CN-122010878-A - Preparation and application of furoic acid and bactericidal composition thereof

Abstract

The invention discloses preparation and application of furoic acid and a bactericidal composition thereof, and relates to the technical field of biological pesticides, wherein the preparation and application comprise the following chemical structural formulas: The furfuroic acid and the bactericidal composition thereof are prepared by adopting the furfuroic acid with a specific structure and the screened specific biological pesticides (kasugamycin, boscalid and ningnanmycin) for scientific compounding, and optimizing and determining the proportion range with obvious synergistic effect (for example, the furoic acid and the kasugamycin are 1:10-10:1), so that each component forms effective complementation on the action mechanism, the defect of single action target point and easy induction of drug resistance of the traditional single pesticide is overcome, and the integral prevention and treatment effect of the composition on various plant diseases (including bacterial, fungal and virus diseases) is remarkably improved.

Inventors

• Ren Mengfan
• ZHANG XIAOYING
• ZHANG YINGLAO
• SHI LEI
• KONG BO
• ZHAO BAOGUO
• MAO MAI
• WANG HONGFENG

Assignees

• 山东蓬勃生物科技有限公司

Dates

Publication Date

20260512

Application Date

20260124

Claims (10)

1. 1. Furoic acid, its characterized in that, the chemical structural formula of furoic acid is: The purity is more than or equal to 98 percent, and the furfurol and sodium hydroxide aqueous solution are mixed with copper oxide, oxygen is introduced at 50 to 60 ℃ for stirring reaction for 4 to 6 hours, and furoic acid is obtained through extraction, acidification, recrystallization and drying.
2. 2. The furoic acid according to claim 1, characterized in that said source is obtained by extraction and separation from the group of harringtoni gracilis or by chemical synthesis.
3. 3. A bactericidal composition suitable for use with furoic acid according to any one of claims 1 to 2, characterized by comprising as active pharmaceutical ingredients furoic acid and one of kasugamycin, boscalid or ningnanmycin, and agropharmaceutically acceptable auxiliary ingredients.
4. 4. The bactericidal composition according to claim 3, wherein the mass ratio of furoic acid to kasugamycin is 1:10-10:1, the mass ratio of boscalid to boscalid is 10:1, and the mass ratio of ningnanmycin to ningnanmycin is 1:5-10:1.
5. 5. The bactericidal composition of claim 3, wherein the mass ratio of furoic acid to kasugamycin is 1:5, 1:1, 1:10, 5:1, 10:1, 1:20, or 20:1, the mass ratio of furoic acid to boscalid is 1:1, 1:5, 1:10, 1:20, 5:1, 10:1, or 20:1, and the mass ratio of furoic acid to ningnanmycin is 1:1, 1:5, 1:10, 1:20, 5:1, 10:1, or 20:1.
6. 6. The bactericidal composition is suitable for preparing the bactericidal composition in any one of claims 3 to 5, and is characterized in that furoic acid and one of kasugamycin, boscalid or ningnanmycin are mixed according to a specified mass ratio, and then auxiliary components acceptable in agriculture and pharmacy are added, and the mixture is uniformly mixed to prepare the applicable pesticide preparation.
7. 7. The method of claim 6, wherein the adjunct ingredients comprise one or more of a carrier, a solvent, a surfactant, a stabilizer, and a dispersant.
8. 8. Use of the fungicidal composition according to any one of claims 3 to 5 for controlling plant diseases.
9. 9. The use of the fungicidal composition according to claim 8, wherein the plant disease comprises bacterial leaf blight of rice, scab of wheat, or tobacco mosaic virus.
10. 10. Use of a fungicidal composition according to claim 8, wherein the fungicidal composition is applied to the surface of a plant by spraying, painting or dipping.

Description

Preparation and application of furoic acid and bactericidal composition thereof Technical Field The invention relates to the technical field of biological pesticides, in particular to preparation and application of a furoic acid and a bactericidal composition thereof. Background Under the large background of sustainable development of agriculture, biopesticide gradually becomes an important direction of plant disease management due to the advantages of good environmental compatibility, safety to non-target organisms, difficulty in inducing drug resistance and the like, scientists find that the control effect can be remarkably improved and the drug resistance development can be delayed by compounding biopesticide with different action mechanisms along with deep research on plant-pathogenic bacteria interaction mechanisms in recent years, and the strategy is based on a synergistic principle, namely, the complementarity of each component on an action target point, permeability or metabolic pathway is utilized, so that more efficient and durable disease control than single agent is realized. However, in the prior art, how to scientifically screen the compound components and accurately determine the proportion thereof so as to realize broad-spectrum synergistic control for a plurality of pathogens, the problem faced by the current biological pesticide compounding technology is that the lack of scientific basis for optimizing the proportion leads to unstable synergistic effect, and the existing compound products depend on experiences or simple experiments to determine the proportion, so that the interaction mechanism of each component on the molecular level cannot be fully revealed, and the compound system is difficult to consider the effective inhibition of different types of pathogens such as bacteria, fungi and viruses in practical application, for example, part of compound products can improve the control effect on a certain type of pathogens, but can reduce the activity of other pathogens even cause antagonism due to unreasonable proportion, and moreover, the unscientific proportion can also lead to increased pesticide use amount, thereby not only increasing the cost, but also aggravate the environmental pollution and the risk of non-target organisms, so that the compound system needs to be improved. Disclosure of Invention The invention aims to provide preparation and application of furoic acid and a bactericidal composition thereof, and aims to solve the problems that the lack of scientific basis for the compounding ratio of biological pesticides in the prior art leads to unstable synergistic effect and is difficult to realize broad-spectrum efficient control. In order to achieve the purpose, the invention provides the following technical scheme that furoic acid has the chemical structural formula: The purity is more than or equal to 98 percent, and the furfurol and sodium hydroxide aqueous solution are mixed with copper oxide, oxygen is introduced at 50 to 60 ℃ for stirring reaction for 4 to 6 hours, and furoic acid is obtained through extraction, acidification, recrystallization and drying. Further, the source is obtained by extraction and separation or chemical synthesis from the harrow tooth bacteria. The bactericidal composition comprises furoic acid and one of kasugamycin, boscalid or ningnanmycin as an effective medicinal component and an auxiliary component acceptable in agriculture and pharmacy. Further, the mass ratio of the furoic acid to the kasugamycin is 1:10-10:1, the mass ratio of the furoic acid to the boscalid is 10:1, and the mass ratio of the boscalid to the ningnanmycin is 1:5-10:1. Further, the mass ratio of the furoic acid to the kasugamycin is 1:5, 1:1, 1:10, 5:1, 10:1, 1:20 or 20:1, the mass ratio of the furoic acid to the boscalid is 1:1, 1:5, 1:10, 1:20, 5:1, 10:1 or 20:1, and the mass ratio of the furoic acid to the ningnanmycin is 1:1, 1:5, 1:10, 1:20, 5:1, 10:1 or 20:1. The bactericidal composition is prepared by mixing furoic acid with one of kasugamycin, boscalid or ningnanmycin according to a specified mass ratio, adding auxiliary components acceptable in agriculture and pharmacy, and uniformly mixing to prepare the applicable pesticide preparation. Further, the auxiliary component comprises one or more of a carrier, a solvent, a surfactant, a stabilizer and a dispersing agent. The application of the bactericidal composition in preventing and controlling plant diseases. Further, the plant diseases include bacterial leaf blight of rice, wheat scab or tobacco mosaic virus. Further, the bactericidal composition is applied to the plant surface by spraying, painting or dipping. Compared with the prior art, the preparation and application of the furoic acid and the bactericidal composition thereof provided by the invention have the advantages that the furoic acid with a specific structure and the screened specific biological pesticides (kasugamycin, boscalid and ningnanmycin) are