CN-122006831-A - Bubble deceleration ablation structure for microfluidic chip

CN122006831ACN 122006831 ACN122006831 ACN 122006831ACN-122006831-A

Abstract

The invention relates to a bubble deceleration ablation structure for a microfluidic chip, which is characterized by comprising bubble ablation units, wherein the bubble ablation units are respectively provided with a multistage baffling channel, a liquid inlet, an ablation channel, a liquid outlet and partition walls, the liquid inlet is communicated with the liquid inlet of the multistage baffling channel, more than one diversion hole is formed in the baffling wall between the multistage baffling channels, a plurality of parallel micro channels are arranged on the ablation channels along the length direction, the liquid inlet of each micro channel is communicated with the liquid outlet of the multistage baffling channel, the liquid outlets of the micro channels are communicated, adjacent micro channels are separated by the partition walls, a plurality of through holes are formed in each partition wall, and the adjacent micro channels are communicated through the through holes. The device has the advantages that for the condition of larger liquid flow rate, the speed of bubbles can be effectively slowed down, so that the capturing rate of the bubbles is improved, and for smaller liquid flow rate, the resistance can be increased, and the bubble elimination rate is increased.

Inventors

LIANG FEILONG
GUO LIHUA
CHEN FEI
JIANG YUQI
ZHANG MIAOCHUN
XU JIAQI
ZOU ZHEXIANG
MA XUEMIN

Assignees

顺德职业技术大学

Dates

Publication Date: 20260512
Application Date: 20260411

Claims (6)

1. The bubble deceleration ablation structure for the microfluidic chip is characterized by comprising bubble ablation units (1), wherein the bubble ablation units (1) are respectively provided with a bubble deceleration ablation structure The device comprises a multi-stage baffling channel (2) and a liquid inlet (11), wherein the liquid inlet (11) is communicated with a liquid inlet of the multi-stage baffling channel (2), and more than one diversion hole (3) is arranged on a baffling wall (22) between the multi-stage baffling channels (2); the device comprises an ablation channel (4) and a liquid outlet (12), wherein a plurality of parallel micro-channels (5) are arranged on the ablation channel (4) along the length direction, the liquid inlet of each micro-channel (5) is communicated with the liquid outlet of the multistage baffling channel (2), and the liquid outlet of the micro-channel (5) is communicated with the liquid outlet (12); The micro-channel structure comprises partition walls (51), wherein adjacent micro-channels (5) are separated by the partition walls (51), a plurality of through holes (6) are formed in each partition wall (51), and the adjacent micro-channels (5) are communicated through the through holes (6).
2. The bubble deceleration ablation structure for a microfluidic chip according to claim 1, wherein the multi-stage baffling channel (2) has a width of 50-500 μm and a depth of 20-300 μm, the channel has a turning angle, the multi-stage baffling channel (2) between adjacent turns has a length of 0.1mm-1mm, and the ablation channel (4) has a depth of 20-300 μm.
3. The bubble deceleration ablation structure for a microfluidic chip according to claim 1, wherein the cross-sectional area of each microchannel (5) is 50 μm 2 -1mm 2 , the wall thickness of the baffle wall (51) is 2 μm-80 μm, and the flow area of the through hole (6) is 1 μm 2 -10000μm 2 .
4. The bubble capturing and eliminating structure for a microfluidic chip according to claim 1, wherein the bubble dissolving unit (1) is made of materials including, but not limited to, high molecular polymers, silicon and glass.
5. The bubble trapping and eliminating structure for a microfluidic chip according to claim 4, wherein the high molecular polymer includes, but is not limited to, polydimethylsiloxane, polymethyl methacrylate, polycarbonate, polyimide or polystyrene, and the glass includes, but is not limited to, borosilicate glass or quartz glass.
6. The bubble deceleration ablation structure for a microfluidic chip according to claim 1, wherein the number of stages of the multistage baffling channels (2) is 3-8, and the width and depth of each stage of baffling channel are kept consistent.

Description

Bubble deceleration ablation structure for microfluidic chip Technical Field The invention relates to a bubble deceleration ablation structure for a microfluidic chip. Background The microfluidic technology is used as an emerging technology for controlling liquid flow under the micrometer scale, and has the core advantages of small reagent consumption (mu L-nL level), high reaction speed (which is shortened by 50% -80% compared with the traditional method), high integration (which can realize sample pretreatment, reaction and detection integration), small volume and the like, so that the microfluidic technology has become a research hot spot and an industrialization key direction in the fields of biomedicine, chemical analysis, environmental monitoring and the like. In the use process, bubbles are easy to form in a micro-channel in the micro-fluidic technology, the forming reasons comprise experimental sample injection, channel leakage, gas heated release and the like, and as the micro-channel size of a micro-fluidic chip is usually in a micron level, the micro-bubbles can bring a plurality of serious problems once entering the micro-channel, on one hand, the bubbles can occupy the circulation space of the micro-channel, so that liquid flow is blocked, flow is unstable, even flow channels are blocked, the normal operation of the chip is influenced, on the other hand, the existence of the bubbles can interfere the reaction process (such as biomolecular hybridization and enzymatic reaction) and detection signals (such as fluorescence detection and electrochemical detection) in the micro-channel, so that the detection precision and experimental repeatability are reduced, and in addition, the bubbles can impact the inner wall of the micro-channel in the flow process, so that the chip structure is damaged after long-term use, and the service life of the chip is shortened. To solve the above problems, various bubble trapping and eliminating schemes have been developed in the prior art. However, such techniques have the following non-negligible drawbacks: 1. The air bubble capturing probability is low, wherein a single through hole or a burr hole structure can only intercept air bubbles with the size larger than the aperture of a channel (generally more than or equal to 100 mu m), and for small-size air bubbles with the size of 1-100 mu m, the inertia force of the air bubbles along with the flowing of liquid is larger than the surface tension, and the air bubbles can easily pass through the intercepting structure directly, so that the capturing probability is only 60% -70%; 2. The degassing speed is slow, the prior art depends on natural floating (depending on buoyancy) or diffusion dissolution (depending on concentration gradient) of bubbles, the degassing time generally needs 10-30 seconds, and the rapid requirement of instant detection (the single detection time is required to be less than or equal to 15 minutes) cannot be met; 3. the stability is insufficient, part of the structure is easy to cause bubble escape due to the change of liquid flowing pressure, and the channel is easy to be blocked after long-term use, so that the reusability of the device is affected. Therefore, developing a micro-fluidic chip bubble capturing and eliminating structure which has the advantages of simple structure, convenient processing, high bubble capturing efficiency, small liquid flow resistance and suitability for mass production and can effectively eliminate bubbles is a technical problem to be solved in the technical field of the current micro-fluidic chip. Disclosure of Invention The invention aims to overcome the defects of the prior art and provide a bubble deceleration ablation structure for a microfluidic chip, which can effectively slow down the speed of bubbles under the condition of larger liquid flow rate, so that the capture rate of the bubbles is improved, and can increase the resistance and the bubble elimination rate under the condition of smaller liquid flow rate. The present invention is achieved by a bubble capturing and eliminating structure for a microfluidic chip, comprising bubble ablation units, wherein the bubble ablation units are respectively provided with The device comprises a multistage baffling channel and a liquid inlet, wherein the liquid inlet is communicated with a liquid inlet of the multistage baffling channel, and more than one diversion hole is arranged on a baffling wall between the multistage baffling channels; The device comprises an ablation channel and a liquid outlet, wherein a plurality of parallel micro-channels are arranged on the ablation channel along the length direction, and the liquid inlet of each micro-channel is communicated with the liquid outlet of the multistage baffling channel; The micro-channels are separated by the partition walls, a plurality of through holes are formed in each partition wall, and the adjacent micro-channels are communicated through the through ho