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CN-122006684-A - Method and system for synthesizing deterministic material by chiral intervention before nucleation

CN122006684ACN 122006684 ACN122006684 ACN 122006684ACN-122006684-A

Abstract

The invention aims to serve the national strategic emerging industry, and discloses a method and a system for synthesizing a deterministic material by Pre-nucleation chiral intervention (Pre-nucleation Chirality Intervention, PNChI for short), which are applicable to one-dimensional or quasi-one-dimensional material systems (such as carbon nano tubes, biological macromolecules and the like) with formalized chiral labels. Before the irreversible closure nucleation of the precursor is completed, the method realizes the deterministic authorization of the target chiral index (n, m) in a controllable time window through at least one distinguishable physical property-based engineering intervention mechanism (such as physical field regulation, catalytic interface design, information coding guidance and the like) and keeps consistency in subsequent growth. The system comprises a programmable intervention unit and an intelligent sequence control module, and does not depend on a separation or screening step after nucleation. The single chiral index abundance in the obtained material is more than or equal to 95%, preferably more than or equal to 98%. The invention breaks through the statistical limitation of the traditional chiral control, constructs a general synthesis range from 'input instruction' to 'structural output', and is suitable for high-consistency application scenes such as semiconductors, quantum devices, catalysts, biological recognition and the like.

Inventors

  • SI XIFENG
  • LI WANWEN

Assignees

  • 陕西太瓦特热能动力科技有限公司

Dates

Publication Date
20260512
Application Date
20251203

Claims (12)

  1. 1. A method for synthesizing a definite material by chiral intervention before nucleation is characterized in that engineering intervention is carried out on a chiral evolution path of a precursor species through at least one selective intervention mechanism based on distinguishable physical properties of the precursor in a time window before irreversible closed nucleation of the precursor species, so that a target chiral index (n, m) or an equivalent chiral label of the target chiral index (n, m) is determined before nucleation event occurs and consistency is maintained in a subsequent growth process, wherein the method does not depend on a separation, screening or enrichment step after nucleation, and single chiral index abundance in the obtained material is more than or equal to 95%, preferably more than or equal to 98%.
  2. 2. The method of claim 1, wherein the selective intervention mechanism includes, but is not limited to, any one or more of altering the energy landscape of the precursor species, extending the nucleation kinetics timescale, inducing symmetry break, imposing topological constraints, biasing the electronic structure, coupling the external physical field.
  3. 3. The method according to claim 1 or 2, wherein the change of the energy landscape is achieved by regulating the adsorption energy difference between the precursor and the interface, which is not less than 0.3 eV, preferably 0.5-3 eV.
  4. 4. A method according to any of claims 1-3, wherein the prolongation of the nucleation kinetics time scale is achieved by at least one of lowering the system pressure, introducing a retarder, providing a labyrinth transport channel, carrier gas dilution, external field damping or low temperature metastable transport, such that the pre-nucleation intervention time window is actively extended by at least one order of magnitude.
  5. 5. The method of claim 1, wherein the chiral material includes, but is not limited to, one-dimensional or quasi-one-dimensional nanostructures, chiral organic helical polymers, chiral crystals, chiral supramolecular assemblies, and biomacromolecules with formalized chiral labels.
  6. 6. The method of claim 1, wherein the method is such that a deterministic mapping relationship is established between the target chiral indices and the input instructions, and no equivalent technical effect is achieved by any process that omits or bypasses the pre-nucleation intervention step.
  7. 7. A system for performing the method of any one of claims 1 to 6, comprising at least one functional unit for applying programmable intervention to a precursor species before statistical spontaneous nucleation occurs, and an intelligent sequence control module for converting chiral instructions into physically performed actions, the intelligent sequence control module being capable of integrating machine learning, reinforcement learning or generating algorithms to effect adaptive pre-nucleation intervention, the system not comprising post-nucleation chiral separation means.
  8. 8. A chiral material obtainable by the process of any one of claims 1 to 6, wherein the abundance of a single chiral index in the material is greater than or equal to 95%, preferably greater than or equal to 98%, and the performance is independent of post-nucleation sorting processes.
  9. 9. Use of the chiral material of claim 8 in a semiconductor device, a quantum computing element, a high selectivity catalyst, a chiral drug, a biosensor, or a high performance composite.
  10. 10. An equivalent process for realizing chiral deterministic synthesis is characterized in that before statistical spontaneous nucleation occurs, decisive bias on a target chiral index is substantially completed, whether the process explicitly shows ' before nucleation ' intervention ', whether stage division is adopted or what technical names and execution sequences are used is considered as an equivalent embodiment of the invention as long as the equivalent process substantially realizes the normal form transformation of chirality from a statistical result to engineering input variables, and the equivalent process falls into the protection scope of the invention.
  11. 11. The chiral one-dimensional or quasi-one-dimensional material is characterized in that single chiral index abundance is more than or equal to 95%, preferably more than or equal to 98%, and the chiral one-dimensional or quasi-one-dimensional material is obtained by completing chiral decisive bias before statistical spontaneous nucleation occurs, and the topological entropy value of chiral distribution is at least 1 k_B lower than that of the same material obtained by a post-nucleation separation process.
  12. 12. A method for realizing chiral deterministic synthesis in a pre-nucleation time window is characterized in that the characteristic time from an activated state to statistical spontaneous closure nucleation of a precursor is actively extended from less than or equal to 100 ms to more than or equal to 1 second, preferably more than or equal to 10 seconds through physical, chemical or information means, so that an engineering time window is provided for selective intervention based on distinguishable physical properties.

Description

Method and system for synthesizing deterministic material by chiral intervention before nucleation Technical Field The invention aims to serve the national strategic emerging industry, belongs to the field of advanced functional material preparation and intelligent manufacturing intersection, and particularly relates to a method and a system for realizing deterministic synthesis of chiral indexes (n, m) or equivalent chiral labels on an atomic or molecular scale. The method is based on the principle of 'Pre-nucleation chiral intervention' (Pre-nucleation Chirality Intervention, hereinafter commonly referred to as: PNChI), and is applicable to all one-dimensional or quasi-one-dimensional nanostructures with formalized chiral degrees of freedom, including but not limited to carbon nanotubes, boron-nitrogen nanotubes, transition metal sulfide nanotubes, chiral silicon/germanium nanowires, chiral organic nanoribbons, and biomacromolecule assemblies with encodable topological labels. The invention is especially suitable for application scenes of semiconductor, quantum, catalysis and biological identification which need high consistency chiral performance. Background The physical, chemical and biological properties of one-or quasi-one-dimensional chiral materials are highly dependent on their chiral configuration. For example, in single-walled carbon nanotubes (SWCNTs), the chiral index (n, m) directly determines their metallic or semiconducting properties, in DNA duplex, right-hand B-type corresponds to a distinct genetic regulatory behavior with left-hand Z-type conformations, in chiral catalysts, enantioselectivity results from the helical arrangement of the active sites. However, the prior art synthesis generally treats chirality as a byproduct of a statistical nucleation event, relying on high temperature kinetic competition or post-treatment separations (e.g., DNA encapsulation, density gradient centrifugation, chiral chromatography) to enrich for target configurations. Such methods have the fundamental drawbacks: 1. the chiral is not programmable, namely the target chiral cannot be directly given to a synthesis system as an input instruction; 2. the performance is not expandable, the yield and the purity are rapidly degraded along with the amplification of the yield, and a 'non-scalable trap' is formed; 3. The mechanism is not feasible because different material systems (such as carbon tube vs proteins) lack uniform chiral control language, resulting in cleavage of academic terms and fragmentation of technical routes. Although research has been attempted in recent years to improve chiral distribution by means of catalyst crystal plane regulation, external field assistance, template induction, etc., the nature of the method is still to guide preference in the natural topological evolution frame, rather than to force chiral authorization before nucleation. The core limitation is that a time window and a physical mechanism which can be subjected to engineering intervention before irreversible closure into a nucleus are not provided. Further, the nature of chiral control is an engineering constraint of topological freedom. In the traditional synthesis, the system topological entropy S= kBln (Ω 6+Ω5+Ω7) is high, so that multiple configurations coexist, while the ideal chiral synthesis should realize topological entropy reduction, so that the output state is limited to S' = kBln (Ω target). However, how to achieve this negative entropy flow under the framework of the second law of thermodynamics, the prior art does not provide a viable path. Therefore, there is a need for a new paradigm of ubiquitous, compilable, interdisciplinary chiral synthesis that converts chirality from "statistics" to "engineering input variables" and provides a unified basis for methodologies for future full spectrum chiral materials from inorganic nanotubes to biological macromolecules. Disclosure of Invention The invention provides a new model of deterministic material synthesis of chiral intervention before nucleation, which is named as Pre-nucleation Chirality Intervention (hereinafter referred to as PNChI). PNChI is defined as a general chiral control principle that forcibly converts a target chiral index (n, m) or its equivalent chiral label from probabilistic statistics to deterministic engineering input variables through at least one precursor-based distinguishable property selective intervention mechanism within an engineering time window before a statistical spontaneous closure nucleation event occurs in the target chiral structure, and maintains topological consistency during subsequent growth. PNChI the principle is applicable to all one-dimensional or quasi-one-dimensional material systems with formalized chiral degrees of freedom, including but not limited to carbon nanotubes, boron-nitrogen nanotubes, transition metal sulfide nanotubes, chiral organic nanoribbons, chiral silicon/germanium nanowires, and biomacromolecule he