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CN-122009591-A - Isolator single-row feeding and in-cabin spacing system

CN122009591ACN 122009591 ACN122009591 ACN 122009591ACN-122009591-A

Abstract

The application relates to a single-row feeding and in-cabin spacing system of an isolator, and relates to the technical field of pharmaceutical production equipment. The system comprises an isolator, a single conveying mechanism and a distance separating mechanism. The wall part of the isolator is provided with a feed inlet, the opening outline of the feed inlet is matched with the outer outline of a single packing material, the single conveying mechanism is used for conveying the packing materials into the isolator in a single-branch arrangement mode along a first direction through the feed inlet in sequence, and the spacing mechanism is arranged in the isolator and is in butt joint with the single conveying mechanism and is configured to arrange the single-branch input packing materials along a second direction intersecting the first direction at preset intervals. According to the application, through single-row feeding and intra-cabin space-apart recombination, the feeding caliber of the isolator is effectively reduced, the internal and external gas exchange is limited to maintain the stability of the negative pressure in the cabin, the risk of toxic substances leakage is reduced, meanwhile, the extrusion and clamping of the packaging material are avoided, and the feeding requirement of a subsequent multi-head filling process is met.

Inventors

  • LU ZHONGMENG
  • WANG LISHENG
  • WANG KAN

Assignees

  • 穆恩制药设备(杭州)有限公司

Dates

Publication Date
20260512
Application Date
20260416

Claims (10)

  1. 1. An isolator single column feed and intrabay separation system comprising: the wall part of the isolator is provided with a feed inlet, and the outline and the size of the opening of the feed inlet are matched with the outline of the single packing material; The single conveying mechanism is configured to convey the packing materials to the inside of the isolator sequentially through the feed inlet in a single-branch arrangement mode along the first direction; The separation mechanism is arranged in the isolator and corresponds to the output end of the single conveying mechanism in space position; the distance separating mechanism is configured to arrange the packing materials which are input through the single-branch arrangement of the feeding holes along a second direction which is different from the first direction according to a preset distance.
  2. 2. The isolator single column feed and intrabay separation system of claim 1, wherein the isolator wall is removably provided with a baffle, the feed inlet opening onto the baffle.
  3. 3. The isolator single column feed and intrabay separation system of claim 2, wherein the bulkheads are replaceable modular structures configured to be replaceable with bulkheads having corresponding opening sizes according to different format packages.
  4. 4. A single column feed and intrabay separation system for an isolator as claimed in claim 2 or claim 3, wherein the baffle is removably disposed within a mousehole of the isolator to at least partially shield the mousehole and form the feed port.
  5. 5. The single column feed and intrabay separation system of claim 1, wherein the edge shape of the feed port comprises a relief notch adapted to the body and/or neck shape of the wrapper, and wherein a predetermined gap is formed between the outer wall of the wrapper and the inner edge of the feed port for restricting gas flow when the wrapper passes through the feed port.
  6. 6. The single-column feeding and in-cabin spacing system of claim 1, wherein the single conveying mechanism comprises a feeding track obliquely arranged downwards along the first direction, one end of the feeding track is positioned outside the isolator, the other end of the feeding track extends into the feeding hole and extends to a feeding area of the spacing mechanism, and the packing materials sequentially slide towards the feeding hole along the feeding track under the action of gravity and/or thrust.
  7. 7. The isolator single column feed and intrabay separation system of claim 6, wherein said single transport mechanism further comprises a propulsion assembly disposed laterally and/or above said feed rail, and wherein a power output of said propulsion assembly is configured to apply a transport driving force to said packs arranged in a single column in said first direction.
  8. 8. The single-column feeding and in-cabin spacing system of the isolator according to claim 1, wherein the spacing mechanism comprises a spacing positioning comb plate and a translation driving assembly, a plurality of positioning grooves are formed in the side wall of the spacing positioning comb plate at intervals along the second direction, the inner wall profile of each positioning groove is matched with the outer wall of each packing material, the center distance between every two adjacent positioning grooves is equal to the preset distance, and the translation driving assembly is in transmission connection with the spacing positioning comb plate and is configured to drive the spacing positioning comb plate to do intermittent translation motion along the second direction so that single packing materials sequentially output through the feeding holes enter the corresponding positioning grooves one by one.
  9. 9. The isolator single column feed and intrabay separation system of claim 8, wherein the separation positioning comb plate is removably mounted to the power take off end of the translational drive assembly by quick release fasteners to serve as a replaceable separation module for replacement matching packing materials of different outside diameter specifications.
  10. 10. The single-column feeding and in-cabin spacing system of the isolator according to claim 9, wherein the translation driving assembly comprises a driving motor, a translation guide shaft arranged along the second direction, a moving seat slidably sleeved on the translation guide shaft, and a synchronous belt transmission mechanism, a power output end of the driving motor is in transmission connection with the moving seat through the synchronous belt transmission mechanism so as to drive the moving seat to slide back and forth along the second direction along the translation guide shaft, and the spacing positioning comb plate is detachably mounted on the moving seat through the quick-release fastener.

Description

Isolator single-row feeding and in-cabin spacing system Technical Field The application relates to the technical field of pharmaceutical equipment, in particular to a single-row feeding and in-cabin spacing system of an isolator. Background In pharmaceutical and high-activity, high-toxicity drug filling processes, it is often necessary to use isolators to maintain the sterility and negative pressure environment of the core filling area to ensure product quality and operator safety. In the conventional packing material feeding process, in order to match with the subsequent multi-head filling process, the packing materials are generally arranged in 5 or 10 rows in advance transversely outside the isolator, and then are integrally sent into the isolator through the rat holes on the side wall of the isolator. However, the conventional multi-column integral feeding method has the unavoidable defects that in order to accommodate the simultaneous passing of multiple columns of packing materials, the size of the opening of the feeding hole on the isolator is inevitably too large, the large opening structure causes extremely difficult establishment and maintenance of the gas pressure difference between the inside and the outside of the isolator (such as between the filling area and the unpacking area), and particularly when the products containing extremely toxic or highly sensitized substances are produced, the excessive feeding gap is extremely easy to cause toxic gas or aerosol in the cabin to leak to the external environment, so that serious potential safety hazards exist. In addition, for the packing material with smaller partial volume, extrusion clamping is easy to occur in a wide feeding channel, and the production efficiency is influenced. Disclosure of Invention In order to solve the problems, the application provides a single-column feeding and in-cabin spacing system of an isolator, which can ensure the continuity of multi-head filling and simultaneously minimize the feeding caliber of the isolator. In order to achieve the above purpose, the single-row feeding and in-cabin spacing system of the isolator comprises: the wall part of the isolator is provided with a feed inlet, and the outline and the size of the opening of the feed inlet are matched with the outline of the single packing material; The single conveying mechanism is configured to convey the packing materials to the inside of the isolator sequentially through the feed inlet in a single-branch arrangement mode along the first direction; The separation mechanism is arranged in the isolator and corresponds to the output end of the single conveying mechanism in space position; the distance separating mechanism is configured to arrange the packing materials which are input through the single-branch arrangement of the feeding holes along a second direction which is different from the first direction according to a preset distance. Preferably, the wall of the separator is detachably provided with a partition plate, and the feed inlet is opened on the partition plate. Preferably, the partition is a replaceable modular structure configured to be replaceable with a partition having a corresponding opening size according to different format of the packing material. Preferably, the baffle is detachably arranged in a rat hole of the isolator so as to at least partially shield the rat hole and form the feed inlet. Preferably, the edge shape of the feed inlet comprises an avoidance gap which is matched with the shape of the bottle body and/or the bottle neck of the packing material, and when the packing material passes through the feed inlet, a preset gap for limiting gas circulation is formed between the outer wall of the packing material and the inner edge of the feed inlet. Preferably, the single conveying mechanism comprises a feeding track which is obliquely arranged downwards along the first direction, one end of the feeding track is positioned outside the isolator, the other end of the feeding track stretches into the feeding hole and extends to a feeding area of the distance separating mechanism, and the packing materials sequentially slide towards the feeding hole along the feeding track under the action of gravity and/or thrust. Preferably, the single conveying mechanism further comprises a pushing assembly, the pushing assembly is arranged on the side and/or the upper side of the feeding track, and the power output end of the pushing assembly is configured to apply conveying driving force to the packing materials arranged in a single row along the first direction. The distance dividing mechanism comprises a distance dividing positioning comb plate and a translation driving assembly, wherein the side wall of the distance dividing positioning comb plate is provided with a plurality of positioning grooves at intervals along the second direction, the outline of the inner wall of each positioning groove is matched with the outline of the outer wall of