CN-122006135-A - Infrared light irradiation parameter optimization system for neuropathic pain after spinal cord injury

CN122006135ACN 122006135 ACN122006135 ACN 122006135ACN-122006135-A

Abstract

The invention relates to the technical field of infrared radiation therapy parameter control, in particular to an infrared radiation parameter optimization system for neuropathic pain after spinal cord injury. The system monitors stress events in real time based on the spasmodic initiation impact and the peripheral perfusion index. The patient's vagal-sympathetic response delay is quantified, and the most unstable moment of centrality rate dynamics over the time period of the event to be analyzed is analyzed, quantifying the response-destabilizing time difference. The event category is accurately identified based on the response-destabilizing time difference and the vago-sympathogenic response delay identification. And further feeding back an accurate control instruction to the event category. The invention converts two cause identification problems with unclear macroscopic physiological data characterization into definite problems with clear sequence on time sequence, and further combines the obtained time domain characteristics to accurately and effectively identify the stress event, thereby ensuring the control accuracy in the infrared light treatment process and reducing the risk of medical accidents.

Inventors

GAO FENG
Tan Guina
LI JIANJUN
YANG MINGLIANG
YANG DEGANG
LI JUN
WANG XIAOXIN
FENG RU
CHEN JING

Assignees

中国康复研究中心

Dates

Publication Date: 20260512
Application Date: 20260326

Claims (10)

1. An infrared light exposure parameter optimization system for neuropathic pain following spinal cord injury, the system comprising: the transient state characterization module is used for extracting the peripheral perfusion index, heart rate variability and spasm starting impact of the patient at each moment according to the heart rate signal of the patient and the motion signal of the trunk muscle in the infrared light irradiation treatment process; The physiological stress event detection module is used for detecting the initial impact of the cramp as a first priority, detecting the peripheral perfusion index as a second priority and detecting a stress event, and dividing unreliable events and events to be analyzed according to the heart rate variability and the distribution confusion of the peripheral perfusion index in a time period contained by the stress event; The multi-domain feature decoupling module is used for dividing a sympathetic response time period and a vagal response time period in an event to be analyzed and obtaining a vagal-sympathetic response delay, setting a sliding window in the time period of the event to be analyzed, counting a variability fluctuation index of heart rate in the sliding window, and counting the most unstable moment of heart rate dynamics in the event to be analyzed according to the variability fluctuation index, wherein the time interval from the starting moment of the sympathetic response time period to the most unstable moment of heart rate dynamics is used as a response-destabilization time difference, and identifying event types of the event to be analyzed according to the response-destabilization time difference and the vagal-sympathetic response delay, wherein the event types comprise muscle cramps, incorrect infrared parameters and unreliable events; and the infrared parameter control module is used for feeding back corresponding control commands according to event types of the stress events.
2. The infrared light irradiation parameter optimization system for neuropathic pain after spinal cord injury according to claim 1, wherein the motion signal is a triaxial acceleration signal, wherein for each moment, the L2 norm of triaxial acceleration is counted, and the first derivative of the L2 norm signal at each moment is used as the spasticity initiation impact.
3. The infrared light irradiation parameter optimization system for neuropathic pain after spinal cord injury according to claim 1, wherein the detection method of stress event comprises: For each moment, firstly comparing the initial cramp impact with a preset impact threshold, and directly taking the corresponding moment as a reference moment of a stress event if the initial cramp impact is larger than the preset impact threshold, otherwise, acquiring the peripheral perfusion index attenuation between the moment and the last moment, and taking the moment as the reference moment of the stress event if the peripheral perfusion index attenuation is larger than a preset difference threshold, otherwise, neglecting the moment; Dividing a time period corresponding to the stress event according to a preset size dividing rule by taking the reference moment of the stress event as the center.
4. The infrared light exposure parameter optimization system of claim 1, wherein the method for classifying unreliable events and events to be analyzed comprises: Dividing an initial time period in the time period of the stress event, counting the standard deviation of the peripheral perfusion index and the standard deviation of the heart rate variability in the initial time period, judging the stress event as an unreliable event if any one of the standard deviation of the peripheral perfusion index and the standard deviation of the heart rate variability is larger than a preset standard deviation threshold value of the corresponding dimension, and judging the emergency events except the unreliable event as events to be analyzed.
5. An infrared light exposure parameter optimization system for neuropathic pain following spinal cord injury as recited in claim 3, wherein said demarcating a sympathetic response time period and a vagal response time period in the event to be analyzed comprises: A first time of continuously presetting a first number of moments when the tip perfusion index is lower than a preset perfusion reference value after the reference moment of the stress event as a sympathetic response starting point, a moment when the tip perfusion index is restored to the preset perfusion reference value for the first time after the sympathetic response starting point as a sympathetic response ending point, and a time period between the sympathetic response starting point and the sympathetic response ending point as the sympathetic response time period; The method comprises the steps of continuously presetting a second number of time points with the heart rate variability lower than a preset heart rate variability reference value for the first time after the emergency event reference time as a vagus nerve response starting point, and enabling the heart rate variability to be restored to the preset perfusion reference value for the first time after the vagus nerve response starting point as a vagus nerve response ending point, wherein the time period between the vagus nerve response starting point and the vagus nerve response ending point is the sympathetic nerve response time period.
6. The infrared light irradiation parameter optimization system for neuropathic pain after spinal cord injury according to claim 1, wherein the variability fluctuation index acquisition method comprises the following steps: And constructing a heart rate interval sequence in a sliding window, obtaining a vertical standard deviation and a projection standard deviation along a diagonal line of the heart rate interval sequence by using a Poincare graph analysis algorithm, taking the vertical standard deviation as a numerator, taking the ratio obtained by taking the projection standard deviation as a denominator as a heart rate variability short-long ratio, and taking the heart rate variability short-long ratio as the variability fluctuation index.
7. The infrared light irradiation parameter optimization system for neuropathic pain after spinal cord injury according to claim 6, wherein the heart rate dynamics minimum stabilization moment acquisition method comprises the following steps: And traversing all sliding windows, and selecting the sliding window center point corresponding to the minimum value of the variability fluctuation index as the most unstable moment of heart rate dynamics.
8. The infrared light exposure parameter optimization system of claim 1, wherein the identifying the event category of the event to be analyzed based on the response-destabilization time difference and the vago-sympathology response delay comprises: If the response-destabilization time difference is larger than a preset first time difference threshold, judging muscle spasm, if the response-destabilization time difference is not larger than the preset first time difference threshold, and the vage-interaction response delay is larger than a preset second time difference threshold, judging infrared parameters to be improper, and judging other events to be analyzed to be unreliable events.
9. The infrared light irradiation parameter optimization system for neuropathic pain after spinal cord injury according to claim 1, wherein the feedback of the corresponding control command according to the event category of the stress event comprises: if the event type is a muscle spasm event, sending a radiation suspension instruction to the infrared light therapeutic instrument, and feeding back physiological information of a patient in real time; If the event type is an improper event of the infrared light parameters, feeding back a parameter degradation instruction to the infrared light therapeutic instrument; If the event type is an uncertain event, feeding back an irradiation stopping instruction to the infrared light therapeutic instrument and feeding back an alarm prompt.
10. The infrared irradiation parameter optimization system for neuropathic pain after spinal cord injury according to claim 1, further comprising an event statistics comparison analysis module, wherein the event statistics comparison analysis module is used for creating two independent parameter sets for each patient in local storage, the independent parameters comprise an independent unsafe parameter set of the patient and an independent safe parameter set of the patient, the independent unsafe parameter set stores infrared information corresponding to the abnormal event of the infrared parameter, the independent safe parameter set stores infrared information which is not used for feeding back a stress event in a complete treatment process, the set infrared information is compared with the infrared information in the independent parameter set before each new treatment process is started, and optimal infrared information is recommended according to comparison results.

Description

Infrared light irradiation parameter optimization system for neuropathic pain after spinal cord injury Technical Field The invention relates to the technical field of infrared radiation therapy parameter control, in particular to an infrared radiation parameter optimization system for neuropathic pain after spinal cord injury. Background Neuropathic pain after spinal cord injury is a clinically common complication that severely affects the quality of life of the patient. Infrared light irradiation as a non-invasive therapy has shown potential for use in the relief of such pain. However, the parameter settings of existing treatments (e.g., power density, irradiation time) are mostly dependent on general guidelines or clinical experience of the operator, lacking real-time, dynamic regulation of individual status of the patient. This problem is particularly pronounced in high-grade spinal cord injury patients with injury planes at and above the 6 th node of the thoracic medulla, which have a life-threatening complication, autonomic nerve reflex abnormality (Autonomic Dysreflexia, AD). Any stimulus below the plane of the lesion may trigger AD, resulting in a sudden rise in blood pressure, a heart rate disturbance, etc. When infrared light treatment is carried out, at least two potential AD triggering sources exist, namely one is the photo-thermal effect of infrared light irradiation per se, if parameters are improperly set, accumulated heat can form a harmful stimulus, and the other is the frequent concurrent unpredictable sudden muscle spasm of patients, and is a strong AD triggering source. In the current clinical practice, when monitoring abnormal early AD physiological indexes such as heart rate, blood pressure and the like, an operator cannot accurately distinguish the root cause of a risk event by using a non-invasive and simple monitoring means, namely, whether the risk is caused by unsafe infrared light parameters or by an independent spasticity event irrelevant to treatment parameters cannot be judged. The dilemma of causality confusion causes difficulty in intervention decision making, namely that if physiological fluctuation caused by spasm is misjudged as a treatment parameter problem to interrupt treatment, the curative effect is reduced, otherwise, if unsafe treatment parameters are not recognized and adjusted in time, injury to a patient is possibly caused. The prior art relies on subjective experience of the operator or introduces equipment that is complex to operate to aid in monitoring cramps, increasing the complexity and cost of use of the system. Disclosure of Invention In order to solve the technical problem that the cause of a stress event cannot be timely and effectively identified in the process of carrying out infrared light irradiation treatment on a spinal cord injury patient, and further effective control operation cannot be carried out, the invention aims to provide an infrared light irradiation parameter optimization system for neuropathic pain after spinal cord injury, and the adopted technical scheme is as follows: The invention provides an infrared light irradiation parameter optimization system for neuropathic pain after spinal cord injury, which comprises the following components: the transient state characterization module is used for extracting the peripheral perfusion index, heart rate variability and spasm starting impact of the patient at each moment according to the heart rate signal of the patient and the motion signal of the trunk muscle in the infrared light irradiation treatment process; The physiological stress event detection module is used for detecting the initial impact of the cramp as a first priority, detecting the peripheral perfusion index as a second priority and detecting a stress event, and dividing unreliable events and events to be analyzed according to the heart rate variability and the distribution confusion of the peripheral perfusion index in a time period contained by the stress event; The multi-domain feature decoupling module is used for dividing a sympathetic response time period and a vagal response time period in an event to be analyzed and obtaining a vagal-sympathetic response delay, setting a sliding window in the time period of the event to be analyzed, counting a variability fluctuation index of heart rate in the sliding window, and counting the most unstable moment of heart rate dynamics in the event to be analyzed according to the variability fluctuation index, wherein the time interval from the starting moment of the sympathetic response time period to the most unstable moment of heart rate dynamics is used as a response-destabilization time difference, and identifying event types of the event to be analyzed according to the response-destabilization time difference and the vagal-sympathetic response delay, wherein the event types comprise muscle cramps, incorrect infrared parameters and unreliable events; and the infrared parameter co