric field applied to the body part, or And when the first temperature information is not greater than the temperature threshold value, controlling a corresponding pair of output terminals to output one path of alternating current signals for establishing a directional electric field applied to the body part.
  10. 10. The apparatus of claim 8, wherein the signal controller is further configured to: acquiring the second temperature information; Comparing the second temperature information with the temperature threshold value, and When the second temperature information is larger than the temperature threshold value, controlling a corresponding pair of the output terminals to stop outputting one of the alternating current signals for establishing the electric field in the other direction applied to the body part, or And when the second temperature information is not greater than the temperature threshold value, controlling a corresponding pair of output terminals to output one path of alternating current signals for establishing the electric field in the other direction applied to the body part.
  11. 11. A temperature control method for the apparatus according to any one of claims 1 to 10, the temperature control method of the apparatus comprising: Acquiring temperature information of a corresponding body part of the subject; comparing the temperature information with a temperature threshold, and When the acquired temperature information is larger than the temperature threshold value, controlling a corresponding pair of output terminals to stop outputting one path of alternating current signal for establishing the electric field applied to the body part, or And when the acquired temperature information is not more than the temperature threshold value, controlling a corresponding pair of output terminals to output one path of alternating current signal for establishing an electric field applied to the body part.
  12. 12. The method of temperature control of the device according to claim 11, wherein the temperature information is first temperature information indicating a temperature at a body part to which an electric field of one of the at least two directions is applied or second temperature information indicating a temperature at a body part to which an electric field of the other of the at least two directions is applied.
  13. 13. A temperature control method for the apparatus according to any one of claims 1 to 10, the temperature control method of the apparatus comprising: acquiring first temperature information indicating a temperature at a body part to which a first electric field of the at least two-direction electric fields is applied and second temperature information indicating a temperature at a body part to which a second electric field of the at least two-direction electric fields is applied; Comparing the first temperature information with a temperature threshold value, and controlling to stop outputting one of the at least two paths of alternating current signals for establishing the first electric field when the first temperature information is larger than the temperature threshold value or controlling to output one path of alternating current signal for establishing the first electric field when the first temperature information is not larger than the temperature threshold value, and And comparing the second temperature information with the temperature threshold value, and controlling to stop outputting one path of alternating current signals establishing the second electric field in the at least two paths of alternating current signals when the second temperature information is larger than the temperature threshold value, or controlling to output one path of second alternating current signals establishing the second electric field when the second temperature information is not larger than the temperature threshold value.
  14. 14. A method of controlling the temperature of a device according to claim 11 or 13, wherein the temperature threshold is in the range 37 ℃ to 41 ℃.
  15. 15. A computer readable storage medium having stored thereon instructions which, when executed by a signal controller of an apparatus according to any of claims 1-10, cause the apparatus to perform the temperature control method according to any of claims 10-14.
  16. 16. A computer program product comprising instructions which, when executed by a signal controller of an apparatus according to any one of claims 1 to 10, cause the apparatus to perform the temperature control method according to any one of claims 10 to 14.

Description

Apparatus for applying electric field to subject and temperature control method thereof The present application is a divisional application of patent application of the application having application date 2021, 12/24/month, application number 202111596993X, and the name of "electric field generator for applying an electric field to a subject, apparatus and temperature control method thereof". Technical Field The present disclosure relates to Tumor electric field therapy (Tumor TREATING FIELDS, TTF) technology, and in particular to an apparatus for applying an electric field to a subject and a temperature control method thereof. Background Tumor electric field therapy (Tumor TREATING FIELDS, TTF) is to prevent the formation of spindle microtubules and inhibit the separation of intracellular organelles in the cell division stage in the mitosis process of some Tumor cells by using a low-intensity medium-frequency (e.g. 100-300 kHz) alternating electric field, and induce apoptosis in the mitosis stage, so that the effect of treating tumors is realized. TTF has an innovative mechanism of action compared to traditional cancer therapies. Some physiological properties of tumor cells, such as geometry and high frequency mitosis, make them susceptible to TTF. TTF disrupts the normal aggregation of tubulin by exerting directed forces on intracellular polar particles (e.g., macromolecules and organelles). These processes may lead to physical disruption of the cell membrane and apoptosis. At the end of cell mitosis, the structural morphology of the cleavage groove can lead to uneven distribution of electric fields around the cleavage groove, meanwhile, under the influence of TTF, the electric field intensity at the cleavage groove is obviously enhanced, and charged substances in cells move to the cleavage groove, so that the formation of cell structures is disturbed or even destroyed, and finally, the cell division failure can be caused, and the cell death is realized. In the related art, TTF applies an alternating electric field to a site on the skin of a subject adjacent to a tumor via an electric field generator. The heat of the application surface of the subject rises due to the application of the alternating electric field. In order to avoid skin burn at low temperature, it is necessary to design a device and a temperature control method capable of rapidly controlling the output of the corresponding alternating electric field based on the detected temperature of the application surface of the subject. Disclosure of Invention It would be advantageous to provide a mechanism that alleviates, mitigates or even eliminates one or more of the above problems. According to one aspect of the present disclosure, there is provided an apparatus for applying an electric field to a subject, comprising at least two pairs of electrode arrays configured to be in contact with respective body parts of the subject, at least two pairs of temperature sensor arrays configured to acquire temperature information corresponding to temperature signals at respective body parts of the subject, an alternating current signal generator configured to generate at least two alternating current signals to be output to the respective at least two pairs of electrode arrays to establish an electric field in at least two directions for application to the respective body parts of the subject, at least two pairs of output terminals configured to be electrically connected with the alternating current signal generator, and each pair of output terminals further configured to output an alternating current signal from the alternating current signal generator to a pair of the electrode arrays electrically connected therewith, respectively, and a signal controller configured to acquire temperature information of each body part of the subject, and further configured to (1) control a corresponding pair of output terminals to stop outputting the alternating current signal to the body part when the acquired temperature information at the respective body part of the subject is greater than a temperature threshold, and (2) output a corresponding to the body part of the subject to which the output signal is not established when the acquired temperature information at the respective body part of the subject is greater than the temperature threshold. Optionally, the electric field generator further comprises at least two pairs of switches, each switch is arranged between the alternating current signal generator and a corresponding one of the output terminals, wherein the signal controller is configured to stop or continue outputting one path of the alternating current electric signal which establishes the electric field applied to the corresponding body part to the pair of the output terminals electrically connected with the pair of the switches by controlling the opening or closing of the corresponding pair of the switches. Optionally, the alternating current signal genera