CN-122006138-A - Dynamic irradiance regulation and control method and system for phototherapy equipment based on neonatal jaundice index

CN122006138ACN 122006138 ACN122006138 ACN 122006138ACN-122006138-A

Abstract

The invention discloses a phototherapy equipment irradiance dynamic regulation and control method and system based on neonatal jaundice index, relates to the field of irradiance dynamic regulation and control, and predicts bilirubin decline rate under ideal conditions by combining with individual baseline characteristics of an infant patient through a preset phototherapy dynamics model. In the treatment process, the real bilirubin decline rate of the infant is monitored and calculated in real time, and the bilirubin decline rate is subjected to differential comparison of physiological response dimension with an expected target value. The current physical attenuation coefficient of the hardware is deduced reversely by using the difference value. And finally, the attenuation coefficient is acted on an original set value, and the driving output of the hardware is corrected in real time by dynamically generating an irradiance compensation command. The method realizes automatic closed-loop regulation from clinical effect evaluation to hardware power compensation, fundamentally eliminates the influence of hardware performance fluctuation on treatment accuracy, and ensures continuous stability and high efficiency of phototherapy irradiance.

Inventors

WANG HONGZHU
JIANG CHUAN
JIANG YANGZHENG
FANG TING
Ma Zongya
QIU LI
PENG LINJING

Assignees

浙江大学医学院附属妇产科医院(浙江省妇女医院、浙江省妇女保健院)

Dates

Publication Date: 20260512
Application Date: 20260413

Claims (10)

1. A phototherapy device irradiance dynamic regulation method based on neonatal jaundice index is characterized by comprising the following steps: S1, acquiring baseline physiological characteristic data and set irradiance of a neonate subject; S2, extracting a neonatal baseline feature set from baseline physiological feature data of a neonatal subject, and estimating expected response of set irradiance based on the neonatal baseline feature set to obtain an expected bilirubin reduction rate in an ideal output state of the equipment without aging; S3, continuously monitoring baseline physiological characteristic data, and when a new bilirubin measured value is detected, performing differential verification and matching on the newly acquired current bilirubin concentration and the current timestamp by utilizing the initial bilirubin concentration and the initial timestamp in the neonatal baseline characteristic set to obtain the neonatal actual bilirubin decline rate; s4, carrying out hardware attenuation coefficient reverse inference on the neonatal actual bilirubin decline rate and the expected bilirubin decline rate to obtain a verified attenuation coefficient; And S5, carrying out irradiance dynamic compensation on the set irradiance based on the verified attenuation coefficient to obtain a compensated irradiance control instruction, and sending the compensated irradiance control instruction to the hardware LED driving module.
2. The neonatal jaundice index-based dynamic regulation of irradiance of phototherapy devices of claim 1, wherein the baseline physiological characteristic data of the neonatal subject includes an initial bilirubin concentration, an initial timestamp, an infant weight, and a risk factor weighting score.
3. The method for dynamically adjusting irradiance of phototherapy equipment based on neonatal jaundice index of claim 1, further comprising performing a safety assessment on the verified attenuation coefficient, and triggering a hardware maintenance early warning signal when the verified attenuation coefficient is below a preset limit tolerance threshold.
4. The method for dynamically adjusting irradiance of phototherapy device based on neonatal jaundice index according to claim 2, wherein step S2 comprises: Characteristic stripping and packaging are carried out on baseline physiological characteristic data of a neonate object through an analysis and extraction means, so that initial bilirubin concentration, initial timestamp, weight of the infant and weighted score of risk factors are extracted, and a baseline characteristic set is generated by packaging; Based on the phototherapy dynamic response model, the baseline feature set and the set irradiance are normalized and the expected response calculated to obtain the expected bilirubin decline rate.
5. The method for dynamically adjusting irradiance of phototherapy device based on neonatal jaundice index according to claim 2, wherein step S3 comprises performing differential verification and matching on the newly obtained current bilirubin concentration and the current timestamp to obtain an actual bilirubin decrease rate of the neonate according to the following formula: Wherein, the For the initial bilirubin concentration, For the current bilirubin concentration, A current timestamp that is a current bilirubin concentration; as an initial timestamp of the initial bilirubin concentration, Is the actual bilirubin decline rate of the neonate.
6. The method for dynamically adjusting irradiance of phototherapy device based on neonatal jaundice index according to claim 1, wherein step S4 comprises: Performing hardware attenuation coefficient initial reverse inference on the neonatal actual bilirubin decline rate and the expected bilirubin decline rate to obtain an original inferred attenuation coefficient; and pressing the original inferred attenuation coefficient into a historical inferred attenuation coefficient queue, and performing sliding average filtering processing on the updated historical inferred queue to obtain the verified attenuation coefficient.
7. The method for dynamic regulation and control of irradiance of phototherapy device based on neonatal jaundice index according to claim 6, wherein performing hardware attenuation coefficient initial reverse inference on the neonatal actual bilirubin decrease rate and the expected bilirubin decrease rate to obtain an initial inferred attenuation coefficient comprises: Comparing the physiological response difference between the actual bilirubin decline rate and the expected bilirubin decline rate of the neonate to obtain a physiological response ratio; and mapping the physical attenuation state of the physiological response ratio and the set irradiance to obtain an original inferred attenuation coefficient.
8. The neonatal jaundice index-based dynamic regulation of irradiance of phototherapy devices of claim 7, wherein the pushing of the original inferred attenuation coefficient into the historical inferred attenuation coefficient queue and the performing of a sliding average filter process on the updated historical inferred queue to obtain the validated attenuation coefficient comprises: Carrying out data push and out-of-range rejection processing on the original inferred attenuation coefficient and the historical inferred attenuation coefficient queue to obtain a historical inferred queue for completing the state updating operation; And based on the sliding average filtering module, physiological noise filtering and physical characteristic curing are carried out on the history inference queue so as to obtain the verified attenuation coefficient.
9. The method for dynamically adjusting irradiance of phototherapy device based on neonatal jaundice index according to claim 1, wherein step S5 comprises: Based on the verified attenuation coefficient and the hardware thermal resistance factor, performing junction temperature rise look-ahead estimation on the set irradiance to obtain a predicted junction temperature rise; Determining a nonlinear correction factor based on the predicted junction temperature rise; Based on the nonlinear correction factor and the verified attenuation coefficient, synthesizing the multidimensional nonlinear control instruction of the set irradiance to obtain a compensated irradiance control instruction.
10. A phototherapy device irradiance dynamic regulation and control system based on neonatal jaundice index, comprising: The neonatal subject data acquisition module is used for acquiring baseline physiological characteristic data and setting irradiance of a neonatal subject; An expected bilirubin decline rate calculation module for extracting a neonatal baseline feature set from baseline physiological feature data of a neonatal subject, and estimating an expected response to the set irradiance based on the neonatal baseline feature set to obtain an expected bilirubin decline rate in an ideal output state of the device without aging; The actual bilirubin decline rate calculation module is used for continuously monitoring baseline physiological characteristic data, and when a new round of bilirubin measured value is detected, utilizing the initial bilirubin concentration and the initial timestamp in the neonatal baseline characteristic set to carry out differential verification and matching on the newly acquired current bilirubin concentration and the current timestamp so as to obtain the neonatal actual bilirubin decline rate; the attenuation coefficient analysis module is used for carrying out hardware attenuation coefficient reverse inference on the actual bilirubin decline rate and the expected bilirubin decline rate of the neonate so as to obtain a verified attenuation coefficient; The irradiance control instruction generation module is used for dynamically compensating the irradiance of the set irradiance based on the verified attenuation coefficient to obtain a compensated irradiance control instruction, and the compensated irradiance control instruction is sent to the hardware LED driving module.

Description

Dynamic irradiance regulation and control method and system for phototherapy equipment based on neonatal jaundice index Technical Field The invention belongs to the field of dynamic irradiance regulation and control, and particularly relates to a dynamic irradiance regulation and control method and system for phototherapy equipment based on neonatal jaundice index. Background Hyperbilirubinemia (jaundice) of newborns is one of the most common clinical problems in neonates, and if not intervened in time, serious neurological damage such as bilirubin encephalopathy may result. Phototherapy is the most commonly used and effective first-line treatment scheme, and the core principle is that isomerization of non-binding bilirubin in skin and mucous membrane is promoted by illumination with specific wavelength, so that bile and urine are discharged out of the body. The effectiveness of phototherapy is directly related to the irradiation intensity (irradiance) and its rate of decrease often depends on the degree of coupling of bilirubin levels to the illumination energy. Therefore, a set of phototherapy equipment irradiance dynamic regulation and control scheme based on neonatal jaundice index is constructed, and has clinical value and industrial application significance for improving treatment efficiency, accurately controlling the reduction rate of serum total bilirubin (TSB) and shortening hospitalization time of the sick infants. In current neonatal phototherapy practice, regulation of irradiance is primarily dependent on preset clinical guidelines. The medical staff usually manually sets or simply selects the output intensity of the light source according to the birth age, weight and day age of the newborn and whether the newborn is accompanied by high risk factors such as hemolysis, infection and the like by referring to a standard phototherapy threshold curve. However, such empirical or fixed threshold based modulation schemes have exposed significant drawbacks in long-term clinical applications. The existing irradiance regulation algorithm generally lacks real-time perception capability of hardware health status of phototherapy equipment, and especially ignores natural attenuation and hardware aging phenomena generated by a light source (such as an LED module) along with the increase of the service time. In departments such as NICU, phototherapy equipment is in a state of high-frequency and long-time continuous operation, and light source attenuation is an unavoidable physical rule. The current solutions are mostly manually calibrated at regular intervals, but during the interval between two maintenance, the set power displayed by the device may deviate significantly from the effective irradiance actually received by the child patient. This implicit energy output reduction results in the clinically frequent occurrence of the phenomenon that the device parameters are displayed normally, but the therapeutic effect of the infant is poor, i.e., the actual bilirubin decline rate of the infant is significantly lower than the expected response at its baseline profile. Because the prior proposal fails to establish a closed loop link of physiological index feedback-hardware attenuation inference-output self-adaptive compensation, the system can not reversely identify the performance degradation of hardware according to the individualized treatment data of the newborn. The lack of hardware performance real-time monitoring and the lack of a self-adaptive compensation mechanism make it difficult for phototherapy equipment to maintain consistent treatment intensity in a full life cycle, and the disconnection of the actual output of the equipment and a set value directly influences the prognosis safety of the infant. Therefore, there is a strong need in the art for a dynamic irradiance regulation scheme that avoids the conventional open loop control limitations, and enables real-time monitoring and adaptive compensation of hardware attenuation to ensure that the phototherapy device can provide a stable and accurate therapeutic dose throughout the life cycle. Disclosure of Invention The invention provides a dynamic irradiance regulation method for phototherapy equipment based on neonatal jaundice index. The phototherapy equipment irradiance dynamic regulation method based on the neonatal jaundice index comprises the following steps of S1, obtaining baseline physiological characteristic data of a neonate object and set irradiance, S2, extracting a neonate baseline characteristic set from the baseline physiological characteristic data of the neonate object, estimating expected response of the set irradiance based on the neonate baseline characteristic set to obtain expected irradiance descending rate in an ideal equipment aging-free output state, S3, continuously monitoring the baseline physiological characteristic data, when a new bilirubin measured value is detected, utilizing initial bilirubin concentration and an initia