CN-122006115-A - Wireless battery-free electric stimulation system and application thereof

Abstract

The invention discloses a wireless battery-free electric stimulation system and application thereof, the system includes an external transmitting end and a wireless batteryless stimulator. The wireless battery-free stimulator sequentially comprises a receiving coil, a voltage doubling rectifying unit, a voltage stabilizing unit, an oscillating unit, an output protecting unit and a stimulating electrode along a signal link, wherein the receiving coil receives a high-frequency alternating current signal through electromagnetic induction coupling, the receiving coil is rectified into a high-voltage direct current signal through voltage doubling and then is stabilized into a direct current bias voltage, the oscillating unit generates a low-frequency stimulating signal based on the high-voltage direct current signal, and finally the low-frequency stimulating signal is output to a target tissue through the stimulating electrode after being processed by the output protecting unit. The system solves the technical problems that the near-field inductive coupling wireless battery-free electric stimulation system in the prior art is low in stimulation voltage, short in wireless working distance, high in position sensitivity, mismatched in energy supply frequency and treatment frequency, non-adjustable in stimulation parameters and poor in system universality.

Inventors

• Ye Zhilu
• ZHANG XIAOHUI
• WANG YIJING
• Yang Minye

Assignees

• 西安交通大学

Dates

Publication Date

20260512

Application Date

20260403

Claims (10)

1. 1. A wireless batteryless electrical stimulation system, comprising an external transmitting end and a wireless batteryless stimulator; The external transmitting end comprises a signal source, a power amplifier and a transmitting coil which are electrically connected in sequence; The wireless battery-free stimulator sequentially comprises a receiving coil, a voltage doubling rectifying unit, a voltage stabilizing unit, an oscillating unit, an output protection unit and a stimulating electrode along a signal link; the output end of the signal source is connected with the input end of the power amplifier, the output end of the power amplifier is connected with the transmitting coil, and the transmitting coil is used for generating an alternating electromagnetic field; the receiving coil and the transmitting coil are coupled through electromagnetic induction and are used for receiving an alternating electromagnetic field and inducing a high-frequency alternating current signal; the voltage doubling rectifying unit converts the high-frequency alternating current signal into a high-voltage direct current signal; the voltage stabilizing unit converts the high-voltage direct-current signal into direct-current bias voltage; the oscillation unit generates a low-frequency stimulation signal based on the direct-current bias voltage; and the output protection unit carries out safety treatment on the low-frequency stimulation signals and then outputs the low-frequency stimulation signals to target tissues through the stimulation electrodes.
2. 2. The wireless batteryless electrical stimulation system of claim 1, wherein the receiving coil is in a planar spiral configuration with an inner diameter of 20 mm, a number of turns of 8 turns, a line width and a line spacing of 0.13 mm, and an inductance of about 2.9 microhenries at the operating frequency.
3. 3. The wireless batteryless electrical stimulation system according to claim 1, wherein the voltage doubler rectifier unit is formed by a plurality of diodes and a plurality of capacitors connected in a cascade manner.
4. 4. The wireless batteryless electric stimulation system according to claim 1, wherein the voltage doubling rectifying unit is a four-stage voltage doubling rectifying circuit, and is formed by connecting four schottky diodes D1, D2, D3, D4 and four capacitors C1, C2, C3, C4 in a cascading manner.
5. 5. The wireless batteryless electrical stimulation system according to claim 1, wherein the voltage stabilizing unit comprises a low dropout linear voltage regulator U1, an input filter capacitor C5, an output filter capacitor C6, a resistor R1, a resistor R2, and a resistor R3, wherein the low dropout linear voltage regulator U1 has an input pin, a ground pin, an enable pin, an adjustment pin, and an output pin; The input pin is connected to the output end of the voltage doubling rectifying unit, the enabling pin is connected to the output end of the voltage doubling rectifying unit, the adjusting pin is grounded through a resistor R3, a resistor R2 is connected between the adjusting pin and the output pin, the output pin is connected to the input end of the subsequent oscillating unit, the input filter capacitor C5 is connected between the input pin and the ground after being connected with the resistor R1 in parallel, and the output filter capacitor C6 is connected between the output pin and the ground.
6. 6. The wireless batteryless electrical stimulation system according to claim 5, wherein the output voltage of the voltage stabilizing unit is: ; wherein R 2 is the resistance of the resistor R2, and R 3 is the resistance of the resistor R3.
7. 7. The wireless batteryless electrical stimulation system according to claim 1, wherein the oscillating unit comprises a 555 timer U2, a resistor R4, a resistor R5, a resistor R6, a capacitor C7, a capacitor C8, a capacitor C9, and a schottky diode D5, wherein the 555 timer U2 has a ground pin, a trigger pin, an output pin, a reset pin, a control pin, a threshold pin, a discharge pin, and a power pin; The trigger pin is connected with a threshold pin and grounded through a capacitor C7, the output pin is connected to the input end of the post-stage output protection unit, the reset pin is connected with the power pin and connected to the output end of the voltage stabilizing unit, the control pin is grounded through a capacitor C8, the discharge pin is connected with the power pin through a resistor R6, the resistor R4 is connected between the trigger pin and the discharge pin after being connected with a Schottky diode D5 in parallel, the resistor R5 is connected between the output pin and the power pin, and the capacitor C9 is connected between the power pin and the ground.
8. 8. The wireless batteryless electrical stimulation system according to claim 7, wherein the frequency and duty cycle of the oscillating unit output voltage are respectively: ; ; wherein R 4 is the resistance of the resistor R4, R 6 is the resistance of the resistor R6, and C 7 is the capacitance of the capacitor C7.
9. 9. The wireless batteryless electrical stimulation system according to claim 1, wherein the output protection unit comprises a protection resistor R7, a capacitor C10, a protection resistor R8 and a resistor R9, wherein the capacitor C10, the protection resistor R8 and the resistor R9 form a high-pass filter for filtering direct current components in the output signal; the protection resistor R7, the capacitor C10 and the protection resistor R8 are sequentially connected to form a serial branch, one end of the serial branch is connected to the output end of the oscillating unit, the other end of the serial branch is connected to the final output end of the wireless batteryless stimulator, the resistor R9 is connected between the final output end of the wireless batteryless stimulator and the ground, and the final output end and the ground are respectively provided with a stimulation electrode so as to output a stimulation signal to a target tissue.
10. 10. Use of a wireless batteryless electrical stimulation system according to any one of claims 1-9 in at least one of tissue wound repair, peripheral nerve injury treatment, and cardiac pacing.

Description

Wireless battery-free electric stimulation system and application thereof Technical Field The invention belongs to the technical field of electrical stimulation treatment equipment, and relates to a wireless battery-free electrical stimulation system and application thereof. Background Electrical stimulation treatment is a type of treatment technique that regulates and controls tissue electrical activity, promotes cellular response, and improves recovery of tissue function by applying electrical pulses to biological tissue, and belongs to an important direction of the cross development of biomedical and engineering techniques. In recent years, electrical stimulation has shown wide application prospects in various fields of pain management, functional rehabilitation, tissue regeneration, cardiac pacing, targeted drug delivery and the like. In particular to the aspect of tissue injury repair, the electrical stimulation can accelerate the recovery process of various tissue injuries such as epidermis wound surface, central and peripheral nerve injuries and the like by promoting cell proliferation, migration and nerve plasticity. Although electrical stimulation therapy has definite efficacy, its practical application is always faced with a fundamental problem of how to continuously and stably supply electrical energy to the target tissue and output a suitable stimulation signal. Existing clinical and experimental systems still rely to a large extent on external wired power supply means. This approach, while capable of providing effective electrical stimulation, can limit patient activity and use scenarios and increase the risk of infection in implantation scenarios. Although the battery device improves portability, the battery device generally has the problems of larger device size, heavier weight, frequent maintenance, unfavorable long-term wearing or implantation and the like, so that the further popularization and popularization of the electric stimulation treatment technology are obviously restricted. In order to address the above-described deficiencies of both wired power and battery systems, a variety of wireless, batteryless electrical stimulation techniques have been developed in recent years. These techniques mainly include wireless energy supply based on electromagnetic resonance, such as near-field inductive coupling and far-field antenna radiation, wireless energy supply based on electromechanical conversion, such as piezoelectric or triboelectric devices driven by ultrasound or human body motion, and wireless energy supply based on photoelectric conversion, such as achieving stimulus output using the photoinduced electrical response of an electroactive material. Although the technologies realize wireless and battery removal to a certain extent, the problems of low stimulation voltage, unstable output, single stimulation condition and the like are common. In various wireless battery-free schemes, the near-field inductive coupling mode realizes energy transmission by adopting magnetic field coupling between a transmitting coil and a receiving coil, has the advantages of relatively simple structure, small side effect on biological tissues, easy compatibility with flexible printed circuit board and integrated circuit technology, suitability for low-cost and large-scale manufacturing and the like, is widely considered as a route most potential for practical bioelectricity wireless treatment, and is applied to various treatment scenes such as spinal cord stimulation, cerebral cortex stimulation and the like. Therefore, the near-field inductive coupling radio stimulation system has important research and application values. However, there are several key bottlenecks in their prior art routes that remain to be resolved. The existing near-field inductive coupling radio stimulation system is faced with basic contradiction between miniaturization, energy transmission efficiency and transmission distance. For wearable and implant applications, the receiver must typically be of the order of centimeters or even smaller to reduce foreign body sensation, reduce implant burden, and accommodate limited anatomical space. However, after the size of the receiving coil is reduced, the inductance and coupling efficiency of the receiving coil are reduced synchronously, resulting in lower available induced voltage at the receiving end. Meanwhile, as the distance between the transmitting coil and the receiving coil increases, the coupling coefficient, the transmission efficiency and the receiving voltage are continuously reduced, so that the wireless working distance which can be realized by the conventional system is limited when the required output voltage is ensured. Second, existing near field inductive coupling systems are highly sensitive to the relative position between the transmitting and receiving ends. In practical use, it is difficult to maintain precise alignment of the transmit coil and the receive coil for a l