CN-122010068-A - Preparation method of water-soluble calcium phosphate

Abstract

The application discloses a preparation method of water-soluble calcium phosphate, which comprises the following steps of S1, respectively preparing a phosphoric acid solution and a calcium carbonate suspension, wherein citric acid and hexametaphosphate are also added into the phosphoric acid solution, S2, mixing the phosphoric acid solution and the calcium carbonate suspension for reaction until the solution is clear, S3, spray-drying to obtain a water-soluble calcium phosphate product. The application has the advantages of simple whole reaction, no redundant waste in the reaction process, good product solubility, high calcium-phosphorus ratio of 2:1, high solubility of more than 9g/100ml water, stable product, wide application field and good application effect, and is not easy to separate out calcium after the solution is placed.

Inventors

• LI PEIJIE
• ZHANG HUIYAN
• SHANG ZHI
• SONG WENCHAO
• BAN YINGYING
• LIU FENGLI
• CHENG YANAN

Assignees

• 河南瑞贝佳生物科技有限公司

Dates

Publication Date

20260512

Application Date

20260123

Claims (8)

1. 1. The preparation method of the water-soluble calcium phosphate is characterized by comprising the following steps of: S1, respectively preparing a phosphoric acid solution and a calcium carbonate suspension, wherein citric acid and hexametaphosphate are also added into the phosphoric acid solution, the addition amount of the citric acid is 1.5-2 times of the molar amount of phosphoric acid in the phosphoric acid solution, and the addition amount of the hexametaphosphate is 0.1-0.3% of the molar amount of phosphoric acid in the phosphoric acid solution; s2, mixing the phosphoric acid solution and the calcium carbonate suspension, and reacting until the solution is clear, wherein the dosage ratio of phosphoric acid to calcium carbonate is 1 (1-1.3); S3, spray drying to obtain a water-soluble calcium phosphate product.
2. 2. The method for producing water-soluble calcium phosphate according to claim 1, wherein, The hexametaphosphate is at least one selected from potassium hexametaphosphate and sodium hexametaphosphate.
3. 3. The method for producing water-soluble calcium phosphate according to claim 1, wherein, The concentration of phosphoric acid in the phosphoric acid solution is 0.3-0.7 mol/L; The concentration of calcium carbonate in the calcium carbonate suspension is 2-4 mol/L.
4. 4. The method for producing water-soluble calcium phosphate according to claim 1, wherein, The phosphoric acid solution is prepared by the following steps: Firstly, adding water to dissolve the citric acid and the phosphoric acid, then adding the hexametaphosphate, and obtaining the phosphoric acid solution after dissolution.
5. 5. The method for producing water-soluble calcium phosphate according to claim 1, wherein, Step S2, slowly adding the calcium carbonate suspension into the phosphoric acid solution.
6. 6. The method for producing water-soluble calcium phosphate according to claim 5, wherein, The adding rate of the calcium carbonate suspension is 2-5 ml/min.
7. 7. The method for producing water-soluble calcium phosphate according to claim 1, wherein, And the reaction time in the step S2 is 20-40 min.
8. 8. The method for producing water-soluble calcium phosphate according to claim 1, wherein, And step S3, the air inlet temperature of spray drying is 140-150 ℃, and the air outlet temperature is 90-100 ℃.

Description

Preparation method of water-soluble calcium phosphate Technical Field The invention belongs to the technical field of food processing, and particularly relates to a preparation method of water-soluble calcium phosphate. Background Calcium can promote bone growth and development, maintain electrolyte balance of human body, maintain normal blood pumping function of heart, and has effect on muscle. The content of phosphorus in human body is inferior to calcium, 85.7% of phosphorus in human body is concentrated in bones and teeth, the rest is distributed in all tissues and body fluids of the whole body, and half of phosphorus exists in muscle tissues, so that the phosphorus not only constitutes human body components, but also participates in very important metabolic processes in life activities, and is an important element of the organism. Calcium and phosphorus are abundant in human body, and form bones and teeth together in the form of hydroxyapatite and the like, and play a key role in physiological processes such as metabolism, signal transduction, energy conversion and the like. Most of the domestic calcium phosphate is insoluble or slightly soluble in water at present, the water-soluble calcium phosphate is unstable and is easy to separate out after being placed for a long time, and the application discloses a synthesis method of water-soluble calcium phosphate, which has significant significance for promoting mass production, industrial synthesis and application of the water-soluble calcium phosphate. Disclosure of Invention The invention aims to overcome the defects of the prior art and provides a preparation method of water-soluble calcium phosphate. In order to achieve the above purpose, the invention adopts the following technical scheme: a method for preparing water-soluble calcium phosphate, comprising the following steps: S1, respectively preparing a phosphoric acid solution and a calcium carbonate suspension, wherein citric acid and hexametaphosphate are also added into the phosphoric acid solution, the addition amount of the citric acid is 1.5-2 times of the molar amount of phosphoric acid in the phosphoric acid solution, and the addition amount of the hexametaphosphate is 0.1-0.3% of the molar amount of phosphoric acid in the phosphoric acid solution; S2, mixing the phosphoric acid solution and the calcium carbonate suspension, and reacting until the solution is clear, wherein the dosage ratio of the phosphoric acid to the calcium carbonate is 1 (1-1.3); S3, spray drying to obtain a water-soluble calcium phosphate product. Preferably, the hexametaphosphate is selected from at least one of potassium hexametaphosphate or sodium hexametaphosphate. Preferably, the concentration of phosphoric acid in the phosphoric acid solution is 0.3-0.7 mol/L; The concentration of calcium carbonate in the calcium carbonate suspension is 2-4 mol/L. Preferably, the phosphoric acid solution is prepared by the steps of: Firstly, adding water to dissolve the citric acid and the phosphoric acid, then adding the hexametaphosphate, and obtaining the phosphoric acid solution after dissolution. Preferably, step S2 adds the calcium carbonate suspension slowly to the phosphoric acid solution. Preferably, the adding rate of the calcium carbonate suspension is 2-5 ml/min. Preferably, the reaction time in the step S2 is 20-40 min. Preferably, in the step S3, the air inlet temperature of spray drying is 140-150 ℃ and the air outlet temperature is 90-100 ℃. The application has the advantages of simple whole reaction, no redundant waste in the reaction process, good product solubility, high calcium-phosphorus ratio of 2:1, high solubility of more than 9g/100ml water, stable product, wide application field and good application effect, and is not easy to separate out calcium after the solution is placed. Detailed Description The application provides a preparation method of water-soluble calcium phosphate, which comprises the following steps: S1, preparing a phosphoric acid solution and a calcium carbonate suspension respectively, wherein citric acid and hexametaphosphate are added into the phosphoric acid solution, the addition amount of the citric acid is 1.5-2 times of the molar amount of phosphoric acid in the phosphoric acid solution, the addition amount of the hexametaphosphate is 0.1-0.3% of the molar amount of phosphoric acid in the phosphoric acid solution, and calcium carbonate is insoluble in water. S2, mixing a phosphoric acid solution and a calcium carbonate suspension for reaction until the solution is clear, wherein the calcium carbonate reaction is proved to be complete, and the dosage ratio of phosphoric acid to calcium carbonate is 1 (1-1.3); phosphoric acid and calcium carbonate can react at normal temperature, and if the reaction is carried out at high temperature, calcium is easy to separate out after heating, so as to form insoluble calcium salt. Under the condition of the reaction proportion of phosphoric acid