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CN-122006291-A - Intelligent switching control method and system for multi-way valve in radionuclide separation

CN122006291ACN 122006291 ACN122006291 ACN 122006291ACN-122006291-A

Abstract

The invention relates to the technical field of radioactive separation control, and discloses an intelligent switching control method and system of a multi-way valve in radionuclide separation, comprising the following steps of 1, pushing inert liquid to calibrate dead volume of a liquid outlet section, and determining quantitative clear line volume and target channel pre-filling volume; step 2, pushing the prewetting liquid according to a preset prewetting volume and a target channel pre-filling volume, step 3, pushing the liquid according to a loading volume, executing a safe flushing volume according to a pressing force signal, step 4, sweeping the first and second leaches according to a quantitative line cleaning volume, step 5, collecting an activity signal to generate an activity window entering signal and an activity window exiting signal, step 6, responding to the signals, switching to a target collecting channel according to an isolation section volume, the quantitative line cleaning volume and the target channel pre-filling volume, and step 7, cleaning, sweeping, resetting a default safe position, and recording a pump accumulated pushing volume. The invention realizes quantitative and time-series management of flow path switching in the radionuclide separation process.

Inventors

  • GU LONG
  • WANG GUAN
  • Su Xingkang

Assignees

  • 福建睿斯科医疗技术有限公司

Dates

Publication Date
20260512
Application Date
20260409

Claims (10)

  1. 1. The intelligent switching control method of the multi-way valve in radionuclide separation is characterized by comprising the following steps of: step 1, switching an outlet multi-way valve to a waste liquid channel, switching an inlet multi-way valve to an inert liquid channel, controlling a pump to push inert liquid, recording dead volume of a liquid outlet section, and determining quantitative clear line volume and target channel pre-filling volume; step 2, switching an inlet multi-way valve to a pre-wetting liquid channel, and keeping a waste liquid channel by an outlet multi-way valve, controlling a pump to push according to a preset pre-wetting volume, and pushing according to a target channel pre-filling volume; Step 3, switching the inlet multi-way valve to a feed liquid channel, and keeping the waste liquid channel by the outlet multi-way valve, controlling the pump to push according to the loading volume, and executing the safe flushing volume according to the pressure signal; step 4, switching the inlet multi-way valve to a first leaching solution channel and a second leaching solution channel in sequence, pushing according to the volume, opening an air source purging valve and purging according to the volume of a quantitative cleaning line; step 5, switching the inlet multi-way valve to a target eluent channel, keeping the outlet multi-way valve in a waste liquid channel, collecting activity signals, calculating the smoothed activity signals, and generating activity window entering signals and activity window exiting signals; Step 6, calling a three-section zero-residue switching unit in response to an activity window entering signal or an activity window exiting signal, and sequentially executing and switching to a target collecting channel according to the volume of the isolation section, the quantitative line clearing volume and the target channel pre-charging volume; And 7, switching the inlet multi-way valve to a cleaning liquid channel after the elution is finished, keeping the waste liquid channel by the outlet multi-way valve, pushing according to the cleaning volume, sweeping according to the quantitative cleaning line volume, resetting to a default safety position, and recording the accumulated pushing volume of the pump.
  2. 2. The method of intelligent switching control of a multi-way valve in radionuclide separation according to claim 1, wherein switching the outlet multi-way valve to the waste liquid channel and the inlet multi-way valve to the inert liquid channel, controlling the pump to push the inert liquid and record dead volume of the liquid outlet section, and determining the quantitative purge volume and the target channel pre-charge volume, comprises: Step 11, switching and maintaining the outlet multi-way valve to a waste liquid channel, switching and maintaining the inlet multi-way valve to an inert liquid channel, determining the initial reading of the accumulated pushing volume of the pump as a volume pushing metering starting point when the valve position signal indicates that the outlet multi-way valve and the inlet multi-way valve are in place, and keeping the valve position signal in place before the dead volume recording of the liquid outlet section is completed; step 12, under the holding condition of step 11, controlling the pump to continuously push inert liquid and collect activity signals, and differentiating the activity signals with the activity probe base line to obtain activity deviation signals, and triggering a criterion event when the activity deviation signals are not smaller than a preset threshold value and continuously reach a preset duration; and 13, reading the dead volume of the liquid outlet section, determining the dead volume as a target channel pre-filling volume, and multiplying the quantitative line clearing multiple by the dead volume of the liquid outlet section to obtain the quantitative line clearing volume, wherein the quantitative line clearing multiple is a pre-stored fixed integer and is unchanged in the same radionuclide separation process.
  3. 3. The method of intelligent switching control of a multi-way valve in radionuclide separation according to claim 1, wherein switching the inlet multi-way valve to a pre-wetting liquid channel and the outlet multi-way valve to hold a waste liquid channel, the control pump advances according to a preset pre-wetting volume and advances according to a target channel pre-filling volume, comprises: Step 21, switching the inlet multi-way valve to a prewetting liquid channel and keeping the outlet multi-way valve in a waste liquid channel, recording the initial reading of the accumulated pushing volume of the pump as the starting point of the prewetting volume when the valve position signal indicates that the inlet multi-way valve and the outlet multi-way valve are in place, and stopping the pump and keeping the outlet multi-way valve in the waste liquid channel when the valve position signal does not indicate that the inlet multi-way valve and the outlet multi-way valve are in place; Step 22, under the valve position maintaining condition of step 21, controlling the pump to push the prewetting liquid according to the preset prewetting volume, subtracting the start point of the prewetting volume push from the current accumulated pump push volume to obtain the prewetting push increment, and ending the push and recording the accumulated pump push volume when the prewetting push increment reaches the preset prewetting volume; And 23, reading the target channel priming volume, recording the accumulated pump propelling volume at the end of the step 22 as a target channel priming volume propelling start point, controlling the pump to continuously propel the prewetting liquid, subtracting the target channel priming volume propelling start point from the current pump accumulated propelling volume to obtain a propelling increment, and finishing propelling and recording the pump accumulated propelling volume when the propelling increment reaches the target channel priming volume.
  4. 4. The intelligent switching control method of a multi-way valve in radionuclide separation according to claim 1, wherein switching the inlet multi-way valve to the feed liquid channel and the outlet multi-way valve to the waste liquid channel, controlling the pump to push according to the loading volume, and executing the safe flushing volume according to the pressure signal, comprises: step 31, switching the inlet multi-way valve to a feed liquid channel and keeping the inlet multi-way valve and keeping the outlet multi-way valve in a waste liquid channel, recording the initial reading of the accumulated pushing volume of the pump as a pushing starting point of the sample loading volume when the valve position signal indicates that the inlet multi-way valve and the outlet multi-way valve are in place, and stopping the pump and keeping the outlet multi-way valve in the waste liquid channel when the valve position signal is not in place; Step 32, under the valve position maintaining condition of step 31, controlling the pump to advance the feed liquid, collecting a pressure signal, and maintaining the continuous measurement of the accumulated pump advance volume during the advance period; and step 33, comparing the pressure signal with the upper limit and the lower limit of the system pressure allowable range, stopping the pushing of the step 32 and keeping the outlet multi-way valve in the waste liquid channel, switching the inlet multi-way valve to the inert liquid channel and keeping the inlet multi-way valve, controlling the pump to push the inert liquid according to the safe flushing volume and recording the accumulated pushing volume of the pump when the pressure signal is larger than the upper limit or smaller than the lower limit of the system pressure allowable range.
  5. 5. The method of intelligent switching control of multi-way valves in radionuclide separation according to claim 1, wherein switching the inlet multi-way valve to the first and second leacheate channels in sequence and advancing by volume, opening the gas source purge valve and performing purging by quantitative purge volume, comprises: Step 41, switching an inlet multi-way valve to a first leacheate channel and keeping the inlet multi-way valve in a waste liquid channel, when a valve position signal indicates that the valve position is in place, recording a starting reading of the accumulated propulsion volume of the pump as a first leacheate propulsion starting point, controlling the pump to propel the first leacheate according to the volume, subtracting the propulsion starting point of the first leacheate from the accumulated propulsion volume of the current pump to obtain propulsion increment, and ending propulsion when the propulsion increment reaches the volume of the first leacheate and recording the accumulated propulsion volume of the pump; Step 42, keeping the outlet multi-way valve in the waste liquid channel, opening the air source purge valve and keeping when the valve position signal indicates in place, controlling the pump to push inert liquid according to the quantitative line cleaning volume and synchronously completing purging, closing the air source purge valve and recording purging records after pushing is completed; And 43, switching an inlet multi-way valve to a second leacheate channel and keeping the inlet multi-way valve in a waste liquid channel, recording the initial reading of the accumulated propulsion volume of the pump as a second leacheate propulsion starting point when a valve position signal indicates that the valve position is in place, controlling the pump to propel the second leacheate according to the volume, subtracting the propulsion starting point of the second leacheate from the current accumulated propulsion volume of the pump to obtain propulsion increment, ending propulsion when the propulsion increment reaches the volume of the second leacheate, recording the accumulated propulsion volume of the pump, then opening an air source purge valve and propelling inert liquid according to the quantitative line cleaning volume to complete purging, closing the air source purge valve and recording the purging record.
  6. 6. The method of claim 1, wherein switching the inlet multi-way valve to the target eluent channel and the outlet multi-way valve to maintain the waste liquid channel, collecting activity signals, calculating smoothed activity signals, and generating activity window entry signals and activity window exit signals comprises: Step 51, switching the inlet multi-way valve to a target eluent channel and keeping the outlet multi-way valve in the waste liquid channel, starting to collect activity signals when the valve position in-place signal indicates that the inlet multi-way valve and the outlet multi-way valve are in place, stopping collecting and keeping the outlet multi-way valve in the waste liquid channel when the valve position in-place signal is not in place, and restarting collecting and re-accounting for threshold keeping time when the valve position in-place signal is restored in place; Step 52, acquiring an activity signal according to a preset sampling period, reading an activity probe baseline, and performing difference between the activity signal and the activity probe baseline to obtain an activity deviation signal; taking the activity deviation signals corresponding to the current sampling time and the continuous preset smooth window length before the current sampling time as a group, accumulating the group of activity deviation signals to obtain a sum, and dividing the sum with the preset smooth window length to obtain a smoothed activity signal; Step 53, reading the product activity window entering threshold, the product activity window exiting threshold and the threshold holding time, starting to accumulate the threshold holding time when the smoothed activity signal is not smaller than the product activity window entering threshold, resetting the accumulation when the condition is not satisfied, generating an activity window entering signal when the accumulation reaches the threshold holding time, and accumulating and generating an activity window exiting signal according to the same rule when the smoothed activity signal is not larger than the product activity window exiting threshold.
  7. 7. The method of claim 1, wherein the steps of invoking the three-stage zero-residual switching unit in response to the activity window entry signal or the activity window exit signal, sequentially executing and switching to the target collection channel according to the isolated-stage volume, the quantitative line clearing volume, and the target channel pre-charge volume comprise: Step 61, reading a valve position in-place signal when an activity window entering signal or an activity window exiting signal appears, calling a three-section type zero-residue switching unit when the valve position in-place signal indicates that the outlet multi-way valve is in place, stopping a pump when the valve position in-place signal is not in place, keeping the outlet multi-way valve in a waste liquid channel, and calling the three-section type zero-residue switching unit when the valve position in-place signal is recovered to be in place; step 62, switching the outlet multi-way valve to a waste liquid channel and keeping, recording the initial reading of the accumulated propulsion volume of the pump as the propulsion starting point of the isolation section, controlling the pump to propel inert liquid, subtracting the propulsion starting point of the isolation section from the current accumulated propulsion volume of the pump to obtain propulsion increment, ending propulsion when the propulsion increment reaches the volume of the isolation section, and recording the accumulated propulsion volume of the pump; and 63, keeping the outlet multi-way valve in the waste liquid channel, opening an air source purge valve, controlling a pump to push inert liquid according to the quantitative line cleaning volume, closing the air source purge valve and stopping the pump when a valve position signal is not in place during purging, closing the air source purge valve after the quantitative line cleaning volume is pushed, switching the outlet multi-way valve to a target collecting channel and keeping the outlet multi-way valve, recording the initial reading of the accumulated pushing volume of the pump as a pushing starting point of the target channel pre-charging volume, controlling the pump to push the inert liquid, subtracting the pushing starting point of the target channel pre-charging volume from the current accumulated pushing volume of the pump to obtain a pushing increment, and ending pushing when the pushing increment reaches the target channel pre-charging volume and recording the accumulated pushing volume of the pump.
  8. 8. The method of intelligent switching control of a multi-way valve in radionuclide separation according to claim 1, wherein switching the inlet multi-way valve to a cleaning liquid channel and the outlet multi-way valve to a waste liquid channel after elution is completed, pushing according to a cleaning volume, purging according to a quantitative cleaning line volume, resetting to a default safety position, and recording a pump accumulated pushing volume, comprises: Step 71, switching the inlet multi-way valve to a cleaning liquid channel and keeping the outlet multi-way valve in a waste liquid channel, recording the initial reading of the accumulated pushing volume of the pump as the pushing starting point of the cleaning volume when the valve position signal indicates that the inlet multi-way valve and the outlet multi-way valve are in place, and stopping the pump and keeping the outlet multi-way valve in the waste liquid channel when the valve position signal is not in place; Step 72, controlling the pump to push the cleaning liquid, subtracting the starting point of the pushing of the cleaning volume from the current accumulated pushing volume of the pump to obtain the pushing increment of the cleaning, and ending pushing and recording the accumulated pushing volume of the pump when the pushing increment of the cleaning reaches the cleaning volume; Step 73, keeping the outlet multi-way valve in the waste liquid channel, opening the air source purge valve, recording the initial reading of the accumulated pushing volume of the pump as the pushing start point of the quantitative clearing line volume, controlling the pump to push inert liquid, subtracting the pushing start point of the quantitative clearing line volume from the current accumulated pushing volume of the pump to obtain pushing increment, ending pushing when the pushing increment reaches the quantitative clearing line volume, closing the air source purge valve, recording the accumulated pushing volume of the pump when the pushing of the quantitative clearing line volume is ended, closing the air source purge valve and stopping the pump when a valve position signal is not in place during purging, resetting the inlet multi-way valve to the inert liquid channel and resetting the outlet multi-way valve to the waste liquid channel as a default safety position, reading the valve position signal to confirm that the valve position signal is in place, and recording the accumulated pushing volume of the pump when the resetting is completed.
  9. 9. The method of claim 1, wherein the generating of the activity window entry signal is stopped after the generating of the activity window entry signal, and the generating of the activity window exit signal is performed only on the smoothed activity signal, and wherein the generating of the activity window exit signal is stopped after the generating of the activity window exit signal, and the generating of the activity window entry signal is performed only on the smoothed activity signal.
  10. 10. An intelligent switching control system for a multi-way valve in radionuclide separation, characterized in that an intelligent switching control method for a multi-way valve in radionuclide separation according to any one of claims 1-9 is adopted, comprising: The dead volume determining module is used for switching the outlet multi-way valve to the waste liquid channel and switching the inlet multi-way valve to the inert liquid channel, controlling the pump to push the inert liquid, recording the dead volume of the liquid outlet section, and determining the quantitative line clearing volume and the target channel pre-filling volume; The prewetting and pre-charging module is used for switching the inlet multi-way valve to the prewetting liquid channel and the outlet multi-way valve to keep the waste liquid channel, and controlling the pump to advance according to the preset prewetting volume and advance according to the pre-charging volume of the target channel; The sampling safety control module is used for switching the inlet multi-way valve to the feed liquid channel and the outlet multi-way valve to keep the waste liquid channel, controlling the pump to push according to the sampling volume and executing the safety flushing volume according to the pressure signal; The sectional leaching line cleaning module is used for sequentially switching the inlet multi-way valve into a first leaching liquid channel and a second leaching liquid channel, pushing the first leaching liquid channel and the second leaching liquid channel according to the volume, opening an air source purging valve and performing purging according to the volume of the quantitative line cleaning; The activity window judging module is used for switching the inlet multi-way valve to a target eluent channel, keeping the outlet multi-way valve in a waste liquid channel, collecting activity signals, calculating the smoothed activity signals, and generating activity window entering signals and activity window exiting signals; the zero-residue switching module is used for calling the three-section zero-residue switching unit in response to the activity window entering signal or the activity window exiting signal, and sequentially executing and switching to the target collecting channel according to the volume of the isolation section, the quantitative line clearing volume and the target channel pre-charging volume; and the end cleaning reset module is used for switching the inlet multi-way valve to the cleaning liquid channel after the elution is finished, keeping the waste liquid channel by the outlet multi-way valve, pushing according to the cleaning volume, sweeping according to the quantitative cleaning line volume, resetting to a default safety position, and recording the accumulated pushing volume of the pump.

Description

Intelligent switching control method and system for multi-way valve in radionuclide separation Technical Field The invention belongs to the technical field of radioactive separation control, and particularly relates to an intelligent switching control method and system of a multi-way valve in radionuclide separation. Background Radionuclide separation technology is widely applied to the fields of nuclear chemistry research, radiopharmaceutical preparation and related nuclear technology. In such processes, the separation of the target radionuclide from the impurity components on the stationary phase medium is typically achieved by separation steps such as adsorption, leaching, elution, and the like. The separation process involves the sequential passing of various liquid media through the separation column or adsorbent material and switching of different flow paths at different stages to accomplish loading, leaching, elution, washing, etc. In the prior art, multi-way valves are commonly used to achieve flow path switching between different sources and different output channels. The switching of the multi-way valve is usually carried out by adopting a preset time control or manual intervention mode, and a volume reference and signal judging mechanism matched with the actual fluid state is lacked. In the actual operation process, because the flow path has the factors of dead volume, residual liquid, pressure fluctuation and the like, the flow path is only dependent on time control or empirical parameters, so that fluid mixing between different stages is easy to occur, and the separation purity of the target radionuclide is influenced. Meanwhile, in the aspect of identification of an elution interval, if stability judgment is not performed by combining the activity signals, the situation that the target collection channel is switched in advance or behind possibly occurs, and the separation effect is reduced. In addition, radionuclide separation processes have high requirements on flow path safety. When pressure abnormality or valve position is not in place, if treatment measures are not taken in time, damage to the separation column or pollution to the flow path may be caused. Disclosure of Invention The invention provides an intelligent switching control method and system for a multi-way valve in radionuclide separation, which solve the technical problems that in the related art, the multi-way valve switching process depends on fixed time or empirical parameter control, a judging mechanism based on the actual volume and activity state of a flow path is lacked, the flow path residue is difficult to eliminate, the inter-stage fluid mixing risk is high, and the switching time of a target collecting channel is inaccurate. The invention provides an intelligent switching control method of a multi-way valve in radionuclide separation, which comprises the following steps: step 1, switching an outlet multi-way valve to a waste liquid channel, switching an inlet multi-way valve to an inert liquid channel, controlling a pump to push inert liquid, recording dead volume of a liquid outlet section, and determining quantitative clear line volume and target channel pre-filling volume; step 2, switching an inlet multi-way valve to a pre-wetting liquid channel, and keeping a waste liquid channel by an outlet multi-way valve, controlling a pump to push according to a preset pre-wetting volume, and pushing according to a target channel pre-filling volume; Step 3, switching the inlet multi-way valve to a feed liquid channel, and keeping the waste liquid channel by the outlet multi-way valve, controlling the pump to push according to the loading volume, and executing the safe flushing volume according to the pressure signal; step 4, switching the inlet multi-way valve to a first leaching solution channel and a second leaching solution channel in sequence, pushing according to the volume, opening an air source purging valve and purging according to the volume of a quantitative cleaning line; step 5, switching the inlet multi-way valve to a target eluent channel, keeping the outlet multi-way valve in a waste liquid channel, collecting activity signals, calculating the smoothed activity signals, and generating activity window entering signals and activity window exiting signals; Step 6, calling a three-section zero-residue switching unit in response to an activity window entering signal or an activity window exiting signal, and sequentially executing and switching to a target collecting channel according to the volume of the isolation section, the quantitative line clearing volume and the target channel pre-charging volume; And 7, switching the inlet multi-way valve to a cleaning liquid channel after the elution is finished, keeping the waste liquid channel by the outlet multi-way valve, pushing according to the cleaning volume, sweeping according to the quantitative cleaning line volume, resetting to a default safety position, and re